메뉴 건너뛰기




Volumn 5, Issue 2, 2015, Pages

B-cell activating factor in the pathophysiology of multiple myeloma: A target for therapy?

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATACICEPT; B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; B CELL MATURATION ANTIGEN; GSK 2857916; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TABALUMAB; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR; UNCLASSIFIED DRUG; TNFRSF13B PROTEIN, HUMAN; TNFSF13B PROTEIN, HUMAN;

EID: 84927940092     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2015.3     Document Type: Review
Times cited : (68)

References (80)
  • 4
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or suppressor?
    • Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or suppressor? Nature 2003; 3: 756-767.
    • (2003) Nature , vol.3 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 6
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • Roccaro M, Sacco A, Maiso P, Kareem A, Azab A, Tai Y et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest 2013; 123: 1542-1555.
    • (2013) J Clin Invest , vol.123 , pp. 1542-1555
    • Roccaro, M.1    Sacco, A.2    Maiso, P.3    Kareem, A.4    Azab, A.5    Tai, Y.6
  • 7
    • 84901475378 scopus 로고    scopus 로고
    • Microenvironment and multiple myeloma spread
    • Ribatti D, Moschetta M, Vacca A. Microenvironment and multiple myeloma spread. Thromb Res 2014; 133: S102-S106.
    • (2014) Thromb Res , vol.133 , pp. S102-S106
    • Ribatti, D.1    Moschetta, M.2    Vacca, A.3
  • 8
    • 33847368961 scopus 로고    scopus 로고
    • Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: A role for vascular endothelial cell growth factor and osteopontin
    • Tanaka Y, Abe M, Hiasha M. Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. Clin Cancer Res 2007; 13: 816-823.
    • (2007) Clin Cancer Res , vol.13 , pp. 816-823
    • Tanaka, Y.1    Abe, M.2    Hiasha, M.3
  • 9
    • 0034012201 scopus 로고    scopus 로고
    • Human myeloma cells promote the production of interleukin 6 by primary human osteoblasts
    • Karadag A, Oyajobi B, Apperley J, Russell R, Croucher P. Human myeloma cells promote the production of interleukin 6 by primary human osteoblasts. Br J Haematol 2000; 108: 383-390.
    • (2000) Br J Haematol , vol.108 , pp. 383-390
    • Karadag, A.1    Oyajobi, B.2    Apperley, J.3    Russell, R.4    Croucher, P.5
  • 10
    • 11144355586 scopus 로고    scopus 로고
    • BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
    • Moreaux J, Legouffe E, Jourdan E, Quittet P, Rème T, Lugagne C et al. BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood 2003; 103: 3148-3157.
    • (2003) Blood , vol.103 , pp. 3148-3157
    • Moreaux, J.1    Legouffe, E.2    Jourdan, E.3    Quittet, P.4    Rème, T.5    Lugagne, C.6
  • 11
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
    • Navarra S, Guzmán R, Gallacher A, Hall S, Levy R, Jimenez R et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 2011; 377: 721-731.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.1    Guzmán, R.2    Gallacher, A.3    Hall, S.4    Levy, R.5    Jimenez, R.6
  • 12
    • 0033538468 scopus 로고    scopus 로고
    • BlyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore P, Belvedere O, Orr A, Pieri K, LaFleur D, Feng P et al. BlyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285: 260-263.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.1    Belvedere, O.2    Orr, A.3    Pieri, K.4    Lafleur, D.5    Feng, P.6
  • 13
    • 0033522907 scopus 로고    scopus 로고
    • Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κB, and c-Jun NH2-terminal kinase
    • Mukhopadhyay A, Ni J, Zhai Y, Yu G, Aggarwal B. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κB, and c-Jun NH2-terminal kinase. J Biol Chem 1999; 274: 15978-15981.
    • (1999) J Biol Chem , vol.274 , pp. 15978-15981
    • Mukhopadhyay, A.1    Ni, J.2    Zhai, Y.3    Yu, G.4    Aggarwal, B.5
  • 14
    • 0032915632 scopus 로고    scopus 로고
    • TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
    • Shu H, Hu W, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999; 65: 680-683.
    • (1999) J Leukoc Biol , vol.65 , pp. 680-683
    • Shu, H.1    Hu, W.2    Johnson, H.3
  • 15
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    • Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer J, Holler N et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999; 189: 1747-1756.
