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Volumn 18, Issue 6, 2014, Pages

Determining the mechanisms underlying augmented renal drug clearance in the critically ill: Use of exogenous marker compounds

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; CREATININE; FLUCONAZOLE; FRUCTAN; PINDOLOL; BIOLOGICAL MARKER; OLIGOSACCHARIDE; SINISTRIN;

EID: 84927721954     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0657-z     Document Type: Article
Times cited : (67)

References (47)
  • 1
    • 72249093367 scopus 로고    scopus 로고
    • Augmented renal clearance: implications for antibacterial dosing in the critically ill
    • 20000886
    • Udy AA, Roberts JA, Boots RJ, Paterson DL, Lipman J. Augmented renal clearance: implications for antibacterial dosing in the critically ill. Clin Pharmacokinet 2010, 49:1-16. 10.2165/11318140-000000000-00000, 20000886.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 1-16
    • Udy, A.A.1    Roberts, J.A.2    Boots, R.J.3    Paterson, D.L.4    Lipman, J.5
  • 2
    • 33751508210 scopus 로고    scopus 로고
    • Influence of renal function on trough serum concentrations of piperacillin in intensive care unit patients
    • 17061021
    • Conil JM, Georges B, Mimoz O, Dieye E, Ruiz S, Cougot P, Samii K, Houin G, Saivin S. Influence of renal function on trough serum concentrations of piperacillin in intensive care unit patients. Intensive Care Med 2006, 32:2063-2066. 10.1007/s00134-006-0421-1, 17061021.
    • (2006) Intensive Care Med , vol.32 , pp. 2063-2066
    • Conil, J.M.1    Georges, B.2    Mimoz, O.3    Dieye, E.4    Ruiz, S.5    Cougot, P.6    Samii, K.7    Houin, G.8    Saivin, S.9
  • 3
    • 84863807810 scopus 로고    scopus 로고
    • Subtherapeutic initial β-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations
    • 22194591
    • Udy AA, Varghese JM, Altukroni M, Briscoe S, McWhinney BC, Ungerer JP, Lipman J, Roberts JA. Subtherapeutic initial β-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations. Chest 2012, 142:30-39. 10.1378/chest.11-1671, 22194591.
    • (2012) Chest , vol.142 , pp. 30-39
    • Udy, A.A.1    Varghese, J.M.2    Altukroni, M.3    Briscoe, S.4    McWhinney, B.C.5    Ungerer, J.P.6    Lipman, J.7    Roberts, J.A.8
  • 4
    • 84883558584 scopus 로고    scopus 로고
    • Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy
    • 23683557
    • Claus BO, Hoste EA, Colpaert K, Robays H, Decruyenaere J, De Waele JJ. Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy. J Crit Care 2013, 28:695-700. 10.1016/j.jcrc.2013.03.003, 23683557.
    • (2013) J Crit Care , vol.28 , pp. 695-700
    • Claus, B.O.1    Hoste, E.A.2    Colpaert, K.3    Robays, H.4    Decruyenaere, J.5    De Waele, J.J.6
  • 5
    • 84859420783 scopus 로고    scopus 로고
    • Augmented renal clearance in septic patients and implications for vancomycin optimisation
    • 22386742
    • Baptista JP, Sousa E, Martins PJ, Pimentel JM. Augmented renal clearance in septic patients and implications for vancomycin optimisation. Int J Antimicrob Agents 2012, 39:420-423. 10.1016/j.ijantimicag.2011.12.011, 22386742.
    • (2012) Int J Antimicrob Agents , vol.39 , pp. 420-423
    • Baptista, J.P.1    Sousa, E.2    Martins, P.J.3    Pimentel, J.M.4
  • 6
    • 59849085517 scopus 로고    scopus 로고
    • You only find what you look for: the importance of high creatinine clearance in the critically ill
    • 19157339
    • Udy A, Roberts JA, Boots RJ, Lipman J. You only find what you look for: the importance of high creatinine clearance in the critically ill. Anaesth Intensive Care 2009, 37:11-13. 19157339.
