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Volumn 66, Issue 5, 2015, Pages 422-432

Association Between MTHFR C677T Polymorphism and Venous Thromboembolism Risk in the Chinese Population: A Meta-Analysis of 24 Case-Controlled Studies

Author keywords

Chinese population; meta analysis; MTHFR C677T; venous thromboembolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

EID: 84928040724     PISSN: 00033197     EISSN: 19401574     Source Type: Journal    
DOI: 10.1177/0003319714546368     Document Type: Article
Times cited : (20)

References (50)
  • 1
    • 0034056725 scopus 로고    scopus 로고
    • Risk factors for venous thromboembolism following prolonged air travel. Coach class thrombosis
    • Arfvidsson B, Eklof B, Kistner RL, Masuda EM, Sato DT. Risk factors for venous thromboembolism following prolonged air travel. Coach class thrombosis. Hematol Oncol Clin North Am. 2000 ; 14 (2). 391-400, ix
    • (2000) Hematol Oncol Clin North Am , vol.14 , Issue.2
    • Arfvidsson, B.1    Eklof, B.2    Kistner, R.L.3    Masuda, E.M.4    Sato, D.T.5
  • 2
    • 0037944170 scopus 로고    scopus 로고
    • Thrombophilia: Hereditary and acquired in cardiovascular disease
    • Khare A, Ghosh K, Kulkarni B, Mohanty D. Thrombophilia: hereditary and acquired in cardiovascular disease. Haematologia. 2002 ; 32 (4). 293-311
    • (2002) Haematologia , vol.32 , Issue.4 , pp. 293-311
    • Khare, A.1    Ghosh, K.2    Kulkarni, B.3    Mohanty, D.4
  • 3
    • 34147192480 scopus 로고    scopus 로고
    • Epidemiology and risk factors for venous thrombosis
    • Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007 ; 44 (2). 62-69
    • (2007) Semin Hematol , vol.44 , Issue.2 , pp. 62-69
    • Cushman, M.1
  • 4
    • 34547146470 scopus 로고    scopus 로고
    • Folate deficiency and plasma homocysteine during increased oxidative stress
    • Rogers EJ, Chen S, Chan A. Folate deficiency and plasma homocysteine during increased oxidative stress. N Engl J Med. 2007 ; 357 (4). 421-422
    • (2007) N Engl J Med , vol.357 , Issue.4 , pp. 421-422
    • Rogers, E.J.1    Chen, S.2    Chan, A.3
  • 5
    • 0028487161 scopus 로고
    • Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification
    • Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet. 1994 ; 7 (2). 195-200
    • (1994) Nat Genet , vol.7 , Issue.2 , pp. 195-200
    • Goyette, P.1    Sumner, J.S.2    Milos, R.3
  • 6
    • 0031904465 scopus 로고    scopus 로고
    • Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
    • Goyette P, Pai A, Milos R, et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome. 1998 ; 9 (8). 652-656
    • (1998) Mamm Genome , vol.9 , Issue.8 , pp. 652-656
    • Goyette, P.1    Pai, A.2    Milos, R.3
  • 7
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995 ; 10 (1). 111-113
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 8
    • 84884351471 scopus 로고    scopus 로고
    • Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: A meta-analysis involving over 11,000 cases and 21,000 controls
    • Simone B, De Stefano V, Leoncini E, et al. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol. 2013 ; 28 (8). 621-647
    • (2013) Eur J Epidemiol , vol.28 , Issue.8 , pp. 621-647
    • Simone, B.1    De Stefano, V.2    Leoncini, E.3
  • 9
    • 84878892613 scopus 로고    scopus 로고
    • The 677C > T mutation of the MTHFR gene increases the risk of venous thromboembolism in Koreans and a meta-analysis from Asian population
    • Jang MJ, Jeon YJ, Choi WI, et al. The 677C > T mutation of the MTHFR gene increases the risk of venous thromboembolism in Koreans and a meta-analysis from Asian population. Clin Appl Thromb Hemost. 2013 ; 19 (3). 309-314
