MiR-29b suppresses proliferation, migration, and invasion of tongue squamous cell carcinoma through PTEN-AKT signaling pathway by targeting Sp1

Oral Oncology

Volumn 50, Issue 11, 2014, Pages 1062-1071

  Jia, Ling Fei ^a   Huang, Yi Ping ^a   Zheng, Yun Fei ^a   Lyu, Ming Yue ^a   Wei, Su Bi ^b   Meng, Zhen ^a   Gan, Ye Hua ^a  

^a PEKING UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

AKT; MiR 29b; Oral cancer; PTEN; Sp1; Tongue squamous cell carcinoma

Indexed keywords

MICRORNA 29B; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR SP1; MICRORNA; MIRN29 MICRORNA, HUMAN; PRIMER DNA; PTEN PROTEIN, HUMAN;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TONGUE CARCINOMA; UPREGULATION; GENETICS; METABOLISM; METASTASIS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA; TONGUE TUMOR; TUMOR INVASION;

BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DNA PRIMERS; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; TONGUE NEOPLASMS;

EID: 84928093343     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2014.07.010     Document Type: Article

References (40)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
2. Silverman Jr S. Demographics and occurrence of oral and pharyngeal cancers. The outcomes, the trends, the challenge. J Am Dental Assoc 2001;132:7S-11S.
3. Sano D, Myers JN. Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metast. Rev. 2007;26:645-62.
4. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97.
5. Li J, Huang H, Sun L, Yang M, Pan C, Chen W, et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin Cancer Res 2009;15:3998-4008.
6. Jia LF, Wei SB, Gong K, Gan YH, Yu GY. Prognostic Implications of MicoRNA miR-195 Expression in Human Tongue Squamous Cell Carcinoma. PLoS ONE 2013;8:e56634.
7. Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP, Wei WI. Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 2008;14:2588-92.
8. Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, et al. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138- mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer 2010;127:505-12.
9. Jia LF, Wei SB, Gan YH, Guo Y, Gong K, Mitchelson K, et al. Expression, regulation and roles of MiR-26a and MEG3 in tongue squamous cell carcinoma. Int J Cancer 2014 (accepted article).
10. Zhang YK, Wang H, Leng Y, Li ZL, Yang YF, Xiao FJ, et al. Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1. Biochem Biophys Res Commun 2011;414:233-9.
11. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007;26:6133-40.
12. Amodio N, Di Martino MT, Foresta U, Leone E, Lionetti M, Leotta M, et al. MiR- 29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Disease 2012;3:e436.
13. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 2007;104:15805-10.
14. Park SY, Lee JH, Ha M, Nam JW, Kim VN. MiR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 2009;16:23-9.
15. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-74.
16. Li Ning, Gui Juanlian, Duan Xuanchu, Chen Huihui, Fan F. Suppression of Type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human tenon's fibroblasts. Invest Ophthalmol Vis Sci 2012;53:1670-8.
17. Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 2009;113:6411-8.
18. Kou XX, Hao T, Meng Z, Zhou YH, Gan YH. Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1and promotes cancer cell migration and invasion. Carcinogenesis 2013;34:58-67.
19. Lu Y, Thomson JM, Wong HY, Hammond SM, Hogan BL. Transgenic overexpression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol 2007;310:442-53.
20. Amodio N, Bellizzi D, Leotta M, Raimondi L, Biamonte L, D'Aquila P, et al. MiR- 29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells. Cell Cycle 2013;12:3650-62.
21. Qiang W, Liu Z, Serna VA, Ann Druschitz S, Liu Y, Espona-Fiedler M, et al. Downregulation of miR-29b is essential for pathogenesis of uterine leiomyoma. Endocrinology 2014;155:663-9.
22. Pandey M, Sultana S, Gupta KP. Involvement of epigenetics and microRNA-29b in the urethane induced inception and establishment of mouse lung tumors. Exp Mol Pathol 2014;96:61-70.
23. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, et al. MicroRNA 29b functions in acute myeloid leukemia. Blood 2009;114:5331-41.
24. Gong J, Li J, Wang Y, Liu C, Jia H, Jiang C, et al. Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis 2014;35:497-506.
25. Xu F, Zhang Q, Cheng W, Zhang Z, Wang J, Ge J. Effect of miR-29b and miR-29c knockdown on cell growth of the bladder cancer cell line T24. J Int Med Res 2013;41:1803-10.
26. Wang C, Bian Z, Wei D, Zhang JG. MiR-29b regulates migration of human breast cancer cells. Mol Cell Biochem 2011;352:197-207.
27. Cawley S, Bekiranov S, Ng HH, Kapranov P, Sekinger EA, Kampa D, et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 2004;116:499-509.
28. Villa C, Ridolfi E, Fenoglio C, Ghezzi L, Vimercati R, Clerici F, et al. Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease. J Alzheimer's Disease 2013;35:487-94.
29. Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 1998;273:13375-8.
30. Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, et al. Regulation of PTEN transcription by p53. Mol Cell 2001;8:317-25.
31. Virolle T, Adamson ED, Baron V, Birle D, Mercola D, Mustelin T, et al. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol 2001;3:1124-8.
32. Choi HJ, Chung TW, Kim SJ, Cho SY, Lee YS, Lee YC, et al. The AP-2 alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene. Glycobiology 2008;18:395-407.
33. Hettinger K, Vikhanskaya F, Poh MK, Lee MK, de Belle I, Zhang JT, et al. C-Jun promotes cellular survival by suppression of PTEN. Cell Death Differ 2007;14:218-29.
34. Escriva M, Peiró S, Herranz N, Villagrasa P, Dave N, Montserrat-Sentís B, et al. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol 2008;28:1528-40.
35. Li G, Zhao J, Peng X, Liang J, Deng X, Chen Y. The mechanism involved in the loss of PTEN expression in NSCLC tumor cells. Biochem Biophys Res Commun 2012;418:547-52.
36. Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses García A, et al. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 2007;17:4964-73.
37. Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, et al. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: A potential target for UCN-01. Clin Cancer Res 2004;10:4029-37.
38. Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PTEN deficiency contributes to the development and progression of head and neck Cancer. Neoplasia 2013;15:461-71.
39. Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 2009;4:127-50.
40. Zhang LY, Ho-Fun Lee V, Wong AM, Kwong DL, Zhu YH, Dong SS, et al. MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis 2013;34:454-63.