메뉴 건너뛰기




Volumn 48, Issue 2-3, 2015, Pages 226-235

Emperipolesis Mediated by CD8 T Cells Is a Characteristic Histopathologic Feature of Autoimmune Hepatitis

Author keywords

Autoimmune hepatitis; Autoimmune liver disease; Chronic hepatitis; Emperipolesis; Hepatocyte injury; Inflammation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3;

EID: 84928123243     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-014-8432-0     Document Type: Article
Times cited : (76)

References (36)
  • 1
    • 84896711879 scopus 로고    scopus 로고
    • Autoimmune hepatitis: 50 years of (slow) progress
    • PID: 24712041
    • Gershwin M, Krawitt E (2014) Autoimmune hepatitis: 50 years of (slow) progress. Hepatology 59:754–756
    • (2014) Hepatology , vol.59 , pp. 754-756
    • Gershwin, M.1    Krawitt, E.2
  • 2
    • 77952711598 scopus 로고    scopus 로고
    • Diagnosis and management of autoimmune hepatitis
    • COI: 1:CAS:528:DC%2BC3cXnslyqtbc%3D, PID: 20513004
    • Manns MP, Czaja AJ, Gorham JD et al (2010) Diagnosis and management of autoimmune hepatitis. Hepatology 51(6):2193–2213
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 2193-2213
    • Manns, M.P.1    Czaja, A.J.2    Gorham, J.D.3
  • 3
    • 79958826525 scopus 로고    scopus 로고
    • Autoimmune hepatitis
    • COI: 1:CAS:528:DC%2BC3MXnslehtL8%3D, PID: 21167232
    • Lohse AW, Mieli-Vergani G (2011) Autoimmune hepatitis. J Hepatol 55(1):171–182
    • (2011) J Hepatol , vol.55 , Issue.1 , pp. 171-182
    • Lohse, A.W.1    Mieli-Vergani, G.2
  • 4
    • 78751569585 scopus 로고    scopus 로고
    • Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients
    • PID: 21056494
    • Qiu D, Wang Q, Wang H et al (2011) Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. J Hepatol 54(2):340–347
    • (2011) J Hepatol , vol.54 , Issue.2 , pp. 340-347
    • Qiu, D.1    Wang, Q.2    Wang, H.3
  • 5
    • 75149198542 scopus 로고    scopus 로고
    • Aetiopathogenesis of autoimmune hepatitis
    • COI: 1:CAS:528:DC%2BC3cXhtlGjsbc%3D, PID: 19766456
    • Longhi MS, Ma Y, Mieli-Vergani G, Vergani D (2010) Aetiopathogenesis of autoimmune hepatitis. J Autoimmun 34(1):7–14
    • (2010) J Autoimmun , vol.34 , Issue.1 , pp. 7-14
    • Longhi, M.S.1    Ma, Y.2    Mieli-Vergani, G.3    Vergani, D.4
  • 6
    • 84855923011 scopus 로고    scopus 로고
    • Current trends in the diagnosis and treatment of autoimmune hepatitis in Japan
    • COI: 1:CAS:528:DC%2BC38XjvVaksro%3D, PID: 22044759
    • Ohira H, Takahashi A (2012) Current trends in the diagnosis and treatment of autoimmune hepatitis in Japan. Hepatol Res 42(2):131–138
    • (2012) Hepatol Res , vol.42 , Issue.2 , pp. 131-138
    • Ohira, H.1    Takahashi, A.2
  • 7
    • 0024575618 scopus 로고
    • Viral and autoimmune hepatitis. Morphologic and pathogenetic aspects of cell damage in hepatitis with potential chronicity
    • COI: 1:STN:280:DyaL1M3mvFSktQ%3D%3D, PID: 2524940
    • Dienes HP (1989) Viral and autoimmune hepatitis. Morphologic and pathogenetic aspects of cell damage in hepatitis with potential chronicity. Veroff Pathol 132:1–107
    • (1989) Veroff Pathol , vol.132 , pp. 1-107
    • Dienes, H.P.1
  • 8
    • 0032718310 scopus 로고    scopus 로고
    • International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis
    • COI: 1:STN:280:DC%2BD3c%2Fks1Ggug%3D%3D, PID: 10580593
    • Alvarez F, Berg PA, Bianchi FB et al (1999) International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 31(5):929–938
    • (1999) J Hepatol , vol.31 , Issue.5 , pp. 929-938
    • Alvarez, F.1    Berg, P.A.2    Bianchi, F.B.3
  • 9
    • 47149112922 scopus 로고    scopus 로고
    • Simplified criteria for the diagnosis of autoimmune hepatitis
    • PID: 18537184
    • Hennes EM, Zeniya M, Czaja AJ et al (2008) Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 48(1):169–176
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 169-176
    • Hennes, E.M.1    Zeniya, M.2    Czaja, A.J.3
