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Volumn 16, Issue 1, 2015, Pages

Lung inflammatory pattern and antibiotic treatment in pneumonia

Author keywords

Community acquired pneumonia; Lung inflammation; Macrolides

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZITHROMYCIN; BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CILASTATIN PLUS IMIPENEM; CLINDAMYCIN; CORTICOSTEROID; ERTAPENEM; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LEVOFLOXACIN; LINEZOLID; MACROLIDE; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TUMOR NECROSIS FACTOR ALPHA; VANCOMYCIN; ANTIINFECTIVE AGENT; AUTACOID; BIOLOGICAL MARKER; CYTOKINE;

EID: 84927767348     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-015-0165-y     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 0033925423 scopus 로고    scopus 로고
    • Antimicrobial treatment failures in patients with community-acquired pneumonia: causes and prognostic implications
    • 10903235.
    • Arancibia F, Ewig S, Martinez JA, Ruiz M, Bauer T, Marcos MA, et al. Antimicrobial treatment failures in patients with community-acquired pneumonia: causes and prognostic implications. Am J Respir Crit Care Med. 2000, 162:154-60. 10.1164/ajrccm.162.1.9907023, 10903235.
    • (2000) Am J Respir Crit Care Med. , vol.162 , pp. 154-160
    • Arancibia, F.1    Ewig, S.2    Martinez, J.A.3    Ruiz, M.4    Bauer, T.5    Marcos, M.A.6
  • 2
    • 1842738502 scopus 로고    scopus 로고
    • Causes and predictors of non-response to treatment of intensive care unit-acquired pneumonia
    • 15071382.
    • Ioanas M, Ferrer M, Cavalcanti M, Ferrer R, Ewig S, Filella X, et al. Causes and predictors of non-response to treatment of intensive care unit-acquired pneumonia. Crit Care Med. 2004, 32:938-45. 10.1097/01.CCM.0000114580.98396.91, 15071382.
    • (2004) Crit Care Med. , vol.32 , pp. 938-945
    • Ioanas, M.1    Ferrer, M.2    Cavalcanti, M.3    Ferrer, R.4    Ewig, S.5    Filella, X.6
  • 3
    • 41749113189 scopus 로고    scopus 로고
    • Markers of treatment failure in hospitalised community-acquired pneumonia
    • 18245147.
    • Menéndez R, Cavalcanti M, Reyes S, Mensa J, Martinez R, Marcos MA, et al. Markers of treatment failure in hospitalised community-acquired pneumonia. Thorax. 2008, 63:447-52. 10.1136/thx.2007.086785, 18245147.
    • (2008) Thorax. , vol.63 , pp. 447-452
    • Menéndez, R.1    Cavalcanti, M.2    Reyes, S.3    Mensa, J.4    Martinez, R.5    Marcos, M.A.6
  • 4
    • 34548022149 scopus 로고    scopus 로고
    • Understanding the inflammatory cytokine response in pneumonia and sepsis. Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    • 17698689.
    • Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis. Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007, 167:1655-63. 10.1001/archinte.167.15.1655, 17698689.
    • (2007) Arch Intern Med , vol.167 , pp. 1655-1663
    • Kellum, J.A.1    Kong, L.2    Fink, M.P.3    Weissfeld, L.A.4    Yealy, D.M.5    Pinsky, M.R.6
  • 5
    • 0035840852 scopus 로고    scopus 로고
    • Anti-inflammatory effects of macrolide antibiotics
    • 11698042.
    • Culic O, Erakovic V, Parnham MJ. Anti-inflammatory effects of macrolide antibiotics. Eur J Pharmacol. 2001, 429:209-29. 10.1016/S0014-2999(01)01321-8, 11698042.
    • (2001) Eur J Pharmacol. , vol.429 , pp. 209-229
    • Culic, O.1    Erakovic, V.2    Parnham, M.J.3
  • 6
    • 0032795313 scopus 로고    scopus 로고
    • The anti-inflammatory effects of macrolides
    • Wales D, Woodhead M. The anti-inflammatory effects of macrolides. Thorax. 1999, 54(Suppl 2):58-62. 10.1136/thx.54.2008.S58.
    • (1999) Thorax. , vol.54 , pp. 58-62
    • Wales, D.1    Woodhead, M.2
  • 7
    • 84863690101 scopus 로고    scopus 로고
    • Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics
    • 22778497.
    • Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C. Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. Mediators Inflamm. 2012, 2012:584262. doi:10.1155/2012/584262, 10.1155/2012/584262, 22778497.
    • (2012) Mediators Inflamm. , vol.2012 , pp. 584262
    • Steel, H.C.1    Theron, A.J.2    Cockeran, R.3    Anderson, R.4    Feldman, C.5
  • 8
    • 77951209165 scopus 로고    scopus 로고
    • Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia
    • 19953222.
    • Martin-Loeches I, Lisboa T, Rodriguez A, Putensen C, Annane D, Garnacho-Montero J, et al. Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med. 2010, 36:612-20. 10.1007/s00134-009-1730-y, 19953222.
    • (2010) Intensive Care Med. , vol.36 , pp. 612-620
    • Martin-Loeches, I.1    Lisboa, T.2    Rodriguez, A.3    Putensen, C.4    Annane, D.5    Garnacho-Montero, J.6
  • 9
    • 15044339741 scopus 로고    scopus 로고
    • Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections
    • 15735416.
    • Parnham MJ. Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections. Curr Opin Infect Dis. 2005, 18:125-31. 10.1097/01.qco.0000160901.71813.fe, 15735416.
    • (2005) Curr Opin Infect Dis. , vol.18 , pp. 125-131
    • Parnham, M.J.1
  • 10
    • 58849166805 scopus 로고    scopus 로고
    • Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumonia
    • 18768577.
    • Restrepo MI, Mortensen EM, Waterer GW, Wunderink RG, Coalson JJ, Anzueto A. Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumonia. Eur Respir J. 2009, 33:153-9. 10.1183/09031936.00054108, 18768577.
    • (2009) Eur Respir J. , vol.33 , pp. 153-159
    • Restrepo, M.I.1    Mortensen, E.M.2    Waterer, G.W.3    Wunderink, R.G.4    Coalson, J.J.5    Anzueto, A.6
  • 11
    • 33847173420 scopus 로고    scopus 로고
    • Antibiotics for bacteremic pneumonia: improve outcomes with macrolides but not fluorquinolones
    • 17296649.
    • Metersky ML, Ma A, Houck PM, Bratzler DW. Antibiotics for bacteremic pneumonia: improve outcomes with macrolides but not fluorquinolones. Chest. 2007, 131:466-73. 10.1378/chest.06-1426, 17296649.
    • (2007) Chest. , vol.131 , pp. 466-473
    • Metersky, M.L.1    Ma, A.2    Houck, P.M.3    Bratzler, D.W.4
  • 12
    • 4544244010 scopus 로고    scopus 로고
    • International Pneumococcal study group. Combination antibiotic therapy lowers mortality among severily ill patients with pneumococcal pneumonia
    • 15184200.
    • Baddour LM, Yu VL, Klugman KP, Feldman C, Ortqvist A, Rello J, et al. International Pneumococcal study group. Combination antibiotic therapy lowers mortality among severily ill patients with pneumococcal pneumonia. Am J Respir Crit Care Med 2004, 170:440-4. 10.1164/rccm.200311-1578OC, 15184200.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 440-444
    • Baddour, L.M.1    Yu, V.L.2    Klugman, K.P.3    Feldman, C.4    Ortqvist, A.5    Rello, J.6
  • 14
    • 33751039945 scopus 로고    scopus 로고
    • Pneumococcal Pneumonia in Spain study group. Impact of initial antibiotic choice on mortality from pneumococcal pneumonia
    • 16455824.
    • Aspa J, Rajas O, Rodriguez DeCastro F, Huertas MC, Borderías L, Cabello FJ, et al. Pneumococcal Pneumonia in Spain study group. Impact of initial antibiotic choice on mortality from pneumococcal pneumonia. Eur Respir J 2006, 27:1010-9. 16455824.
    • (2006) Eur Respir J , vol.27 , pp. 1010-1019
    • Aspa, J.1    Rajas, O.2    Rodriguez DeCastro, F.3    Huertas, M.C.4    Borderías, L.5    Cabello, F.J.6
  • 15
    • 0032513753 scopus 로고    scopus 로고
    • Time to clinical stability in patients hospitalized with community-acquired pneumonia
    • 9600479.
