Transcriptional activation of transforming growth factor α by estradiol: Requirement for both a GC-rich site and an estrogen response element half-site

Journal of Molecular Endocrinology

Volumn 24, Issue 3, 2000, Pages 329-338

  Vyhlidal, C ^a   Samudio, I ^a   Kladde, M P ^a   Safe, S ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTRADIOL RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

CELL STRAIN MCF 7; CONFERENCE PAPER; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENE SEQUENCE; HORMONAL REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

EID: 0034046040     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0240329     Document Type: Conference Paper

References (39)

1. Aaronson SA 1991 Growth factors and cancer. Science 254 1146-1153.
2. Bates SE, Davidson NE, Valverius EM, Freter CE, Dickson RB, Tam JP, Kudlow JE, Lippman ME & Salomon DS 1988 Expression of transforming growth factor-α and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Molecular Endocrinology 2 543-555.
3. Batistuzzo de Medeiros SR, Krey G, Hihi AK & Wahli W 1997 Functional interactions between the estrogen receptor and the transcription activator Sp1 regulate the estrogen-dependent transcriptional activity of the vitellogenin A1 io promoter. Journal of Biological Chemistry 272 18250-18260.
4. Cavailles V, Garcia M & Rochefort H 1989 Regulation of cathepsin D and pS2 gene expression by growth factors in MCF-7 human breast cancer cells. Molecular Endocrinology 3 552-558.
5. Cavailles V, Augereau P & Rochefort H 1993 Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription. Proceedings of the National Academy of Sciences of the USA 90 203-207.
6. Clarke R, Brunner N, Katz D, Glanz P, Dickson RB, Lippman ME & Kern FG 1989 The effects of a constitutive expression of transforming growth factor-α on the growth of MCF-7 human breast cancer cells in vitro and in vivo. Molecular Endocrinology 3 372-380.
7. Cross M & Dexter TM 1991 Growth factors in development, transformation, and tumorigenesis. Cell 64 271-280.
8. Derynck R 1988 Transforming growth factor α. Cell 54 593-595.
9. Dickson RB & Lippman ME 1995 Growth factors in breast cancer. Endocrine Reviews 16 559-589.
10. Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Klade M, Vyhlidal C & Safe S 1999 Mechanisms of transcriptional activation of bcl-2 gene expression by 17β-estradiol in breast cancer cells. Journal of Biological Chemistry 174 32099-32107.
11. Duan R, Porter W & Safe S 1998 Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. Endocrinology 139 1981-1990.
12. Dubik D & Shiu RPC 1992 Mechanism of estrogen activation of c-myc oncogene expression. Oncogens 7 1587-1594.
13. El-Ashry D, Chrysogelos SA, Lippman ME & Kern FG 1996 Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromes. Journal of Steroid Biochemistry and Molecular Biology 59 261-269.
14. Ethier SP 1995 Growth factor synthesis and human breast cancer progression. Journal of the National Cancer Institute 87 964-973.
15. Gillesby B, Santostefano M, Porter W, Wu ZF, Safe S & Zacharewski T 1997 Identification of a motif within the 5′-regulatory region on pS2 which is responsible for Ap1 binding and TCDD-mediated suppression. Biochemistry 36 6080-6089.
16. Gong Y, Ballejo G, Murphy LC & Murphy LJ 1992 Differential effects of estrogen and antiestrogen on transforming growth factor gene expression in endometrial adenocarcinoma cells. Cancer Research 52 1704-1709.
17. Kenney NJ, Saeki T, Gottardis M, Kim N, Garcia-Morales P, Martin MB, Normanno N, Ciardiello F, Day A & Cutler ML 1993 Expression of transforming growth factor α antisense mRNA inhibits the estrogen-induced production of TGFα and estrogen-induced proliferation of estrogen-responsive human breast cancer cells. Journal of Cell Physiology 156 497-514.
