Insights into laccase engineering from molecular simulations: Toward a binding-focused strategy

Journal of Physical Chemistry Letters

Volumn 6, Issue 8, 2015, Pages 1447-1453

  Monza, Emanuele ^a   Lucas, M Fatima ^a   Camarero, Susana ^b   Alejaldre, Lorea C ^b   Martínez, Angel T ^b   Guallar, Victor ^a,c  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

copper oxidoreductases; directed evolution; in silico enzyme engineering; PELE; substrate binding; substrate oxidation

Indexed keywords

BINDING ENERGY; COPPER; ENZYME ACTIVITY; OXIDATION; REDOX REACTIONS; SUBSTRATES;

DIRECTED EVOLUTION; ENZYME ENGINEERING; OXIDO-REDUCTASES; PELE; SUBSTRATE BINDING; SUBSTRATE OXIDATION;

ENZYMES;

COPPER; FUNGAL PROTEIN; LACCASE; PROTEIN BINDING;

CHEMISTRY; ENZYME ACTIVE SITE; FUNGUS; MOLECULAR DYNAMICS; OXIDATION REDUCTION REACTION; PROTEIN ENGINEERING;

CATALYTIC DOMAIN; COPPER; FUNGAL PROTEINS; FUNGI; LACCASE; MOLECULAR DYNAMICS SIMULATION; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN ENGINEERING;

EID: 84927918112     PISSN: None     EISSN: 19487185     Source Type: Journal    
DOI: 10.1021/acs.jpclett.5b00225     Document Type: Article

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