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Volumn 53, Issue , 2015, Pages 296-308

Human three-dimensional engineered neural tissue reveals cellular and molecular events following cytomegalovirus infection

Author keywords

Infection; Nerve tissue engineering; Neural cell; Stem cell

Indexed keywords

BRAIN; CELL ENGINEERING; CYTOLOGY; HISTOLOGY; PHYSIOLOGICAL MODELS; STEM CELLS; TISSUE ENGINEERING;

EID: 84927942085     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.02.094     Document Type: Article
Times cited : (15)

References (49)
  • 1
    • 0025972908 scopus 로고
    • Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease
    • Demmler G.J. Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 1991, 13:315-329.
    • (1991) Rev Infect Dis , vol.13 , pp. 315-329
    • Demmler, G.J.1
  • 2
    • 33645885918 scopus 로고    scopus 로고
    • Fetal effects of primary and secondary cytomegalovirus infection in pregnancy
    • Ornoy A., Diav-Citrin O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol 2006, 21:399-409.
    • (2006) Reprod Toxicol , vol.21 , pp. 399-409
    • Ornoy, A.1    Diav-Citrin, O.2
  • 3
    • 59649086482 scopus 로고    scopus 로고
    • Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention
    • Cheeran M.C., Lokensgard J.R., Schleiss M.R. Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev 2009, 22:99-126.
    • (2009) Clin Microbiol Rev , vol.22 , pp. 99-126
    • Cheeran, M.C.1    Lokensgard, J.R.2    Schleiss, M.R.3
  • 4
    • 0036781318 scopus 로고    scopus 로고
    • Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
    • Revello M.G., Gerna G. Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin Microbiol Rev 2002, 15:680-715.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 680-715
    • Revello, M.G.1    Gerna, G.2
  • 5
    • 0036721453 scopus 로고    scopus 로고
    • Arecombinant rhesus cytomegalovirus expressing enhanced green fluorescent protein retains the wild-type phenotype and pathogenicity in fetal macaques
    • Chang W.L., Tarantal A.F., Zhou S.S., Borowsky A.D., Barry P.A. Arecombinant rhesus cytomegalovirus expressing enhanced green fluorescent protein retains the wild-type phenotype and pathogenicity in fetal macaques. JVirol 2002, 76:9493-9504.
    • (2002) JVirol , vol.76 , pp. 9493-9504
    • Chang, W.L.1    Tarantal, A.F.2    Zhou, S.S.3    Borowsky, A.D.4    Barry, P.A.5
  • 6
    • 80053032920 scopus 로고    scopus 로고
    • Cytomegalovirus antivirals and development of improved animal models
    • McGregor A., Choi K.Y. Cytomegalovirus antivirals and development of improved animal models. Expert Opin Drug Metab Toxicol 2011, 7:1245-1265.
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , pp. 1245-1265
    • McGregor, A.1    Choi, K.Y.2
  • 7
    • 42549141204 scopus 로고    scopus 로고
    • Roles of neural stem progenitor cells in cytomegalovirus infection of the brain in mouse models
    • Tsutsui Y., Kosugi I., Kawasaki H., Arai Y., Han G.P., Li L., et al. Roles of neural stem progenitor cells in cytomegalovirus infection of the brain in mouse models. Pathol Int 2008, 58:257-267.
    • (2008) Pathol Int , vol.58 , pp. 257-267
    • Tsutsui, Y.1    Kosugi, I.2    Kawasaki, H.3    Arai, Y.4    Han, G.P.5    Li, L.6
  • 9
    • 84989895651 scopus 로고    scopus 로고
    • Comparative genome and virion structure
    • Cambridge University Press, Cambridge, Chapter 14, A. Arvin, G. Campadelli-Fiume, E. Mocarski, P.S. Moore, B. Roizman, R. Whitley (Eds.)
    • Davison A.J., Bhella D. Comparative genome and virion structure. Human herpesviruses: biology, therapy, and immunoprophylaxis 2007, Cambridge University Press, Cambridge, Chapter 14. A. Arvin, G. Campadelli-Fiume, E. Mocarski, P.S. Moore, B. Roizman, R. Whitley (Eds.).
