메뉴 건너뛰기




Volumn 64, Issue 6, 2015, Pages 666-676

Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins

Author keywords

Adipose; Microarray; Obesity; Omega 3 PUFA; Protectins

Indexed keywords

CD59 ANTIGEN; CHOLESTEROL; CNR1 PROTEIN; CNR2 PROTEIN; FATTY ACID AMIDASE; G PROTEIN COUPLED RECEPTOR; INSULIN; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN; RNA; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; CAENORHABDITIS ELEGANS PROTEIN; FAT-1 PROTEIN, C ELEGANS;

EID: 84927971036     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.01.017     Document Type: Article
Times cited : (41)

References (60)
  • 1
    • 0032041972 scopus 로고    scopus 로고
    • The insulin resistance-dyslipidemic syndrome of visceral obesity: Effect on patients' risk
    • J.P. Despres The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk Obes Res 6 Suppl. 1 1998 8S 17S
    • (1998) Obes Res , vol.6 , pp. 8S-17S
    • Despres, J.P.1
  • 2
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • C.N. Lumeng, and A.R. Saltiel Inflammatory links between obesity and metabolic disease J Clin Invest 121 2011 2111 2117
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 3
    • 0001362641 scopus 로고
    • The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity
    • L.B. Salans, J.L. Knittle, and J. Hirsch The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity J Clin Invest 47 1968 153 165
    • (1968) J Clin Invest , vol.47 , pp. 153-165
    • Salans, L.B.1    Knittle, J.L.2    Hirsch, J.3
  • 4
    • 0018701268 scopus 로고
    • Relationship between adipocyte hypertrophy and metabolic disturbances
    • H. Haller, W. Leonhardt, M. Hanefeld, and U. Julius Relationship between adipocyte hypertrophy and metabolic disturbances Endokrinologie 74 1979 63 72
    • (1979) Endokrinologie , vol.74 , pp. 63-72
    • Haller, H.1    Leonhardt, W.2    Hanefeld, M.3    Julius, U.4
  • 6
    • 78649326546 scopus 로고    scopus 로고
    • Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity
    • J. Hoffstedt, E. Arner, H. Wahrenberg, D.P. Andersson, V. Qvisth, and P. Lofgren Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity Diabetologia 53 2010 2496 2503
    • (2010) Diabetologia , vol.53 , pp. 2496-2503
    • Hoffstedt, J.1    Arner, E.2    Wahrenberg, H.3    Andersson, D.P.4    Qvisth, V.5    Lofgren, P.6
  • 7
    • 0033006868 scopus 로고    scopus 로고
    • Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: Is there a contribution of subcutaneous fat cell hypertrophy?
    • P. Imbeault, S. Lemieux, D. Prud'homme, A. Tremblay, A. Nadeau, and J.P. Despres Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: is there a contribution of subcutaneous fat cell hypertrophy? Metabolism 48 1999 355 362
    • (1999) Metabolism , vol.48 , pp. 355-362
    • Imbeault, P.1    Lemieux, S.2    Prud'Homme, D.3    Tremblay, A.4    Nadeau, A.5    Despres, J.P.6
  • 8
    • 32944455133 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: The Alaska Siberia project
    • S.O. Ebbesson, P.M. Risica, L.O. Ebbesson, J.M. Kennish, and M.E. Tejero Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: the Alaska Siberia project Int J Circumpolar Health 64 2005 396 408
    • (2005) Int J Circumpolar Health , vol.64 , pp. 396-408
    • Ebbesson, S.O.1    Risica, P.M.2    Ebbesson, L.O.3    Kennish, J.M.4    Tejero, M.E.5
  • 9
    • 0023244805 scopus 로고
    • Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes
    • C. Popp-Snijders, J.A. Schouten, R.J. Heine, J. van der Meer, and E.A. van der Veen Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes Diabetes Res 4 1987 141 147
    • (1987) Diabetes Res , vol.4 , pp. 141-147
    • Popp-Snijders, C.1    Schouten, J.A.2    Heine, R.J.3    Van Der Meer, J.4    Van Der Veen, E.A.5
  • 11
    • 0842349501 scopus 로고    scopus 로고
    • An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia
    • L. Calabresi, B. Villa, M. Canavesi, C.R. Sirtori, R.W. James, and F. Bernini An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia Metabolism 53 2004 153 158
    • (2004) Metabolism , vol.53 , pp. 153-158
    • Calabresi, L.1    Villa, B.2    Canavesi, M.3    Sirtori, C.R.4    James, R.W.5    Bernini, F.6