    • (1999) J Exp Med , vol.189 , pp. 1747-1756
    • Schneider, P.1    MacKay, F.2    Steiner, V.3    Hofmann, K.4    Bodmer, J.5    Holler, N.6
  • 16
    • 0037108490 scopus 로고    scopus 로고
    • BlyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    • Roschke V, Sosnovsteva S, Ward C, Hong J, Smith R, Albert V et al. BlyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol 2002; 169: 4314-4321.
    • (2002) J Immunol , vol.169 , pp. 4314-4321
    • Roschke, V.1    Sosnovsteva, S.2    Ward, C.3    Hong, J.4    Smith, R.5    Albert, V.6
  • 17
    • 0036183318 scopus 로고    scopus 로고
    • Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands
    • Liu Y, Xu L, Opalka N, Kappler J, Shu H, Zhang G. Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 2002; 108: 383-394.
    • (2002) Cell , vol.108 , pp. 383-394
    • Liu, Y.1    Xu, L.2    Opalka, N.3    Kappler, J.4    Shu, H.5    Zhang, G.6
  • 18
    • 33747837100 scopus 로고    scopus 로고
    • BAFF APRIL and their receptors: Structure, function and signaling
    • Bossen C, Schneider P. BAFF, APRIL and their receptors: Structure, function and signaling. Sem Immunol 2006; 18: 263-275.
    • (2006) Sem Immunol , vol.18 , pp. 263-275
    • Bossen, C.1    Schneider, P.2
  • 19
    • 21244506678 scopus 로고    scopus 로고
    • ΔbAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models
    • Gavin A, Duong B, Skog P, Aït-Azzouzene D, Greaves D, Scott M et al. ΔBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models. J Immunol 2005; 175: 319-328.
    • (2005) J Immunol , vol.175 , pp. 319-328
    • Gavin, A.1    Duong, B.2    Skog, P.3    Aït-Azzouzene, D.4    Greaves, D.5    Scott, M.6
  • 20
    • 13544261427 scopus 로고    scopus 로고
    • Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA
    • Day E, Cachero T, Qian F, Sun Y, Wen D, Pelletier M et al. Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA. Biochemistry-US 2005; 44: 1919-1931.
    • (2005) Biochemistry-US , vol.44 , pp. 1919-1931
    • Day, E.1    Cachero, T.2    Qian, F.3    Sun, Y.4    Wen, D.5    Pelletier, M.6
  • 21
    • 38949206321 scopus 로고    scopus 로고
    • TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B-cells and plasmablasts
    • Bossen C, Cachero T, Tardivel A, Ingold K, Willen L, Dobles M et al. TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B-cells and plasmablasts. Blood 2008; 111: 1004-1012.
    • (2008) Blood , vol.111 , pp. 1004-1012
    • Bossen, C.1    Cachero, T.2    Tardivel, A.3    Ingold, K.4    Willen, L.5    Dobles, M.6
  • 22
    • 66049091564 scopus 로고    scopus 로고
    • Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor
    • Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M et al. Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J Neurosci 2009; 29: 6348-6352.
    • (2009) J Neurosci , vol.29 , pp. 6348-6352
    • Zhang, L.1    Zheng, S.2    Wu, H.3    Wu, Y.4    Liu, S.5    Fan, M.6
  • 23
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann B, Gommerman J, Vora K, Cachero T, Shulga-Morskaya S, Dobles M et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001; 293: 2111-2114.
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1    Gommerman, J.2    Vora, K.3    Cachero, T.4    Shulga-Morskaya, S.5    Dobles, M.6
  • 24
    • 4544318248 scopus 로고    scopus 로고
    • The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF
    • Tardivel A, Tinel A, Lens S, Steiner Q, Sauberli E, Wilson A et al. The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF. Eur J Immunol 2004; 34: 509-518.
    • (2004) Eur J Immunol , vol.34 , pp. 509-518
    • Tardivel, A.1    Tinel, A.2    Lens, S.3    Steiner, Q.4    Sauberli, E.5    Wilson, A.6
  • 25
    • 4043075603 scopus 로고    scopus 로고
    • TNF family member B-cell activating factor (BAFF) receptor-dependent and-independent roles for BAFF in B-cell physiology
    • Sasaki Y, Casola S, Kutok J, Rajewsky K, Schmidt-Supprian M. TNF family member B-cell activating factor (BAFF) receptor-dependent and-independent roles for BAFF in B-cell physiology. J Immunol 2004; 173: 2242-2252.