    • (2009) Anaesth Intensive Care , vol.37 , pp. 11-13
    • Udy, A.1    Roberts, J.A.2    Boots, R.J.3    Lipman, J.4
  • 7
    • 84855393537 scopus 로고    scopus 로고
    • Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story
    • 22165348
    • Lipman J, Udy AA, Roberts JA. Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story. Anaesth Intensive Care 2011, 39:999-1000. 22165348.
    • (2011) Anaesth Intensive Care , vol.39 , pp. 999-1000
    • Lipman, J.1    Udy, A.A.2    Roberts, J.A.3
  • 8
    • 0344514152 scopus 로고    scopus 로고
    • Principles and clinical application of assessing alterations in renal elimination pathways
    • 14606929
    • Tett SE, Kirkpatrick CM, Gross AS, McLachlan AJ. Principles and clinical application of assessing alterations in renal elimination pathways. Clin Pharmacokinet 2003, 42:1193-1211. 10.2165/00003088-200342140-00002, 14606929.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 1193-1211
    • Tett, S.E.1    Kirkpatrick, C.M.2    Gross, A.S.3    McLachlan, A.J.4
  • 9
    • 0034825501 scopus 로고    scopus 로고
    • Simultaneous administration of a cocktail of markers to measure renal drug elimination pathways: absence of a pharmacokinetic interaction between fluconazole and sinistrin, p-aminohippuric acid and pindolol
    • 11422014
    • Gross AS, McLachlan AJ, Minns I, Beal JB, Tett SE. Simultaneous administration of a cocktail of markers to measure renal drug elimination pathways: absence of a pharmacokinetic interaction between fluconazole and sinistrin, p-aminohippuric acid and pindolol. Br J Clin Pharmacol 2001, 51:547-555. 10.1046/j.1365-2125.2001.01390.x, 11422014.
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 547-555
    • Gross, A.S.1    McLachlan, A.J.2    Minns, I.3    Beal, J.B.4    Tett, S.E.5
  • 10
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • 1303622
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6    Schein, R.M.7    Sibbald, W.J.8
  • 11
    • 10244236377 scopus 로고    scopus 로고
    • AAcute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    • 15312219
    • Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. AAcute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8:R204-R212. 10.1186/cc2872, 15312219.
    • (2004) Crit Care , vol.8 , pp. R204-R212
    • Bellomo, R.1    Ronco, C.2    Kellum, J.A.3    Mehta, R.L.4    Palevsky, P.5
  • 13
    • 1842289168 scopus 로고    scopus 로고
    • Sinistrin clearance for determination of glomerular filtration rate: a reappraisal of various approaches using a new analytical method
    • 9378840
    • Buclin T, Pechère-Bertschi A, Séchaud R, Décosterd LA, Munafo A, Burnier M, Biollaz J. Sinistrin clearance for determination of glomerular filtration rate: a reappraisal of various approaches using a new analytical method. J Clin Pharmacol 1997, 37:679-692. 10.1002/j.1552-4604.1997.tb04355.x, 9378840.
    • (1997) J Clin Pharmacol , vol.37 , pp. 679-692
    • Buclin, T.1    Pechère-Bertschi, A.2    Séchaud, R.3    Décosterd, L.A.4    Munafo, A.5    Burnier, M.6    Biollaz, J.7
  • 14
    • 0022356236 scopus 로고
    • Stereoselective renal clearance of pindolol in humans
    • 4056049
    • Hsyu PH, Giacomini KM. Stereoselective renal clearance of pindolol in humans. J Clin Invest 1985, 76:1720-1726. 10.1172/JCI112161, 4056049.
    • (1985) J Clin Invest , vol.76 , pp. 1720-1726
    • Hsyu, P.H.1    Giacomini, K.M.2
  • 15
    • 84877003713 scopus 로고    scopus 로고
    • Meropenem and piperacillin/tazobactam prescribing in critically ill patients: Does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?
