Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: In vitro and in vivo evaluation

European Journal of Pharmaceutical Sciences

Volumn 74, Issue , 2015, Pages 1-10

  Inugala, Spandana ^a   Eedara, Basanth Babu ^a   Sunkavalli, Sharath ^a   Dhurke, Rajeshri ^a   Kandadi, Prabhakar ^a   Jukanti, Raju ^a   Bandari, Suresh ^a  

^a ST PETER'S INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

Bioavailability; Darunavir; Dissolution; Globule size; Solid self nanoemulsifying drug delivery system

Indexed keywords

CREMOPHOR; DARUNAVIR; DIETHYLENE GLYCOL MONOETHYL ETHER; LABRAFAC CC; LABRAFIL M; LABRASOL; LAUROGLYCOL; OCTANOIN; POLYSORBATE 80; SURFACTANT; TRANSCUTOL P; UNCLASSIFIED DRUG; ACYLGLYCEROL; CAPMUL MCM C8; DELAYED RELEASE FORMULATION; EMULSION; ETHYLENE GLYCOL DERIVATIVE; EXCIPIENT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; NANOMATERIAL; OCTANOIC ACID DERIVATIVE; POLYSORBATE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIPOPROTEIN SYNTHESIS; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NANOEMULSION; NONHUMAN; PHASE SEPARATION; PHYSICAL CHEMISTRY; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SYSTEMIC CIRCULATION; TEMPERATURE; THERMODYNAMICS; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY POWDER DIFFRACTION; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANALYSIS; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG STABILITY; EMULSION; HALF LIFE TIME; MALE; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; PHARMACOKINETICS; RANDOMIZATION; SURFACE PROPERTY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CAPRYLATES; DARUNAVIR; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; DRUG STABILITY; EMULSIONS; ETHYLENE GLYCOLS; EXCIPIENTS; GLYCERIDES; HALF-LIFE; HIV PROTEASE INHIBITORS; MALE; NANOSTRUCTURES; PARTICLE SIZE; POLYSORBATES; RANDOM ALLOCATION; RATS, WISTAR; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS;

EID: 84927926114     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.03.024     Document Type: Article

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