The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von willebrand factor to platelet glycoprotein Ibα

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32289-32301

  Ju, Lining ^a   Dong, Jing Fei ^c   Cruz, Miguel A ^d   Zhu, Cheng ^a,b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLANKING REGIONS; FLANKING SEQUENCE; HEMODYNAMIC FORCES; PLATELET ADHESION; ROLLING VELOCITY; STRUCTURAL DETERMINANTS; TRANSITION POINT; VON WILLEBRAND FACTOR;

ADHESION; DISSOCIATION; GLYCOPROTEINS; SHEAR FLOW;

PLATELETS;

GLUTAMIC ACID; GLUTAMINE; GLYCOPROTEIN IB ALPHA; VON WILLEBRAND FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOMECHANICS; CELL TYPE; CONTROLLED STUDY; DNA FLANKING REGION; HEMODYNAMICS; HUMAN; HUMAN CELL; LIGAND BINDING; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SHEAR STRESS; THROMBOCYTE ADHESION;

BIOMEMBRANE FORCE PROBE; CATCH BOND; GLYCOPROTEIN IBΑ; KINETICS; PLATELETS; SINGLE MOLECULE BIOPHYSICS; THROMBOSIS; VON WILLEBRAND FACTOR;

AMINO ACID SUBSTITUTION; BLOOD PLATELETS; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MUTATION, MISSENSE; PLATELET ADHESIVENESS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; VON WILLEBRAND FACTOR;

EID: 84887430287     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.504001     Document Type: Article

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