메뉴 건너뛰기




Volumn 165, Issue 5, 2015, Pages 558-577

Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; DOXORUBICIN; MITHRAMYCIN; MITHRAMYCIN A; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; ANTINEOPLASTIC AGENT; SP1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SP1;

EID: 84927911295     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2014.10.011     Document Type: Article
Times cited : (39)

References (72)
  • 1
    • 84901677321 scopus 로고    scopus 로고
    • Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
    • T. Yi, B. Zhai, and Y. Yu Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells Proc Natl Acad Sci U S A 111 2014 E2182 E2190
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E2182-E2190
    • Yi, T.1    Zhai, B.2    Yu, Y.3
  • 3
    • 0036731788 scopus 로고    scopus 로고
    • Revision of the American Joint Committee on Cancer staging system for breast cancer
    • S.E. Singletary, C. Allred, and P. Ashley Revision of the American Joint Committee on Cancer staging system for breast cancer J Clin Oncol 20 2002 3628 3636
    • (2002) J Clin Oncol , vol.20 , pp. 3628-3636
    • Singletary, S.E.1    Allred, C.2    Ashley, P.3
  • 4
    • 69249216565 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy for locally advanced breast cancer
    • J. Specht, and J.R. Gralow Neoadjuvant chemotherapy for locally advanced breast cancer Semin Radiat Oncol 19 2009 222 228
    • (2009) Semin Radiat Oncol , vol.19 , pp. 222-228
    • Specht, J.1    Gralow, J.R.2
  • 6
    • 0036749681 scopus 로고    scopus 로고
    • The biology of neoadjuvant chemotherapy for breast cancer
    • S. Cleator, M. Parton, and M. Dowsett The biology of neoadjuvant chemotherapy for breast cancer Endocr Relat Cancer 9 2002 183 195
    • (2002) Endocr Relat Cancer , vol.9 , pp. 183-195
    • Cleator, S.1    Parton, M.2    Dowsett, M.3
  • 7
    • 0037768576 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy for operable breast cancer: Is this the future?
    • E.P. Mamounas Neoadjuvant chemotherapy for operable breast cancer: is this the future? Clin Breast Cancer 4 2003 s10 s19
    • (2003) Clin Breast Cancer , vol.4 , pp. s10-s19
    • Mamounas, E.P.1
  • 8
    • 77952685660 scopus 로고    scopus 로고
    • Primary systemic chemotherapy for inflammatory breast cancer
    • S. Sinclair, and S.M. Swain Primary systemic chemotherapy for inflammatory breast cancer Cancer 116 2010 s2821 s2828
    • (2010) Cancer , vol.116 , pp. s2821-s2828
    • Sinclair, S.1    Swain, S.M.2
  • 9
    • 77956178360 scopus 로고    scopus 로고
    • Cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • A. Singh, and J. Settleman Cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Oncogene 29 2010 4741 4751
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 10
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: Cancer stem cells in therapeutic resistance and angiogenesis
    • C.E. Eyler, and J.N. Rich Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis J Clin Oncol 26 2008 2839 2845
    • (2008) J Clin Oncol , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 11
    • 84911411198 scopus 로고    scopus 로고
    • Cancer stem cells under hypoxia as a chemoresistance factor in breast and brain
    • S.W. Crowder, D.A. Balikov, Y.S. Hwang, and H.J. Sung Cancer stem cells under hypoxia as a chemoresistance factor in breast and brain Curr Pathobiol Rep 2 2014 33 40
    • (2014) Curr Pathobiol Rep , vol.2 , pp. 33-40
    • Crowder, S.W.1    Balikov, D.A.2    Hwang, Y.S.3    Sung, H.J.4
  • 12
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • M. Diehn, R.W. Cho, and N.A. Lobo Association of reactive oxygen species levels and radioresistance in cancer stem cells Nature 458 2009 780 783
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 13
    • 79952616429 scopus 로고    scopus 로고
    • Breast cancer stem cells and their role in resistance to endocrine therapy
    • C.S. O'Brien, G. Farnie, S.J. Howell, and R.B. Clarke Breast cancer stem cells and their role in resistance to endocrine therapy Horm Cancer 2 2011 91 103
    • (2011) Horm Cancer , vol.2 , pp. 91-103