    • 23642005
    • Carlier M, Carrette S, Roberts JA, Stove V, Verstraete AG, Hoste E, Decruyenaere J, Depuydt P, Lipman J, Wallis SC, De Waele JJ. Meropenem and piperacillin/tazobactam prescribing in critically ill patients: Does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?. Crit Care 2013, 17:R84. 10.1186/cc12705, 23642005.
    • (2013) Crit Care , vol.17 , pp. R84
    • Carlier, M.1    Carrette, S.2    Roberts, J.A.3    Stove, V.4    Verstraete, A.G.5    Hoste, E.6    Decruyenaere, J.7    Depuydt, P.8    Lipman, J.9    Wallis, S.C.10    De Waele, J.J.11
  • 18
    • 0027473251 scopus 로고
    • The concentration-dependent disposition of intravenous p-aminohippurate in subjects with normal and impaired renal function
    • 8448064
    • Prescott LF, Freestone S, McAuslane JA. The concentration-dependent disposition of intravenous p-aminohippurate in subjects with normal and impaired renal function. Br J Clin Pharmacol 1993, 35:20-29. 8448064.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 20-29
    • Prescott, L.F.1    Freestone, S.2    McAuslane, J.A.3
  • 19
    • 0035166994 scopus 로고    scopus 로고
    • Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine
    • 11135083
    • Dowling TC, Frye RF, Fraley DS, Matzke GR. Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine. Kidney Int 2001, 59:295-303. 10.1046/j.1523-1755.2001.00491.x, 11135083.
    • (2001) Kidney Int , vol.59 , pp. 295-303
    • Dowling, T.C.1    Frye, R.F.2    Fraley, D.S.3    Matzke, G.R.4
  • 20
    • 0015530123 scopus 로고
    • Measurement of renal function without urine collection-a critical evaluation of the constant-infusion technic for determination of inulin and para-aminohippurate
    • 5082190
    • Cole BR, Giangiacomo J, Ingelfinger JR, Robson AM. Measurement of renal function without urine collection-a critical evaluation of the constant-infusion technic for determination of inulin and para-aminohippurate. N Engl J Med 1972, 287:1109-1114. 10.1056/NEJM197211302872202, 5082190.
    • (1972) N Engl J Med , vol.287 , pp. 1109-1114
    • Cole, B.R.1    Giangiacomo, J.2    Ingelfinger, J.R.3    Robson, A.M.4
  • 22
    • 0025194864 scopus 로고
    • An assessment of the effects of impaired renal function and haemodialysis on the pharmacokinetics of fluconazole
    • 2306414
    • Toon S, Ross CE, Gokal R, Rowland M. An assessment of the effects of impaired renal function and haemodialysis on the pharmacokinetics of fluconazole. Br J Clin Pharmacol 1990, 29:221-226. 10.1111/j.1365-2125.1990.tb03623.x, 2306414.
    • (1990) Br J Clin Pharmacol , vol.29 , pp. 221-226
    • Toon, S.1    Ross, C.E.2    Gokal, R.3    Rowland, M.4
  • 23
    • 0030078146 scopus 로고    scopus 로고
    • Urine acidification affects the activity of the organic base transporter in a nonstereoselective manner
    • 8632337
    • Ujhelyi MR, Bottorff MB, Schur M, Roll K, Zhang H, Stewart J, Markel ML. Urine acidification affects the activity of the organic base transporter in a nonstereoselective manner. J Pharmacol Exp Ther 1996, 276:683-689. 8632337.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 683-689
    • Ujhelyi, M.R.1    Bottorff, M.B.2    Schur, M.3    Roll, K.4    Zhang, H.5    Stewart, J.6    Markel, M.L.7
  • 24
    • 0026606632 scopus 로고
    • Stereoselective inhibition of pindolol renal clearance by cimetidine in humans
    • 1563208
    • Somogyi AA, Bochner F, Sallustio BC. Stereoselective inhibition of pindolol renal clearance by cimetidine in humans. Clin Pharmacol Ther 1992, 51:379-387. 10.1038/clpt.1992.37, 1563208.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 379-387
    • Somogyi, A.A.1    Bochner, F.2    Sallustio, B.C.3
  • 25
    • 84855995429 scopus 로고    scopus 로고
    • Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
    • 22072731
    • Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, Sugiyama Y. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. J Pharmacol Exp Ther 2012, 340:393-403. 10.1124/jpet.111.184986, 22072731.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 393-403
    • Ito, S.1    Kusuhara, H.2    Yokochi, M.3    Toyoshima, J.4    Inoue, K.5    Yuasa, H.6    Sugiyama, Y.7
  • 26
    • 84873928187 scopus 로고    scopus 로고
    • Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
    • 23241029
    • Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 2013, 56:781-795. 10.1021/jm301302s, 23241029.