    • (2004) J Immunol , vol.173 , pp. 2242-2252
    • Sasaki, Y.1    Casola, S.2    Kutok, J.3    Rajewsky, K.4    Schmidt-Supprian, M.5
  • 26
    • 24744471433 scopus 로고    scopus 로고
    • Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency
    • Gioia C, Silini A, Fiorini C, Soresina A, Meini A, Ferrari S et al. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol 2005; 25: 496-502.
    • (2005) J Clin Immunol , vol.25 , pp. 496-502
    • Gioia, C.1    Silini, A.2    Fiorini, C.3    Soresina, A.4    Meini, A.5    Ferrari, S.6
  • 27
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay F, Woodcock S, Lawton P, Ambrose C, Baetscher M, Schneider P et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999; 190: 1697-1710.
    • (1999) J Exp Med , vol.190 , pp. 1697-1710
    • MacKay, F.1    Woodcock, S.2    Lawton, P.3    Ambrose, C.4    Baetscher, M.5    Schneider, P.6
  • 28
    • 0035007222 scopus 로고    scopus 로고
    • B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
    • Xu S, Lam K. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol Cell Biol 2001; 21: 4067-4074.
    • (2001) Mol Cell Biol , vol.21 , pp. 4067-4074
    • Xu, S.1    Lam, K.2
  • 29
    • 0347285357 scopus 로고    scopus 로고
    • BCMA is essential for the survival of long-lived bone marrow plasma cells
    • O'Connor B, Raman V, Erickson L, Cook W, Weaver L, Ahonen C et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med 2004; 199: 91-97.
    • (2004) J Exp Med , vol.199 , pp. 91-97
    • O'Connor, B.1    Raman, V.2    Erickson, L.3    Cook, W.4    Weaver, L.5    Ahonen, C.6
  • 30
    • 0037332043 scopus 로고    scopus 로고
    • Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor
    • Seshasayee D, Valdez P, Yan M, Dixit V, Tumas D, Grewal I. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 2003; 18: 279-288.
    • (2003) Immunity , vol.18 , pp. 279-288
    • Seshasayee, D.1    Valdez, P.2    Yan, M.3    Dixit, V.4    Tumas, D.5    Grewal, I.6
  • 31
    • 0036732753 scopus 로고    scopus 로고
    • DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    • Litinskiy M, Nardelli B, Hilbert D, He B, Schaffer A, Casali P et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nature Immunol 2002; 3: 822-829.
    • (2002) Nature Immunol , vol.3 , pp. 822-829
    • Litinskiy, M.1    Nardelli, B.2    Hilbert, D.3    He, B.4    Schaffer, A.5    Casali, P.6
  • 33
    • 33846351257 scopus 로고    scopus 로고
    • To switch or not to switch-the opposing roles of TACI in terminal B cell differentiation
    • Salzer U, Jennings S, Grimbacher B. To switch or not to switch-the opposing roles of TACI in terminal B cell differentiation. Eur J Immunol 2007; 37: 17-20.
    • (2007) Eur J Immunol , vol.37 , pp. 17-20
    • Salzer, U.1    Jennings, S.2    Grimbacher, B.3
  • 34
    • 38549098133 scopus 로고    scopus 로고
    • Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils
    • Scapini P, Bazzoni F, Cassatella M. Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils. Immunol Lett 2008; 116: 1-6.
    • (2008) Immunol Lett , vol.116 , pp. 1-6
    • Scapini, P.1    Bazzoni, F.2    Cassatella, M.3
  • 35
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boulé M, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin I. Toll-like receptor 9-dependent and-independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 2004; 199: 1631-1640.
    • (2004) J Exp Med , vol.199 , pp. 1631-1640
    • Boulé, M.1    Broughton, C.2    MacKay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.6
  • 36
    • 0141672920 scopus 로고    scopus 로고
    • Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells
    • Gorelik L, Gilbride K, Dobles M, Kalled S, Zandman D, Scott M. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J Exp Med 2003; 198: 937-945.
