Local and systemic cytokine profiles in nonsevere and severe community-acquired pneumonia

European Respiratory Journal

Volumn 41, Issue 6, 2013, Pages 1378-1385

  Paats, Marthe S ^a   Bergen, Ingrid M ^a   Hanselaar, Wessel E J J ^b   Van Zoelen, E Christine Groeninx ^a   Hoogsteden, Henk C ^a   Hendriks, Rudi W ^a   Van Der Eerden, Menno M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Dept of Pulmonary Medicine Sint Franciscus Gasthuis ^*  (Netherlands)

Author keywords

Bronchoalveolar lavage; Community acquired pneumonia; Cytokines; Inflammation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22;

ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; LUNG LAVAGE; MALE; PNEUMONIA SEVERITY INDEX; PRIORITY JOURNAL; BLOOD; CASE CONTROL STUDY; COMMUNITY-ACQUIRED INFECTIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; MIDDLE AGED; PNEUMONIA; PROSPECTIVE STUDY;

ADULT; AGED; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; COMMUNITY-ACQUIRED INFECTIONS; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-6; INTERLEUKIN-8; INTERLEUKINS; MALE; MIDDLE AGED; PNEUMONIA; PROSPECTIVE STUDIES;

EID: 84878803283     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00060112     Document Type: Article

References (30)

1. Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997; 336: 243-250. (Pubitemid 27044625)
2. Aujla SJ, Chan YR, Zheng M, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 2008; 14: 275-281. (Pubitemid 351347908)
3. Bhan U, Ballinger MN, Zeng X, et al. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of Gram negative bacterial pneumonia. PLoS One 2010; 5: e9896.
4. Moret I, Lorenzo MJ, Sarria B, et al. Increased lung neutrophil apoptosis and inflammation resolution in nonresponding pneumonia. Eur Respir J 2011; 38: 1158-1164.
5. Antunes G, Evans SA, Lordan JL, et al. Systemic cytokine levels in community-acquired pneumonia and their association with disease severity. Eur Respir J 2002; 20: 990-995. (Pubitemid 35175139)
6. Boutten A, Dehoux MS, Seta N, et al. Compartmentalized IL-8 and elastase release within the human lung in unilateral pneumonia. Am J Respir Crit Care Med 1996; 153: 336-342. (Pubitemid 26026871)
7. Dehoux MS, Boutten A, Ostinelli J, et al. Compartmentalized cytokine production within the human lung in unilateral pneumonia. Am J Respir Crit Care Med 1994; 150: 710-716. (Pubitemid 24291499)
8. Endeman H, Meijvis SCA, Rijkers GT, et al. Systemic cytokine response in patients with community-acquired pneumonia. Eur Respir J 2011; 37: 1431-1438.
9. Glynn P, Coakley R, Kilgallen I, et al. Circulating interleukin 6 and interleukin 10 in community acquired pneumonia. Thorax 1999; 54: 51-55. (Pubitemid 29103752)
10. Igonin AA, Armstrong VW, Shipkova M, et al. Circulating cytokines as markers of systemic inflammatory response in severe community-acquired pneumonia. Clin Biochem 2004; 37: 204-209. (Pubitemid 38221568)
11. Kolsuz M, Erginel S, Alatas O, et al. Acute phase reactants and cytokine levels in unilateral community-acquired pneumonia. Respiration 2003; 70: 615-622. (Pubitemid 38142314)
12. Lee YL, Chen W, Chen LY, et al. Systemic and bronchoalveolar cytokines as predictors of in-hospital mortality in severe community-acquired pneumonia. J CritCare 2010; 25: 176 e177-e113.
13. Martinez R, Menendez R, Reyes S, et al. Factors associated with inflammatory cytokine patterns in community-acquired pneumonia. Eur Respir J 2011; 37: 393-399.
14. Monton C, Torres A, El-Ebiary M, et al. Cytokine expression in severe pneumonia: a bronchoalveolar lavage study. Crit Care Med 1999; 27: 1745-1753. (Pubitemid 29455099)
15. Puren AJ, Feldman C, Savage N, et al. Patterns of cytokine expression in community-acquired pneumonia. Chest 1995; 107: 1342-1349.
16. Cazzola M, Matera MG, Pezzuto G. Inflammation - a new therapeutic target in pneumonia. Respiration 2005; 72: 117-126. (Pubitemid 40591521)
17. Koh YY, Park Y, Lee HJ, et al. Levels of interleukin-2, interferon-γ, and interleukin-4 in bronchoalveolar lavage fluid from patients with Mycoplasma pneumonia: implication of tendency toward increased immunoglobulin E production. Pediatrics 2001; 107: E39.
18. Schutte H, Lohmeyer J, Rosseau S, et al. Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. Eur Respir J 1996; 9: 1858-1867. (Pubitemid 26294756)
19. SWAB The Dutch Working Party on Antibiotic Policy. Guideline on Antimicrobial Treatment of Community-acquired Pneumonia (CAP). Amsterdam, SWAB, 2005.
20. British Thoracic Society Bronchoscopy Guidelines Committee a Subcommittee of Standards of Care Committee of British Thoracic Society. British Thoracic Society guidelines on diagnostic flexible bronchoscopy. Thorax 2001; 56: Suppl. 1, i1-i21.
21. Jain MK, Ridker PM. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov 2005; 4: 977-987.
22. Christ-Crain M, Opal SM. Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia. Crit Care 2010; 14: 203.
23. Groeneveld AB, Tacx AN, Bossink AW, et al. Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection. Clin Immunol 2003; 106: 106-115. (Pubitemid 36369405)
24. Menendez R, Martinez R, Reyes S, et al. Biomarkers improve mortality prediction by prognostic scales in community-acquired pneumonia. Thorax 2009; 64: 587-591.
25. Kellum JA, Kong L, Fink MP, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007; 167: 1655-1663. (Pubitemid 47280347)
26. Rubins JB, Pomeroy C. Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. Infect Immun 1997; 65: 2975-2977. (Pubitemid 27264133)
27. Dumoutier L, Louahed J, Renauld JC. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol 2000; 164: 1814-1819. (Pubitemid 30108734)
28. Belvisi MG. Regulation of inflammatory cell function by corticosteroids. Proc Am Thorac Soc 2004; 1: 207-214.
29. Cavaillon JM, Cavaillon NH. Characterization of the induction of human interleukin-1 by endotoxins. In: Braquet P, ed. Lipid Mediators in the Immunology of Burn and Sepsis. London, Plenum, 1987.
30. Menendez R, Sahuquillo-Arce JM, Reyes S, et al. Cytokine activation patterns and biomarkers are influenced by microorganisms in community-acquired pneumonia. Chest 2012; 14: 1537-1545.