  • 10
    • 0029039362 scopus 로고
    • Histological grading and staging of chronic hepatitis
    • COI: 1:STN:280:DyaK28%2FjsFWntw%3D%3D, PID: 7560864
    • Ishak K, Baptista A, Bianchi L et al (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22(6):696–699
    • (1995) J Hepatol , vol.22 , Issue.6 , pp. 696-699
    • Ishak, K.1    Baptista, A.2    Bianchi, L.3
  • 11
    • 84893699696 scopus 로고    scopus 로고
    • Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations
    • PID: 24037963
    • Kleiner DE, Chalasani NP, Lee WM et al (2014) Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations. Hepatology 59(2):661–670
    • (2014) Hepatology , vol.59 , Issue.2 , pp. 661-670
    • Kleiner, D.E.1    Chalasani, N.P.2    Lee, W.M.3
  • 12
    • 80052023773 scopus 로고    scopus 로고
    • The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury
    • PID: 21674554
    • Suzuki A, Brunt EM, Kleiner DE et al (2011) The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury. Hepatology 54(3):931–939
    • (2011) Hepatology , vol.54 , Issue.3 , pp. 931-939
    • Suzuki, A.1    Brunt, E.M.2    Kleiner, D.E.3
  • 13
    • 0001438906 scopus 로고
    • Biological interaction between lymphocytes and other cells
    • COI: 1:STN:280:DyaG28%2FpsFSrtw%3D%3D, PID: 13342362
    • Humble JG, Jayne WH, Pulvertaft RJ (1956) Biological interaction between lymphocytes and other cells. Br J Haematol 2(3):283–294
    • (1956) Br J Haematol , vol.2 , Issue.3 , pp. 283-294
    • Humble, J.G.1    Jayne, W.H.2    Pulvertaft, R.J.3
  • 14
    • 52449135089 scopus 로고    scopus 로고
    • The cell biology of cell-in-cell structures
    • COI: 1:CAS:528:DC%2BD1cXhtFGhsLrL, PID: 18784728
    • Overholtzer M, Brugge JS (2008) The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol 9(10):796–809
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.10 , pp. 796-809
    • Overholtzer, M.1    Brugge, J.S.2
  • 15
    • 0014772217 scopus 로고
    • Emperipolesis of granular leukocytes within megakaryocytes in human hemopoietic bone marrow
    • COI: 1:STN:280:DyaE3c7osFOgtw%3D%3D, PID: 5444722
    • Larsen TE (1970) Emperipolesis of granular leukocytes within megakaryocytes in human hemopoietic bone marrow. Am J Clin Pathol 53(4):485–489
    • (1970) Am J Clin Pathol , vol.53 , Issue.4 , pp. 485-489
    • Larsen, T.E.1
  • 16
    • 0036738222 scopus 로고    scopus 로고
    • Emperipolesis in a common breast malignancy. A case report
    • PID: 12365224
    • Saxena S, Beena KR, Bansal A, Bhatnagar A (2002) Emperipolesis in a common breast malignancy. A case report. Acta Cytol 46(5):883–886
    • (2002) Acta Cytol , vol.46 , Issue.5 , pp. 883-886
    • Saxena, S.1    Beena, K.R.2    Bansal, A.3    Bhatnagar, A.4
  • 18
    • 0018152153 scopus 로고
    • Lymphocyte emperipolesis revisited: I. Development of in vitro assay and preliminary characterisation of the lymphocyte subpopulation involved
    • COI: 1:STN:280:DyaE1M7ntF2gsg%3D%3D, PID: 312253
    • Sandilands GP, Reid FM, Gray KG, Anderson JR (1978) Lymphocyte emperipolesis revisited: I. Development of in vitro assay and preliminary characterisation of the lymphocyte subpopulation involved. Immunology 35(2):381–389
    • (1978) Immunology , vol.35 , Issue.2 , pp. 381-389
    • Sandilands, G.P.1    Reid, F.M.2    Gray, K.G.3    Anderson, J.R.4
  • 19
    • 84875541118 scopus 로고    scopus 로고
    • Prevalence of heterotypic tumor/immune cell-in-cell structure in vitro and in vivo leading to formation of aneuploidy
    • COI: 1:CAS:528:DC%2BC3sXmtVentrs%3D, PID: 23555668
    • Chen YH, Wang S, He MF et al (2013) Prevalence of heterotypic tumor/immune cell-in-cell structure in vitro and in vivo leading to formation of aneuploidy. PLoS One 8(3):e59418
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e59418
    • Chen, Y.H.1    Wang, S.2    He, M.F.3
  • 20
    • 77955974851 scopus 로고    scopus 로고