    • O'Brien, C.S.1    Farnie, G.2    Howell, S.J.3    Clarke, R.B.4
  • 14
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • X. Li, M.T. Lewis, and J. Huang Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy J Natl Cancer Inst 100 2008 672 679
    • (2008) J Natl Cancer Inst , vol.100 , pp. 672-679
    • Li, X.1    Lewis, M.T.2    Huang, J.3
  • 15
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • C.J. Creighton, X. Li, and M. Landis Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features Proc Natl Acad Sci U S A 106 2009 13820 13825
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3
  • 16
    • 67449113764 scopus 로고    scopus 로고
    • Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers
    • T. Tanei, K. Morimoto, and K. Shimazu Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers Clin Cancer Res 15 2009 4234 4241
    • (2009) Clin Cancer Res , vol.15 , pp. 4234-4241
    • Tanei, T.1    Morimoto, K.2    Shimazu, K.3
  • 17
    • 84863201206 scopus 로고    scopus 로고
    • - phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma
    • - phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma J Exp Clin Cancer Res 31 2012 59
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 59
    • Lin, Y.1    Zhong, Y.2    Guan, H.3    Zhang, X.4    Sun, Q.5
  • 18
    • 84901649147 scopus 로고    scopus 로고
    • Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer
    • M. Alamgeer, V. Ganju, and B. Kumar Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer Breast Cancer Res 16 2014 R44
    • (2014) Breast Cancer Res , vol.16 , pp. R44
    • Alamgeer, M.1    Ganju, V.2    Kumar, B.3
  • 19
    • 79952993517 scopus 로고    scopus 로고
    • Multidrug efflux pumps and cancer stem cells: Insights into multidrug resistance and therapeutic development
    • K. Moitra, H. Lou, and M. Dean Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development Clin Pharmacol Ther 89 2011 491 502
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 491-502
    • Moitra, K.1    Lou, H.2    Dean, M.3
  • 20
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • M.M. Gottesman, T. Fojo, and S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nat Rev Cancer 2 2014 48 58
    • (2014) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 21
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • R. Krishna, and L.D. Mayer Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs Eur J Pharm Sci 11 2000 265 283
    • (2000) Eur J Pharm Sci , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 22
    • 84888432948 scopus 로고    scopus 로고
    • Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype
    • W.J. Yang, M.J. Song, and E.Y. Park Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype Mol Cells 36 2013 368 375
    • (2013) Mol Cells , vol.36 , pp. 368-375
    • Yang, W.J.1    Song, M.J.2    Park, E.Y.3
  • 23
    • 84880931435 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line
    • J. Li, X. Wu, and J. Gong Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line Acta Biochim Biophys Sin (Shanghai) 45 2013 656 663
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , pp. 656-663
    • Li, J.1    Wu, X.2    Gong, J.3
  • 24
    • 0345688182 scopus 로고    scopus 로고
    • Transcriptional regulation of ABC drug transporters
    • K.W. Scotto Transcriptional regulation of ABC drug transporters Oncogene 22 2003 7496 7511
    • (2003) Oncogene , vol.22 , pp. 7496-7511
    • Scotto, K.W.1
  • 25
    • 27544439766 scopus 로고    scopus 로고
    • Sp1 transcription factor family and its role in cancer
    • S. Safe, and M. Abdelrahim Sp1 transcription factor family and its role in cancer Eur J Cancer 41 2005 2438 2448
    • (2005) Eur J Cancer , vol.41 , pp. 2438-2448
    • Safe, S.1    Abdelrahim, M.2
  • 26
    • 84898999261 scopus 로고    scopus 로고
    • Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: Implications for epithelial-mesenchymal transition
    • N. Kolesnikoff, J.L. Attema, and S. Roslan Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition J Biol Chem 289 2014 11194 11205