    • (2007) Human herpesviruses: biology, therapy, and immunoprophylaxis
    • Davison, A.J.1    Bhella, D.2
  • 10
    • 25144507994 scopus 로고    scopus 로고
    • Neuropathogenesis in cytomegalovirus infection: indication of the mechanisms using mouse models
    • Tsutsui Y., Kosugi I., Kawasaki H. Neuropathogenesis in cytomegalovirus infection: indication of the mechanisms using mouse models. Rev Med Virol 2005, 15(5):327-345.
    • (2005) Rev Med Virol , vol.15 , Issue.5 , pp. 327-345
    • Tsutsui, Y.1    Kosugi, I.2    Kawasaki, H.3
  • 11
  • 12
    • 79952295879 scopus 로고    scopus 로고
    • Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process
    • Kawasaki H., Kosugi I., Arai Y., Iwashita T., Tsutsui Y. Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. PLoS One 2011, 6:e17492.
    • (2011) PLoS One , vol.6 , pp. e17492
    • Kawasaki, H.1    Kosugi, I.2    Arai, Y.3    Iwashita, T.4    Tsutsui, Y.5
  • 13
    • 28544433757 scopus 로고    scopus 로고
    • Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways
    • Cheeran M.C., Hu S., Ni H.T., Sheng W., Palmquist J.M., Peterson P.K., et al. Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways. JNeurosci Res 2005, 82(6):839-850.
    • (2005) JNeurosci Res , vol.82 , Issue.6 , pp. 839-850
    • Cheeran, M.C.1    Hu, S.2    Ni, H.T.3    Sheng, W.4    Palmquist, J.M.5    Peterson, P.K.6
  • 14
    • 53749104269 scopus 로고    scopus 로고
    • Neonatal neural progenitor cells and their neuronal and glial cell derivatives are fully permissive for human cytomegalovirus infection
    • Luo M.H., Schwartz P.H., Fortunato E.A. Neonatal neural progenitor cells and their neuronal and glial cell derivatives are fully permissive for human cytomegalovirus infection. JVirol 2008, 82:9994-10007.
    • (2008) JVirol , vol.82 , pp. 9994-10007
    • Luo, M.H.1    Schwartz, P.H.2    Fortunato, E.A.3
  • 15
    • 0028862930 scopus 로고
    • Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest
    • Jault F.M., Jault J.M., Ruchti F., Fortunato E.A., Clark C., Corbeil J., et al. Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest. JVirol 1995, 69:6697-6704.
    • (1995) JVirol , vol.69 , pp. 6697-6704
    • Jault, F.M.1    Jault, J.M.2    Ruchti, F.3    Fortunato, E.A.4    Clark, C.5    Corbeil, J.6
  • 16
    • 0029861077 scopus 로고    scopus 로고
    • Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S
    • Lu M., Shenk T. Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S. JVirol 1996, 70:8850-8857.
    • (1996) JVirol , vol.70 , pp. 8850-8857
    • Lu, M.1    Shenk, T.2
  • 17
    • 0031031453 scopus 로고    scopus 로고
    • Human cytomegalovirus infection inhibits G1/S transition
    • Dittmer D., Mocarski E.S. Human cytomegalovirus infection inhibits G1/S transition. JVirol 1997, 71:1629-1634.
    • (1997) JVirol , vol.71 , pp. 1629-1634
    • Dittmer, D.1    Mocarski, E.S.2
  • 18
    • 0031968822 scopus 로고    scopus 로고
    • Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription
    • Salvant B.S., Fortunato E.A., Spector D.H. Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription. JVirol 1998, 72:3729-3741.
    • (1998) JVirol , vol.72 , pp. 3729-3741
    • Salvant, B.S.1    Fortunato, E.A.2    Spector, D.H.3
  • 19
    • 33748488245 scopus 로고    scopus 로고
    • Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells
    • Odeberg J., Wolmer N., Falci S., Westgren M., Seiger A., Söderberg-Nauclér C. Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells. JVirol 2006, 80(18):8929-8939.