    • Cell-in-cell structures formed between human cancer cell lines and the cytotoxic regulatory T-cell line HOZOT
    • COI: 1:CAS:528:DC%2BC3cXot1erurc%3D, PID: 20348186
    • Takeuchi M, Inoue T, Otani T, Yamasaki F, Nakamura S, Kibata M (2010) Cell-in-cell structures formed between human cancer cell lines and the cytotoxic regulatory T-cell line HOZOT. J Mol Cell Biol 2(3):139–151
    • (2010) J Mol Cell Biol , vol.2 , Issue.3 , pp. 139-151
    • Takeuchi, M.1    Inoue, T.2    Otani, T.3    Yamasaki, F.4    Nakamura, S.5    Kibata, M.6
  • 21
    • 20244363654 scopus 로고    scopus 로고
    • Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells
    • COI: 1:CAS:528:DC%2BD2MXjtlOrs7Y%3D, PID: 15809309
    • Tamura A, Kikuchi S, Hata M et al (2005) Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol 169(1):21–28
    • (2005) J Cell Biol , vol.169 , Issue.1 , pp. 21-28
    • Tamura, A.1    Kikuchi, S.2    Hata, M.3
  • 22
    • 0030880876 scopus 로고    scopus 로고
    • Adhesion molecule LFA-1/ICAM-1 influences on LPS-induced megakaryocytic emperipolesis in the rat bone marrow
    • COI: 1:CAS:528:DyaK2sXmtlCksrc%3D, PID: 9381658
    • Tanaka M, Aze Y, Fujita T (1997) Adhesion molecule LFA-1/ICAM-1 influences on LPS-induced megakaryocytic emperipolesis in the rat bone marrow. Vet Pathol 34(5):463–466
    • (1997) Vet Pathol , vol.34 , Issue.5 , pp. 463-466
    • Tanaka, M.1    Aze, Y.2    Fujita, T.3
  • 23
    • 0018512151 scopus 로고
    • Emperipolesis as a cancer antagonism: report of 2 cases
    • COI: 1:STN:280:DyaL3c%2FotFCqsg%3D%3D, PID: 515723
    • Okuyama S, Mishina H, Yamamoto K, Matsuzawa T (1979) Emperipolesis as a cancer antagonism: report of 2 cases. Sci Rep Res Inst Tohoku Univ Med 26(1–2):11–17
    • (1979) Sci Rep Res Inst Tohoku Univ Med , vol.26 , Issue.1-2 , pp. 11-17
    • Okuyama, S.1    Mishina, H.2    Yamamoto, K.3    Matsuzawa, T.4
  • 24
    • 46749125139 scopus 로고
    • Mechanisms of natural killer cell-mediated tumor cell cytolysis at a single cell level
    • COI: 1:STN:280:DyaL1c%2Fpslemtg%3D%3D
    • Wang X, Li W (1987) Mechanisms of natural killer cell-mediated tumor cell cytolysis at a single cell level. J Med Coll PLA 2:107–117
    • (1987) J Med Coll PLA , vol.2 , pp. 107-117
    • Wang, X.1    Li, W.2
  • 25
    • 71749094873 scopus 로고    scopus 로고
    • Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death
    • COI: 1:CAS:528:DC%2BD1MXhsFSgsrnI, PID: 19786985
    • Wang S, Guo Z, Xia P et al (2009) Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death. Cell Res 19(12):1350–1362
    • (2009) Cell Res , vol.19 , Issue.12 , pp. 1350-1362
    • Wang, S.1    Guo, Z.2    Xia, P.3
  • 26
    • 84860352883 scopus 로고    scopus 로고
    • Emperipolesis: an additional common histopathologic finding in H syndrome and Rosai–Dorfman disease
    • PID: 22356918
    • Colmenero I, Molho-Pessach V, Torrelo A, Zlotogorski A, Requena L (2012) Emperipolesis: an additional common histopathologic finding in H syndrome and Rosai–Dorfman disease. Am J Dermatopathol 34(3):315–320
    • (2012) Am J Dermatopathol , vol.34 , Issue.3 , pp. 315-320
    • Colmenero, I.1    Molho-Pessach, V.2    Torrelo, A.3    Zlotogorski, A.4    Requena, L.5
  • 27
    • 0020123981 scopus 로고
    • Emperipolesis by megakaryocytes in patients with non-Hodgkin's lymphoma and megaloblastic anemia
    • COI: 1:STN:280:DyaL387pt1Ghsg%3D%3D, PID: 7077719
    • Djaldetti M, Strauss Z (1982) Emperipolesis by megakaryocytes in patients with non-Hodgkin's lymphoma and megaloblastic anemia. J Submicrosc Cytol 14(2):407–413
    • (1982) J Submicrosc Cytol , vol.14 , Issue.2 , pp. 407-413
    • Djaldetti, M.1    Strauss, Z.2
  • 28
    • 84873410522 scopus 로고    scopus 로고
    • Significance of histopathological features in differentiating autoimmune liver disease from nonautoimmune chronic liver disease in children
    • PID: 23085577