    • (2013) Clin Appl Thromb Hemost , vol.19 , Issue.3 , pp. 309-314
    • Jang, M.J.1    Jeon, Y.J.2    Choi, W.I.3
  • 10
    • 70350442915 scopus 로고    scopus 로고
    • The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls
    • Gohil R, Peck G, Sharma P. The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls. Thromb Haemost. 2009 ; 102 (2). 360-370
    • (2009) Thromb Haemost , vol.102 , Issue.2 , pp. 360-370
    • Gohil, R.1    Peck, G.2    Sharma, P.3
  • 11
    • 0034685429 scopus 로고    scopus 로고
    • Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group
    • Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000 ; 283 (15). 2008-2012
    • (2000) JAMA , vol.283 , Issue.15 , pp. 2008-2012
    • Stroup, D.F.1    Berlin, J.A.2    Morton, S.C.3
  • 12
    • 84874009492 scopus 로고    scopus 로고
    • The association between MTHFR gene polymorphisms and hepatocellular carcinoma risk: A meta-analysis
    • Qin X, Peng Q, Chen Z, et al. The association between MTHFR gene polymorphisms and hepatocellular carcinoma risk: a meta-analysis. PloS One. 2013 ; 8 (2). e56070
    • (2013) PloS One , vol.8 , Issue.2 , pp. e56070
    • Qin, X.1    Peng, Q.2    Chen, Z.3
  • 13
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003 ; 327 (7414). 557-560
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 14
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 ; 21 (11). 1539-1558
    • (2002) Stat Med , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 15
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trial. 1986 ; 7 (3). 177-188
    • (1986) Control Clin Trial , vol.7 , Issue.3 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 16
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 ; 22 (4). 719-748
    • (1959) J Natl Cancer Inst , vol.22 , Issue.4 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 17
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 ; 315 (7109). 629-634
    • (1997) BMJ , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 18
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994 ; 50 (4). 1088-1101
    • (1994) Biometrics , vol.50 , Issue.4 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 19
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis
    • Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000 ; 56 (2). 455-463
    • (2000) Biometrics , vol.56 , Issue.2 , pp. 455-463
    • Duval, S.1    Tweedie, R.2
  • 20
    • 0033861598 scopus 로고    scopus 로고
    • Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population
    • Zheng YZ, Tong J, Do XP, Pu XQ, Zhou BT. Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population. Br J Haematol. 2000 ; 109 (4). 870-874
    • (2000) Br J Haematol , vol.109 , Issue.4 , pp. 870-874
    • Zheng, Y.Z.1    Tong, J.2    Do, X.P.3    Pu, X.Q.4    Zhou, B.T.5
  • 21
    • 84868573713 scopus 로고    scopus 로고
    • C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: A population-based case-control study
    • Yin G, Yan L, Zhang Z, Chen K, Jin X. C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population-based case-control study. Mol Med Rep. 2012 ; 6 (6). 1271-1275
    • (2012) Mol Med Rep , vol.6 , Issue.6 , pp. 1271-1275
    • Yin, G.1    Yan, L.2    Zhang, Z.3    Chen, K.4    Jin, X.5
  • 22
    • 0036544888 scopus 로고    scopus 로고
    • Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population
    • Lu Y, Zhao Y, Liu G, et al. Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population. Thromb Res. 2002 ; 106 (1). 7-12
    • (2002) Thromb Res , vol.106 , Issue.1 , pp. 7-12
    • Lu, Y.1    Zhao, Y.2    Liu, G.3
  • 23
    • 0033972749 scopus 로고    scopus 로고