    • (2006) JVirol , vol.80 , Issue.18 , pp. 8929-8939
    • Odeberg, J.1    Wolmer, N.2    Falci, S.3    Westgren, M.4    Seiger, A.5    Söderberg-Nauclér, C.6
  • 20
    • 33847288752 scopus 로고    scopus 로고
    • Late human cytomegalovirus (HCMV) proteins inhibit differentiation of human neural precursor cells into astrocytes
    • Odeberg J., Wolmer N., Falci S., Westgren M., Sundtröm E., Seiger A., et al. Late human cytomegalovirus (HCMV) proteins inhibit differentiation of human neural precursor cells into astrocytes. JNeurosci Res 2007, 85(3):583-593.
    • (2007) JNeurosci Res , vol.85 , Issue.3 , pp. 583-593
    • Odeberg, J.1    Wolmer, N.2    Falci, S.3    Westgren, M.4    Sundtröm, E.5    Seiger, A.6
  • 21
    • 84870274844 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells
    • D'Aiuto L., Di Maio R., Heath B., Raimondi G., Milosevic J., Watson A.M., et al. Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells. PLoS One 2012, 7(11).
    • (2012) PLoS One , vol.7 , Issue.11
    • D'Aiuto, L.1    Di Maio, R.2    Heath, B.3    Raimondi, G.4    Milosevic, J.5    Watson, A.M.6
  • 23
    • 77949356639 scopus 로고    scopus 로고
    • Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells
    • Luo M.H., Hannemann H., Kulkarni A.S., Schwartz P.H., O'Dowd J.M., Fortunato E.A. Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells. JVirol 2010, 84:3528-3541.
    • (2010) JVirol , vol.84 , pp. 3528-3541
    • Luo, M.H.1    Hannemann, H.2    Kulkarni, A.S.3    Schwartz, P.H.4    O'Dowd, J.M.5    Fortunato, E.A.6
  • 24
    • 0033807122 scopus 로고    scopus 로고
    • Human cytomegalovirus causes productive infection and neuronal injury in differentiating fetal human central nervous system neuroepithelial precursor cells
    • McCarthy M., Auger D., Whittemore S.R. Human cytomegalovirus causes productive infection and neuronal injury in differentiating fetal human central nervous system neuroepithelial precursor cells. JHum Virol 2000, 3:215-228.
    • (2000) JHum Virol , vol.3 , pp. 215-228
    • McCarthy, M.1    Auger, D.2    Whittemore, S.R.3
  • 25
    • 84896932772 scopus 로고    scopus 로고
    • Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA
    • Belzile J.P., Stark T.J., Yeo G.W., Spector D.H. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA. JVirol 2014, 88(8):4021-4039.
    • (2014) JVirol , vol.88 , Issue.8 , pp. 4021-4039
    • Belzile, J.P.1    Stark, T.J.2    Yeo, G.W.3    Spector, D.H.4
  • 26
    • 84886922589 scopus 로고    scopus 로고
    • Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection
    • Pan X., Li X.J., Liu X.J., Yuan H., Li J.F., Duan Y.L., et al. Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection. JVirol 2013, 87(20):10968-10979.
    • (2013) JVirol , vol.87 , Issue.20 , pp. 10968-10979
    • Pan, X.1    Li, X.J.2    Liu, X.J.3    Yuan, H.4    Li, J.F.5    Duan, Y.L.6
  • 27
    • 0031471702 scopus 로고    scopus 로고
    • Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs
    • Zhu H., Cong J.P., Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci U S A 1997, 94(25):13985-13990.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.25 , pp. 13985-13990
    • Zhu, H.1    Cong, J.P.2    Shenk, T.3
  • 28
    • 0032564342 scopus 로고    scopus 로고
    • Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays
    • Zhu H., Cong J.P., Mamtora G., Gingeras T., Shenk T. Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci U S A 1998, 95(24):14470-14475.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.24 , pp. 14470-14475
    • Zhu, H.1    Cong, J.P.2    Mamtora, G.3    Gingeras, T.4    Shenk, T.5
  • 30
    • 0035194167 scopus 로고    scopus 로고
    • Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs
    • Browne E.P., Wing B., Coleman D., Shenk T. Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. JVirol 2001, 75(24):12319-12330.
