The neurobiology, investigation, and treatment of chronic insomnia

The Lancet Neurology

Volumn 14, Issue 5, 2015, Pages 547-558

  Riemann, Dieter ^a   Nissen, Christoph ^a   Palagini, Laura ^b   Otte, Andreas ^c   Perlis, Michael L ^d   Spiegelhalder, Kai ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF PISA   (Italy)

^c OFFENBURG UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT;

AROUSAL; ATTENTION DEFICIT DISORDER; AUTONOMIC NERVOUS SYSTEM; BRAIN DEPTH STIMULATION; CENTRAL NERVOUS SYSTEM; CHRONIC DISEASE; COGNITIVE DEFECT; COGNITIVE THERAPY; ELECTROENCEPHALOGRAM; EPIGENETICS; FATIGUE; HERITABILITY; HUMAN; INSOMNIA; MENTAL INSTABILITY; NEUROBIOLOGY; NEUROIMAGING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSYCHOTHERAPY; REVIEW; SLEEP WAKING CYCLE; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT INDICATION; GENETICS; SLEEP INITIATION AND MAINTENANCE DISORDERS;

CHRONIC DISEASE; HUMANS; SLEEP INITIATION AND MAINTENANCE DISORDERS;

EID: 84928008283     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(15)00021-6     Document Type: Review

References (110)

