Zinc monotherapy increases serum brainderived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: A double-blind, randomized, placebo-controlled trial

Nutritional Neuroscience

Volumn 18, Issue 4, 2015, Pages 162-168

  Solati, Zahra ^a   Jazayeri, Shima ^b   Tehrani Doost, Mehdi ^c   Mahmoodianfard, Salma ^a   Gohari, Mahmood Reza ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Brain derived neurotrophic factor (BDNF); Depression; Obesity; Zinc

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUCONATE ZINC; PLACEBO; ZINC;

ADULT; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BECK DEPRESSION INVENTORY; BODY MASS; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; MONOTHERAPY; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TREATMENT RESPONSE; ZINC BLOOD LEVEL; BLOOD; DIET SUPPLEMENTATION; DIET THERAPY; MIDDLE AGED; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PSYCHIATRIC STATUS RATING SCALES; ZINC;

EID: 84927759544     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830513Y.0000000105     Document Type: Article

References (41)

1. 1 de Wit L, van Straten A, van Herten M, Penninx B, Cuijpers P. Depression and body mass index, a u-shaped association. BMC Public Health 2009;9(1):14.
2. 2 Sadeghirad B, Haghdoost AA, Amin-Esmaeili M, Ananloo ES, Ghaeli P, Rahimi-Movaghar A, et al. Epidemiology of major depressive disorder in Iran: a systematic review and meta¬analysis. Int J Prev Med 2010;1(2):81-91.
3. 3 Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3(11): e442.
4. 4 Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007;10(9): 1089-93.
5. 5 Duman R. Pathophysiology of depression: the concept of synap¬tic plasticity. Eur Psychiatry 2002;17:306-10.
6. 6 Lee B-H, Kim Y-K. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Invest 2010;7(4):231-5.
7. 7 Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998;37(12): 1553-61.
8. 8 Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54(1):70-5.
9. 9 Castren E, Vöikar V, Rantamäki T. Role of neurotrophic factors in depression. Curr Opin Pharmacol 2007;7(1):18-21.
10. 10 Lee B-H, Kim H, Park S-H, Kim Y-K. Decreased plasma BDNF level in depressive patients. J Affect Disord 2007; 101(1):239-44.
11. 11 Castren E, Rantamäki T. The role of BDNF and its receptors in depression and antidepressant drug action: reactivation ofdevel-opmental plasticity. Dev Neurobiol 2010;70(5):289-97.
12. 12 Nowak G, Siwek M, Dudek D, Zieba A, Pilc A. Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Pol J Pharmacol 2003;55(6):1143-7.
13. 13 Siwek M, Dudek D, Schlegel-Zawadzka M, Morawska A, Piekoszewski W, Opoka W, et al. Serum zinc level in depressed patients during zinc supplementation of imipramine treatment. J Affect Disord 2010;126(3):447-52.
14. 14 Amani R, Saeidi S, Nazari Z, Nematpour S. Correlation between dietary zinc intakes and its serum levels with depression scales in young female students. Biol Trace Elem Res 2010;137(2):150-8.
15. 15 Siwek M, Dudek D, Paul IA, Sowa-Kucma M, Zieba A, Popik P, et al. Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. J Affect Disord 2009;118(1-3):187-95.
16. 16 Szewczyk B, Kubera M, Nowak G. The role of zinc in neuro¬degenerative inflammatory pathways in depression. Prog Neuropsychopharmacol Biol Psychiatry 2011;35(3):693-701.
17. 17 Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. Overweight, obesity, and depression: a sys¬tematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 2010;67(3):220-9.
18. 18 Monteleone P, Tortorella A, Martiadis V, Serritella C, Fuschino A, Maj M. Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity. Psychosom Med 2004;66(5):744-8.
19. 19 Araya AV, Orellana X, Espinoza J. Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese sub¬jects: preliminary evidences. Endocrine 2008;33(3):300-4.
20. 20 Voruganti VS, Cai G, Klohe DM, Jordan KC, Lane MA, Freeland-Graves JH. Short-term weight loss in overweight/ obese low-income women improves plasma zinc and metabolic syndrome risk factors. J Trace Elem Med Biol 2010;24(4):271-6.
21. 21 Ozata M, Mergen M, Oktenli C, Aydin A, Yavuz Sanisoglu S, Bolu E, et al. Increased oxidative stress and hypozincemia in male obesity. Clin Biochem 2002;35(8):627-31.
22. 22 Sawada T, Yokoi K. Effect of zinc supplementation on mood states in young women: a pilot study. Eur J Clin Nutr 2010; 64(3):331-3.
23. Ghassemzadeh H, Mojtabai R, Karamghadiri N, Ebrahimkhani N. Psychometric properties of a Persian-language version of the Beck Depression Inventory - Second edition: BDI-II-PERSIAN. Depress Anxiety 2005;21(4):185-92.
24. 24 Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 195(9131/03):1381-1395.
25. 25 Zich JM, Attkisson CC, Greenfield TK. Screening for depression in primary care clinics: the CES-D and the BDI. Int J Psychiatry Med 1990;20(3):259-77.
26. 26 Cieslik K, Klenk-Majewska B, Danilczuk Z, Wróbel A, Lupina T, Ossowska G. Influence of zinc supplementation on imi-pramine effect in a chronic unpredictable stress (CUS) model in rats. Pharmacol Rep 2006;59(l):46-52.
27. 27 Corona C, Masciopinto F, Silvestri E, Del Viscovo A, Lattanzio R, La Sorda R, et al. Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction. Cell Death Dis 2010; 1(10):e91.
28. 28 Sowa-Kucsma M, Legutko B, Szewczyk B, Novak K, Znojek P, Poleszak E, et al. Antidepressant-like activity of zinc: further be¬havioral and molecular evidence. J Neural Transm 2008;115(12): 1621-8.
29. 29 Nowak G, Legutko B, Szewczyk B, Papp M, Sanak M, Pilc A. Zinc treatment induces cortical brain-derived neurotrophic factor gene expression. Eur J Pharmacol 2004;492(1):57-9.
30. 30 Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 2008;63(7):642-9.
31. 31 Gould E, Gross CG. Neurogenesis in adult mammals: some pro¬gress and problems. J Neurosci 2002;22(3):619-23.
32. 32 Lee E, Son H. Adult hippocampal neurogenesis and related neurotrophic factors. BMB Rep 2009;42(5):239-44.
33. 33 Radka SF, Hoist PA, Fritsche M, Altar CA. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoas-say. Brain Res 1996;709(1):122-30.
34. 34 Yamamoto H, Gurney ME. Human platelets contain brain-derived neurotrophic factor. J Neurosci 1990;10(11):3469-78.
35. 35 Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry J-M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002;109(2):143-8.
36. 36 Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry J-M, Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005;57(9):1068-72.
37. 37 Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005;255(6):381-6.
38. 38 Carpenter WT, Jr. Placebo effect in depression. Am J Psychiatry 2009;166(8):935.
39. 39 de Fuente-Fernández R, Schulzer M, Stoessl AJ. The placebo effect in neurological disorders. Lancet Neurol 2002;1(2):85-91.
40. 40 Makonnen B, Venter A, Joubert G. A randomized controlled study of the impact of dietary zinc supplementation in the man¬agement of children with protein-energy malnutrition in Lesotho. I: mortality and morbidity. J Trop Pediatr 2003;49(6): 340-52.
41. 41 Hwang JJ, Park M-H, Choi S-Y, Koh J-Y. Activation of the Trk signaling pathway by extracellular Zinc: role of metalloprotei-nases. J Biol Chem 2005;280(12):11995-2001.