    • (2001) JVirol , vol.75 , Issue.24 , pp. 12319-12330
    • Browne, E.P.1    Wing, B.2    Coleman, D.3    Shenk, T.4
  • 31
    • 0031862729 scopus 로고    scopus 로고
    • Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex
    • Navarro L., Mowen K., Rodems S., Weaver B., Reich N., Spector D., et al. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol 1998, 18(7):3796-3802.
    • (1998) Mol Cell Biol , vol.18 , Issue.7 , pp. 3796-3802
    • Navarro, L.1    Mowen, K.2    Rodems, S.3    Weaver, B.4    Reich, N.5    Spector, D.6
  • 32
    • 0032931994 scopus 로고    scopus 로고
    • Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway
    • Boyle K.A., Pietropaolo R.L., Compton T. Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway. Mol Cell Biol 1999, 19(5):3607-3613.
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3607-3613
    • Boyle, K.A.1    Pietropaolo, R.L.2    Compton, T.3
  • 33
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler A.J., Williams B.R. Interferon-inducible antiviral effectors. Nat Rev Immunol 2008, 8(7):559-568.
    • (2008) Nat Rev Immunol , vol.8 , Issue.7 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 34
    • 65249134409 scopus 로고    scopus 로고
    • Development of human nervous tissue upon differentiation of embryonic stem cells in three dimensional culture
    • Preynat-Seauve O., Suter D.M., Tirefort D., Turchi L., Virolle T., Chneiweiss H., et al. Development of human nervous tissue upon differentiation of embryonic stem cells in three dimensional culture. Stem Cells 2009.
    • (2009) Stem Cells
    • Preynat-Seauve, O.1    Suter, D.M.2    Tirefort, D.3    Turchi, L.4    Virolle, T.5    Chneiweiss, H.6
  • 35
    • 84881664356 scopus 로고    scopus 로고
    • The relationship between brain tumor cell invasion of engineered neural tissues and invivo features of glioblastoma
    • Nayernia Z., Turchi L., Cosset E., Peterson H., Dutoit V., Dietrich P.Y., et al. The relationship between brain tumor cell invasion of engineered neural tissues and invivo features of glioblastoma. Biomaterials 2013, 34(33):8279-8290.
    • (2013) Biomaterials , vol.34 , Issue.33 , pp. 8279-8290
    • Nayernia, Z.1    Turchi, L.2    Cosset, E.3    Peterson, H.4    Dutoit, V.5    Dietrich, P.Y.6
  • 36
  • 37
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson W.E., Li C., Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007, 8(1):118-127.
    • (2007) Biostatistics , vol.8 , Issue.1 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 38
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: open software development for computational biology and bioinformatics
    • Gentleman R.C., Carey V.J., Bates D.M., Bolstad B., Dettling M., Dudoit S. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004, 5(10):R80.
    • (2004) Genome Biol , vol.5 , Issue.10 , pp. R80
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5    Dudoit, S.6
  • 39
    • 34547571030 scopus 로고    scopus 로고
    • G:Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments
    • Reimand J., Kull M., Peterson H., Hansen J., Vilo J. g:Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res 2007, 35(Web Server issue):W193-W200.
    • (2007) Nucleic Acids Res , vol.35 , Issue.WEB SERVER ISSUE , pp. W193-W200
    • Reimand, J.1    Kull, M.2    Peterson, H.3    Hansen, J.4    Vilo, J.5
  • 40
    • 79959923522 scopus 로고    scopus 로고
    • G:Profiler-a web server for functional interpretation of gene lists (2011 update)
    • Reimand J., Arak T., Vilo J. g:Profiler-a web server for functional interpretation of gene lists (2011 update). Nucleic Acids Res 2011, 39(Web Server issue):W307-W315. 10.1093/nar/gkr378.