1. Ohayon MM Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 2002, 6:97-111.
2. Kyle SD, Morgan K, Espie CA Insomnia and health-related quality of life. Sleep Med Rev 2010, 14:69-82.
3. Morin CM, Bélanger L, LeBlanc M, et al. The natural history of insomnia-a population-based 3-year longitudinal study. Arch Intern Med 2009, 169:447-453.
4. Laugsand LE, Vatten LJ, Platou C, Janszky I Insomnia and the risk of acute myocardial infarction: a population study. Circulation 2011, 124:2073-2081.
5. Palagini L, Bruno RM, Gemignani A, et al. Sleep loss and hypertension: a systematic review. Curr Pharm Des 2013, 19:2409-2419.
6. Fernandez-Mendoza J, Vgontzas AN, Liao D, et al. Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort. Hypertension 2012, 60:929-935.
7. Mayer G, Jennum P, Riemann D, et al. Insomnia in neurological diseases-occurrence and management. Sleep Med Rev 2011, 15:369-378.
8. Yaffe K, Falvey CM, Hoang T Connections between sleep and cognition in older adults. Lancet Neurol 2014, 10:1017-1028.
9. Sexton CE, Storsve AB, Walhovd KB, et al. Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults. Neurology 2014, 83:967-973.
10. Baglioni C, Battagliese G, Feige B, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 2011, 135:10-19.
11. Bjørngaard JH, Bjerkeset O, Romundstad P, et al. Sleeping problems and suicide in 75,000 Norwegian adults: A 20 year follow-up of the HUNT I Study. Sleep 2011, 34:1155-1159.
12. Pigeon WR, Pinquart M, Conner K Meta-analysis of sleep disturbance and suicidal thoughts and behaviors. J Clin Psychiat 2012, 73:e1160-e1167.
13. Kucharczyk ER, Morgan K, Hall AP The occupational impact of sleep quality and insomnia symptoms. Sleep Med Rev 2012, 16:547-559.
14. Léger D, Bayon V Societal costs of insomnia. Sleep Med Rev 2010, 14:379-389.
15. Ellis JG, Gehrman P, Espie CA, Riemann D, Perlis ML Acute insomnia: current conceptualizations and future directions. Sleep Med Rev 2012, 16:5-14.
16. Diagnostic and Statistical Manual of Mental Disorders, DSM-5 2013, American Psychiatric Association, American Psychiatric Publishing, Washington, DC.
17. ICSD-3-International Classification of Sleep Disorders 2014, American Academy of Sleep Medicine, American Academy of Sleep Medicine, Chicago.
18. Harvey A, Tang A (Mis)-perception of sleep in insomnia: a puzzle and a resolution. Psychol Bull 2012, 138:77-101.
19. Vgontzas AN, Fernandez-Mendoza J, Liao D, et al. Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder. Sleep Med Rev 2013, 17:241-254.
20. Borbély AA A two-process model of sleep regulation. Hum Neurobiol 1982, 1:195-204.
21. Perlis ML, Zee J, Swinkels C, et al. The incidence and temporal patterning of insomnia: a second study. J Sleep Res 2014, 23:499-507.
22. Vallieres A, Ivers H, Bastien CH, et al. Variability and predictability in sleep patterns of chronic insomniacs. J Sleep Res 2005, 14:447-453.
23. Buysse DJ, Cheng Y, Germain A, et al. Night-to-night variability in older adults with and without chronic insomnia. Sleep Med 2010, 11:56-64.
24. Fisher SP, Foster RG, Peirson SN The circadian control of sleep. Handb Exp Pharmacol 2013, 217:157-183.
25. Liu ZW, Gao XB Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep promoting effect. J Neurophysiol 2007, 97:837-848.
26. Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 1997, 276:1265-1268.
27. Provini F, Lombardi C, Lugaresi E Insomnia in neurological diseases. Semin Neurol 2005, 25:81-89.
28. Quellet MC, Savard J, Morin CM Insomnia following traumatic brain injury: a review. Neurorehabil Neural Repair 2004, 18:187-198.
29. Koenigs M, Holliday J, Solomon J, et al. Left dorsomedial frontal brain damage is associated with insomnia. J Neurosci 2010, 30:16041-16043.
30. Saper CB, Fuller PM, Pedersen NP, et al. Sleep state switching. Neuron 2010, 68:1023-1042.
31. Feige B, Al-Shajlawi A, Nissen C, et al. Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients. J Sleep Res 2008, 17:180-190.
32. Baglioni C, Regen W, Teghen A, et al. Sleep changes in the disorder of insomnia: a meta-analysis of polysomnographic studies. Sleep Med Rev 2014, 18:195-213.
33. Spiegelhalder K, Regen W, Feige B, et al. Increased EEG sigma and beta power during NREM sleep in primary insomnia. Biol Psychol 2012, 91:329-333.
34. Riemann D, Spiegelhalder K, Nissen C, et al. REM sleep instability - a new pathway for insomnia?. Pharmacopsychiatry 2012, 45:167-176.
35. Kryger MH, Roth T, Dement WC Principles and practice of sleep medicine 2005, Elsevier, Philadelphia. 4th edn.
36. Revel FG, Gottowik J, Gatti S, et al. Rodent models of insomnia: a review of experimental procedures that induce sleep disturbances. Neurosci Biobehav Rev 2009, 33:874-899.
37. Cano G, Mochizuki T, Saper CB Neural circuitry of stress-induced insomnia in rats. J Neurosci 2008, 28:10167-10184.
38. Huber R, Ghilardi MF, Massimini M, et al. Local sleep and learning. Nature 2004, 430:78-81.
39. Krueger JM, Rector DM, Roy S, et al. Sleep as a fundamental property of neuronal assemblies. Nat Rev Neurosci 2008, 12:910-919.
40. Beaulieu-Bonneau S, LeBlanc M, Merette C, et al. Family history of insomnia in a population-based sample. Sleep 2007, 30:1739-1745.