    • (2014) J Biol Chem , vol.289 , pp. 11194-11205
    • Kolesnikoff, N.1    Attema, J.L.2    Roslan, S.3
  • 27
    • 4644274880 scopus 로고    scopus 로고
    • Role of Sp1 proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells
    • M. Abdelrahim, R. Smith III, R. Burghardt, and S. Safe Role of Sp1 proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells Cancer Res 64 2004 6740 6749
    • (2004) Cancer Res , vol.64 , pp. 6740-6749
    • Abdelrahim, M.1    Smith, R.2    Burghardt, R.3    Safe, S.4
  • 28
    • 56049125650 scopus 로고    scopus 로고
    • Expression and prognostic value of transcriptional factor Sp1 in breast cancer
    • X.B. Wang, W.Q. Peng, Z.J. Yi, S.L. Zhu, and Q.H. Gan Expression and prognostic value of transcriptional factor Sp1 in breast cancer Ai Zheng 26 2007 996 1000
    • (2007) Ai Zheng , vol.26 , pp. 996-1000
    • Wang, X.B.1    Peng, W.Q.2    Yi, Z.J.3    Zhu, S.L.4    Gan, Q.H.5
  • 29
    • 84882719818 scopus 로고    scopus 로고
    • Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts
    • Y. Zhao, W. Zhang, and Z. Guo Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts Oncol Rep 30 2013 1782 1792
    • (2013) Oncol Rep , vol.30 , pp. 1782-1792
    • Zhao, Y.1    Zhang, W.2    Guo, Z.3
  • 30
    • 84865114153 scopus 로고    scopus 로고
    • Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells
    • M. Zhang, A. Mathur, and Y. Zhang Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells Cancer Res 72 2012 4178 4192
    • (2012) Cancer Res , vol.72 , pp. 4178-4192
    • Zhang, M.1    Mathur, A.2    Zhang, Y.3
  • 31
    • 0035089787 scopus 로고    scopus 로고
    • Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons
    • S. Chatterjee, K. Zaman, H. Ryu, A. Conforto, and R.R. Ratan Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons Ann Neurol 49 2001 345 354
    • (2001) Ann Neurol , vol.49 , pp. 345-354
    • Chatterjee, S.1    Zaman, K.2    Ryu, H.3    Conforto, A.4    Ratan, R.R.5
  • 32
    • 79955755623 scopus 로고    scopus 로고
    • Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration
    • S.F. Leiman, B.C. Langley, and M. Basso Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration J Neurosci 31 2011 6858 6870
    • (2011) J Neurosci , vol.31 , pp. 6858-6870
    • Leiman, S.F.1    Langley, B.C.2    Basso, M.3
  • 34
    • 0033050164 scopus 로고    scopus 로고
    • Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy
    • H.M. Kuerer, L.A. Newman, and T.L. Smith Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy J Clin Oncol 17 1999 460 469
    • (1999) J Clin Oncol , vol.17 , pp. 460-469
    • Kuerer, H.M.1    Newman, L.A.2    Smith, T.L.3
  • 35
    • 36448985969 scopus 로고    scopus 로고
    • Preoperative chemotherapy treatment of breast cancer - A review
    • A.U. Buzdar Preoperative chemotherapy treatment of breast cancer - a review Cancer 110 2007 2394 2407
    • (2007) Cancer , vol.110 , pp. 2394-2407
    • Buzdar, A.U.1
  • 36
    • 82355163145 scopus 로고    scopus 로고
    • Phase III randomized trial of dose intensive neoadjuvant chemotherapy with or without G-CSF in locally advanced breast cancer: Long-term results
    • B.K. Arun, K. Dhinghra, and V. Valero Phase III randomized trial of dose intensive neoadjuvant chemotherapy with or without G-CSF in locally advanced breast cancer: long-term results Oncologist 16 2011 1527 1534
    • (2011) Oncologist , vol.16 , pp. 1527-1534
    • Arun, B.K.1    Dhinghra, K.2    Valero, V.3
  • 37
    • 1642322306 scopus 로고    scopus 로고
    • Clinical practice guidelines for the care and treatment of breast cancer: Treatment for women with stage III or locally advanced breast cancer
    • Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
    • T. Shenkier, L. Weir, M. Levine, I. Olivotto, T. Whelan, L. Reyno Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer Clinical practice guidelines for the care and treatment of breast cancer: treatment for women with stage III or locally advanced breast cancer CMAJ 170 2004 983 994
    • (2004) CMAJ , vol.170 , pp. 983-994
    • Shenkier, T.1    Weir, L.2    Levine, M.3    Olivotto, I.4    Whelan, T.5    Reyno, L.6
