Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death

Cell Research

Volumn 19, Issue 12, 2009, Pages 1350-1362

  Wang, Shan ^a,b   Guo, Zhen ^c   Xia, Peng ^c   Liu, Tingting ^a   Wang, Jufang ^a   Li, Shan ^a   Sun, Lihua ^a   Lu, Jianxin ^b   Wen, Qian ^d   Zhou, Mingqian ^d   Ma, Li ^d   Ding, Xia ^e   Wang, Xiaoning ^a,b,d   Yao, Xuebiao ^c  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d Nanfang Medical University   (China)

^e BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Adherent junction; Entosis; Ezrin; NK cells; Tumor cells

Indexed keywords

ACTIN; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOSKELETON PROTEIN; ENZYME INHIBITOR; EZRIN; PEPTIDE CHLOROMETHYL KETONE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CYTOLOGY; CYTOSKELETON; DNA FRAGMENTATION; DOWN REGULATION; ENDOCYTOSIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMAGE PROCESSING; IMMUNOLOGY; METABOLISM; NATURAL KILLER CELL; NEOPLASM; PHAGOCYTOSIS; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

ACTINS; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETAL PROTEINS; CYTOSKELETON; DNA FRAGMENTATION; DOWN-REGULATION; ENDOCYTOSIS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KILLER CELLS, NATURAL; NEOPLASMS; PHAGOCYTOSIS; PHOSPHORYLATION; RNA, SMALL INTERFERING;

EID: 71749094873     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2009.114     Document Type: Article

References (25)

1. Lewis WH. The engulfment of living blood cells by others of the same type. Anat Rec 1925; 31:43-49.
2. Humble JG, Jayne WHW, Pulvertaft RJV. Biological interaction between lymphocytes and other cells. Br J Haematol 1956; 2:283-294.
3. Reid FM, Sandilands GP, Gray KG, Anderson JR. Lymphocyte emperipolesis revisited. II. Further characterization of the lymphocyte sub-population involved. Immunol 1979; 36:267-372.
4. Overholtzer M, Mailleux AA, Mouneimne G, et al. A nonapoptotic cell death process, entosis, that occurs by cell-incell invasion. Cell 2007; 131:966-979.
5. Wang X, Li W. Mechanisms of natural killer cell-mediated tumor cell cytolysis at a single cell level. J Med Col PLA 1987; 2:107-117.
6. P Xia, S Wang, Z Guo, et al. Emperipolesis, entosis and beyond: dance with fate. Cell Res 2008; 18:705-707.
7. Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002; 3:586-599
8. Yao X, Cheng L, Forte JG. Characterization of the interaction of gastric ezrin with actin. J Biol Chem 1996; 271:7224-7229.
9. Zhou R, Cao X, Watson C, et al. Characterization of PKAmediated phosphorylation of ezrin in gastric parietal cell activation. J Biol Chem 2003; 278:35651-35659.
10. Zhou R, Zhu L, Kodani A, et al. Phosphorylation of ezrin on threonine 567 produces a change in secretory phenotype and repolarizes the gastric parietal cell. J Cell Sci 2005; 118:4381-4391.
11. Tamura A, Kikuchi S, Hata M, et al. Achlorhydria by ezrin knockdown: defects in the formation/ expansion of apical canaliculi in gastric parietal cells. J Cell Biol 2005; 169:1-8.
12. Helander TS, Carpen O, Turunen O, et al. ICAM-2 redistributed by ezrin as a target for killer cells Nature 1996; 382:265-269.
13. Ramoni C, Luciani F, Spadaro F, et al. Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells. Eur J Immunol 2002, 32:11:3059-3065.
14. Hunter T and Cooper JA. Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell 1981; 24:741-752.
15. Adams CL, Chen YT, Smith SJ, Nelson WJ. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J Cell Biol 1998; 142:1105-1119.
16. Davis DM. Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response. Nat Rev Immunol 2007; 7:238-243.
17. Lugini L, Matarrese P, Tinari A, et al. Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Cancer Res 2006; 66:3629-3638.
18. Fais S. Cannibalism: a way to feed on metastatic tumors. Cancer Lett 2007; 258:155-164.
19. De Milito A, Iessi E, Logozzi M, et al. Proton pump inhibitors induce apoptosis of human b-cell tumors through a caspaseindependent mechanism involving reactive oxygen species. Cancer Res 2007; 67:5408-5417.
20. Liu D, Ge L, Wang F, et al. Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation. FEBS Lett 2007; 581:3563-3571
21. Khanna C, Wan X, Bose S, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 2004; 10:182-186.
22. Ren L, Hong SH, Cassavaugh J, et al. The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene 2009; 28:792-802.
23. Cao X, Ding X, Guo Z, et al. PALS1 specifies the apical localization of ezrin in gastric prietal cells. J Biol Chem 2006; 280:13584-13592.
24. Yao X, Zheng Y, Sullivan KF, et al. CENP-E forms a link between attachment of spindle microtubules to kinetochore and the mitotic checkpoint. Nat Cell Biol 2000; 2:484-491.
25. Yuan K, Hu H, Guo Z, et al. Phospho-regulation of HsCDC14A by polo-like kinase 1 is essential for mitotic progression. J Biol Chem 2007; 282:27414-27423.