  • 12
    • 79958769479 scopus 로고    scopus 로고
    • Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome
    • J. Lu, F. Borthwick, Z. Hassanali, Y. Wang, R. Mangat, and M. Ruth Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome Br J Nutr 105 2011 1572 1582
    • (2011) Br J Nutr , vol.105 , pp. 1572-1582
    • Lu, J.1    Borthwick, F.2    Hassanali, Z.3    Wang, Y.4    Mangat, R.5    Ruth, M.6
  • 13
    • 79251497698 scopus 로고    scopus 로고
    • Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults
    • L.M. Neff, J. Culiner, S. Cunningham-Rundles, C. Seidman, D. Meehan, and J. Maturi Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults J Nutr 141 2011 207 213
    • (2011) J Nutr , vol.141 , pp. 207-213
    • Neff, L.M.1    Culiner, J.2    Cunningham-Rundles, S.3    Seidman, C.4    Meehan, D.5    Maturi, J.6
  • 14
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • D.Y. Oh, S. Talukdar, E.J. Bae, T. Imamura, H. Morinaga, and W. Fan GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Cell 142 2010 687 698
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1    Talukdar, S.2    Bae, E.J.3    Imamura, T.4    Morinaga, H.5    Fan, W.6
  • 15
    • 33746772121 scopus 로고    scopus 로고
    • Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids
    • J. Todoric, M. Loffler, J. Huber, M. Bilban, M. Reimers, and A. Kadl Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids Diabetologia 49 2006 2109 2119
    • (2006) Diabetologia , vol.49 , pp. 2109-2119
    • Todoric, J.1    Loffler, M.2    Huber, J.3    Bilban, M.4    Reimers, M.5    Kadl, A.6
  • 16
    • 78650060401 scopus 로고    scopus 로고
    • Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice
    • P.J. White, M. Arita, R. Taguchi, J.X. Kang, and A. Marette Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice Diabetes 59 2010 3066 3073
    • (2010) Diabetes , vol.59 , pp. 3066-3073
    • White, P.J.1    Arita, M.2    Taguchi, R.3    Kang, J.X.4    Marette, A.5
  • 17
    • 33746688578 scopus 로고    scopus 로고
    • Is omega-3 key to unlocking inflammation in obesity?
    • P.J. White, and A. Marette Is omega-3 key to unlocking inflammation in obesity? Diabetologia 49 2006 1999 2001
    • (2006) Diabetologia , vol.49 , pp. 1999-2001
    • White, P.J.1    Marette, A.2
  • 18
    • 33745305434 scopus 로고    scopus 로고
    • Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice
    • S. Neschen, K. Morino, J.C. Rossbacher, R.L. Pongratz, G.W. Cline, and S. Sono Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice Diabetes 55 2006 924 928
    • (2006) Diabetes , vol.55 , pp. 924-928
    • Neschen, S.1    Morino, K.2    Rossbacher, J.C.3    Pongratz, R.L.4    Cline, G.W.5    Sono, S.6
  • 19
    • 27744482030 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat
    • P. Flachs, O. Horakova, P. Brauner, M. Rossmeisl, P. Pecina, and N. Franssen-van Hal Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat Diabetologia 48 2005 2365 2375
    • (2005) Diabetologia , vol.48 , pp. 2365-2375
    • Flachs, P.1    Horakova, O.2    Brauner, P.3    Rossmeisl, M.4    Pecina, P.5    Franssen-Van Hal, N.6
  • 20
    • 34249812073 scopus 로고    scopus 로고
    • Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids
    • J. Huber, M. Loffler, M. Bilban, M. Reimers, A. Kadl, and J. Todoric Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids Int J Obes (Lond) 31 2007 1004 1013
    • (2007) Int J Obes (Lond) , vol.31 , pp. 1004-1013
    • Huber, J.1    Loffler, M.2    Bilban, M.3    Reimers, M.4    Kadl, A.5    Todoric, J.6
  • 21
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • B.M. Forman, J. Chen, and R.M. Evans Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta Proc Natl Acad Sci U S A 94 1997 4312 4317
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 22
    • 52049125233 scopus 로고    scopus 로고
    • Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha
    • O.A. Gani, and I. Sylte Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha J Mol Graph Model 27 2008 217 224
    • (2008) J Mol Graph Model , vol.27 , pp. 217-224
    • Gani, O.A.1    Sylte, I.2
  • 23
