CYP2J2 and EETs protect against lung ischemia/reperfusion injury via anti-inflammatory effects in vivo and in vitro

Cellular Physiology and Biochemistry

Volumn 35, Issue 5, 2015, Pages 2043-2054

  Chen, Wenshu ^a,b   Yang, Shijiang ^c   Ping, Wei ^a   Fu, Xiangning ^a   Xu, Qinzi ^a   Wang, Jianing ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c CENTRAL HOSPITAL OF WUHAN   (China)

Author keywords

Cytochrome P450 epoxygenase 2J2; Epoxyeicosatrienoic acid; Inflammation; Lung ischemia reperfusion injury

Indexed keywords

11,12 EPOXYICOSATRIENOIC ACID; ANTIINFLAMMATORY AGENT; CYTOCHROME P450 2J2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPOXYICOSATRIENOIC ACID; I KAPPA B ALPHA; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PADGEM PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTECTIVE AGENT; PROTEIN; RESPIRATORY TRACT AGENT; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; 11,12-EPOXY-5,8,14-EICOSATRIENOIC ACID; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; ARACHIDONATE EPOXYGENASE; AUTACOID; CYTOCHROME P450; CYTOKINE; DIHOMO GAMMA LINOLENIC ACID; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ANTIINFLAMMATORY ACTIVITY; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRY WEIGHT; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIA; LUNG EDEMA; LUNG ENDOTHELIUM; LUNG HILUS; LUNG INJURY; LUNG ISCHEMIA; LUNG LAVAGE; LUNG PROTECTION; LUNG WEIGHT; MALE; MICROSCOPY; NONHUMAN; NONVIRAL GENE THERAPY; PNEUMONIA; PRIORITY JOURNAL; PROPHYLAXIS; PROTECTION; PROTEIN DEGRADATION; PULMONARY ARTERY ENDOTHELIAL CELL; RAT; REOXYGENATION; REPERFUSION INJURY; TRANSCRIPTION INITIATION; UPREGULATION; WEIGHT, MASS AND SIZE; WET WEIGHT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CELL HYPOXIA; CELL LINE; DOWN REGULATION; DRUG EFFECTS; GENETICS; LUNG; METABOLISM; PATHOLOGY; TRANSGENIC RAT; WISTAR RAT;

RATTUS;

8,11,14-EICOSATRIENOIC ACID; ANILIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL HYPOXIA; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; CYTOKINES; DOWN-REGULATION; E-SELECTIN; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; LUNG; MALE; P-SELECTIN; PPAR GAMMA; RATS; RATS, TRANSGENIC; RATS, WISTAR; REPERFUSION INJURY; TRANSCRIPTION FACTOR RELA;

EID: 84927917540     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374011     Document Type: Article

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