Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 15, 2015, Pages 4648-4653

  Kim, Jongseong ^a   Hudson, Nathan E ^a   Springer, Timothy A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN IB ALPHA; VON WILLEBRAND FACTOR; PROTEIN BINDING; THROMBIN RECEPTOR;

ARTICLE; BINDING KINETICS; CRYSTAL STRUCTURE; DISSOCIATION; FORCE; GAIN OF FUNCTION MUTATION; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THROMBOCYTE; VON WILLEBRAND DISEASE; ALGORITHM; AMINO ACID SEQUENCE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HYDRODYNAMICS; KINETICS; MECHANICAL STRESS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; TIME;

ALGORITHMS; AMINO ACID SEQUENCE; BLOOD PLATELETS; HUMANS; HYDRODYNAMICS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRESS, MECHANICAL; TIME FACTORS; VON WILLEBRAND DISEASES; VON WILLEBRAND FACTOR;

EID: 84928121813     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501689112     Document Type: Article

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