    • (2011) Nucleic Acids Res , vol.39 , Issue.WEB SERVER ISSUE , pp. W307-W315
    • Reimand, J.1    Arak, T.2    Vilo, J.3
  • 42
    • 0026544277 scopus 로고
    • Lethal cytomegalovirus infection in preterm infants: clinical, radiological, and neuropathological findings
    • Perlman J.M., Argyle C. Lethal cytomegalovirus infection in preterm infants: clinical, radiological, and neuropathological findings. Ann Neurol 1992, 31(1):64-68.
    • (1992) Ann Neurol , vol.31 , Issue.1 , pp. 64-68
    • Perlman, J.M.1    Argyle, C.2
  • 43
    • 66949159103 scopus 로고    scopus 로고
    • Effects of cytomegalovirus infection on embryogenesis and brain development
    • Tsutsui Y. Effects of cytomegalovirus infection on embryogenesis and brain development. Congenit Anom (Kyoto) 2009, 49(2):47-55.
    • (2009) Congenit Anom (Kyoto) , vol.49 , Issue.2 , pp. 47-55
    • Tsutsui, Y.1
  • 44
    • 0036636120 scopus 로고    scopus 로고
    • Reactivation of latent cytomegalovirus infection in mouse brain cells detected after transfer to brain slice cultures
    • Tsutsui Y., Kawasaki H., Kosugi I. Reactivation of latent cytomegalovirus infection in mouse brain cells detected after transfer to brain slice cultures. JVirol 2002, 76(14):7247-7254.
    • (2002) JVirol , vol.76 , Issue.14 , pp. 7247-7254
    • Tsutsui, Y.1    Kawasaki, H.2    Kosugi, I.3
  • 45
    • 0030979562 scopus 로고    scopus 로고
    • Disordered migration and loss of virus-infected neuronal cells in developing mouse brains infected with murine cytomegalovirus
    • Shinmura Y., Kosugi I., Aiba-Masago S., Baba S., Yong L.R., Tsutsui Y. Disordered migration and loss of virus-infected neuronal cells in developing mouse brains infected with murine cytomegalovirus. Acta Neuropathol 1997, 93(6):551-557.
    • (1997) Acta Neuropathol , vol.93 , Issue.6 , pp. 551-557
    • Shinmura, Y.1    Kosugi, I.2    Aiba-Masago, S.3    Baba, S.4    Yong, L.R.5    Tsutsui, Y.6
  • 46
    • 0030695158 scopus 로고    scopus 로고
    • Differential expression of the immediate-early and early antigens in neuronal and glial cells of developing mouse brains infected with murine cytomegalovirus
    • Shinmura Y., Aiba-Masago S., Kosugi I., Li R.Y., Baba S., Tsutsui Y. Differential expression of the immediate-early and early antigens in neuronal and glial cells of developing mouse brains infected with murine cytomegalovirus. Am J Pathol 1997, 151(5):1331-1340.
    • (1997) Am J Pathol , vol.151 , Issue.5 , pp. 1331-1340
    • Shinmura, Y.1    Aiba-Masago, S.2    Kosugi, I.3    Li, R.Y.4    Baba, S.5    Tsutsui, Y.6
  • 48
    • 0033573448 scopus 로고    scopus 로고
    • Cytomegalovirus cell tropism, replication, and gene transfer in brain
    • van Den Pol A.N., Mocarski E., Saederup N., Vieira J., Meier T.J. Cytomegalovirus cell tropism, replication, and gene transfer in brain. JNeurosci 1999, 19(24):10948-10965.
    • (1999) JNeurosci , vol.19 , Issue.24 , pp. 10948-10965
    • van Den Pol, A.N.1    Mocarski, E.2    Saederup, N.3    Vieira, J.4    Meier, T.J.5
  • 49
    • 0027406459 scopus 로고
    • Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia
    • Lois C., Alvarez-Buylla A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc Natl Acad Sci U S A 1993, 90(5):2074-2077.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.5 , pp. 2074-2077
    • Lois, C.1    Alvarez-Buylla, A.2


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