Cortical GABA levels in primary insomnia

Sleep

Volumn 35, Issue 6, 2012, Pages 807-814

  Morgan, Peter T ^a   Pace Schott, Edward F ^b   Mason, Graeme F ^a   Forselius, Erica ^a   Fasula, Madonna ^a   Valentine, Gerald W ^a   Sanacora, Gerard ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

GABA; Hyperarousal; Insomnia; Magnetic resonance spectroscopy; Polysomnography

Indexed keywords

4 AMINOBUTYRIC ACID; CAFFEINE; CREATINE;

ADULT; ARTICLE; BODY MASS; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; INSOMNIA; MALE; OUTCOME ASSESSMENT; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SELF REPORT; SLEEP PARAMETERS; SLEEP PATTERN; SLEEP WAKING CYCLE; WAKEFULNESS;

ADULT; BRAIN CHEMISTRY; CASE-CONTROL STUDIES; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; POLYSOMNOGRAPHY; SLEEP INITIATION AND MAINTENANCE DISORDERS;

EID: 84861842261     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.1880     Document Type: Article

References (61)

1. Ishigooka J, Suzuki M, Isawa S, Muraoka H, Murasaki M, Okawa M. Epidemiological study on sleep habits and insomnia of new outpatients visiting general hospitals in Japan. Psychiatry Clin Neurosci 1999;53:515-22. (Pubitemid 29404175)
2. Ancoli-Israel S, Roth T. Characteristics of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. I. Sleep 1999;22 Suppl 2:S347-53. (Pubitemid 29293494)
3. Ohayon MM, Caulet M, Lemoine P. Comorbidity of mental and insomnia disorders in the general population. Compr Psychiatry 1998;39:185-97. (Pubitemid 28326190)
4. Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med 2007;3:S7-10.
5. Ohayon MM, Roth T. Place of chronic insomnia in the course of depressive and anxiety disorders. J Psychiatr Res 2003;37:9-15. (Pubitemid 35449766)
6. Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ. Comorbidity of chronic insomnia with medical problems. Sleep 2007;30:213-8.
7. Taylor DJ, Lichstein KL, Durrence HH, Reidel BW, Bush AJ. Epidemiology of insomnia, depression, and anxiety. Sleep 2005;28:1457-64. (Pubitemid 41572796)
8. Katz DA, McHorney CA. The relationship between insomnia and health-related quality of life in patients with chronic illness. J Fam Pract 2002;51:229-35. (Pubitemid 34219685)
9. Leger D, Guilleminault C, Bader G, Levy E, Paillard M. Medical and socio-professional impact of insomnia. Sleep 2002;25:625-9. (Pubitemid 34977501)
10. Kuppermann M, Lubeck DP, Mazonson PD, et al. Sleep problems and their correlates in a working population. J Gen Intern Med 1995;10:25-32.
11. Roth T, Roehrs T, Pies R. Insomnia: pathophysiology and implications for treatment. Sleep Med Rev 2007;11:71-9. (Pubitemid 46096785)
12. Bonnet MH, Arand DL. Hyperarousal and insomnia: state of the science. Sleep Med Rev 2010;14:9-15.
13. Bonnet MH, Arand DL. 24-Hour metabolic rate in insomniacs and matched normal sleepers. Sleep 1995;18:581-8.
14. Bonnet MH, Arand DL. Heart rate variability in insomniacs and matched normal sleepers. Psychosom Med 1998;60:610-5. (Pubitemid 28453026)
15. Lushington K, Dawson D, Lack L. Core body temperature is elevated during constant wakefulness in elderly poor sleepers. Sleep 2000;23:504-10. (Pubitemid 30409236)
16. Vgontzas AN, Tsigos C, Bixler EO, et al. Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res 1998;45:21-31. (Pubitemid 28339937)
17. Lichstein KL, Wilson NM, Noe SL, Aguillard RN, Bellur SN. Daytime sleepiness in insomnia: behavioral, biological and subjective indices. Sleep 1994;17:693-702.
18. Nofzinger EA, Buysse DJ, Germain A, Price JC, Miewald JM, Kupfer DJ. Functional neuroimaging evidence for hyperarousal in insomnia. Am J Psychiatry 2004;161:2126-8.
19. Perlis ML, Smith MT, Andrews PJ, Orff H, Giles DE. Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls. Sleep 2001;24:110-7. (Pubitemid 32096740)
20. John J, Wu MF, Boehmer LN, Siegel JM. Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 2004;42:619-34. (Pubitemid 38639881)
21. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 2001;24:726-31. (Pubitemid 33097540)
22. Gottesman CV, Intraub H. Surface construal and the mental representation of scenes. J Exp Psychol Hum Percept Perform 2002;28:589-99.
23. Siegel JM. The neurotransmitters of sleep. J Clin Psychiatry 2004;65 Suppl 16:4-7.
24. Winsky-Sommerer R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur J Neurosci 2009;29:1779-94.
25. Koch U, Magnusson AK. Unconventional GABA release: mechanisms and function. Curr Opin Neurobiol 2009;19:305-10.
26. Krystal AD. The treatment of primary insomnia. CNS Spectr 2009;14:6-10.
27. Bhagwagar Z, Wylezinska M, Jezzard P, et al. Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biol Psychiatry 2007;61:806-12. (Pubitemid 46330250)
28. Bhagwagar Z, Wylezinska M, Jezzard P, et al. Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. Int J Neuropsychopharmacol 2008;11:255-60. (Pubitemid 351231824)
