Pineal gland volume in primary insomnia and healthy controls: A magnetic resonance imaging study

Journal of Sleep Research

Volumn 23, Issue 3, 2014, Pages 276-282

  Bumb, Jan M ^a   Schilling, Claudia ^a   Enning, Frank ^a   Haddad, Leila ^a   Paul, Franc ^a   Lederbogen, Florian ^a   Deuschle, Michael ^a   Schredl, Michael ^a   Nolte, Ingo ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Magnetization prepared rapid gradient echo; Melatonin; Polysomnography; Rapid eye movement sleep; Sleep disorder

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; EDUCATIONAL STATUS; FEMALE; HUMAN; IMAGE RECONSTRUCTION; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PINEAL BODY; PINEAL GLAND VOLUME; POLYSOMNOGRAPHY; PRIMARY INSOMNIA; PRIORITY JOURNAL; REM SLEEP; SLEEP DISORDER; SLEEP QUALITY;

MAGNETIZATION PREPARED RAPID GRADIENT ECHO; MELATONIN; POLYSOMNOGRAPHY; RAPID EYE MOVEMENT SLEEP; SLEEP DISORDER;

ADULT; AGED; EDUCATIONAL STATUS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MELATONIN; MIDDLE AGED; ORGAN SIZE; PINEAL GLAND; POLYSOMNOGRAPHY; REPRODUCIBILITY OF RESULTS; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; SLEEP, REM; YOUNG ADULT;

EID: 84900417724     PISSN: 09621105     EISSN: 13652869     Source Type: Journal    
DOI: 10.1111/jsr.12125     Document Type: Article

References (31)

1. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders, 4th edn-text revision (DSM-IV-TR). American Psychiatric Association, Washington, DC, 2000.
2. Bersani, G., Garavini, A., Iannitelli, A. et al. Reduced pineal volume in male patients with schizophrenia: no relationship to clinical features of the illness. Neurosci. Lett., 2002, 329: 246-248.
3. Bonnet, M., Carley, B., Carskadon, M. et al. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep, 1992, 15: 173-184.
4. Bonnet, M., Carley, B., Carskadon, M. et al. Recording and scoring leg movements. The Atlas Task Force. Sleep, 1993, 16: 748-759.
5. Bumb, J. M., Brockmann, M. A., Groden, C., Al-Zghloul, M. and Nolte, I. TrueFISP of the pediatric pineal gland: volumetric and microstructural analysis. Clin. Neuroradiol., 2012, 22: 69-77.
6. Bumb, J. M., Brockmann, M. A., Groden, C. and Nolte, I. Microstructural analysis of pineal volume using trueFISP imaging. World J. Radiol., 2013, 5: 166-172.
7. Caldwell, J. L. The use of melatonin: an information paper. Aviat. Space Environ. Med., 2000, 71: 238-244.
8. Edinger, J. D., Bonnet, M. H., Bootzin, R. R. et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep, 2004, 27: 1567-1596.
9. Feige, B., Baglioni, C., Spiegelhalder, K., Hirscher, V., Nissen, C. and Riemann, D. The microstructure of sleep in primary insomnia: an overview and extension. Int. J. Psychophysiol., 2013, 89: 171-180.
10. Feng, P., Hu, Y., Vurbic, D. and Guo, Y. Maternal stress induces adult reduced REM sleep and melatonin level. Dev. Neurobiol., 2012, 72: 677-687.
11. Goertelmeyer, R. On the development of a standardized sleep inventory for the assessment of sleep. In: S. Kubicke and W. M. Herrmann (Eds) Methods of Sleep Research. Fischer, Stuttgart, 1985: 93-98.
12. Golan, J., Torres, K., Staskiewicz, G. J., Opielak, G. and Maciejewski, R. Morphometric parameters of the human pineal gland in relation to age, body weight and height. Folia Morphol. (Warsz), 2002, 61: 111-113.
13. Hasegawa, A., Ohtsubo, K. and Mori, W. Pineal gland in old a≥ quantitative and qualitative morphological study of 168 human autopsy cases. Brain Res., 1987, 409: 343-349.
14. Iber, C., Ancoli-Israel, S., Chesson, A. and Quan, S. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, 1st edn. American Academy of Sleep Medicine, Westchester, IL, 2007.
15. Kunz, D., Bes, F., Schlattmann, P. and Herrmann, W. M. On pineal calcification and its relation to subjective sleep perception: a hypothesis-driven pilot study. Psychiatry Res., 1998, 82: 187-191.
16. Kunz, D., Schmitz, S., Mahlberg, R. et al. A new concept for melatonin deficit: on pineal calcification and melatonin excretion. Neuropsychopharmacology, 1999, 21: 765-772.
17. Kunz, D., Mahlberg, R., Muller, C., Tilmann, A. and Bes, F. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J. Clin. Endocrinol. Metab., 2004, 89: 128-134.
18. Liebrich, L. S., Schredl, M., Findeisen, P. et al. Morphology and function: MR pineal volume and melatonin level in human saliva are correlated. J Magn Reson Imaging, 2013 [Epub ahead of print].
19. Mahlberg, R., Kienast, T., Hadel, S., Heidenreich, J. O., Schmitz, S. and Kunz, D. Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Med., 2009, 10: 439-445.
20. Monti, J. M., Alvarino, F., Cardinali, D., Savio, I. and Pintos, A. Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia. Arch. Gerontol. Geriatr., 1999, 28: 85-98.
21. Nolte, I., Lutkhoff, A. T., Stuck, B. A. et al. Pineal volume and circadian melatonin profile in healthy volunteers: an interdisciplinary approach. J. Magn. Reson. Imaging, 2009, 30: 499-505.
22. Riemann, D., Klein, T., Rodenbeck, A. et al. Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatry Res., 2002, 113: 17-27.
23. Riemann, D., Spiegelhalder, K., Feige, B. et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med. Rev., 2010, 14: 19-31.
24. Sarrazin, S., Etain, B., Vederine, F. E., et al. MRI exploration of pineal volume in bipolar disorder. J. Affect. Disord., 2011, 135: 377-379.
25. Schmidt, F., Penka, B., Trauner, M. et al. Lack of pineal growth during childhood. J. Clin. Endocrinol. Metab., 1995, 80: 1221-1225.
26. Seron-Ferre, M., Ducsay, C. A. and Valenzuela, G. J. Circadian rhythms during pregnancy. Endocr. Rev., 1993, 14: 594-609.
27. Seron-Ferre, M., Torres, C., Parraguez, V. H. et al. Perinatal neuroendocrine regulation. Development of the circadian time-keeping system. Mol. Cell. Endocrinol., 2002, 186: 169-173.
28. Sun, B., Wang, D., Tang, Y. et al. The pineal volume: a three-dimensional volumetric study in healthy young adults using 3.0 T MR data. Int. J. Dev. Neurosci., 2009, 27: 655-660.
29. Touitou, Y. Human aging and melatonin. Clinical relevance. Exp. Gerontol., 2001, 36: 1083-1100.
30. Unruh, M. L., Redline, S., An, M. W. et al. Subjective and objective sleep quality and aging in the sleep heart health study. J. Am. Geriatr. Soc., 2008, 56: 1218-1227.
31. Wetterberg, L., Iselius, L. and Lindsten, J. Genetic regulation of melatonin excretion in urine. A preliminary report. Clin. Genet., 1983, 24: 399-402.