    • (2013) J Med Chem , vol.56 , pp. 781-795
    • Wittwer, M.B.1    Zur, A.A.2    Khuri, N.3    Kido, Y.4    Kosaka, A.5    Zhang, X.6    Morrissey, K.M.7    Sali, A.8    Huang, Y.9    Giacomini, K.M.10
  • 27
    • 0035132763 scopus 로고    scopus 로고
    • Analytical validation for a series of marker compounds used to assess renal drug elimination processes
    • 11206041
    • McLachlan AJ, Gross AS, Beal JL, Minns I, Tett SE. Analytical validation for a series of marker compounds used to assess renal drug elimination processes. Ther Drug Monit 2001, 23:39-46. 10.1097/00007691-200102000-00008, 11206041.
    • (2001) Ther Drug Monit , vol.23 , pp. 39-46
    • McLachlan, A.J.1    Gross, A.S.2    Beal, J.L.3    Minns, I.4    Tett, S.E.5
  • 28
    • 0019149744 scopus 로고
    • Effects of pindolol on renal function
    • 7002425
    • Wainer E, Boner G, Rosenfeld JB. Effects of pindolol on renal function. Clin Pharmacol Ther 1980, 28:575-580. 10.1038/clpt.1980.205, 7002425.
    • (1980) Clin Pharmacol Ther , vol.28 , pp. 575-580
    • Wainer, E.1    Boner, G.2    Rosenfeld, J.B.3
  • 29
    • 0024269607 scopus 로고
    • Renal excretion and metabolism of p-aminohippurate in the isolated perfused rat kidney
    • 3247282
    • Lee LJ, Smith DE. Renal excretion and metabolism of p-aminohippurate in the isolated perfused rat kidney. Pharm Res 1988, 5:745-747. 10.1023/A:1015924331585, 3247282.
    • (1988) Pharm Res , vol.5 , pp. 745-747
    • Lee, L.J.1    Smith, D.E.2
  • 30
    • 0035090910 scopus 로고    scopus 로고
    • Pharmacokinetics of sequential intravenous and enteral fluconazole in critically ill surgical patients with invasive mycoses and compromised gastro-intestinal function
    • 11280621
    • Buijk SL, Gyssens IC, Mouton JW, Verbrugh HA, Touw DJ, Bruining HA. Pharmacokinetics of sequential intravenous and enteral fluconazole in critically ill surgical patients with invasive mycoses and compromised gastro-intestinal function. Intensive Care Med 2001, 27:115-121. 10.1007/s001340000771, 11280621.
    • (2001) Intensive Care Med , vol.27 , pp. 115-121
    • Buijk, S.L.1    Gyssens, I.C.2    Mouton, J.W.3    Verbrugh, H.A.4    Touw, D.J.5    Bruining, H.A.6
  • 32
    • 84894437155 scopus 로고    scopus 로고
    • Augmented renal clearance in the ICU: results of a multicenter observational study of renal function in critically Ill patients with normal plasma creatinine concentrations
    • 24201175
    • Udy AA, Baptista JP, Lim NL, Joynt GM, Jarrett P, Wockner L, Boots RJ, Lipman J. Augmented renal clearance in the ICU: results of a multicenter observational study of renal function in critically Ill patients with normal plasma creatinine concentrations. Crit Care Med 2014, 42:520-527. 10.1097/CCM.0000000000000029, 24201175.