    • (2003) J Exp Med , vol.198 , pp. 937-945
    • Gorelik, L.1    Gilbride, K.2    Dobles, M.3    Kalled, S.4    Zandman, D.5    Scott, M.6
  • 37
    • 0037363315 scopus 로고    scopus 로고
    • Rapid and specific targeting of 125 I-labeled B lymphocyte stimulator to lymphoid tissues and B cell tumors in mice
    • Riccobene T, Miceli R, Lincoln C, Knight Y, Meadows J, Stabi M et al. Rapid and specific targeting of 125 I-labeled B lymphocyte stimulator to lymphoid tissues and B cell tumors in mice. J Nucl Med 2003; 44: 422-433.
    • (2003) J Nucl Med , vol.44 , pp. 422-433
    • Riccobene, T.1    Miceli, R.2    Lincoln, C.3    Knight, Y.4    Meadows, J.5    Stabi, M.6
  • 38
    • 0942298590 scopus 로고    scopus 로고
    • Expression of BCMA, TACI, and BAFF-R in multiple myeloma: A mechanism for growth and survival
    • Novak A, Darce J, Arendt B, Harder B, Henderson K, Kindsvogel W et al. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood 2004; 103: 689-694.
    • (2004) Blood , vol.103 , pp. 689-694
    • Novak, A.1    Darce, J.2    Arendt, B.3    Harder, B.4    Henderson, K.5    Kindsvogel, W.6
  • 39
    • 23044512143 scopus 로고    scopus 로고
    • The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature
    • Moreaux J, Cremer F, Reme T, Raab M, Mahtouk K, Kaukel P et al. The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature. Blood 2005; 106: 1021-1030.
    • (2005) Blood , vol.106 , pp. 1021-1030
    • Moreaux, J.1    Cremer, F.2    Reme, T.3    Raab, M.4    Mahtouk, K.5    Kaukel, P.6
  • 41
    • 77956908100 scopus 로고    scopus 로고
    • New targets of PS-341: BAFF and APRIL
    • Li W, Li J, Su C, Zou W, Luo S. New targets of PS-341: BAFF and APRIL. Med Oncol 2010; 27: 439-445.
    • (2010) Med Oncol , vol.27 , pp. 439-445
    • Li, W.1    Li, J.2    Su, C.3    Zou, W.4    Luo, S.5
  • 42
    • 67650721105 scopus 로고    scopus 로고
    • APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop
    • Moreaux J, Sprynski A, Dillon S, Mahtouk K, Jourdan M, Ythier A et al. APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop. Eur J Haematol 2009; 83: 119-129.
    • (2009) Eur J Haematol , vol.83 , pp. 119-129
    • Moreaux, J.1    Sprynski, A.2    Dillon, S.3    Mahtouk, K.4    Jourdan, M.5    Ythier, A.6
  • 43
    • 33746122751 scopus 로고    scopus 로고
    • Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment
    • Tai Y, Li X, Breitkreutz I, Song W, Neri P, Catley L et al. Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Cancer Res 2006; 66: 6675-6682.
    • (2006) Cancer Res , vol.66 , pp. 6675-6682
    • Tai, Y.1    Li, X.2    Breitkreutz, I.3    Song, W.4    Neri, P.5    Catley, L.6
  • 44
    • 35348915408 scopus 로고    scopus 로고
    • Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model
    • Neri P, Kumar S, Fulciniti M, Vallet S, Chhetri S, Mukherjee S et al. Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model. Clin Cancer Res 2007; 13: 5903-5909.
    • (2007) Clin Cancer Res , vol.13 , pp. 5903-5909
    • Neri, P.1    Kumar, S.2    Fulciniti, M.3    Vallet, S.4    Chhetri, S.5    Mukherjee, S.6
  • 45
    • 84870430551 scopus 로고    scopus 로고
    • A role of both NF-kappaB pathways in expression and transcription regulation of BAFF-R gene in multiple myeloma cells
    • Shen X, Zhu W, Zhang X, Xu G, Ju S. A role of both NF-kappaB pathways in expression and transcription regulation of BAFF-R gene in multiple myeloma cells. Mol Cell Biol 2011; 357: 21-30.
