Flurbiprofen PLGA-PEG nanospheres: Role of hydroxy-β-cyclodextrin on ex vivo human skin permeation and in vivo topical anti-inflammatory efficacy

Colloids and Surfaces B: Biointerfaces

Volumn 110, Issue , 2013, Pages 339-346

  Vega, Estefanía ^a   Egea, M Antònia ^a   Garduño Ramírez, M Luisa ^b   García, M Luisa ^a   Sánchez, Elena ^a   Espina, Marta ^a   Calpena, Ana Cristina ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

Author keywords

Flurbiprofen; Hydroxypropyl cyclodextrin; Nanospheres; Poly(d,l lactide co glycolide); Poly(ethylene glycol); Skin penetration; Topical drug delivery

Indexed keywords

ANTI-INFLAMMATORIES; CONTROLLED DELIVERY; FLURBIPROFEN; MOLECULAR DISPERSIONS; PARTICLE AGGREGATION; POLY(D ,L-LACTIDE-CO- GLYCOLIDE); SKIN PENETRATION; TOPICAL DRUG DELIVERIES;

AGGLOMERATION; DISPERSIONS; DRUG DELIVERY; NANOSPHERES; POLYETHYLENE GLYCOLS; SKIN; X RAY DIFFRACTION;

COPOLYMERS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; FLURBIPROFEN; MACROGOL; POLYGLACTIN;

ADULT; ANALYZER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EAR EDEMA; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; MOUSE; NANOPHARMACEUTICS; NONHUMAN; OTITIS; PHYSICAL PHASE; PRIORITY JOURNAL; SKIN PERMEABILITY; SKIN TOXICITY; SURFACE PROPERTY; TOXICITY TESTING;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-CYCLODEXTRINS; FEMALE; FLURBIPROFEN; HUMANS; INFLAMMATION; LACTIC ACID; NANOSPHERES; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; SKIN; SKIN ABSORPTION;

EID: 84878912257     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2013.04.045     Document Type: Article

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