    • 12544260664 scopus 로고    scopus 로고
    • Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue
    • J. Ruzickova, M. Rossmeisl, T. Prazak, P. Flachs, J. Sponarova, and M. Veck Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue Lipids 39 2004 1177 1185
    • (2004) Lipids , vol.39 , pp. 1177-1185
    • Ruzickova, J.1    Rossmeisl, M.2    Prazak, T.3    Flachs, P.4    Sponarova, J.5    Veck, M.6
  • 24
    • 0036088134 scopus 로고    scopus 로고
    • Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
    • H. Wang, L.H. Storlien, and X.F. Huang Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression Am J Physiol Endocrinol Metab 282 2002 E1352 E1359
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , pp. E1352-E1359
    • Wang, H.1    Storlien, L.H.2    Huang, X.F.3
  • 25
    • 73249130793 scopus 로고    scopus 로고
    • Anti-obesity effect of fish oil and fish oil-fenofibrate combination in female KK mice
    • T. Arai, H.J. Kim, H. Chiba, and A. Matsumoto Anti-obesity effect of fish oil and fish oil-fenofibrate combination in female KK mice J Atheroscler Thromb 16 2009 674 683
    • (2009) J Atheroscler Thromb , vol.16 , pp. 674-683
    • Arai, T.1    Kim, H.J.2    Chiba, H.3    Matsumoto, A.4
  • 26
    • 84950170977 scopus 로고    scopus 로고
    • Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids
    • J.D. Buckley, and P.R. Howe Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids Obes Rev 10 2009 648 659
    • (2009) Obes Rev , vol.10 , pp. 648-659
    • Buckley, J.D.1    Howe, P.R.2
  • 27
    • 77957606885 scopus 로고    scopus 로고
    • Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: Importance of hepatic lipogenesis
    • A. Sato, H. Kawano, T. Notsu, M. Ohta, M. Nakakuki, and K. Mizuguchi Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis Diabetes 59 2010 2495 2504
    • (2010) Diabetes , vol.59 , pp. 2495-2504
    • Sato, A.1    Kawano, H.2    Notsu, T.3    Ohta, M.4    Nakakuki, M.5    Mizuguchi, K.6
  • 28
    • 1142310943 scopus 로고    scopus 로고
    • Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids
    • J.X. Kang, J. Wang, L. Wu, and Z.B. Kang Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids Nature 427 2004 504
    • (2004) Nature , vol.427 , pp. 504
    • Kang, J.X.1    Wang, J.2    Wu, L.3    Kang, Z.B.4
  • 29
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • T.D. Schmittgen, and K.J. Livak Analyzing real-time PCR data by the comparative C(T) method Nat Protoc 3 2008 1101 1108
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 31
    • 0348143180 scopus 로고    scopus 로고
    • A random variance model for detection of differential gene expression in small microarray experiments
    • G.W. Wright, and R.M. Simon A random variance model for detection of differential gene expression in small microarray experiments Bioinformatics 19 2003 2448 2455
    • (2003) Bioinformatics , vol.19 , pp. 2448-2455
    • Wright, G.W.1    Simon, R.M.2
  • 33
    • 50949133177 scopus 로고    scopus 로고
    • Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism
    • P. Dallaire, K. Bellmann, M. Laplante, S. Gelinas, C. Centeno-Baez, and P. Penfornis Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism Diabetes 57 2008 1999 2011
    • (2008) Diabetes , vol.57 , pp. 1999-2011
    • Dallaire, P.1    Bellmann, K.2    Laplante, M.3    Gelinas, S.4    Centeno-Baez, C.5    Penfornis, P.6
  • 34
    • 0034613375 scopus 로고    scopus 로고
    • Function of GATA transcription factors in preadipocyte-adipocyte transition
    • Q. Tong, G. Dalgin, H. Xu, C.N. Ting, J.M. Leiden, and G.S. Hotamisligil Function of GATA transcription factors in preadipocyte-adipocyte transition Science 290 2000 134 138
    • (2000) Science , vol.290 , pp. 134-138
    • Tong, Q.1    Dalgin, G.2    Xu, H.3    Ting, C.N.4    Leiden, J.M.5    Hotamisligil, G.S.6
  • 35
    • 34047166373 scopus 로고    scopus 로고
    • N-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner
    • S. Neschen, K. Morino, J. Dong, Y. Wang-Fischer, G.W. Cline, and A.J. Romanelli n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner Diabetes 56 2007 1034 1041
    • (2007) Diabetes , vol.56 , pp. 1034-1041