29. Price RB, Shungu DC, Mao X, et al. Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. Biol Psychiatry 2009;65:792-800.
30. Sanacora G, Gueorguieva R, Epperson CN, et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 2004;61:705-13. (Pubitemid 38890805)
31. Sanacora G, Mason GF, Rothman DL, et al. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 1999;56:1043-7. (Pubitemid 29526389)
32. Goddard AW, Mason GF, Almai A, et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch Gen Psychiatry 2001;58:556-61. (Pubitemid 32523735)
33. Yoon JH, Maddock RJ, Rokem A, et al. GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. J Neurosci 2010;30:3777-81.
34. Edden RA, Muthukumaraswamy SD, Freeman TC, Singh KD. Orientation discrimination performance is predicted by GABA concentration and gamma oscillation frequency in human primary visual cortex. J Neurosci 2009;29:15721-6.
35. Muthukumaraswamy SD, Edden RA, Jones DK, Swettenham JB, Singh KD. Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Proc Natl Acad Sci U S A 2009;106:8356-61.
36. Muthukumaraswamy SD, Evans CJ, Edden RA, Wise RG, Singh KD. Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition. Hum Brain Mapp 2012;33:455-65.
37. Golomb JD, McDavitt JR, Ruf BM, et al. Enhanced visual motion perception in major depressive disorder. J Neurosci 2009;29:9072-7.
38. Winkelman JW, Buxton OM, Jensen JE, et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep 2008;31:1499-506.
39. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213. (Pubitemid 19144991)
40. Morgan PT, Pace-Schott EF, Sahul ZH, Coric V, Stickgold R, Malison RT. Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomnia. Drug Alcohol Depend 2006;82:238-49.
41. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Brain Information Service, University of California, Los Angeles, 1968.
42. Shen J, Rycyna RE, Rothman DL. Improvements on an in vivo automatic shimming method [FASTERMAP]. Magn Reson Med 1997;38:834-9. (Pubitemid 27467724)
43. Rothman DL, Petroff OA, Behar KL, Mattson RH. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci U S A 1993;90:5662-6. (Pubitemid 23176221)
44. Rothman D, Behar K, Petroff OA. Improved quantitation of shor TE 1H NMR human brain spectra by removal of short T1 macromolecule resonances. In: Soc Magn Reson, 2nd Meeting; 1994, p. 47.
45. Behar K, Rothman DL, Spencer DD, Petroff OAC. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med 1994;32:294-302. (Pubitemid 24274907)
46. Shen J, Yang J, Choi IY, Li SS, Chen Z. A new strategy for in vivo spectral editing. Application to GABA editing using selective homonuclear polarization transfer spectroscopy. J Magn Reson 2004;170:290-8.
47. Henry PG, Dautry C, Hantraye P, Bloch G. Brain GABA editing without macromolecule contamination. Magn Reson Med 2001;45:517-20. (Pubitemid 32173281)
48. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005;437:1257-63. (Pubitemid 41568665)
49. Wafford KA, Ebert B. Gaboxadol - a new awakening in sleep. Curr Opin Pharmacol 2006;6:30-6. (Pubitemid 43103817)
50. Nofzinger EA, Nissen C, Germain A, et al. Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia. J Clin Sleep Med 2006;2:316-22. (Pubitemid 44299556)
51. Perlis ML, Merica H, Smith MT, Giles DE. Beta EEG activity and insomnia. Sleep Med Rev 2001;5:363-74.
52. Perlis ML, Kehr EL, Smith MT, Andrews PJ, Orff H, Giles DE. Temporal and stagewise distribution of high frequency EEG activity in patients with primary and secondary insomnia and in good sleeper controls. J. Sleep Res 2001;10:93-104. (Pubitemid 32525679)
53. Hall M, Buysse DJ, Nowell PD, et al. Symptoms of stress and depression as correlates of sleep in primary insomnia. Psychosom Med 2000;62:227-30. (Pubitemid 30194209)
54. Hall M, Thayer JF, Germain A, et al. Psychological stress is associated with heightened physiological arousal during NREM sleep in primary insomnia. Behav Sleep Med 2007;5:178-93.
55. De Zambotti M, Covassin N, De Min Tona G, Sarlo M, Stegagno L. Sleep onset and cardiovascular activity in primary insomnia. J Sleep Res 2011;20:318-25.
56. Bonnet MH, Arand DL. Caffeine use as a model of acute and chronic insomnia. Sleep 1992;15:526-36.
57. Cano G, Mochizuki T, Saper CB. Neural circuitry of stress-induced insomnia in rats. J Neurosci 2008;28:10167-84.
58. Alam MN, Kumar S, Bashir T, et al. GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurones during sleep in rats. J Physiol 2005;563:569-82. (Pubitemid 40360914)
59. McGinty D, Szymusiak R. Hypothalamic regulation of sleep and arousal. Front Biosci 2003;8:s1074-83. (Pubitemid 38925371)
60. Herman JP, Tasker JG, Ziegler DR, Cullinan WE. Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connections. Pharmacol Biochem Behav 2002;71:457-68. (Pubitemid 34117714)
61. Park JB, Jo JY, Zheng H, Patel KP, Stern JE. Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters. J Physiol 2009;587:4645-60.