    • (2014) Crit Care Med , vol.42 , pp. 520-527
    • Udy, A.A.1    Baptista, J.P.2    Lim, N.L.3    Joynt, G.M.4    Jarrett, P.5    Wockner, L.6    Boots, R.J.7    Lipman, J.8
  • 35
    • 84874380062 scopus 로고    scopus 로고
    • Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients
    • 23448570
    • Udy AA, Roberts JA, Shorr AF, Boots RJ, Lipman J. Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients. Crit Care 2013, 17:R35. 10.1186/cc12544, 23448570.
    • (2013) Crit Care , vol.17 , pp. R35
    • Udy, A.A.1    Roberts, J.A.2    Shorr, A.F.3    Boots, R.J.4    Lipman, J.5
  • 36
    • 77955706083 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic considerations in the design of hospital-acquired or ventilator-associated bacterial pneumonia studies: Look before you leap!
    • 20597657
    • Ambrose PG, Bhavnani SM, Ellis-Grosse EJ, Drusano GL. Pharmacokinetic-pharmacodynamic considerations in the design of hospital-acquired or ventilator-associated bacterial pneumonia studies: Look before you leap!. Clin Infect Dis 2010, 51:S103-S110. 10.1086/653057, 20597657.
    • (2010) Clin Infect Dis , vol.51 , pp. S103-S110
    • Ambrose, P.G.1    Bhavnani, S.M.2    Ellis-Grosse, E.J.3    Drusano, G.L.4
  • 37
    • 84866652053 scopus 로고    scopus 로고
    • High creatinine clearance in critically ill patients with community-acquired acute infectious meningitis
    • 23013403
    • Lautrette A, Phan TN, Ouchchane L, Aithssain A, Tixier V, Heng AE, Souweine B. High creatinine clearance in critically ill patients with community-acquired acute infectious meningitis. BMC Nephrol 2012, 13:124. 10.1186/1471-2369-13-124, 23013403.
    • (2012) BMC Nephrol , vol.13 , pp. 124
    • Lautrette, A.1    Phan, T.N.2    Ouchchane, L.3    Aithssain, A.4    Tixier, V.5    Heng, A.E.6    Souweine, B.7
  • 38
    • 0018977952 scopus 로고
    • Renal function in critically ill postoperative patients: sequential assessment of creatinine osmolar and free water clearance
    • 7353390
    • Brown R, Babcock R, Talbert J, Gruenberg J, Czurak C, Campbell M. Renal function in critically ill postoperative patients: sequential assessment of creatinine osmolar and free water clearance. Crit Care Med 1980, 8:68-72. 10.1097/00003246-198002000-00004, 7353390.
    • (1980) Crit Care Med , vol.8 , pp. 68-72
    • Brown, R.1    Babcock, R.2    Talbert, J.3    Gruenberg, J.4    Czurak, C.5    Campbell, M.6
  • 40
    • 84879119267 scopus 로고    scopus 로고
    • Systemic inflammatory response syndrome criteria and vancomycin dose requirement in patients with sepsis
    • 23604132
    • Shimamoto Y, Fukuda T, Tanaka K, Komori K, Sadamitsu D. Systemic inflammatory response syndrome criteria and vancomycin dose requirement in patients with sepsis. Intensive Care Med 2013, 39:1247-1252. 10.1007/s00134-013-2909-9, 23604132.
    • (2013) Intensive Care Med , vol.39 , pp. 1247-1252
    • Shimamoto, Y.1    Fukuda, T.2    Tanaka, K.3    Komori, K.4    Sadamitsu, D.5
  • 41
    • 0027976580 scopus 로고
    • What does the renal reserve mean?
