Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples

Experimental Biology and Medicine

Volumn 240, Issue 4, 2015, Pages 488-497

  Fang, Nianbai ^a,b   Yu, Shanggong ^b   Ronis, Martin J J ^a,b   Badger, Thomas M ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Arkansas Children's Nutrition Center   (United States)

Author keywords

bile acid; LC behavior; Liquid chromatography tandem mass spectrometry; matrix effect; piglet urine

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; DEOXYCHOLIC ACID; GLYCOCHOLIC ACID;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET; GENDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX EFFECT; NONHUMAN; PROTEIN STRUCTURE; RETENTION TIME; STATISTICAL PARAMETERS; URINALYSIS; ANIMAL; ANIMAL MODEL; BODY FLUID; CHEMISTRY; COMPARATIVE STUDY; COMPUTER PROGRAM; FEMALE; MALE; METABOLOMICS; PIG; PROCEDURES; STANDARDS; TANDEM MASS SPECTROMETRY; URINE;

ANIMALIA; SUIDAE;

ANIMALS; BILE ACIDS AND SALTS; BODY FLUIDS; CHROMATOGRAPHY, LIQUID; FEMALE; MALE; METABOLOMICS; MODELS, ANIMAL; SOFTWARE; SWINE; TANDEM MASS SPECTROMETRY;

EID: 84927797905     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214554545     Document Type: Article

References (23)

1. Matuszewski BK,Constanzer ML,Chavez-Eng CM.Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.Anal Chem. 2003;75:3019-30
2. Fu I,Woolf EJ,Matuszewski BK.Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection.J Pharm Biomed Anal. 1998;18:347-57
3. Buhrman D,Price P,Rudewicz P.Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: a study of ion suppression.J Am Mass Spectrom. 1996;7:1099-105
4. Hall TG, Smukste I, Bresciano KR, Wang Y, McKearn D, Savage RE. In: Prasain J (ed.) Tandem mass spectrometry-applications and principles. Rijeka, Croatia: InTech, 2012, chap. 18.
5. Chambers E,Wagrowski-Diehl DM,Lu Z,Mazzeo JR.Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses.J Chromatogr B Analyt Technol Biomed Life Sci. 2007;852:22-34
6. Ismaiel OA,Zhang T,Jenkins RG,Karnes HT.Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography/mass spectrometry.J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:3303-16
7. Little JL,Wempe MF,Buchanan CM.Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: examining lipid matrix ionization effects in plasma.J Chromatogr B Analyt Technol Biomed Life Sci. 2006;833:219-30
8. Mallet CR,Lu Z,Mazzeo JR.A study of ion suppression effects in electrospray ionization from mobile phase additives and solid-phase extracts.Rapid Commun Mass Spectrom. 2004;19:49-58
9. Marchi I,Viette V,Badoud F,Fathi M,Saugy M,Rudaz S,Veuthey JL.Characterization and classification of matrix effects in biological samples analyses.J Chromatogr A. 2010;1217:4071-8
10. Muller C,Schafer P,Stortzel M,Vogt S,Weinmann W.Ion suppression effects in liquid chromatography-electrospray-ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries.J Chromatogr B Analyt Technol Biomed Life Sci. 2002;773:47-52
11. Xu X,Mei H,Wang S,Zhou Q,Wang G,Broske L,Pena A,Korfmacher WA.A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays.Rapid Commun Mass Spectrom. 2005;19:2643-50
12. King R,Bonfiglio R,Fernandez-Metzler C,Miller-Stein C,Olah T.Mechanistic investigation of ionization suppression in electrospray ionization.J Am Soc Mass Spectrom. 2000;11:942-50
13. Jessome LL,Volmer DA.Ion Suppression: a major concern in mass spectrometry.LCGC North Am. 2006;24:498-510
14. Trufelli H,Palma P,Famiglini G,Cappiello A.An overview of matrix effects in liquid chromatography-mass spectrometry.Mass Spectrom Rev. 2011;30:491-509
15. Chiu ML,Lawi W,Snyder ST,Wong PK,Liao JC,Gau V.Matrix effects–a challenge toward automation of molecular analysis.J Assoc Lab Automat. 2010;15:233-42
16. Van De Steene JC,Lambert WE.Comparison of matrix effects in HPLC-MS/MS and UPLC-MS/MS analysis of nine basic pharmaceuticals in surface waters.J Am Soc Mass Spectrom. 2008;19:713-8
17. Chen JR,Lazarenko OP,Blackburn ML,Badeaux JV,Badger TM,Ronis MJJ.Infant formula promotes bone growth in neonatal piglets by enhancing osteoblastogenesis through bone morphogenic protein signaling.J Nutr. 2009;139:1839-47
18. Ronis MJJ,Chen Y,Shankar K,Gomez-Acevedo H,Cleves MA,Badeaux J,Blackburn ML,Badger TM.Formula feeding alters hepatic gene expression signature, iron and cholesterol homeostasis in the neonatal pig.Physiol Genomics. 2011;43:1281-93
19. Helm RM,Golden C,McMahon M,Thampi P,Badger TM,Nagarajan S.Diet regulates the development of gut-associated lymphoid tissue in neonatal piglets.Neonatology. 2007;91:248-55
20. Hofmann AF. In: Feldman M, Scharschmidt BF, Sleisenger MH (eds) Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology, diagnosis, management. 6th ed. Philadelphia: WB Saunders Company, 1998, pp.937–48.
21. Heuman DM,Hylemon PB,Vlahcevic ZR.Regulation of bile acid synthesis. III. Correlation between biliary bile acid hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat.J Lipid Res. 1989;30:1161-71
22. Hofmann AF. In: Arias IM (ed.) The liver, biology and pathobiology. 3 rd ed. New York: Raven Press, 1994, pp.677–718.
23. Heuman DM.Quantitative estimation of the hydrophilic- hydrophobic balance of mixed bile salt solutions.J Lipid Res. 1989;30:719-30