Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 2, 2010, Pages 757-762

  Nakamura, Shigeki ^a   Yanagihara, Katsunori ^a   Araki, Nobuko ^a   Yamada, Koichi ^a   Morinaga, Yoshitomo ^a   Izumikawa, Koichi ^a   Seki, Masafumi ^a   Kakeya, Hiroshi ^a   Yamamoto, Yoshihiro ^a   Kamihira, Shimeru ^a   Kohno, Shigeru ^a,b  

^a NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CLARITHROMYCIN; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL COUNT; BACTERIAL STRAIN; BACTERIAL VIABILITY; BACTERICIDAL ACTIVITY; CELL AGGREGATION; CELL COUNT; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFICACY; DRUG PENETRATION; DRUG SENSITIVITY; EXPERIMENTAL MOUSE; HAEMOPHILUS INFLUENZAE; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY CELL; INTRACELLULAR BACTERIUM; LUNG ALVEOLUS WALL; LUNG LAVAGE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; TREATMENT DURATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BRONCHIOLES; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE, TUMOR; CHEMOKINE CXCL2; CLARITHROMYCIN; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; INTERLEUKIN-1BETA; MALE; MICE; MICROBIAL SENSITIVITY TESTS; NEUTROPHILS; PNEUMONIA; PULMONARY ALVEOLI;

EID: 75749098848     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00524-09     Document Type: Article

References (40)