    • Halm EA, Fine MJ, Marrie TJ, Coley CM, Kapoor WN, Obrosky DS, et al. Time to clinical stability in patients hospitalized with community-acquired pneumonia. JAMA. 1998, 279:1452-7. 10.1001/jama.279.18.1452, 9600479.
    • (1998) JAMA. , vol.279 , pp. 1452-1457
    • Halm, E.A.1    Fine, M.J.2    Marrie, T.J.3    Coley, C.M.4    Kapoor, W.N.5    Obrosky, D.S.6
  • 16
    • 10644246746 scopus 로고    scopus 로고
    • Reaching stability in community-acquired pneumonia: the effects of the severity of disease, treatment, and the characteristics of patients
    • 15578400.
    • Menéndez R, Torres A, Rodríguez de Castro F, Zalacaín R, Aspa J, Martín Villasclaras JJ, et al. Reaching stability in community-acquired pneumonia: the effects of the severity of disease, treatment, and the characteristics of patients. Clin Infect Dis 2004, 39:1783-90. 10.1086/426028, 15578400.
    • (2004) Clin Infect Dis , vol.39 , pp. 1783-1790
    • Menéndez, R.1    Torres, A.2    Rodríguez de Castro, F.3    Zalacaín, R.4    Aspa, J.5    Martín Villasclaras, J.J.6
  • 17
    • 0031012761 scopus 로고    scopus 로고
    • A prediction rule to identify low-risk patients with community-acquired pneumonia
    • 8995086.
    • Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997, 336:243-50. 10.1056/NEJM199701233360402, 8995086.
    • (1997) N Engl J Med. , vol.336 , pp. 243-250
    • Fine, M.J.1    Auble, T.E.2    Yealy, D.M.3    Hanusa, B.H.4    Weissfeld, L.A.5    Singer, D.E.6
  • 18
    • 24144495448 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of community-acquired pneumonia. Spanish Society of Pneumology and Thoracic Surgery (SEPAR)
    • 15919009.
    • Alfageme I, Aspa J, Bello S, Blanquer J, Blanquer R, Borderías L, et al. Guidelines for the diagnosis and management of community-acquired pneumonia. Spanish Society of Pneumology and Thoracic Surgery (SEPAR). Arch Bronconeumol 2005, 41:272-89. 15919009.
    • (2005) Arch Bronconeumol , vol.41 , pp. 272-289
    • Alfageme, I.1    Aspa, J.2    Bello, S.3    Blanquer, J.4    Blanquer, R.5    Borderías, L.6
  • 19
    • 0024338103 scopus 로고
    • Report of the European Society of Pneumology Task Group
    • Technical recommendations and guidelines for bronchoalveolar lavage
    • Technical recommendations and guidelines for bronchoalveolar lavage. Report of the European Society of Pneumology Task Group. Eur Respir J. 1989;2:561-585.
    • (1989) Eur Respir J , vol.2 , pp. 561-585
  • 21
  • 22
    • 79960892841 scopus 로고    scopus 로고
    • Increased lung neutrophil apoptosis and inflammation resolution in nonresponding pneumonia
    • 21436352.
    • Moret I, Lorenzo MJ, Sarria B, Cases E, Morcillo E, Perpiñá M, et al. Increased lung neutrophil apoptosis and inflammation resolution in nonresponding pneumonia. Eur Respir J. 2011, 38:1158-64. 10.1183/09031936.00190410, 21436352.
    • (2011) Eur Respir J. , vol.38 , pp. 1158-1164
    • Moret, I.1    Lorenzo, M.J.2    Sarria, B.3    Cases, E.4    Morcillo, E.5    Perpiñá, M.6
  • 23
    • 80052270552 scopus 로고    scopus 로고
    • Immunomodulatory agents in the treatment of community-acquired pneumonia: a systematic review
    • 21763343.
    • Corrales-Medina VF, Musher DM. Immunomodulatory agents in the treatment of community-acquired pneumonia: a systematic review. J Infect. 2011, 63:187-99. 10.1016/j.jinf.2011.06.009, 21763343.
    • (2011) J Infect. , vol.63 , pp. 187-199
    • Corrales-Medina, V.F.1    Musher, D.M.2
  • 24
    • 84862663670 scopus 로고    scopus 로고
    • Treatment with anti-inflammatory drugs in community-adquired pneumonia
    • 22583070.
