The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan

Human Heredity

Volumn 51, Issue 1-2, 2001, Pages 41-45

  Hsu, Lung An ^a   Ko, Yu Lin ^a   Wang, Shu Mei ^a   Chang, Chi Jen ^a   Hsu, Tsu Shiu ^a   Chiang, Cheng Wen ^a   Lee, Ying Shiung ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Coronary disease; Methylenetetrahydrofolate reductase; Mutation; Venous thrombosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHINESE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DNA DETERMINATION; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HEART INFARCTION; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK ASSESSMENT; TAIWAN; VEIN THROMBOSIS;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; CORONARY DISEASE; FEMALE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TAIWAN; VENOUS THROMBOSIS;

EID: 0035212179     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022958     Document Type: Article

References (28)

1. Boers GHJ, Smals AGH, Trijbels FJM, Fowler B, Bakkeren JAJM, Schoonderwaldt HC, Kleijer WJ, Kloppenborg PWC: Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive artery disease. N Engl J Med 1985;313:709-715.
2. Clarke R, Daly L, Robinson K, Naughton E, Cahalane S, Fowler B, Graham I: Hyperhomocysteinemia: An independent risk factor for vascular disease. N Engl J Med 1991;324: 1149-1155.
3. Wilcken DEL, Wilcken B: The pathogenesis of coronary artery disease: A possible role for methionine metabolism. J Clin Invest 1976;57: 1079-1082.
4. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, Tishler PV, Hennekens CH: A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 1992;268:881-887.
5. den Heijer M, Koster T, Blom HJ, Bos GMJ, Briet E, Reitsma PH, Vandenbroucke JP, Rosendaal FR: Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996;334:759-762.
6. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995;274:1049-1057.
7. Rosenblatt DS: Inherited disorders of folate transport and metabolism; in Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease. New York, McGraw-Hill, 1989, pp 2049-2064.
8. Kang SS, Wong PWK, Zhou J, Sora J, Lessick M, Ruggie N, Grcevich G: Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism. 1988;37:611-613.
9. Kang SS, Zhou J, Wong PWK, Kowalisyn J, Strokosch G: Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 1988; 43:414-421.
10. Kang SS, Wong PWK, Susmano A, Sora J, Norusis M, Ruggie N: Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary artery disease. Am J Hum Genet 1991;48:536-545.
11. Kang SS, Passen El, Ruggie N, Wong PWK, Sora H: Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1993;88:1463-1469.
12. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LPW, Rozen R: A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
13. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9.
14. Kluijtmans LAJ, van den Heuvel LPW, Boers GJH, Frosst P, Stevens EMB, van Oost BA, den Heijer M, Trijbels FJM, Rozen R, Blom HJ: Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 1996;58:35-41.
15. Gallagher PM, Meleady R, Shields DC, Tan KS, McMaster D, Rozen R, Evans A, Graham JM, Whitehead AS: Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation. Circulation 1996; 94:2154-2158.
16. Christensen B, Frosst P, Lussier-Cacan S, Selhub J, Goyette P, Rosenblatt DS, Genest J, Rozen R: Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol 1997;17:569-573.
17. Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y: Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 1997;95: 2032-2036.
18. Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, Willett WC, Rozen R: Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996;94;2410-2416.
19. Wilcken DEL, Wang XL, Sim AS, McCredie M: Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase C677T mutation. Arterioscler Thromb Vasc Biol 1996;16:878-882.
20. Schmitz C, Lindpaintner K, Verhoef P, Gaziano JM, Buring J: Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study. Circulation 1996;94:1812-1814.
21. Brugada R, Marian AJ: A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis 1997; 128:107-112.
22. Cattaneo M, Tsai MY, Bucciarelli P, Tailoli E, Zighetti ML, Bignell M, Mannucci PM: A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506). Arterioscler Thromb Vasc Biol 1997;17:1662-1666.
23. Dilley A, Austin H, Hooper WC, Lally C, Ribeiro MJ, Wenger NK, Silva V, Rawlins P, Evatt B: Relation of three genetic traits to venous thrombosis in an African-American population. Am J Epidemiol 1998;147:30-35.
24. Kluijtmans LA, den Heijer M, Reitsma PH, Heil SG, Blom HJ, Rosendaal FR: Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis. Thromb Haemost 1998;79:254-258.
25. Ko YL, Ko YS, Wang SM, Hsu LA, Chang CJ, Chu PS, Cheng NJ, Chen WJ, Chiang CW, Lee YS: The Gln-Arg 191 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan. Atherosclerosis 1998;141:259-264.
26. Ko YL, Ko YS, Wang SM, Chu PH, Teng MS, Cheng NJ, Chen WJ, Hsu TS, Kuo CT, Chiang CW, Lee YS: Angiotensinogen and angiotensin-I converting enzyme gene polymorphisms and the risk of coronary artery disease in Chinese. Hum Genet 1997;100:210-214.
27. Ko YL, Hsu TS, Wu SM, Ko YS, Chang CJ, Wang SM, Chen WJ, Cheng NJ, Kuo CT, Chiang CW, Lee YS: The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: An analysis of 618 individuals. Hum Genet 1996;98:176-177.
28. Ko YL, Ko YS, Wu SM, Teng MS, Chen FR, Hsu TS, Chiang CW, Lee YS: Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese. Hum Genet 1997;100:327-333.