    • The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese
    • Lin JS, Shen MC, Tsai W, Lin B. The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese. Thromb Res. 2000 ; 97 (3). 89-94
    • (2000) Thromb Res , vol.97 , Issue.3 , pp. 89-94
    • Lin, J.S.1    Shen, M.C.2    Tsai, W.3    Lin, B.4
  • 24
    • 0036712720 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome
    • Li XM, Wei YF, Hao HL, et al. Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome. Am J Hematol. 2002 ; 71 (1). 11-14
    • (2002) Am J Hematol , vol.71 , Issue.1 , pp. 11-14
    • Li, X.M.1    Wei, Y.F.2    Hao, H.L.3
  • 25
    • 0035370630 scopus 로고    scopus 로고
    • Importance of hyperhomocysteinemia as a risk factor for venous thromboembolism in a Taiwanese population. A case-control study
    • Hsu TS, Hsu LA, Chang CJ, et al. Importance of hyperhomocysteinemia as a risk factor for venous thromboembolism in a Taiwanese population. A case-control study. Thromb Res. 2001 ; 102 (5). 387-395
    • (2001) Thromb Res , vol.102 , Issue.5 , pp. 387-395
    • Hsu, T.S.1    Hsu, L.A.2    Chang, C.J.3
  • 26
    • 0035212179 scopus 로고    scopus 로고
    • The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan
    • Hsu LA, Ko YL, Wang SM, et al. The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan. Hum Hered. 2001 ; 51 (1-2). 41-45
    • (2001) Hum Hered , vol.51 , Issue.1-2 , pp. 41-45
    • Hsu, L.A.1    Ko, Y.L.2    Wang, S.M.3
  • 27
    • 0343238134 scopus 로고    scopus 로고
    • Prevalence of prothrombin 20210A allele and methylenetetrahydrofolate reductase C677T genetic mutations in the Chinese population
    • Ho CH. Prevalence of prothrombin 20210A allele and methylenetetrahydrofolate reductase C677T genetic mutations in the Chinese population. Ann Hematol. 2000 ; 79 (5). 239-242
    • (2000) Ann Hematol , vol.79 , Issue.5 , pp. 239-242
    • Ho, C.H.1
  • 28
    • 77950031190 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia, Low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis
    • He JA, Hu XH, Fan YY, et al. Hyperhomocysteinaemia, Low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis. Eur J Vasc Endovasc Surg. 2010 ; 39 (4). 508-513
    • (2010) Eur J Vasc Endovasc Surg , vol.39 , Issue.4 , pp. 508-513
    • He, J.A.1    Hu, X.H.2    Fan, Y.Y.3
  • 29
    • 39749111325 scopus 로고    scopus 로고
    • MTHFR C677T mutation in central retinal vein occlusion: A case-control study in Chinese population
    • Gao W, Wang YS, Zhang P, Wang HY. MTHFR C677T mutation in central retinal vein occlusion: a case-control study in Chinese population. Thromb Res. 2008 ; 121 (5). 699-703
    • (2008) Thromb Res , vol.121 , Issue.5 , pp. 699-703
    • Gao, W.1    Wang, Y.S.2    Zhang, P.3    Wang, H.Y.4
  • 30
    • 84884999020 scopus 로고    scopus 로고
    • Plasma homocysteine concentrations in the acute phase after central retinal vein occlusion in a Chinese population
    • Dong N, Wang B, Chu L, Xiao L. Plasma homocysteine concentrations in the acute phase after central retinal vein occlusion in a Chinese population. Curr Eye Res. 2013 ; 38 (11). 1153-1158
    • (2013) Curr Eye Res , vol.38 , Issue.11 , pp. 1153-1158
    • Dong, N.1    Wang, B.2    Chu, L.3    Xiao, L.4
  • 31
    • 33845890516 scopus 로고    scopus 로고
    • Study on the association of polymorphisms in homocysteine metabolism related enzymes with deep venous thrombosis
    • Yu Hd, Zheng H, Qi H, Lian Jh, He Y, Dong Zm. Study on the association of polymorphisms in homocysteine metabolism related enzymes with deep venous thrombosis. Chin J Med Genet. 2006 ; 23 (6). 635-639
    • (2006) Chin J Med Genet , vol.23 , Issue.6 , pp. 635-639