    • 8164427
    • Thomas DM, Coles GA, Williams JD. What does the renal reserve mean?. Kidney Int 1994, 45:411-416. 10.1038/ki.1994.53, 8164427.
    • (1994) Kidney Int , vol.45 , pp. 411-416
    • Thomas, D.M.1    Coles, G.A.2    Williams, J.D.3
  • 42
    • 84887400558 scopus 로고    scopus 로고
    • A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations
    • 24225349
    • Udy AA, Morton FJ, Nguyen-Pham S, Jarrett P, Lassig-Smith M, Stuart J, Dunlop R, Starr T, Boots RJ, Lipman J. A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations. BMC Nephrol 2013, 14:250. 10.1186/1471-2369-14-250, 24225349.
    • (2013) BMC Nephrol , vol.14 , pp. 250
    • Udy, A.A.1    Morton, F.J.2    Nguyen-Pham, S.3    Jarrett, P.4    Lassig-Smith, M.5    Stuart, J.6    Dunlop, R.7    Starr, T.8    Boots, R.J.9    Lipman, J.10
  • 43
    • 84878895235 scopus 로고    scopus 로고
    • Assessing glomerular filtration rate (GFR) in critically ill patients with acute kidney injury - true GFR versus urinary creatinine clearance and estimating equations
    • 23767877
    • Bragadottir G, Redfors B, Ricksten SE. Assessing glomerular filtration rate (GFR) in critically ill patients with acute kidney injury - true GFR versus urinary creatinine clearance and estimating equations. Crit Care 2013, 17:R108. 10.1186/cc12777, 23767877.
    • (2013) Crit Care , vol.17 , pp. R108
    • Bragadottir, G.1    Redfors, B.2    Ricksten, S.E.3
  • 44
    • 0029052822 scopus 로고
    • Bioavailability of fluconazole administered via a feeding tube in intensive care unit patients
    • 8522469
    • Nicolau DP, Crowe H, Nightingale CH, Quintiliani R. Bioavailability of fluconazole administered via a feeding tube in intensive care unit patients. J Antimicrob Chemother 1995, 36:395-401. 10.1093/jac/36.2.395, 8522469.
    • (1995) J Antimicrob Chemother , vol.36 , pp. 395-401
    • Nicolau, D.P.1    Crowe, H.2    Nightingale, C.H.3    Quintiliani, R.4
  • 45
    • 0017379878 scopus 로고
    • Pindolol, a β-adrenoceptor blocking agent with a negligible first-pass effect
    • 901706
    • Meier J, Nuesch E. Pindolol, a β-adrenoceptor blocking agent with a negligible first-pass effect. Br J Clin Pharmacol 1977, 4:371-372. 10.1111/j.1365-2125.1977.tb00726.x, 901706.
    • (1977) Br J Clin Pharmacol , vol.4 , pp. 371-372
    • Meier, J.1    Nuesch, E.2
  • 46
    • 0030837139 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses
    • 9250423
    • Debruyne D. Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses. Clin Pharmacokinet 1997, 33:52-77. 10.2165/00003088-199733010-00005, 9250423.
    • (1997) Clin Pharmacokinet , vol.33 , pp. 52-77
    • Debruyne, D.1
  • 47
    • 0028345631 scopus 로고
    • Evaluation of two intravenous single-bolus methods for measuring effective renal plasma flow
    • 8128938
    • Hirata-Dulas CA, Awni WM, Matzke GR, Halstenson CE, Guay DR. Evaluation of two intravenous single-bolus methods for measuring effective renal plasma flow. Am J Kidney Dis 1994, 23:374-381. 10.1016/S0272-6386(12)80999-1, 8128938.
    • (1994) Am J Kidney Dis , vol.23 , pp. 374-381
    • Hirata-Dulas, C.A.1    Awni, W.M.2    Matzke, G.R.3    Halstenson, C.E.4    Guay, D.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.