Study on the association of polymorphisms in homocysteine metabolism related enzymes with deep venous thrombosis

Chinese Journal of Medical Genetics

Volumn 23, Issue 6, 2006, Pages 635-639

  Yu, Hai Dong ^a   Zheng, Hong ^a   Qi, Hua ^a   Lian, Jian Hua ^a   He, Ying ^a   Dong, Zi Ming ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cystathionine synthase; Deep venous thrombosis; Genetic polymorphism; Haplotype; Methionine synthase; Methylenetetrahydrofolate reductase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYSTATHIONINE BETA SYNTHASE; HOMOCYSTEINE; METHIONINE SYNTHASE;

ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DNA POLYMORPHISM; GENE AMPLIFICATION; GENE MUTATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREVALENCE; PROMOTER REGION; PROTEIN METABOLISM;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADULT; ALLELES; CYSTATHIONINE BETA-SYNTHASE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POINT MUTATION; POLYMORPHISM, GENETIC; VENOUS THROMBOSIS;

EID: 33845890516     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ray JG. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch Intern Med, 1998, 158:2101-2106.
2. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor forvascular disease: a common mutation in methylene-tetrahydrofolate reductase. Nat Genet, 1995, 10:111.
3. Leclerc D, Campeau E, Coyette P, et al. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet, 1996, 5:1867-1874.
4. Tsai MY, Bignell M, Yang F, et al. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine β-synthase and A2756G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis, 2000, 149:131-137.
5. Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res, 2005, 15:97-98.
6. Mattson MP, Shea TB. Folate and homoeysteine metabolisminneural plasticity and neurodegenerative disorders. Trends Neurosci, 2003, 26:137-146.
7. Valder RA, Paula M, Luiz C, et al. The mutation Ala667-Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost, 1997, 77:818-821.
8. Alberto T, Edoardo M, Maurizio F, et al. C667T mutation in the methylene tetrahydrofolate reductase gene and risk of venous thromboembolism. Thromb Haemost, 1997, 97:804-806.
9. Dai CW, Zhang GS. Study on homocysteine metabolism related enzymes genemutation in Chinese patients with ischemic cardiovascular cerebrovascular disease. Chin J Hematol, 2001, 22:484-487.
10. Zhou YB, Xu K, Lau RB, et al. An association study of methylenetetrahydrofolate reductase gene polymorphism with deep venous thrombosis. Chin J Thromb Hemost, 2003, 9:52-55.
11. Lalouschek W, Aull S, Series W, et al. C677T MTHFR mutation in patients with TIA/minor stroke: a case-control study. Thromb Res, 1999, 93:61-69.
12. Chen J, Stampfer MJ, Ma J, et al. Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis, 2001, 154:667-672.
13. Hyndman ME, Bridge PJ, Warnica JW, et al. Effect of heterozygosity for the methionine synthase 2756A → G mutation on the risk for recurrent cardiovascular events. Am J Cardiol, 2000, 86:1144-1146.
14. Wang XL, Duarte N, Cai H, et al. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolismrelated enzymes, risk factors and coronary artery disease in the Australian hospital-based population. Atherosclerosis, 1999, 146:133-140.
15. Tsai MY, Welge BG, Hanson NQ, et al. Genetic cause of mild hyperhomocysteinemia in patients with premature occlusive coronary artery disease. Atherosclerosis, 1999, 143:163-170.