41. Wing YK, Zhang J, Lam SP, et al. Familial aggregation and heritability of insomnia in a community-based study. Sleep Med 2012, 13:985-990.
42. Watson NF, Goldberg J, Arguelles L, et al. Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins. Sleep 2006, 29:645-649.
43. Barclay NL, Eley TC, Buysse DJ, Archer SN, Gregory AM Diurnal preference and sleep quality: same genes? A study of young adult twins. Chronobiol Int 2010, 27:278-296.
44. Hublin C, Partinen M, Koskenvuo M, et al. Heritability and mortality risk of insomnia-related symptoms: a genetic epidemiologic study in a population-based twin cohort. Sleep 2011, 34:957-964.
45. Drake CL, Friedman NP, Wright KP, et al. Sleep reactivity and insomnia: genetic and environmental influences. Sleep 2011, 34:1179-1188.
46. Buhr A, Bianchi MT, Baur R, et al. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Hum Genet 2002, 111:154-160.
47. Serretti A, Benedetti F, Mandelli L, et al. Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. Am J Med Genet B Neuropsychiatr Genet 2003, 121:35-38.
48. Deuschle M, Schredl M, Schilling C, et al. Association between a serotonin transporter length polymorphism and primary insomnia. Sleep 2010, 33:343-347.
49. Ban Hj, Kim SC, Seo J, et al. Genetic and metabolic characterization of insomnia. PLoS One 2011, 6:e18455.
50. Byrne E, Gehrman PR, Medland SE, et al. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet 2013, 162B:439-451.
51. Palagini L, Biber K, Riemann D The genetics of insomnia-evidence for epigenetic mechanisms. Sleep Med Rev 2014, 18:225-235.
52. Barclay NL, Gregory AM Quantitative genetic research on sleep: a review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties. Sleep Med Rev 2013, 17:29-40.
53. Riemann D, Spiegelhalder K, Feige B, et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev 2010, 14:19-31.
54. Zhang J, Lam SP, Li SX, et al. A community-based study on the association between insomnia and hypothalamic-pituitary-adrenal axis: sex and pubertal influences. J Clin Endocrinol Metab 2014, 99:2277-2287.
55. Xia L, Chen GH, Li ZH, et al. Alterations in hypothalamus-pituitary-adrenal/thyroid axes and gonadotropin-releasing hormone in the patients with primary insomnia: a clinical research. PLoS One 2013, 8:e71065.
56. Seelig E, Keller U, Klarhöfer M, et al. Neuroendocrine regulation and metabolism of glucose and lipids in primary chronic insomnia: a prospective case-control study. PLoS One 2013, 8:e61780.
57. Farina B, Dittoni S, Colicchio S, et al. Heart rate and heart rate variability modification in chronic insomnia patients. Behav Sleep Med 2014, 12:290-306.
58. Maes J, Verbraecken J, Willemen M, et al. Sleep misperception, EEG characteristics and autonomous nervous system activity in primary insomnia: a retrospective study on polysomnographic data. Int J Psychophysiol 2014, 91:163-171.
59. Israel B, Buysse DJ, Krafty RT, et al. Short-term stability of sleep and heart rate variability in good sleepers and patients with insomnia: for some measures, one night is enough. Sleep 2012, 35:1285-1291.
60. Spiegelhalder K, Fuchs L, Ladwig J, et al. Heart rate and heart rate variability in subjectively reported insomnia. J Sleep Res 2011, 20:137-145.
61. De Zambotti M, Covassin N, De Min T, et al. Sleep onset and cardiovascular activity in primary insomnia. J Sleep Res 2011, 20:318-325.
62. Yang AC, Tsai SJ, Yang CH, et al. Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia. J Affect Disord 2011, 131:179-185.
63. Wu YM, Pietrone R, Cashmere JD, et al. EEG power during waking and NREM sleep in primary insomnia. J Clin Sleep Med 2013, 9:1031-1037.
64. St-Jean G, Turcotte I, Pérusse AD, et al. REM and NREM power spectral analysis on two consecutive nights in psychophysiological and paradoxical insomnia sufferers. Int J Psychophysiol 2013, 89:181-194.
65. Corsi-Cabrera M, Figueredo-Rodriguez P, del Rio-Portilla Y, et al. Enhanced frontoparietal synchronized activation during the wake-sleep transition in patients with primary insomnia. Sleep 2012, 35:501-511.
66. Otte A, Nofzinger EA, Audenaert K, et al. Nuclear Medicine asleep in sleep research?. Eur J Nucl Med 2002, 29:1417-1420.
67. Altena E, Vrenken H, van der Werf YD, et al. Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry 2010, 67:182-185.
68. Stoffers D, Moens S, Benjamins J, et al. Orbitofrontal gray matter relates to early morning awakening: a neural correlate of insomnia complaints?. Front Neurol 2012, 3:105.
69. Winkelman JW, Plante DT, Schoerning L, et al. Increased rostral anterior cingulate cortex volume in chronic primary insomnia. Sleep 2013, 36:991-998.
70. Joo EY, Noh HJ, Kim JS, et al. Brain gray matter deficits in patients with chronic primary insomnia. Sleep 2013, 36:999-1007.
71. Spiegelhalder K, Regen W, Baglioni C, et al. Insomnia does not appear to be associated with substantial structural brain changes. Sleep 2013, 36:731-737.
72. Riemann D, Voderholzer U, Spiegelhalder K, et al. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep 2007, 30:955-958.
73. Neylan TC, Mueller SG, Wang Z, et al. Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield. Biol Psychiatry 2010, 68:494-496.