18. Keski-Oja J, Postlethwaite AE & Moses HL 1988 Transforming growth factors in the regulation of malignant cell growth and invasion. Cancer Investigation 6 705-724.
19. Kladde MP, Xu M & Simpson RT 1996 Direct study of DNA-protein interactions in repressed and active chromatin in living cells. EMBO Journal 15 6290-6300.
20. Krishnan V, Wang X & Safe S 1994 Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells. Journal of Biological Chemistry 269 15912-15917.
21. Krishnan V, Porter W, Santostefano M, Wang X & Safe S 1995 Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzop-dioxin (TCDD) in MCF-7 cells. Molecular Cellular Biology 15 6710-6719.
22. Manni A, Wright C, Badger B, Bartholomew M, Herlyn M, Mendelsohn J, Masui H & Demers L 1990 Role of transforming growth factor-α-related peptides in the autocrine/paracrine control of experimental breast cancer growth in vitro by estradiol, prolactin, and progesterone. Breast Cancer Research and Treatment 15 73-83.
23. Porter W, Wang F, Wang W, Duan R & Safe S 1996 Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression. Molecular Endocrinology 10 1371-1378.
24. Porter W, Saville B, Hoivik D & Safe S 1997 Functional synergy between the transcription factor Sp1 and the estrogen receptor. Molecular Endocrinology 11 1569-1580.
25. Qin C, Singh P & Safe S 1999 Transcriptional activation of insulin-like growth factor binding protein 4 by 17β-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. Endocrinology 140 2501-2508.
26. Reddy KB, Yee D, Hilsenbeck SG, Coffey RJ & Osborne CK 1994 Inhibition of estrogen-induced breast cancer cell proliferation by reduction in autocrine transforming growth factor α expression. Cell Growth and Differentiation 5 1275-1282.
27. Rishi AK, Shao ZM, Baumann RG, Li XS, Sheikh MS, Kimura S, Bashirelahi N & Fontana JA 1995 Estradiol regulation of the human retinoic acid receptor α gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Sp1 motifs. Cancer Research 55 4999-5006.
28. Saeki T, Cristiano A, Lynch MJ, Brattain M, Kim N, Normanno N, Kenney N, Ciardiello F & Salomon DS 1991 Regulation by estrogen through the 5′-flanking region of the transforming growth factor α gene. Molecular Endocrinology 5 1955-1963.
29. Safe S 1995 Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacology and Therapeutics 67 247-281.
30. Savouret JF, Bailly A, Misrahi M, Rarch C, Redeuilh G, Chauchereau A & Milgrom E 1991 Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene. EMBO Journal 10 1875-1883.
31. Scholz A, Truss M & Beato M 1998 Hormone-induced recruitment of Sp1 mediates estrogen activation of the rabbit uteroglobin gene in endometrial epithelium. Journal of Biological Chemistry 273 4360-4366.
32. Sporn MB & Roberts AB 1985 Autocrine growth factors and cancer. Nature 313 745-747.
33. Sun G, Porter W & Safe S 1998 Estrogen-induced retinoic acid receptor α1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology 12 882-890.
34. Wang F, Hoivik D, Pollenz R & Safe S 1998 Functional and physical interactions between the estrogen receptor-Sp1 and the nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Research 26 3044-3052.
35. Wang W, Dong L, Saville B & Safe S 1999 Transcriptional activation of E2F1 gene expression by 17β-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Molecular Endocrinology 13 1373-1387.
36. Weisz A & Rosales R 1990 Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Research 18 5097-5106.
37. Xie W, Duan R & Safe S 1999 Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions. Endocrinology 140 219-227.
38. Zacharewski T & Safe S 1998 Antiestrogenic activity of TCDD and related compounds. In Reproductive and Developmental Toxicology, pp 431-448. Ed. KS Korach. New York: Marcel Dekker, Inc.
39. Zacharewski TR, Bondy KL, McDonell P & Wu ZF 1994 Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17β-estradiol-induced pS2 expression. Cancer Research 54 2707-2713.