A phase IIa open-label dose-escalation pilot study using allogeneic human dermal fibroblasts for nasolabial folds

Dermatologic Surgery

Volumn 36, Issue 10, 2010, Pages 1578-1585

  Lowe, Nicholas J ^a   Lowe, Philippa L ^b   St Clair Roberts, John ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cranley Clinic   (United Kingdom)

^c Intercytex Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FILLER;

ADULT; ALLOTRANSPLANTATION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; SKIN ATROPHY; SKIN FIBROBLAST; SOFT TISSUE DEFECT; TREATMENT OUTCOME; WRINKLE;

ADULT; COHORT STUDIES; DERMIS; FEMALE; FIBROBLASTS; HUMANS; MALE; PATIENT SATISFACTION; PILOT PROJECTS; RHYTIDOPLASTY; SKIN AGING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 77957315007     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2010.01686.x     Document Type: Article

References (23)

1. Zimber MS, Koskaska MS, Thomas JR. Anatomy and pathophysiology of facial aging. Facial Plast Surg Clin North Am 2001 9 : 179 87.
2. Wulf HC, Sanby-Moller J, Kobayasai T, et al. Skin aging and natural photoprotection. Micron 2004 35 : 185 91.
3. Placzeck M, Kerkmann U, Bell S, et al. Tobacco smoke is phototoxic. Br J Dermatol 2004 150 : 991 3. (Pubitemid 38903534)
4. Aizen E, Gilhar A. Smoking effect on skin wrinkling in the aged population. Int J Dermatol 2001 40 : 431 3. (Pubitemid 32982293)
5. Lowe NJ. Temporary dermal fillers - European experience. In: Lowe NJ, editor, Carruthers A, Carruthers J, Draelos ZD. Griffiths CEM, Glogau RD, Klein AW, Lask GP co-editors. Textbook of facial rejuvenation. The art of minimally invasive combination therapy. Martin Dunitz, 2002 p. 185-87.
6. Homicz MR, Watson D. Review of injectable materials for soft tissue augmentation. Facial Plast Surg 2004 20 : 21 9. (Pubitemid 38451772)
7. Lowe NJ, Maxwell A, Harper H. Botulinum A exotoxin for glabellar folds: a double-blind, placebo controlled study with an electromyographic injection technique. J Am Acad Dermatol 1996 35 : 569 72. (Pubitemid 26427059)
8. Lowe PL, Patnaik R, Lowe NJ. A comparison of two botulinum type a toxin preparations for the treatment of glabellar lines: double-blind, randomized, pilot study. Dermatol Surg 2005 31 : 1651 4. (Pubitemid 43031167)
9. Lowe NJ. Overview of botulinum neurotoxins. J Cosmet Laser Ther 2007 9 (Suppl 1) : 11 6.
10. Dastoor SF, Misch CE, Wang H-L. Dermal fillers for facial soft tissue augmentation. J Oral Implant 2008 33 : 191 204.
11. Weiss RA, Weiss MA, Beasley KL, et al. Autologous cultured fibroblast injection for facial contour deformities. A prospective, placebo-controlled, phase III clinical trial. Dermatol Surg 2007 33 : 263 8.
12. Boss WK, Usal H, Chernoff G, et al. Autologous cultured fibroblasts as cellular therapy in plastic surgery. Clin Plast Surg 2000 27 : 613 26.
13. Wong T, McGrath J, Navsaria H. The role of fibroblasts in tissue engineering and regeneration. Br J Dermatol 2007 156 : 1149 55. (Pubitemid 47029846)
14. Lowe NJ. Optimizing poly-L-lactic acid use. J Cosmet Laser Ther 2008 10 : 43 6.
15. Narins RS. Minimizing adverse events associated with poly-L-lactic acid injection. Dermatol Surg 2008 34 (Suppl 1) : S100 4.
16. Hamilton DG, Gauthier N, Robertson BF. Late-onset, recurrent facial nodules associated with injection of poly-L-lactic acid. Dermatol Surg 2008 34 : 123 6. (Pubitemid 350308607)
17. Lowe NJ, Maxwell CA, Lowe P, et al. Injectable poly-L-lactic acid: 3-years of aesthetic experience. Dermatol Surg 2009 35 : 344 9.
18. Lanning JC, Deluca JE, Isaacs CM, Hardin-Young J. In vitro analysis of CD40-CD154 and CD28-CD8086 interactions in the primary T-cell response to allogeneic "nonprofessional" antigen presenting cells. Transplantation 2001 71 : 1467 74. (Pubitemid 32507123)
19. Klein AW. Techniques for soft tissue augmentation: an 'a to z'. Am J Clin Dermatol 2006 7 : 107 20.
20. Abraham LC, Vorrasi J, Kaplan DL. Impact of collagen structure on matrix trafficking by human fibroblasts. J Biomed Mater Res 2004 70A : 39 48. (Pubitemid 38849811)
21. Zhao Y, Wang J, Yan X, et al. Preliminary survival studies on autologous cultured skin fibroblasts transplantation by injection. Cell Transplant 2008 17 : 775 83.
22. th Annual Meeting of Dermatology, Los Angeles, California, May 9-13, 2007.
23. Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch Dermatol 1998 134 : 293 300. (Pubitemid 28141616)