    • (2011) Mol Cell Biol , vol.357 , pp. 21-30
    • Shen, X.1    Zhu, W.2    Zhang, X.3    Xu, G.4    Ju, S.5
  • 46
    • 84866753747 scopus 로고    scopus 로고
    • BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells
    • Xu G, Shen X, Pu J, Chu S, Wang X, Wu X et al. BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells. Cytokine 2012; 60: 505-513.
    • (2012) Cytokine , vol.60 , pp. 505-513
    • Xu, G.1    Shen, X.2    Pu, J.3    Chu, S.4    Wang, X.5    Wu, X.6
  • 47
    • 0037103205 scopus 로고    scopus 로고
    • Generation of polyclonal plasmablasts from peripheral blood B cells: A normal counterpart of malignant plasmablasts
    • Tarte K, Vos JD, Thykjaer T, Zhan F, Fiol G, Costes V et al. Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts. Blood 2002; 100: 1113-1122.
    • (2002) Blood , vol.100 , pp. 1113-1122
    • Tarte, K.1    Vos, J.D.2    Thykjaer, T.3    Zhan, F.4    Fiol, G.5    Costes, V.6
  • 49
    • 9144224762 scopus 로고    scopus 로고
    • Complete response to donor lymphocyte infusion in multiple myeloma is associated withantibody responses to highly expressed antigens
    • Bellucci R, Wu C, Chiaretti S, Weller E, Davies F, Alyea E et al. Complete response to donor lymphocyte infusion in multiple myeloma is associated withantibody responses to highly expressed antigens. Blood 2004; 103: 656-663.
    • (2004) Blood , vol.103 , pp. 656-663
    • Bellucci, R.1    Wu, C.2    Chiaretti, S.3    Weller, E.4    Davies, F.5    Alyea, E.6
  • 50
    • 23744457431 scopus 로고    scopus 로고
    • Expression of BAFF-R (BR3) in normal and neoplastic lymphoid tissues characterized with a newly developed monoclonal antibody
    • Nakamura N, Hase H, Sakurai D, Yoshida S, Abe M, Tsukada N et al. Expression of BAFF-R (BR3) in normal and neoplastic lymphoid tissues characterized with a newly developed monoclonal antibody. Virchows Arch 2005; 447: 53-60.
    • (2005) Virchows Arch , vol.447 , pp. 53-60
    • Nakamura, N.1    Hase, H.2    Sakurai, D.3    Yoshida, S.4    Abe, M.5    Tsukada, N.6
  • 51
    • 80051663822 scopus 로고    scopus 로고
    • BAFF-R gene induced by IFN-γ in multiple myeloma cells is related to NF-κB signals
    • Shen X, Zhang X, Xu G, Ju S. BAFF-R gene induced by IFN-γ in multiple myeloma cells is related to NF-κB signals. Cell Biochem Funct 2011; 29: 513-520.
    • (2011) Cell Biochem Funct , vol.29 , pp. 513-520
    • Shen, X.1    Zhang, X.2    Xu, G.3    Ju, S.4
  • 52
    • 26644472949 scopus 로고    scopus 로고
    • BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders
    • Rodig S, Shahsafaei A, Li B, Mackay C, Dorfman D. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. Hum Pathol 2005; 36: 1113-1119.
    • (2005) Hum Pathol , vol.36 , pp. 1113-1119
    • Rodig, S.1    Shahsafaei, A.2    Li, B.3    MacKay, C.4    Dorfman, D.5
  • 53
    • 58649102919 scopus 로고    scopus 로고
    • Expression of BAFF-R and TACI in reactive lymphoid tissues and B-cell lymphomas
    • Wada K, Maeda K, Tajima K, Kato T, Kobata T, Yamakawa M. Expression of BAFF-R and TACI in reactive lymphoid tissues and B-cell lymphomas. Histopathology 2009; 54: 221-232.
    • (2009) Histopathology , vol.54 , pp. 221-232
    • Wada, K.1    Maeda, K.2    Tajima, K.3    Kato, T.4    Kobata, T.5    Yamakawa, M.6
  • 54
    • 63849239722 scopus 로고    scopus 로고
    • APRIL is overexpressed in cancer: Link with tumor progression
    • Moreaux J, Veyrune J, Jd Vos, Klein B. APRIL is overexpressed in cancer: link with tumor progression. BMC Cancer 2009; 9: 1-9.