    • Meijvis SC, van de Garde EM, Rijkers GT, Bos WJ. Treatment with anti-inflammatory drugs in community-adquired pneumonia. J Intern Med. 2012, 272:25-35. 10.1111/j.1365-2796.2012.02554.x, 22583070.
    • (2012) J Intern Med. , vol.272 , pp. 25-35
    • Meijvis, S.C.1    van de Garde, E.M.2    Rijkers, G.T.3    Bos, W.J.4
  • 26
    • 84896367599 scopus 로고    scopus 로고
    • Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease
    • Epub 2013 Dec 25, 24453422
    • Steel HC, Cockeran R, Anderson R, Feldman C. Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease. Mediators Inflamm 2013, 2013:490346. doi:10.1155/2013/490346. Epub 2013 Dec 25, 10.1155/2013/490346, 24453422.
    • (2013) Mediators Inflamm , vol.2013 , pp. 490346
    • Steel, H.C.1    Cockeran, R.2    Anderson, R.3    Feldman, C.4
  • 27
    • 1942454728 scopus 로고    scopus 로고
    • Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFN gamma and IL-10 plasma levels in patients with community acquired pneumonia
    • 15078004.
    • Demartini G, Esposti D, Marthyn P, Lapidari A, Fraschini F, Scaglione F. Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFN gamma and IL-10 plasma levels in patients with community acquired pneumonia. J Chemother. 2004, 16:82-5. 10.1179/joc.2004.16.1.82, 15078004.
    • (2004) J Chemother. , vol.16 , pp. 82-85
    • Demartini, G.1    Esposti, D.2    Marthyn, P.3    Lapidari, A.4    Fraschini, F.5    Scaglione, F.6
  • 28
    • 84862557241 scopus 로고    scopus 로고
    • Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by gram-negative bacteria: results from a randomized clinical study
    • 22564837.
    • Spyridaki A, Raftogiannis M, Antonopoulou A, Tsaganos T, Routsi C, Baziaka F, et al. Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by gram-negative bacteria: results from a randomized clinical study. Antimicrob Agents Chemother. 2012, 56:3819-25. 10.1128/AAC.05798-11, 22564837.
    • (2012) Antimicrob Agents Chemother. , vol.56 , pp. 3819-3825
    • Spyridaki, A.1    Raftogiannis, M.2    Antonopoulou, A.3    Tsaganos, T.4    Routsi, C.5    Baziaka, F.6
  • 29
    • 75749098848 scopus 로고    scopus 로고
    • Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice
    • 19949056.
    • Nakamura S, Yanagihara K, Araki N, Yamada K, Morinaga Y, Izumikawa K, et al. Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice. Antimicrob Agents Chemother. 2010, 54:757-62. 10.1128/AAC.00524-09, 19949056.
    • (2010) Antimicrob Agents Chemother. , vol.54 , pp. 757-762
    • Nakamura, S.1    Yanagihara, K.2    Araki, N.3    Yamada, K.4    Morinaga, Y.5    Izumikawa, K.6
  • 30
    • 13444283445 scopus 로고    scopus 로고
    • Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression
    • 15665859.
    • Sanz MJ, Nabah YN, Cerdá-Nicolás M, O'Connor JE, Issekutz AC, Cortijo J, et al. Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression. Br J Pharmacol. 2005, 144:190-201. 10.1038/sj.bjp.0706021, 15665859.
    • (2005) Br J Pharmacol. , vol.144 , pp. 190-201
    • Sanz, M.J.1    Nabah, Y.N.2    Cerdá-Nicolás, M.3    O'Connor, J.E.4    Issekutz, A.C.5    Cortijo, J.6
  • 31
    • 77956707732 scopus 로고    scopus 로고
    • Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis
    • 20591166.
    • Beigelman A, Mikols CL, Gunsten SP, Cannon CL, Brody SL, Walter MJ. Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis. Respir Res. 2010, 11:90. 10.1186/1465-9921-11-90, 20591166.
    • (2010) Respir Res. , vol.11 , pp. 90
    • Beigelman, A.1    Mikols, C.L.2    Gunsten, S.P.3    Cannon, C.L.4    Brody, S.L.5    Walter, M.J.6
  • 33
    • 33947509104 scopus 로고    scopus 로고
    • Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae
    • 17218449.
    • Anderson R, Steel HC, Cockeran R, von Gottberg A, de Gouveia L, Klugman KP, et al. Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. J Antimicrob Chemother. 2007, 59:224-9. 10.1093/jac/dkl479, 17218449.
