The effect of injection using narrow-bore needles on mammalian cells: Administration and formulation considerations for cell therapies

Journal of Pharmacy and Pharmacology

Volumn 67, Issue 5, 2015, Pages 640-650

  Amer, Mahetab H ^a   White, Lisa J ^a   Shakesheff, Kevin M ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

apoptosis; cell injection; cell therapies; NIH 3T3; viability

Indexed keywords

ALGINIC ACID; SUSPENSION;

3T3 CELL LINE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL DENSITY; CELL FATE; CELL SUSPENSION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; FLOW CYTOMETRY; HYDROGEL; INJECTION; MOUSE; NARROW BORE NEEDLE; NEEDLE; NONHUMAN; ADVERSE EFFECTS; ANIMAL; BIOLOGICAL THERAPY; CELL SURVIVAL; DEVICES; PROCEDURES; SUSPENSION;

ANIMALS; APOPTOSIS; CELL AGING; CELL SURVIVAL; CELL- AND TISSUE-BASED THERAPY; INJECTIONS; MICE; NEEDLES; NIH 3T3 CELLS; SUSPENSIONS;

EID: 84928107945     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12362     Document Type: Article

References (36)

1. Freed CR, et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001; 10: 710-719.
2. Olanow CW, et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 2003; 3: 403-414.
3. Bang OY, et al. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005; 6: 874-882.
4. Kondziolka D, et al. Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurgery 2005; 1: 38-45.
5. Bliss TM, et al. Optimizing the success of cell transplantation therapy for stroke. Neurobiol Dis 2010; 2: 275-283.
6. Eckert MA, et al. Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. J Cereb Blood Flow Metab 2013; 9: 1322-1334.
7. Rosado-de-Castro PH, et al. The rise of cell therapy trials for stroke: review of published and registered studies. Stem Cells Dev 2013; 15: 2095-2111.
8. Assmus B, et al. Long-term clinical outcome after intracoronary application of bone marrow-derived mononuclear cells for acute myocardial infarction: migratory capacity of administered cells determines event-free survival. Eur Heart J 2014; 19: 1275-1283.
9. Bull ND, Martin KR,. Concise review: toward stem cell-based therapies for retinal neurodegenerative diseases. Stem Cells 2011; 8: 1170-1175.
10. Chen FM, et al. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: Promises, strategies, and translational perspectives. Biomaterials 2011; 12: 3189-3209.
11. Miljan EA, Sinden JD,. Stem cell treatment of ischemic brain injury. Curr Opin Mol Ther 2009; 4: 394-403.
12. Seif-Naraghi SB, et al. Design and characterization of an injectable pericardial matrix gel: a potentially autologous scaffold for cardiac tissue engineering. Tissue Eng Part A 2010; 6: 2017-2027.
13. Aguado BA, et al. Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng Part A 2012; 7-8: 806-815.
14. Bliss TM, et al. Transplantation of hNT neurons into the ischemic cortex: cell survival and effect on sensorimotor behavior. J Neurosci Res 2006; 6: 1004-1014.
15. Tol M, et al. Comparison of different needle diameters and flow rates on bone marrow mononuclear stem cell viability: an ex vivo experimental study. Cytotherapy 2008; 1: 98-99.
16. Agashi K, et al. The effect of delivery via narrow-bore needles on mesenchymal cells. Regen Med 2009; 1: 49-64.
17. Heng BC, et al. Transcatheter injection-induced changes in human bone marrow-derived mesenchymal stem cells. Cell Transplant 2009; 10-11: 1111-1121.
18. Walker PA, et al. Effect of needle diameter and flow rate on rat and human mesenchymal stromal cell characterization and viability. Tissue Eng Part C Methods 2010; 5: 989-997.
19. Mamidi MK, et al. Impact of passing mesenchymal stem cells through smaller bore size needles for subsequent use in patients for clinical or cosmetic indications. J Transl Med 2012; 10: 229.
20. Kondziolka D, et al. Evaluation of surgical techniques for neuronal cell transplantation used in patients with stroke. Cell Transplant 2004; 7-8: 749-754.
21. Agashi K,. The analysis of cell fate post-ejection through parenteral devices and the development of systems that aid the transportation of cell therapy products. University of Nottingham, 2010.
22. Ranzato E, et al. Hmgb1 promotes wound healing of 3T3 mouse fibroblasts via rage-dependent ERK1/2 activation. Cell Biochem Biophys 2010; 1: 9-17.
23. Kuonen R, et al. Effects of lipophilic extract of Viscum album L. and oleanolic acid on migratory activity of NIH/3T3 fibroblasts and on HaCat keratinocytes. Evid Based Complement Alternat Med 2013. doi: 10.1155/2013/718105. [Epub ahead of print].
24. Spielmann H, et al. The international EU/COLIPA in vitro phototoxicity validation study: results of phase II (blind trial). Part 1. The 3T3 NRU phototoxicity test. Toxicol in Vitro 1998; 3: 305-327.
25. Fletcher DA, Mullins D,. Cell mechanics and the cytoskeleton. Nature 2010; 7280: 485-492.
26. Lowe NJ, et al. A phase IIa open-label dose-escalation pilot study using allogeneic human dermal fibroblasts for nasolabial folds. Dermatol Surg 2010; 10: 1578-1585.
27. Chugh AR, et al. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation 2012; 11 (Suppl. 1): S54-S64.
28. Schwartz SD, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 2012; 9817: 713-720.
29. Orozco L, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation 2013; 12: 1535-1541.
30. Glass JD, et al. Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem Cells 2012; 6: 1144-1151.
31. Misra V, et al. Intra-arterial delivery of cell therapies for stroke. Stem Cells Dev 2012; 7: 1007-1015.
32. Rieger AM, et al. Modified annexin V/propidium iodide apoptosis assay for accurate assessment of cell death. J Vis Exp 2011; 50.
33. Takashina T, Nakayama M,. Modifications enhance the apoptosis-inducing activity of FADD. Mol Cancer Ther 2007; 6: 1793-1803.
34. Gallant ND, et al. Micropatterned surfaces to engineer focal adhesions for analysis of cell adhesion strengthening. Langmuir 2002; 14: 5579-5584.
35. Bayoussef Z, et al. Aggregation promotes cell viability, proliferation, and differentiation in an in vitro model of injection cell therapy. J Tissue Eng Regen Med 2012; 10: e61-e73.
36. Olsen BD, et al. Yielding behavior in injectable hydrogels from telechelic proteins. Macromolecules 2010; 21: 9094-9099.