    • (2009) BMC Cancer , vol.9 , pp. 1-9
    • Moreaux, J.1    Veyrune, J.2    Vos, J.3    Klein, B.4
  • 55
    • 49449098218 scopus 로고    scopus 로고
    • NIK-expression amplifies, whereas ablation of its TRAF-3 binding domain replaces BAFF:BAFF-R mediated survival signals in B-cells
    • Sasaki Y, Calado D, Derudder E, Zhang B, Shimizu Y, Mackay F et al. NIK-expression amplifies, whereas ablation of its TRAF-3 binding domain replaces BAFF:BAFF-R mediated survival signals in B-cells. PNAS 2008; 105: 10883-10888.
    • (2008) PNAS , vol.105 , pp. 10883-10888
    • Sasaki, Y.1    Calado, D.2    Derudder, E.3    Zhang, B.4    Shimizu, Y.5    MacKay, F.6
  • 56
    • 80052887167 scopus 로고    scopus 로고
    • A critical role for the NFkB pathway in multiple myeloma
    • Demchenko Y, Kuehl W. A critical role for the NFkB pathway in multiple myeloma. Oncotarget 2010; 1: 59-68.
    • (2010) Oncotarget , vol.1 , pp. 59-68
    • Demchenko, Y.1    Kuehl, W.2
  • 57
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kB pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata C, Davis E, Demchen Y, Bellamy W, Gabrea A, Zhan F et al. Frequent engagement of the classical and alternative NF-kB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007; 12: 115-130.
    • (2007) Cancer Cell , vol.12 , pp. 115-130
    • Annunziata, C.1    Davis, E.2    Demchen, Y.3    Bellamy, W.4    Gabrea, A.5    Zhan, F.6
  • 58
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kB pathway in multiple myeloma
    • Keats J, Fonseca R, Chesi M, Schop R, Baker A, Chng W et al. Promiscuous mutations activate the noncanonical NF-kB pathway in multiple myeloma. Cancer Cell 2007; 12: 131-144.
    • (2007) Cancer Cell , vol.12 , pp. 131-144
    • Keats, J.1    Fonseca, R.2    Chesi, M.3    Schop, R.4    Baker, A.5    Chng, W.6
  • 59
    • 33750993177 scopus 로고    scopus 로고
    • Analysis of an anti-B lymphocyte stimulator monoclonal antibody B7 and its binding activity to myeloma and lymphoma cell lines
    • Sun J, Li Y, Yu M, Sun Y, Feng J, Shen B. Analysis of an anti-B lymphocyte stimulator monoclonal antibody B7 and its binding activity to myeloma and lymphoma cell lines. Hybridoma 2006; 25: 238-242.
    • (2006) Hybridoma , vol.25 , pp. 238-242
    • Sun, J.1    Li, Y.2    Yu, M.3    Sun, Y.4    Feng, J.5    Shen, B.6
  • 60
    • 0024503249 scopus 로고
    • Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
    • Klein B, Zhang X, Jourdan M, Content J, Houssiau F, Aarden L et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 1989; 73: 517-526.
    • (1989) Blood , vol.73 , pp. 517-526
    • Klein, B.1    Zhang, X.2    Jourdan, M.3    Content, J.4    Houssiau, F.5    Aarden, L.6
  • 61
    • 60949097931 scopus 로고    scopus 로고
    • Correlation of expression levels of BLyS and its receptors with multiple myeloma
    • Ju S, Wang Y, Ni H, Wang X, Jiang P, Kong X et al. Correlation of expression levels of BLyS and its receptors with multiple myeloma. Clin Biochem 2009; 42: 387-399.
    • (2009) Clin Biochem , vol.42 , pp. 387-399
    • Ju, S.1    Wang, Y.2    Ni, H.3    Wang, X.4    Jiang, P.5    Kong, X.6
  • 63
    • 84862523180 scopus 로고    scopus 로고
    • Serum BAFF levels are related to angiogenesis and prognosis in patients with multiple myeloma
    • Fragioudaki M, Tsikaris G, Pappa C, Aristeidou I, Tsioutis C, Alegakis A et al. Serum BAFF levels are related to angiogenesis and prognosis in patients with multiple myeloma. Leuk Res 2012; 36: 1004-1008.
