Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation

Respiratory Research

Volumn 16, Issue 1, 2015, Pages

  Manitsopoulos, Nikolaos ^a   Orfanos, Stylianos E ^a   Kotanidou, Anastasia ^a   Nikitopoulou, Ioanna ^a   Siempos, Ilias ^a   Magkou, Christina ^b   Dimopoulou, Ioanna ^a   Zakynthinos, Spyros G ^a   Armaganidis, Apostolos ^a   Maniatis, Nikolaos A ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Endothelial permeability; Lung compliance; Lung function; Pulmonary edema; Statin; Ventilator lung injury

Indexed keywords

GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 6; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR ENDOTHELIAL CADHERIN; ANTIINFLAMMATORY AGENT; AUTACOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; LUNG COMPLIANCE; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; OSCILLATION; PLEOCYTOSIS; PRESSURE VOLUME CURVE; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY; ANIMAL; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CAPILLARY PERMEABILITY; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; ELASTICITY; ENDOTHELIUM CELL; ENZYMOLOGY; LUNG; METABOLISM; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PATHOPHYSIOLOGY; PNEUMONIA; PULMONARY EDEMA; TIME FACTOR; VENTILATOR-INDUCED LUNG INJURY;

AIRWAY RESISTANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY PERMEABILITY; DISEASE MODELS, ANIMAL; ELASTICITY; ENDOTHELIAL CELLS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION MEDIATORS; LUNG; LUNG COMPLIANCE; MALE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NEUTROPHILS; PNEUMONIA; PULMONARY EDEMA; SIMVASTATIN; TIME FACTORS; VENTILATOR-INDUCED LUNG INJURY;

EID: 84927745503     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-015-0173-y     Document Type: Article

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