    • Neschen, S.1    Morino, K.2    Dong, J.3    Wang-Fischer, Y.4    Cline, G.W.5    Romanelli, A.J.6
  • 37
    • 0029018196 scopus 로고
    • Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects
    • F. Ahmad, R.V. Considine, and B.J. Goldstein Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects J Clin Invest 95 1995 2806 2812
    • (1995) J Clin Invest , vol.95 , pp. 2806-2812
    • Ahmad, F.1    Considine, R.V.2    Goldstein, B.J.3
  • 38
    • 0001601479 scopus 로고
    • Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis
    • E.J. Corey, C. Shih, and J.R. Cashman Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis Proc Natl Acad Sci U S A 80 1983 3581 3584
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 3581-3584
    • Corey, E.J.1    Shih, C.2    Cashman, J.R.3
  • 39
    • 0001599097 scopus 로고
    • Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties
    • P. Needleman, A. Raz, M.S. Minkes, J.A. Ferrendelli, and H. Sprecher Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties Proc Natl Acad Sci U S A 76 1979 944 948
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 944-948
    • Needleman, P.1    Raz, A.2    Minkes, M.S.3    Ferrendelli, J.A.4    Sprecher, H.5
  • 40
    • 0018702408 scopus 로고
    • Triene prostaglandins: Prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances
    • M.O. Whitaker, A. Wyche, F. Fitzpatrick, H. Sprecher, and P. Needleman Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances Proc Natl Acad Sci U S A 76 1979 5919 5923
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 5919-5923
    • Whitaker, M.O.1    Wyche, A.2    Fitzpatrick, F.3    Sprecher, H.4    Needleman, P.5
  • 41
    • 84894095946 scopus 로고    scopus 로고
    • Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date
    • L. Balas, M. Guichardant, T. Durand, and M. Lagarde Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date Biochimie 99 2014 1 7
    • (2014) Biochimie , vol.99 , pp. 1-7
    • Balas, L.1    Guichardant, M.2    Durand, T.3    Lagarde, M.4
  • 42
    • 0035430576 scopus 로고    scopus 로고
    • Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance
    • C.J. de Souza, M. Eckhardt, K. Gagen, M. Dong, W. Chen, and D. Laurent Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance Diabetes 50 2001 1863 1871
    • (2001) Diabetes , vol.50 , pp. 1863-1871
    • De Souza, C.J.1    Eckhardt, M.2    Gagen, K.3    Dong, M.4    Chen, W.5    Laurent, D.6
  • 43
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • A. Okuno, H. Tamemoto, K. Tobe, K. Ueki, Y. Mori, and K. Iwamoto Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats J Clin Invest 101 1998 1354 1361
    • (1998) J Clin Invest , vol.101 , pp. 1354-1361
    • Okuno, A.1    Tamemoto, H.2    Tobe, K.3    Ueki, K.4    Mori, Y.5    Iwamoto, K.6
  • 45
    • 78650302579 scopus 로고    scopus 로고
    • Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARgamma mRNA, in 3 T3-L1 adipocytes
    • R.T. Oster, J.M. Tishinsky, Z. Yuan, and L.E. Robinson Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARgamma mRNA, in 3 T3-L1 adipocytes Appl Physiol Nutr Metab 35 2010 783 789
    • (2010) Appl Physiol Nutr Metab , vol.35 , pp. 783-789
    • Oster, R.T.1    Tishinsky, J.M.2    Yuan, Z.3    Robinson, L.E.4
  • 46
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • U. Ozcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, and E. Ozdelen Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 47
    • 58149500277 scopus 로고    scopus 로고
    • Emerging role of adipose tissue hypoxia in obesity and insulin resistance
    • J. Ye Emerging role of adipose tissue hypoxia in obesity and insulin resistance Int J Obes (Lond) 33 2009 54 66
    • (2009) Int J Obes (Lond) , vol.33 , pp. 54-66
    • Ye, J.1
  • 49
    • 79251559674 scopus 로고    scopus 로고
    • Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARgamma-mediated mechanisms in Alzheimer's disease models
    • Y. Zhao, F. Calon, C. Julien, J.W. Winkler, N.A. Petasis, and W.J. Lukiw Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARgamma-mediated mechanisms in Alzheimer's disease models PLoS One 6 2011 e15816
    • (2011) PLoS One , vol.6 , pp. e15816