    • (2012) Leuk Res , vol.36 , pp. 1004-1008
    • Fragioudaki, M.1    Tsikaris, G.2    Pappa, C.3    Aristeidou, I.4    Tsioutis, C.5    Alegakis, A.6
  • 64
    • 84896371260 scopus 로고    scopus 로고
    • BAFF and APRIL as TNF superfamily molecules and angio-genesis parallel progression of human multiple myeloma
    • Bolkun L, Lemancewicz D, Jablonska E, Kulczynska A, Bolkun-Skornicka U, Kloczko J et al. BAFF and APRIL as TNF superfamily molecules and angio-genesis parallel progression of human multiple myeloma. Ann Hematol 2014; 93: 635-644.
    • (2014) Ann Hematol , vol.93 , pp. 635-644
    • Bolkun, L.1    Lemancewicz, D.2    Jablonska, E.3    Kulczynska, A.4    Bolkun-Skornicka, U.5    Kloczko, J.6
  • 65
    • 84880964855 scopus 로고    scopus 로고
    • Evaluation of TNF superfamily molecules in multiple myeloma patients: Correlation with biological and clinical features
    • Lemancewicz D, Bolkun L, Jablonska E, Kulczynska A, Bolkun-Skornicka U, Kloczko J et al. Evaluation of TNF superfamily molecules in multiple myeloma patients: Correlation with biological and clinical features. Leuk Res 2013; 37: 1089-1093.
    • (2013) Leuk Res , vol.37 , pp. 1089-1093
    • Lemancewicz, D.1    Bolkun, L.2    Jablonska, E.3    Kulczynska, A.4    Bolkun-Skornicka, U.5    Kloczko, J.6
  • 66
    • 84881504556 scopus 로고    scopus 로고
    • Relationship between circulating BAFF serum levels with proliferating markers in patients with multiple myeloma
    • Alexandrakis M, Roussou P, Pappa C, Messaritakis I, Xekalou A, Goulidaki N et al. Relationship between circulating BAFF serum levels with proliferating markers in patients with multiple myeloma. BioMed Res Int 2013; 2013: 1-6.
    • (2013) BioMed Res Int , vol.2013 , pp. 1-6
    • Alexandrakis, M.1    Roussou, P.2    Pappa, C.3    Messaritakis, I.4    Xekalou, A.5    Goulidaki, N.6
  • 68
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab M, Vallet S, Hideshima T, Raje N, Mitsiades C et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008; 22: 1925-1932.
    • (2008) Leukemia , vol.22 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.2    Vallet, S.3    Hideshima, T.4    Raje, N.5    Mitsiades, C.6
  • 69
    • 33745193755 scopus 로고    scopus 로고
    • BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: A rationale for TACI-Fc treatment in patients with multiple myeloma
    • Abe M, Kido S, Hiasa M, Nakano A, Oda A, Amou H et al. BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma. Leukemia 2006; 20: 1313-1315.
    • (2006) Leukemia , vol.20 , pp. 1313-1315
    • Abe, M.1    Kido, S.2    Hiasa, M.3    Nakano, A.4    Oda, A.5    Amou, H.6
  • 70
    • 39149085356 scopus 로고    scopus 로고
    • Atacicept (TACI-Ig) inhibits growth of TACIhigh primary myeloma cells in SCID-hu mice and in coculture with osteoclasts
    • Yaccoby S, Pennisi A, Li X, Dillon S, Zhan F, Barlogie B et al. Atacicept (TACI-Ig) inhibits growth of TACIhigh primary myeloma cells in SCID-hu mice and in coculture with osteoclasts. Leukemia 2008; 22: 406-413.
    • (2008) Leukemia , vol.22 , pp. 406-413
    • Yaccoby, S.1    Pennisi, A.2    Li, X.3    Dillon, S.4    Zhan, F.5    Barlogie, B.6
  • 71
    • 70349675652 scopus 로고    scopus 로고
    • Atacicept in relapsed/refractory multiple myeloma or active Waldenstrom's macro-globulinemia: A phase i study
    • Rossi J, Moreaux J, Hose D, Requirand G, Rose M, Rouille V et al. Atacicept in relapsed/refractory multiple myeloma or active Waldenstrom's macro-globulinemia: a phase I study. Br J Cancer 2009; 101: 1051-1058.