1. Amsden, G. W. 2001. Advanced-generation macrolides: tissue-directed antibiotics. Int. J. Antimicrob. Agents 18(Suppl. 1):S11-S15.
2. Amsden, G. W., and C. L. Gray. 2001. Serum and WBC pharmacokinetics of 1500 mg of azithromycin when given either as a single dose or over a 3 day period in healthy volunteers. J. Antimicrob. Chemother. 47:61-66.
3. Barry, A. L., P. C. Fuchs, and S. D. Brown. 2001. Identification of β-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae with four methods and eight media. Antimicrob. Agents Chemother. 45:1585-1588.
4. Bosnar, M., Z. Kelnerić, V. Munić, V. Eraković, and M. J. Parnham. 2005. Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin. Antimicrob. Agents Chemother. 49:2372-2377.
5. Carbon, C. 1998. Pharmacodynamics of macrolides, azalides, and streptogramins: effect on extracellular pathogens. Clin. Infect. Dis. 27:28-32.
6. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing, 17th ed. Approved standard M100-S17. CLSI, Wayne, PA.
7. Craig, W. A. 1998. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin. Infect. Dis. 26:1-10.
8. Craig, W. A. 2001. The hidden impact of antibacterial resistance in respiratory tract infection. Re-evaluating current antibiotic therapy. Respir. Med. 95(Suppl. A):S12-S19, S26-S27.
9. Doern, G. V., A. B. Brueggemann, G. Pierce, H. P. Holley, Jr., and A. Rauch. 1997. Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of β-lactamase-positive strains resistant to amoxicillin-clavulanate: results of a national multicenter surveillance study. Antimicrob. Agents Chemother. 41:292-297.
10. Felmingham, D., and R. M. Gruneberg. 2000. The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections. J. Antimicrob. Chemother. 45:191-203.
11. Forsgren, J., A. Samuelson, A. Ahlin, J. Jonasson, B. Rynnel-Dagöö, and A. Lindberg. 1994. Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay. Infect. Immun. 62:673-679.
12. Fukuda, Y., K. Yanagihara, Y. Higashiyama, Y. Miyazaki, Y. Hirakata, H. Mukae, K. Tomono, Y. Mizuta, K. Tsukamoto, and S. Kohno. 2006. Effects of macrolides on pneumolysin of macrolide-resistant Streptococcus pneumoniae. Eur. Respir. J. 27:1020-1025.
13. Hasegawa, K., K. Yamamoto, N. Chiba, R. Kobayashi, K. Nagai, M. R. Jacobs, P. C. Appelbaum, K. Sunakawa, and K. Ubukata. 2003. Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States. Microb. Drug Resist. 9:39-46.
14. Hoban, D. J., and G. G. Zhanel. 2006. Clinical implications of macrolide resistance in community-acquired respiratory tract infections. Expert Rev. Anti Infect. Ther. 4:973-980.
15. Kelley, M. A., D. J. Weber, P. Gilligan, and M. S. Cohen. 2000. Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin. Clin. Infect. Dis. 31:1008-1011.
16. Ketterer, M. R., J. Q. Shao, B. Hornick, B. Buscher, V. K. Bandi, and M. A. Apicella. 1999. Infection of primary human bronchial epithelial cells by Haemophilus influenzae: macropinocytosis as a mechanism of airway epithelial cell entry. Infect. Immun. 67:4161-4170.
17. Kunishima, H., H. Takemura, H. Yamamoto, K. Kanemitsu, and J. Shimada. 2000. Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-1, and an alveolar epithelial cell line, A549. J. Infect. Chemother. 6:206-210.
18. Lieberman, D., F. Schlaeffer, I. Boldur, D. Lieberman, S. Horowitz, M. G. Friedman, M. Leiononen, O. Horovitz, E. Manor, and A. Porath. 1996. Multiple pathogens in adult patients admitted with community-acquired pneumonia: a one year prospective study of 346 consecutive patients. Thorax 51:179-184.
19. Lonks, J. R., J. Garau, L. Gomez, M. Xercavins, E. Ochoa, I. F. Gareen, P. T. Reiss, and A. A. Medeiros. 2002. Failure of macrolide antibiotic treatment in patients with bacteremia due to erythromycin-resistant Streptococcus pneumoniae. Clin. Infect. Dis. 35:556-564.
20. Mandell, L. A. 1995. Community-acquired pneumonia: Etiology, epidemiology, and treatment. Chest 108:35S-41S.
21. Markowitz, S. M. 1980. Isolation of an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzae. Antimicrob. Agents Chemother. 17:80-83.
22. Matsuoka, N., K. Eguchi, A. Kawakami, M. Tsebin, Y. Kawabe, T. Aoyagi, and S. Nagatani. 1996. Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. Clin. Exp. Immunol. 104:501-508.
23. McCarty, J. M. 2000. Clarithromycin in the management of communityacquired pneumonia. Clin. Ther. 22:281-294.
24. Mendelman, P. M., D. O. Chaffin, T. L. Stull, C. E. Rubens, K. D. Mack, and A. L. Smith. 1984. Characterization of non-beta-lactamase-mediated ampicillin resistance in Haemophilus influenzae. Antimicrob. Agents Chemother. 26:235-244.
25. Miyazaki, S., T. Fujikawa, T. Matsumoto, K. Tateda, and K. Yamaguchi. 2001. Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice. J. Antimicrob. Chemother. 48:425-430.
26. Nakamura, S., K. Yanagihara, Y. Morinaga, K. Izumikawa, M. Seki, H. Kakeya, Y. Yamamoto, S. Kamihira, and S. Kohno. 2009. In vivo efficacy of sitafloxacin in a new murine model of nontypable Haemophilus influenzae pneumonia by sterile intratracheal tube. Int. J. Antimicrob. Agents 34: 210-214.
27. Nuermberger, E., and W. R. Bishai. 2004. The clinical significance of macrolide-resistant Streptococcus pneumoniae: it's all relative. Clin. Infect. Dis. 38:99-103.
28. Ohkuksu, K., A. Nakamura, and K. Sawada. 2000. Antibiotic resistance among recent clinical isolates of Haemophilus influenzae in Japanese children. Diagn. Microbiol. Infect. Dis. 36:249-254.
29. Okabe, T., Y. Yamazaki, M. Shiotani, T. Suzuki, M. Shiohara, E. Kasuga, S. Notake, and H. Yanagisawa. 2010. An amino acid substitution in PBP-3 in Haemophilus influenzae associated with the invasion to bronchial epithelial cells. Microbiol. Res. 165:11-20.
30. Piscitelli, S. C., L. H. Danziger, and K. A. Roldvold. 1992. Clarithromycin and azithromycin: new macrolide antibiotics. Clin. Pharm. 11:137-152.
31. Rodvold, K. A., M. H. Gotfried, L. H. Danziger, and R. J. Servi. 1997. Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. Antimicrob. Agents Chemother. 41:1399-1402.
32. Swords, W. E., B. A. Buscher, I. K. Ver Steeg, A. Preston, W. A. Nichols, J. N. Weiser, B. W. Gibson, and M. A. Apicella. 2000. Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol. Microbiol. 37:13-27.
33. Sugiyama, Y., K. Yanagisawa, S. Tominaga, and S. Kitamura. 1999. Effects of long-term administration of erythromycin on cytokine production in rat alveolar macrophages. Eur. Respir. J. 14:1113-1116.
34. Suzuki, K., T. Nishimura, and S. Baba. 2003. Current status of bacterial resistance in the otolaryngology field: results from the second nationwide survey in Japan. J. Infect. Chemother. 9:46-52.
35. Takizawa, H., M. Desaki, T. Ohtoshi, S. Kawasaki, T. Kohyama, M. Sato, M. Tanaka, T. Kasama, K. Kobayashi, J. Nakajima, and K. Ito. 1997. Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. Am. J. Respir. Crit. Care Med. 156:266-271.
36. Taubman, S. B., N. R. Jones, F. E. Young, and J. W. Corcoran. 1966. Sensitivity and resistance to erythromycin in Bacillus subtilis 168: the ribosomal binding of erythromycin and chloramphenicol. Biochim. Biophys. Acta 123:438-440.
37. Tessier, P. R., M. K. Kim, W. Zhou, D. Xuan, C. Li, M. Ye, C. H. Nightingale, and D. P. Nicolau. 2002. Pharmacodynamic assessment of clarithromycin in a murine model of pneumococcal pneumonia. Antimicrob. Agents Chemother. 46:1425-1434.
38. Yanagihara, K., M. Seki, and P.-W. Cheng. 2001. Lipopolysaccharide induces mucus cell metaplasia in mouse lung. Am. J. Respir. Cell Mol. Biol. 24:66-73.
39. Yanagihara, K., K. Tomono, Y. Imamura, Y. Kaneko, M. Kuroki, T. Sawai, Y. Miyazaki, Y. Hirakata, H. Mukae, J. Kadota, and S. Kohno. 2002. Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model. J. Antimicrob. Chemother. 49:867-870.
40. Zhanel, G. G., M. Dueck, D. J. Hoban, L. M. Vercaigne, J. M. Embil, A. S. Gin, and J. A. Karlowsky. 2001. Review of macrolides and ketolides: focus on respiratory tract infections. Drugs 61:443-498.