    • Kumari N, Kathuria R, Srivastav A, Krishnani N, Poddar U, Yachha SK (2013) Significance of histopathological features in differentiating autoimmune liver disease from nonautoimmune chronic liver disease in children. Eur J Gastroenterol Hepatol 25(3):333–337
    • (2013) Eur J Gastroenterol Hepatol , vol.25 , Issue.3 , pp. 333-337
    • Kumari, N.1    Kathuria, R.2    Srivastav, A.3    Krishnani, N.4    Poddar, U.5    Yachha, S.K.6
  • 29
    • 84889590671 scopus 로고    scopus 로고
    • Cytomorphological and morphometric analysis of 22 cases of Rosai–Dorfman disease: a large series from a tertiary care centre
    • PID: 24192148
    • Mallick S, Ghosh R, Iyer VK, Jain D, Mathur SR (2013) Cytomorphological and morphometric analysis of 22 cases of Rosai–Dorfman disease: a large series from a tertiary care centre. Acta Cytol 57(6):625–632
    • (2013) Acta Cytol , vol.57 , Issue.6 , pp. 625-632
    • Mallick, S.1    Ghosh, R.2    Iyer, V.K.3    Jain, D.4    Mathur, S.R.5
  • 30
    • 84877155663 scopus 로고    scopus 로고
    • Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes
    • COI: 1:CAS:528:DC%2BC38Xhs1aqtr%2FI, PID: 23137675
    • Chabot S, Fakhfakh A, Beland K et al (2013) Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes. J Autoimmun 42:19–28
    • (2013) J Autoimmun , vol.42 , pp. 19-28
    • Chabot, S.1    Fakhfakh, A.2    Beland, K.3
  • 31
    • 34249895621 scopus 로고    scopus 로고
    • Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2
    • COI: 1:CAS:528:DC%2BD2sXhtVSisb%2FF, PID: 17559153
    • Longhi MS, Hussain MJ, Bogdanos DP et al (2007) Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2. Hepatology 46(2):472–484
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 472-484
    • Longhi, M.S.1    Hussain, M.J.2    Bogdanos, D.P.3
  • 32
    • 0025675497 scopus 로고
    • T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
    • COI: 1:STN:280:DyaK3M%2Fntl2htg%3D%3D, PID: 1979365
    • Wen L, Peakman M, Lobo-Yeo A et al (1990) T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. Lancet 336(8730):1527–1530
    • (1990) Lancet , vol.336 , Issue.8730 , pp. 1527-1530
    • Wen, L.1    Peakman, M.2    Lobo-Yeo, A.3
  • 33
    • 0023954929 scopus 로고
    • An immunogenetic study of suppressor cell activity in autoimmune chronic active hepatitis
    • COI: 1:STN:280:DyaL1c7htVSqsw%3D%3D, PID: 2962795
    • Krawitt EL, Kilby AE, Albertini RJ et al (1988) An immunogenetic study of suppressor cell activity in autoimmune chronic active hepatitis. Clin Immunol Immunopathol 46(2):249–257
    • (1988) Clin Immunol Immunopathol , vol.46 , Issue.2 , pp. 249-257
    • Krawitt, E.L.1    Kilby, A.E.2    Albertini, R.J.3
  • 34
    • 84877115410 scopus 로고    scopus 로고
    • Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis
    • COI: 1:CAS:528:DC%2BC38XhslCrs7vK, PID: 23200317
    • Ehser J, Holdener M, Christen S et al (2013) Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis. J Autoimmun 42:39–49
    • (2013) J Autoimmun , vol.42 , pp. 39-49
    • Ehser, J.1    Holdener, M.2    Christen, S.3
  • 35
    • 80855148161 scopus 로고    scopus 로고
    • Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model
    • COI: 1:CAS:528:DC%2BC3MXhsVOltLzO, PID: 21795021
    • Hintermann E, Holdener M, Bayer M et al (2011) Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. J Autoimmun 37(3):242–253
    • (2011) J Autoimmun , vol.37 , Issue.3 , pp. 242-253
    • Hintermann, E.1    Holdener, M.2    Bayer, M.3
  • 36
    • 80053653657 scopus 로고    scopus 로고
    • Hepatocyte entry leads to degradation of autoreactive CD8 T cells
    • COI: 1:CAS:528:DC%2BC3MXhtlWksrbE, PID: 21933957
    • Benseler V, Warren A, Vo M et al (2011) Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc Natl Acad Sci U S A 108(40):16735–16740
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.40 , pp. 16735-16740
    • Benseler, V.1    Warren, A.2    Vo, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.