    • (2009) Br J Cancer , vol.101 , pp. 1051-1058
    • Rossi, J.1    Moreaux, J.2    Hose, D.3    Requirand, G.4    Rose, M.5    Rouille, V.6
  • 72
    • 84865530770 scopus 로고    scopus 로고
    • Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival
    • Sanchez E, Li M, Kitto A, Li J, Wang C, Kirk D et al. Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival. Br J Haematol 2012; 158: 727-738.
    • (2012) Br J Haematol , vol.158 , pp. 727-738
    • Sanchez, E.1    Li, M.2    Kitto, A.3    Li, J.4    Wang, C.5    Kirk, D.6
  • 73
    • 36749058984 scopus 로고    scopus 로고
    • Antibody targeting of B-cell maturation antigen on malignant plasma cells
    • Ryan M, Hering M, Peckham D, McDonagh C, Brown L, Kim K et al. Antibody targeting of B-cell maturation antigen on malignant plasma cells. Mol Cancer Ther 2007; 6: 3009-3018.
    • (2007) Mol Cancer Ther , vol.6 , pp. 3009-3018
    • Ryan, M.1    Hering, M.2    Peckham, D.3    McDonagh, C.4    Brown, L.5    Kim, K.6
  • 74
    • 84901433313 scopus 로고    scopus 로고
    • Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma
    • Tai Y, Mayes P, Acharya C, Zhong M, Cea M, Cagnetta A et al. Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. Blood 2014; 123: 3128-3138.
    • (2014) Blood , vol.123 , pp. 3128-3138
    • Tai, Y.1    Mayes, P.2    Acharya, C.3    Zhong, M.4    Cea, M.5    Cagnetta, A.6
  • 75
    • 84877087137 scopus 로고    scopus 로고
    • B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma
    • Carpenter R, Evbuomwam M, Pittaluga S, Rose J, Raffeld M, Yang S et al. B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma. Clin Cancer Res 2013; 19: 2048-2060.
    • (2013) Clin Cancer Res , vol.19 , pp. 2048-2060
    • Carpenter, R.1    Evbuomwam, M.2    Pittaluga, S.3    Rose, J.4    Raffeld, M.5    Yang, S.6
  • 76
    • 49449092839 scopus 로고    scopus 로고
    • Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    • Petri M, Stohl W, Chatham W, McCune W, Chevrier M, Ryel J et al. Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum 2008; 58: 2453-2459.
    • (2008) Arthritis Rheum , vol.58 , pp. 2453-2459
    • Petri, M.1    Stohl, W.2    Chatham, W.3    McCune, W.4    Chevrier, M.5    Ryel, J.6
  • 77
    • 84923330305 scopus 로고    scopus 로고
    • Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor
    • Manetta J, Bina H, Ryan P, Fox N, Witcher D, Kikly K. generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor. J Inflamm Res 2014; 7: 121-131.
    • (2014) J Inflamm Res , vol.7 , pp. 121-131
    • Manetta, J.1    Bina, H.2    Ryan, P.3    Fox, N.4    Witcher, D.5    Kikly, K.6
  • 78
    • 84895813683 scopus 로고    scopus 로고
    • Phase 1 study of tabalumab, a human anti-BAFF antibody and bortezomib in patients with previously-treated multiple myeloma
    • Abstract 447
    • Raje N EF Jr, Richardson P, Schiller G, Hohl R, Cohen A et al. Phase 1 study of tabalumab, a human anti-BAFF antibody and bortezomib in patients with previously-treated multiple myeloma. ASH Annual Meeting and Exposition 2012. Abstract 447.
    • ASH Annual Meeting and Exposition 2012
    • Raje, Jr.N.E.F.1    Richardson, P.2    Schiller, G.3    Hohl, R.4    Cohen, A.5
  • 80
    • 79959531760 scopus 로고    scopus 로고
    • Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas
    • Guadagnoli M, Kimberley F, Phan U, Cameron K, Vink P, Rodermond H et al. Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas. Blood 2011; 117: 6856-6865.
    • (2011) Blood , vol.117 , pp. 6856-6865
    • Guadagnoli, M.1    Kimberley, F.2    Phan, U.3    Cameron, K.4    Vink, P.5    Rodermond, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.