    • (2007) J Antimicrob Chemother. , vol.59 , pp. 224-229
    • Anderson, R.1    Steel, H.C.2    Cockeran, R.3    von Gottberg, A.4    de Gouveia, L.5    Klugman, K.P.6
  • 34
    • 0037442372 scopus 로고    scopus 로고
    • Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia
    • 12567294.
    • Martínez JA, Horcajada JP, Almela M, Marco F, Soriano A, García E, et al. Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin Infect Dis. 2003, 36:389-95. 10.1086/367541, 12567294.
    • (2003) Clin Infect Dis. , vol.36 , pp. 389-395
    • Martínez, J.A.1    Horcajada, J.P.2    Almela, M.3    Marco, F.4    Soriano, A.5    García, E.6
  • 35
    • 19944429796 scopus 로고    scopus 로고
    • Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults
    • 15611810.
    • Weiss K, Low DE, Cortes L, Beaupre A, Gauthier R, Gregoire P, et al. Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults. Can Respir J. 2004, 11:589-93. 15611810.
    • (2004) Can Respir J. , vol.11 , pp. 589-593
    • Weiss, K.1    Low, D.E.2    Cortes, L.3    Beaupre, A.4    Gauthier, R.5    Gregoire, P.6
  • 36
    • 30144440288 scopus 로고    scopus 로고
    • Revisiting combination antibiotic therapy for community-acquired invasive streptococcus pneumoniae pneumonia
    • 16355349.
    • Mufson MA, Stanek RJ. Revisiting combination antibiotic therapy for community-acquired invasive streptococcus pneumoniae pneumonia. Clin Infect Dis. 2006, 42:304-6. 10.1086/499110, 16355349.
    • (2006) Clin Infect Dis. , vol.42 , pp. 304-306
    • Mufson, M.A.1    Stanek, R.J.2
  • 37
    • 84876204283 scopus 로고    scopus 로고
    • Single versus combination antibiotic therapy in adults hospitalized with community-acquired pneumonia
    • 23076390.
    • Rodrigo C, Mckeever TM, Woodhead M, Lim WS. Single versus combination antibiotic therapy in adults hospitalized with community-acquired pneumonia. Thorax 2013, 68:493-5. 10.1136/thoraxjnl-2012-202296, 23076390.
    • (2013) Thorax , vol.68 , pp. 493-495
    • Rodrigo, C.1    Mckeever, T.M.2    Woodhead, M.3    Lim, W.S.4
  • 38
    • 78751682782 scopus 로고    scopus 로고
    • Management of community-acquired pneumonia in adults
    • 20693379.
    • Waterer GW, Rello J, Wunderink RG. Management of community-acquired pneumonia in adults. Am J Respir Crit Care Med. 2011, 183:157-64. 10.1164/rccm.201002-0272CI, 20693379.
    • (2011) Am J Respir Crit Care Med. , vol.183 , pp. 157-164
    • Waterer, G.W.1    Rello, J.2    Wunderink, R.G.3
  • 39
    • 34447560954 scopus 로고    scopus 로고
    • The impact of empiric antimicrobial therapy with β-lactam and fluoroquinolone on mortality for patients hospitalized with severe pneumonia
    • Mortensen EM, Restrepo MI, Anzueto A, Pugh J. The impact of empiric antimicrobial therapy with β-lactam and fluoroquinolone on mortality for patients hospitalized with severe pneumonia. Crit Care Med. 2005, 10:R8. 10.1186/cc3934.
    • (2005) Crit Care Med. , vol.10 , pp. R8
    • Mortensen, E.M.1    Restrepo, M.I.2    Anzueto, A.3    Pugh, J.4
  • 40
    • 84875978870 scopus 로고    scopus 로고
    • Systemic inflammatory pattern of patients with community-acquired pneumonia with and without COPD
    • 23187314.
    • Crisafulli E, Menéndez R, Huerta A, Martinez R, Montull B, Clini E, et al. Systemic inflammatory pattern of patients with community-acquired pneumonia with and without COPD. Chest. 2013, 143:1009-17. 10.1378/chest.12-1684, 23187314.
    • (2013) Chest. , vol.143 , pp. 1009-1017
    • Crisafulli, E.1    Menéndez, R.2    Huerta, A.3    Martinez, R.4    Montull, B.5    Clini, E.6


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