Significance of lymph node ratio in defining risk category in node-positive early stage cervical cancer

Gynecologic Oncology

Volumn 136, Issue 1, 2015, Pages 48-53

  Fleming, Nicole D ^a   Frumovitz, Michael ^a   Schmeler, Kathleen M ^a   Reis, Ricardo Dos ^b   Munsell, Mark F ^a   Eifel, Patricia J ^a   Soliman, Pamela T ^a   Nick, Alpa M ^a   Westin, Shannon N ^a   Ramirez, Pedro T ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BARRETOS CANCER HOSPITAL   (Brazil)

Author keywords

Cervical cancer; Lymph node ratio

Indexed keywords

CISPLATIN;

ADENOSQUAMOUS CARCINOMA; ADJUVANT CHEMORADIOTHERAPY; ADJUVANT THERAPY; ADULT; AGED; ARTICLE; BODY MASS; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; ENDOMETRIUM CARCINOMA; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; LAPAROTOMY; LYMPH NODE METASTASIS; LYMPH NODE RATIO; MAJOR CLINICAL STUDY; MINIMALLY INVASIVE SURGERY; OVERALL SURVIVAL; PELVIS LYMPHADENECTOMY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADICAL HYSTERECTOMY; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; TUMOR VOLUME; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA; ANALYSIS OF VARIANCE; DISEASE FREE SURVIVAL; HYSTERECTOMY; LYMPH NODE; LYMPH NODE DISSECTION; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; RISK; SURVIVAL RATE; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

ADULT; AGED; ANALYSIS OF VARIANCE; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYSTERECTOMY; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; RETROSPECTIVE STUDIES; RISK; SURVIVAL RATE; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 84927726183     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2014.11.010     Document Type: Article

References (25)

1. Sedlis A, Bundy BN, Rotman MZ, Lentz SS, Muderspach LI, Zaino RJ. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group study. Gynecol Oncol 1999;73(2):177-83.
2. Aoki Y, Sasaki M, Watanabe M, et al. High risk group in node-positive patients with stage IB, IIA, and IIB cervical carcinoma after radical hysterectomy and postoperative pelvic irradiation. Gynecol Oncol 2000;77(2):305-9.
3. Horn LC, Hentschel B, Galle D, Bilek K. Extracapsular extension of pelvic lymph node metastases is of prognostic value in carcinoma of the cervix uteri. Gynecol Oncol 2008;108(1):63-7.
4. Riediger H, Keck T, Wellner U, et al. The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer. J Gastrointest Surg 2009;13(7):1337-44.
5. Liu YP, Ma L, Wang SJ, et al. Prognostic value of lymph node metastases and lymph node ratio in esophageal squamous cell carcinoma. Eur J Surg Oncol 2009;36(2):155-9.
6. Maduekwe UN, Lauwers GY, Fernandez-Del-Castillo C, et al. New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma. Ann Surg Oncol 2010;17(5):1267-77.
7. Hong KD, Lee SI, Moon HY. Lymph node ratio as determined by the 7th edition of the AJCC staging system predicts survival in stage III colon cancer. J Surg Oncol 2011;103(5):406-10.
8. Wang J, Hassett JM, Dayton MT, Kulaylat MN. Lymph node ratio: role in staging of node-positive colon cancer. Ann Surg Oncol 2008;15(6):1600-8.
9. Schiffman SC, McMasters KM, Scoggins CR, Martin RC, Chagpar AB. Lymph node ratio: a proposed refinement of current axillary staging in breast cancer patients. J Am Coll Surg 2011;213(1):45-52.
10. Woodward WA, Vinh-Hung V, Ueno NT, et al. Prognostic value of nodal ratio in node-positive breast cancer. J Clin Oncol 2006;24(18):2910-6.
11. Chan JK, Kapp DS, Cheung MK, et al. The impact of the absolute number and ratio of positive lymph nodes on survival of endometrioid uterine cancer patients. Br J Cancer 2007;97(5):605-11.
12. Polterauer S, Khalil S, Zivanovic O, et al. Prognostic value of lymph node ratio and clinicopathologic parameters in patients diagnosed with stage IIIC endometrial cancer. Obstet Gynecol 2012;119(6):1210-8.
13. Polterauer S, Hefler L, Seebacher V, et al. The impact of lymph node density on survival of cervical cancer patients. Br J Cancer 2010;103(5):613-6.
14. Chen Y, Zhang L, Tian J, et al. Significance of the absolute number and ratio of metastatic lymph nodes in predicting postoperative survival for the International Federation of Gynecology and Obstetrics stage IA2 to IIA cervical cancer. Int J Gynecol Cancer 2013;23(1):157-63.
15. Chen Y, Zhang L, Tian J, Ren X, Hao Q. Combining the negative lymph nodes count with the ratio of positive and removed lymph nodes can better predict the postoperative survival in cervical cancer patients. Cancer Cell Int 2013;13(1):6.
16. Williams BA, Mandrekar JN, Mandrekar SJ, Cha S, Furth AF. Finding optimal cutpoints for continuous covariates with binary and time-to-event outcomes. Technical report series #79. Mayo Clinic, Rochester, MN: Department of Health Sciences Research; June 2006.
17. Samlal RA, van der Velden J, Schilthuis MS, et al. Identification of high-risk groups among node-positive patients with stage IB and IIA cervical carcinoma. Gynecol Oncol 1997;64(3):463-7.
18. Tinga DJ, Timmer PR, Bouma J, Aalders JG. Prognostic significance of single versus multiple lymph node metastases in cervical carcinoma stage IB. Gynecol Oncol 1990;39(2):175-80.
19. Inoue T, Morita K. The prognostic significance of number of positive nodes in cervical carcinoma stages IB, IIA, and IIB. Cancer 1990;65(9):1923-7.
20. Alvarez RD, Soong SJ, Kinney WK, et al. Identification of prognostic factors and risk groups in patients found to have nodal metastasis at the time of radical hysterectomy for early-stage squamous cell carcinoma of the cervix. Gynecol Oncol 1989;35(2):130-5.
21. Lai CH, Chang HC, Chang TC, Hsueh S, Tang SG. Prognostic factors and impacts of adjuvant therapy in early-stage cervical carcinoma with pelvic node metastases. Gynecol Oncol 1993;51(3):390-6.
22. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathologic study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 1990;38(3):352-7.
23. Peters III WA, Liu PY, Barrett II RJ, et al. Concurrent chemotherapy and pelvic radiation compared to radiation alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 2000;18(8):1606-13.
24. Jewell EL, Huang JJ, Abu-Rustum NR, et al. Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies. Gynecol Oncol 2014;133(2):274-7.
25. Holman LL, Levenback CF, Frumovitz M. Sentinel lymph node evaluation in women with cervical cancer. J Minim Invasive Gynecol 2014;21(4):540-5.