    • Yu, Hd.1    Zheng, H.2    Qi, H.3    Lian, Jh.4    He, Y.5    Dong, Zm.6
  • 32
    • 33744733114 scopus 로고    scopus 로고
    • Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with venous thromboembolism
    • Wang M-t, Li Q, Han F-l, Yao X-p. Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with venous thromboembolism. Chinese J Intern Med. 2004 ; 43 (8). 591-594
    • (2004) Chinese J Intern Med , vol.43 , Issue.8 , pp. 591-594
    • Wang, M.-T.1    Li, Q.2    Han, F.-L.3    Yao, X.-P.4
  • 34
    • 0036684679 scopus 로고    scopus 로고
    • The C677T mutation in the methylenetetrahydrofolate reductase gene and its association with deep vein thrombophilia in Shandong Hans
    • Guo C, Guo Q, Gong Y, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene and its association with deep vein thrombophilia in Shandong Hans. Chin J Med Genet. 2002 ; 19 (4). 295-297
    • (2002) Chin J Med Genet , vol.19 , Issue.4 , pp. 295-297
    • Guo, C.1    Guo, Q.2    Gong, Y.3
  • 35
    • 84872153824 scopus 로고    scopus 로고
    • Association between gene polymorphisms of methylenetetrahydrofolate reductase and plasma homocysteine in Uygur patients with venous thromboembolism
    • Kailibinuer A, Mahemuti A, Xia Y-n, Hu X-m. Association between gene polymorphisms of methylenetetrahydrofolate reductase and plasma homocysteine in Uygur patients with venous thromboembolism. Zhonghua Xin Xue Guan Bing Za Zhi. 2012 ; 40 (12). 1030-1036
    • (2012) Zhonghua Xin Xue Guan Bing Za Zhi , vol.40 , Issue.12 , pp. 1030-1036
    • Kailibinuer, A.1    Mahemuti, A.2    Xia, Y.-N.3    Hu, X.-M.4
  • 37
    • 33845864785 scopus 로고    scopus 로고
    • An association study of methylenetetrahydrofolate reductase gene polymorphism with deep venous thrombosis
    • Zhou YB, Xu K, Liu RB, Xiao L. An association study of methylenetetrahydrofolate reductase gene polymorphism with deep venous thrombosis. Chin J Thromb Hemost. 2003 ; 9 (2). 52-55
    • (2003) Chin J Thromb Hemost , vol.9 , Issue.2 , pp. 52-55
    • Zhou, Y.B.1    Xu, K.2    Liu, R.B.3    Xiao, L.4
  • 38
    • 84928007048 scopus 로고    scopus 로고
    • Relationship between genetic polymorphism of MTHFR C677T and lower extremeities deep venous thrombosis
    • Zhou WM. Relationship between genetic polymorphism of MTHFR C677T and lower extremeities deep venous thrombosis. J Nanchang University Medical Science. 2010 ; 12 (50). 70-73
    • (2010) J Nanchang University Medical Science , vol.12 , Issue.50 , pp. 70-73
    • Zhou, W.M.1
  • 39
    • 84928013079 scopus 로고    scopus 로고
    • Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and hyperhomocysteinmia and pulmonary thromboembolism
    • Ye YP, Wang C, Liu YM, Huang XX, Pang BS. Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and hyperhomocysteinmia and pulmonary thromboembolism. J Capital Univ Med Sci. 2004 ; 25 (03). 321-325
    • (2004) J Capital Univ Med Sci , vol.25 , Issue.3 , pp. 321-325
    • Ye, Y.P.1    Wang, C.2    Liu, Y.M.3    Huang, X.X.4    Pang, B.S.5
  • 40
    • 84928011488 scopus 로고    scopus 로고
    • The association of the cholesteryl ester transfer protein TaqIB and methylenetetrahydrofolate reductase C677T polymorphism with central retinal vein occlusion
    • Wang XD, Zhang DX. The association of the cholesteryl ester transfer protein TaqIB and methylenetetrahydrofolate reductase C677T polymorphism with central retinal vein occlusion. Shaanxi Med J. 2011 ; 40 (10). 1352-1354
    • (2011) Shaanxi Med J , vol.40 , Issue.10 , pp. 1352-1354
    • Wang, X.D.1    Zhang, D.X.2
  • 41
    • 84863278098 scopus 로고    scopus 로고
    • Correlation of MTHFR C677T gene polymorphism plasma and Hcy levels in young patients with hepatic vein obstruction