  • 38
    • 77954331064 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version)
    • M.E. Hammond, D.F. Hayes, and M. Dowsett American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version) Arch Pathol Lab Med 134 2010 e48 e72
    • (2010) Arch Pathol Lab Med , vol.134 , pp. e48-e72
    • Hammond, M.E.1    Hayes, D.F.2    Dowsett, M.3
  • 39
    • 84862893473 scopus 로고    scopus 로고
    • Pathological complete response and accelerated drug approval in early breast cancer
    • T.M. Prowell, and R. Pazdur Pathological complete response and accelerated drug approval in early breast cancer N Engl J Med 366 2012 2438 2441
    • (2012) N Engl J Med , vol.366 , pp. 2438-2441
    • Prowell, T.M.1    Pazdur, R.2
  • 40
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • E.A. Eisenhauer, P. Therasse, and J. Bogaerts New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) Eur J Cancer 45 2009 228 247
    • (2009) Eur J Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 41
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • G. Dontu, W.M. Abdallah, and J.M. Foley In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells Genes Dev 17 2003 1253 1270
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3
  • 43
    • 84899487799 scopus 로고    scopus 로고
    • ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors
    • S. Mohanty, S. Saha, and D. Md S Hossain ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors Cell Death Dis 5 2014 e1021
    • (2014) Cell Death Dis , vol.5 , pp. e1021
    • Mohanty, S.1    Saha, S.2    Md Hossain S, D.3
  • 44
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • C.M. Fillmore, and C. Kuperwasser Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy Breast Cancer Res 10 2008 R25
    • (2008) Breast Cancer Res , vol.10 , pp. R25
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 45
    • 84908142759 scopus 로고    scopus 로고
    • Contribution of the ROS-p53 feedback loop in thuja-induced apoptosis of mammary epithelial carcinoma cells
    • S. Saha, P. Bhattacharjee, and S. Mukherjee Contribution of the ROS-p53 feedback loop in thuja-induced apoptosis of mammary epithelial carcinoma cells Oncol Rep 31 2014 1589 1598
    • (2014) Oncol Rep , vol.31 , pp. 1589-1598
    • Saha, S.1    Bhattacharjee, P.2    Mukherjee, S.3
  • 46
    • 37349069575 scopus 로고    scopus 로고
    • Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells
    • F. Shen, S. Chu, and A.K. Bence Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells J Pharmacol Exp Ther 324 2008 95 102
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 95-102
    • Shen, F.1    Chu, S.2    Bence, A.K.3
  • 47
    • 84907163267 scopus 로고    scopus 로고
    • Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: Dual role of SMAR1 in breast cancer cells
    • A. Adhikary, S. Chakraborty, and M. Mazumdar Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of SMAR1 in breast cancer cells J Biol Chem 289 2014 25431 25444
    • (2014) J Biol Chem , vol.289 , pp. 25431-25444
    • Adhikary, A.1    Chakraborty, S.2    Mazumdar, M.3
  • 48
    • 84876066080 scopus 로고    scopus 로고
    • Targeting RET to induce medullary thyroid cancer cell apoptosis: An antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways
    • M. Mazumdar, A. Adhikary, and S. Chakraborty Targeting RET to induce medullary thyroid cancer cell apoptosis: an antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways Apoptosis 18 2013 589 604
    • (2013) Apoptosis , vol.18 , pp. 589-604
    • Mazumdar, M.1    Adhikary, A.2    Chakraborty, S.3
  • 49
    • 84908190496 scopus 로고    scopus 로고
    • Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone de-acetylation
    • S. Chakraborty, K. Das, and S. Saha Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone de-acetylation J Biol Chem 289 2014 29074 29085
    • (2014) J Biol Chem , vol.289 , pp. 29074-29085
    • Chakraborty, S.1    Das, K.2    Saha, S.3
  • 50
    • 84865623584 scopus 로고    scopus 로고
    • Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue
    • S.J. Potts, J.S. Krueger, and N.D. Landis Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue Lab Invest 92 2012 1342 1357
    • (2012) Lab Invest , vol.92 , pp. 1342-1357
    • Potts, S.J.1    Krueger, J.S.2    Landis, N.D.3
  • 51
    • 84884996900 scopus 로고    scopus 로고
    • The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy
    • A.D. Hartkopf, F.A. Taran, and M. Wallwiener The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy Breast Cancer Res 15 2013 R94
    • (2013) Breast Cancer Res , vol.15 , pp. R94
    • Hartkopf, A.D.1    Taran, F.A.2    Wallwiener, M.3
  • 52
    • 0022891311 scopus 로고
    • Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea
    • C.A. Koller, and D.M. Miller Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea N Engl J Med 315 1986 1433 1438
    • (1986) N Engl J Med , vol.315 , pp. 1433-1438
    • Koller, C.A.1    Miller, D.M.2
  • 53
    • 77949881949 scopus 로고    scopus 로고
    • An expanded Oct4 interaction network: Implications for stem cell biology, development, and disease
    • M. Pardo, B. Lang, and L. Yu An expanded Oct4 interaction network: implications for stem cell biology, development, and disease Cell Stem Cell 6 2010 382 395
    • (2010) Cell Stem Cell , vol.6 , pp. 382-395
    • Pardo, M.1    Lang, B.2    Yu, L.3
  • 54
    • 27644484522 scopus 로고    scopus 로고
    • Characterization of putative cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter
    • H.M. Yang, H.J. Do, and J.H. Oh Characterization of putative cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter J Cell Biochem 96 2005 821 830
    • (2005) J Cell Biochem , vol.96 , pp. 821-830
    • Yang, H.M.1    Do, H.J.2    Oh, J.H.3
  • 55
    • 33645079382 scopus 로고    scopus 로고
    • Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter
    • D.Y. Wu, and Z. Yao Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter Cell Res 16 2006 319 322
    • (2006) Cell Res , vol.16 , pp. 319-322
    • Wu, D.Y.1    Yao, Z.2
  • 56
    • 12844275026 scopus 로고    scopus 로고
    • Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
    • H. Mizutani, S. Tada-Oikawa, Y. Hiraku, M. Kojima, and S. Kawanishi Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide Life Sci 76 2005 1439 1453
    • (2005) Life Sci , vol.76 , pp. 1439-1453
    • Mizutani, H.1    Tada-Oikawa, S.2    Hiraku, Y.3    Kojima, M.4    Kawanishi, S.5
  • 57
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity Pharmacol Rev 56 2004 185 229
    • (2004) Pharmacol Rev , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 58
    • 0030986845 scopus 로고    scopus 로고
    • Expression of drug resistance proteins in breast cancer, in relation to chemotherapy
    • S.C. Linn, H.M. Pinedo, and J. van Ark-Otte Expression of drug resistance proteins in breast cancer, in relation to chemotherapy Int J Cancer 71 1997 787 795
    • (1997) Int J Cancer , vol.71 , pp. 787-795
    • Linn, S.C.1    Pinedo, H.M.2    Van Ark-Otte, J.3
  • 60
    • 44349152332 scopus 로고    scopus 로고
    • Factors that predict early treatment failure for patients with locally advanced (T4) breast cancer
    • E. Montagna, V. Bagnardi, and N. Rotmensz Factors that predict early treatment failure for patients with locally advanced (T4) breast cancer Br J Cancer 98 2008 1745 1752
    • (2008) Br J Cancer , vol.98 , pp. 1745-1752
    • Montagna, E.1    Bagnardi, V.2    Rotmensz, N.3
  • 61
    • 66349089054 scopus 로고    scopus 로고
    • Phase III trial evaluating the addition of paclitaxel to doxorubicin followed by cyclophosphamide, methotrexate, and fluorouracil, as adjuvant or primary systemic therapy: European Cooperative Trial in Operable Breast Cancer
    • L. Gianni, J. Baselga, and W. Eiermann Phase III trial evaluating the addition of paclitaxel to doxorubicin followed by cyclophosphamide, methotrexate, and fluorouracil, as adjuvant or primary systemic therapy: European Cooperative Trial in Operable Breast Cancer J Clin Oncol 27 2009 2474 2481
    • (2009) J Clin Oncol , vol.27 , pp. 2474-2481
    • Gianni, L.1    Baselga, J.2    Eiermann, W.3
  • 62
    • 41949104971 scopus 로고    scopus 로고
    • Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial
    • M. Dowsett, C. Allred, and J. Knox Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial J Clin Oncol 26 2008 1059 1065
    • (2008) J Clin Oncol , vol.26 , pp. 1059-1065
    • Dowsett, M.1    Allred, C.2    Knox, J.3
  • 63
    • 79952821476 scopus 로고    scopus 로고
    • A role for OCT4 in tumor initiation of drug-resistant prostate cancer cells
    • D.E. Linn, X. Yang, and F. Sun A role for OCT4 in tumor initiation of drug-resistant prostate cancer cells Genes Cancer 1 2010 908 916
    • (2010) Genes Cancer , vol.1 , pp. 908-916
    • Linn, D.E.1    Yang, X.2    Sun, F.3
  • 64
    • 77955699082 scopus 로고    scopus 로고
    • Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway
    • X.Q. Wang, W.M. Ongkeko, and L. Chen Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway Hepatology 52 2010 528 539
    • (2010) Hepatology , vol.52 , pp. 528-539
    • Wang, X.Q.1    Ongkeko, W.M.2    Chen, L.3
  • 65
    • 84896737061 scopus 로고    scopus 로고
    • Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreening
    • Y. Huang, B. Ju, and J. Tian Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreening Oncol Rep 31 2014 1235 1248
    • (2014) Oncol Rep , vol.31 , pp. 1235-1248
    • Huang, Y.1    Ju, B.2    Tian, J.3
  • 66
    • 84894288830 scopus 로고    scopus 로고
    • Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors
    • S. Boichuk, D.J. Lee, and K.R. Mehalek Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors Cancer Res 74 2014 1200 1213
    • (2014) Cancer Res , vol.74 , pp. 1200-1213
    • Boichuk, S.1    Lee, D.J.2    Mehalek, K.R.3
  • 67
    • 84876094075 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer stem cells
    • M. Signore, L. Ricci-Vitiani, and R. De Maria Targeting apoptosis pathways in cancer stem cells Cancer Lett 332 2013 374 382
    • (2013) Cancer Lett , vol.332 , pp. 374-382
    • Signore, M.1    Ricci-Vitiani, L.2    De Maria, R.3
  • 68
    • 84897516001 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction promotes c-Jun signalling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells
    • L. Chen, and L.Y. Bourguignon Hyaluronan-CD44 interaction promotes c-Jun signalling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells Mol Cancer 13 2014 52
    • (2014) Mol Cancer , vol.13 , pp. 52
    • Chen, L.1    Bourguignon, L.Y.2
  • 69
    • 0034046040 scopus 로고    scopus 로고
    • Transcriptional activation of transforming growth factor alpha by estradiol: Requirement for both a GC-rich site and an estrogen response element half-site
    • C. Vyhlidal, I. Samudio, M.P. Kladde, and S. Safe Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site J Mol Endocrinol 24 2000 329 338
    • (2000) J Mol Endocrinol , vol.24 , pp. 329-338
    • Vyhlidal, C.1    Samudio, I.2    Kladde, M.P.3    Safe, S.4
  • 70
    • 33845191515 scopus 로고    scopus 로고
    • Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites
    • T.J. Lee, E.M. Jung, and J.T. Lee Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites Mol Cancer Ther 5 2006 2737 2746
    • (2006) Mol Cancer Ther , vol.5 , pp. 2737-2746
    • Lee, T.J.1    Jung, E.M.2    Lee, J.T.3
  • 71
    • 79952184934 scopus 로고    scopus 로고
    • Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma
    • J. Seznec, B. Silkenstedt, and U. Naumann Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma J Neurooncol 101 2011 365 377
    • (2011) J Neurooncol , vol.101 , pp. 365-377
    • Seznec, J.1    Silkenstedt, B.2    Naumann, U.3
  • 72
    • 84907474354 scopus 로고    scopus 로고
    • Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration, and development, as well as their bone marrow microenvironment
    • A. Ludin, S. Gur-Cohen, and K. Golan Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration, and development, as well as their bone marrow microenvironment Antioxid Redox Signal 21 2014 1605 1619
    • (2014) Antioxid Redox Signal , vol.21 , pp. 1605-1619
    • Ludin, A.1    Gur-Cohen, S.2    Golan, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.