    • Zhao, Y.1    Calon, F.2    Julien, C.3    Winkler, J.W.4    Petasis, N.A.5    Lukiw, W.J.6
  • 50
    • 48249097797 scopus 로고    scopus 로고
    • Endocannabinoids: Synthesis and degradation
    • V. Di Marzo Endocannabinoids: synthesis and degradation Rev Physiol Biochem Pharmacol 160 2008 1 24
    • (2008) Rev Physiol Biochem Pharmacol , vol.160 , pp. 1-24
    • Di Marzo, V.1
  • 51
    • 0021677049 scopus 로고
    • Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils
    • T.H. Lee, J.M. Mencia-Huerta, C. Shih, E.J. Corey, R.A. Lewis, and K.F. Austen Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils J Clin Invest 74 1984 1922 1933
    • (1984) J Clin Invest , vol.74 , pp. 1922-1933
    • Lee, T.H.1    Mencia-Huerta, J.M.2    Shih, C.3    Corey, E.J.4    Lewis, R.A.5    Austen, K.F.6
  • 52
    • 67749139564 scopus 로고    scopus 로고
    • Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats
    • B. Batetta, M. Griinari, G. Carta, E. Murru, A. Ligresti, and L. Cordeddu Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats J Nutr 139 2009 1495 1501
    • (2009) J Nutr , vol.139 , pp. 1495-1501
    • Batetta, B.1    Griinari, M.2    Carta, G.3    Murru, E.4    Ligresti, A.5    Cordeddu, L.6
  • 53
    • 79960167580 scopus 로고    scopus 로고
    • Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high fat-fed mice
    • F. Piscitelli, G. Carta, T. Bisogno, E. Murru, L. Cordeddu, and K. Berge Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high fat-fed mice Nutr Metab (Lond) 8 2011 51
    • (2011) Nutr Metab (Lond) , vol.8 , pp. 51
    • Piscitelli, F.1    Carta, G.2    Bisogno, T.3    Murru, E.4    Cordeddu, L.5    Berge, K.6
  • 54
    • 77956226709 scopus 로고    scopus 로고
    • Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice
    • Y. Ishihara, K. Ohmori, M. Mizukawa, A.U. Hasan, T. Noma, and M. Kohno Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice Atherosclerosis 212 2010 131 138
    • (2010) Atherosclerosis , vol.212 , pp. 131-138
    • Ishihara, Y.1    Ohmori, K.2    Mizukawa, M.3    Hasan, A.U.4    Noma, T.5    Kohno, M.6
  • 55
    • 77953340342 scopus 로고    scopus 로고
    • Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo
    • Y. Kojima, T. Ishida, L. Sun, T. Yasuda, R. Toh, and Y. Rikitake Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo Cardiovasc Res 87 2010 385 393
    • (2010) Cardiovasc Res , vol.87 , pp. 385-393
    • Kojima, Y.1    Ishida, T.2    Sun, L.3    Yasuda, T.4    Toh, R.5    Rikitake, Y.6
  • 56
    • 0031026510 scopus 로고    scopus 로고
    • Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
    • L. Frittitta, J.F. Youngren, P. Sbraccia, M. D'Adamo, A. Buongiorno, and R. Vigneri Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity Diabetologia 40 1997 282 289
    • (1997) Diabetologia , vol.40 , pp. 282-289
    • Frittitta, L.1    Youngren, J.F.2    Sbraccia, P.3    D'Adamo, M.4    Buongiorno, A.5    Vigneri, R.6
  • 57
    • 0033957339 scopus 로고    scopus 로고
    • Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit
    • B.A. Maddux, and I.D. Goldfine Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit Diabetes 49 2000 13 19
    • (2000) Diabetes , vol.49 , pp. 13-19
    • Maddux, B.A.1    Goldfine, I.D.2
  • 58
    • 0035156407 scopus 로고    scopus 로고
    • Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor
    • K. Tsujikawa, N. Kawakami, Y. Uchino, T. Ichijo, T. Furukawa, and H. Saito Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor Mol Endocrinol 15 2001 271 280
    • (2001) Mol Endocrinol , vol.15 , pp. 271-280
    • Tsujikawa, K.1    Kawakami, N.2    Uchino, Y.3    Ichijo, T.4    Furukawa, T.5    Saito, H.6
  • 60
    • 70849131501 scopus 로고    scopus 로고
    • Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3 T3-L1 preadipocytes
    • W.K. Kim, H. Jung, D.H. Kim, E.Y. Kim, J.W. Chung, and Y.S. Cho Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3 T3-L1 preadipocytes J Cell Sci 122 2009 4160 4167
    • (2009) J Cell Sci , vol.122 , pp. 4160-4167
    • Kim, W.K.1    Jung, H.2    Kim, D.H.3    Kim, E.Y.4    Chung, J.W.5    Cho, Y.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.