74. Joo EY, Kim H, Suh S, Hong SB Hippocampal substructural vulnerability to sleep disturbance and cognitive impairment in patients with chronic primary insomnia: MRI morphometry. Sleep 2014, 37:1189-1198.
75. Winkelman JW, Benson KL, Buxton OM Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla. Sleep Med 2010, 11:576-582.
76. Bumb JM, Schilling C, Enning F, et al. Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study. J Sleep Res 2014, 23:274-280.
77. Meyerhoff DJ, Mon A, Metzler T, Neylan TC Cortical GABA and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality. Sleep 2014, 37:893-900.
78. Plante DT, Jensen JE, Schoerning L, Winkelman JW Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?. Neuropsychopharmacology 2012, 37:1548-1557.
79. Winkelman JW, Buxton OM, Jensen JE, et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep 2008, 31:1499-1506.
80. Morgan PT, Pace-Schott EF, Mason GF, et al. Cortical GABA levels in primary insomnia. Sleep 2012, 35:807-814.
81. Harper DG, Plante DT, Jensen JE, et al. Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 Tesla. Sleep 2013, 36:493-500.
82. Altena E, van der Werf YD, Sanz-Arigita EJ, et al. Prefrontal hypoactivation and recovery in insomnia. Sleep 2008, 31:1271-1276.
83. Drummond SP, Walker M, Almklov E, et al. Neural correlates of working memory performance in primary insomnia. Sleep 2013, 36:1307-1316.
84. Stoffers D, Altena E, van der Werf YD, et al. The caudate: a key node in the neuronal network imbalance of insomnia?. Brain 2014, 137:610-620.
85. Spiegelhalder K, Regen W, Prem M, et al. Reduced anterior internal capsule white matter integrity in primary insomnia. Hum Brain Mapp 2014, 35:3431-3438.
86. Baglioni C, Spiegelhalder K, Regen W, et al. Insomnia disorder is associated with increased amygdala reactivity to insomnia-related stimuli. Sleep 2014, 37:1907-1917.
87. Baglioni C, Spiegelhalder K, Lombardo C, Riemann D Sleep and emotions: a focus on insomnia. Sleep Med Rev 2010, 14:227-238.
88. Espie CA, Broomfield NM, MacMahon KM, Macphee LM, Taylor LM The attention-intention-effort pathway in the development of psychophysiologic insomnia: a theoretical review. Sleep Med Rev 2006, 10:215-245.
89. Nofzinger EA, Buysse DJ, Germain A, et al. Functional neuroimaging evidence for hyperarousal in insomnia. Am J Psychiatry 2004, 161:2126-2128.
90. Harvey AG A cognitive model of insomnia. Behav Res Ther 2002, 40:869-893.
91. Sämann PG, Wehrle R, Hoehn D, et al. Development of the brain's default mode network from wakefulness to slow wave sleep. Cereb Cortex 2011, 21:2082-2093.
92. Morin CM, Vallieres A, Guay B, et al. Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia. JAMA 2009, 301:2005-2015.
93. Morin CM, Bootzin RR, Buysse DJ, Edinger JD, Espie CA, Lichstein KL Psychological and behavioral treatment of insomnia: update of the recent evidence (1998-2004). Sleep 2006, 29:1398-1414.
94. Smith MT, Perlis ML, Park K, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 2002, 159:5-11.
95. Krystal AD, Edinger JD Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep Med 2010, 33:669-677.
96. Troxel WM, Germain A, Buysse DJ Clinical management of insomnia with brief behavioral treatment (BBTI). Behav Sleep Med 2012, 10:266-279.
97. Ritterband LM, Thorndike FP, Gonder-Frederick LA, et al. Efficacy of an internet-based behavioral intervention for adults with insomnia. Arch Gen Psychiatry 2009, 66:692-698.
98. Espie CA "Stepped care": a health technology solution for delivering cognitive behavioral therapy as a first line insomnia treatment. Sleep 2009, 32:1549-1558.
99. Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF, Kupfer DJ Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. JAMA 1997, 278:2170-2177.
100. Ashton H The diagnosis and management of benzodiazepine dependence. Curr Opin Psychiatry 2005, 18:249-255.
101. Kripke DF Do hypnotics cause death and cancer? The burden of proof. Sleep Med 2009, 10:275-276.
102. Buscemi N, Vandermeer B, Friesen C, et al. The efficacy and safety of drug treatments for chronic insomnia in adults: a meta-analysis of RCTs. J Gen Intern Med 2007, 22:1335-1350.
103. Michelson D, Snyder E, Paradis E, et al. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol 2014, 13:461-471.
104. Riemann D, Spiegelhalder K Orexin receptor antagonists: a new treatment for insomnia?. Lancet Neurol 2014, 13:441-443.
105. Broese M, Riemann D, Hein L, Nissen C α-adrenergic receptor function, arousal and sleep: mechanisms and therapeutic implications. Pharmacopsychiatry 2012, 45:209-216.
106. Marshall L, Helgadóttir H, Mölle M, Born J Boosting slow oscillations during sleep potentiates memory. Nature 2006, 444:610-613.
107. Nofzinger E, Buysse DJ Frontal cerebral thermal transfer as a treatment for insomnia: a dose-ranging study. Sleep 2011, 34:A0534.
108. Schabus M, Heib DP, Lechinger J, et al. Enhancing sleep quality and memory in insomnia using instrumental sensorimotor rhythm conditioning. Biol Psychol 2014, 95:126-134.
109. Sulzer J, Haller S, Scharnowski F, et al. Real-time fMRI neurofeedback: progress and challenges. Neuroimage 2013, 76:386-399.
110. Tononi G, Cirelli C Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration. Neuron 2014, 81:12-34.