    • Tian H, Xu H, Zu MH, Pei DS. Correlation of MTHFR C677T gene polymorphism plasma and Hcy levels in young patients with hepatic vein obstruction. J Intervent Radiol. 2012 ; 21 (01). 62-65
    • (2012) J Intervent Radiol , vol.21 , Issue.1 , pp. 62-65
    • Tian, H.1    Xu, H.2    Zu, M.H.3    Pei, D.S.4
  • 42
    • 84928030803 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene poly morphism and deep-vein thrombosis
    • Mei L. Methylenetetrahydrofolate reductase gene poly morphism and deep-vein thrombosis. Chin Foreign Med Res. 2010 ; 19 (08). 21-22
    • (2010) Chin Foreign Med Res , vol.19 , Issue.8 , pp. 21-22
    • Mei, L.1
  • 43
    • 84928015476 scopus 로고    scopus 로고
    • Correlection between methylenetetrahydrofolate reductase C677T polymorphism and deep venous thrombosis in Han population of Fujian province
    • Lin SR, Cai XH, Liu QC. Correlection between methylenetetrahydrofolate reductase C677T polymorphism and deep venous thrombosis in Han population of Fujian province. J Shaanxi Coll Trad Chin Med. 2009 ; 10 (1). 45-46
    • (2009) J Shaanxi Coll Trad Chin Med , vol.10 , Issue.1 , pp. 45-46
    • Lin, S.R.1    Cai, X.H.2    Liu, Q.C.3
  • 44
    • 0032895522 scopus 로고    scopus 로고
    • The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
    • Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nature Struct Biol. 1999 ; 6 (4). 359-365
    • (1999) Nature Struct Biol , vol.6 , Issue.4 , pp. 359-365
    • Guenther, B.D.1    Sheppard, C.A.2    Tran, P.3    Rozen, R.4    Matthews, R.G.5    Ludwig, M.L.6
  • 45
    • 20444445722 scopus 로고    scopus 로고
    • Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies
    • Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost. 2005 ; 3 (2). 292-299
    • (2005) J Thromb Haemost , vol.3 , Issue.2 , pp. 292-299
    • Den Heijer, M.1    Lewington, S.2    Clarke, R.3
  • 46
    • 0034190659 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review
    • Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000 ; 151 (9). 862-877
    • (2000) Am J Epidemiol , vol.151 , Issue.9 , pp. 862-877
    • Botto, L.D.1    Yang, Q.2
  • 47
    • 0035987006 scopus 로고    scopus 로고
    • Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population
    • De Marco P, Calevo MG, Moroni A, et al. Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population. J Hum Genet. 2002 ; 47 (6). 319-324
    • (2002) J Hum Genet , vol.47 , Issue.6 , pp. 319-324
    • De Marco, P.1    Calevo, M.G.2    Moroni, A.3
  • 48
    • 0032231408 scopus 로고    scopus 로고
    • Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase
    • Pepe G, Camacho Vanegas O, Giusti B, et al. Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase. Am J Hum Genet. 1998 ; 63 (3). 917-920
    • (1998) Am J Hum Genet , vol.63 , Issue.3 , pp. 917-920
    • Pepe, G.1    Camacho Vanegas, O.2    Giusti, B.3
  • 49
    • 0037163849 scopus 로고    scopus 로고
    • MTHFR 677C - >t polymorphism and risk of coronary heart disease: A meta-analysis
    • Klerk M, Verhoef P, Clarke R, et al. MTHFR 677C - >T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002 ; 288 (16). 2023-2031
    • (2002) JAMA , vol.288 , Issue.16 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3
  • 50
    • 0037216404 scopus 로고    scopus 로고
    • Effect of food fortification on folic acid intake in the United States
    • Quinlivan EP, Gregory JF III. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr. 2003 ; 77 (1). 221-225
    • (2003) Am J Clin Nutr , vol.77 , Issue.1 , pp. 221-225
    • Quinlivan, E.P.1    Gregory, J.F.2


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