Urine acidification affects the activity of the organic base transporter in a nonstereoselective manner

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 683-689

  Ujhelyi, Michael R ^a,b   Bottorff, Michael B ^c   Schur, Michael ^c   Roll, Kevin ^c   Zhang, Hailang ^a   Stewart, James ^a   Markel, Michael L ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM CHLORIDE; PINDOLOL;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; HUMAN; KIDNEY; MALE; METABOLIC CLEARANCE RATE; METABOLISM; RANDOMIZED CONTROLLED TRIAL; STEREOISOMERISM; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; AMMONIUM CHLORIDE; BIOLOGICAL TRANSPORT; BLOOD PRESSURE; CROSS-OVER STUDIES; HUMANS; KIDNEY; MALE; METABOLIC CLEARANCE RATE; PINDOLOL; STEREOISOMERISM;

EID: 0030078146     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BALANT, L., MUIR, K., DAYER, P., GORGIA, A., EBERLIN, J. L., ESTREICHER, J. AND FABRE, J.: Simultaneous tubular excretion and reabsorption of pindolol in man. Eur. J. Clin. Pharmacol. 21: 65-72, 1981.
2. GYORKE, Z. S., SULYOKE AND GUIGNARD, J. P.: Ammonium chloride metabolic acidosis and the activity of renin-angiotensin-aldosterone system in children. Eur. J. Pediatr. 150: 547-549, 1991.
3. HOLOHAN, P. D. AND Ross, C. R.: Mechanisms of organic cation transport in kidney plasma membrane vesicles: 2. ΔpH studies. J. Pharmacol. Exp. Ther. 216(2): 294-298, 1981.
4. HSYU, P-H AND GIACOMINI, K. M.: Stereoselective renal clearance of pindolol in humans. J. Clin. Invest. 76: 1720-1726, 1985.
5. HSYU, P-H AND GIACOMINI, K. M.: The pH gradient-dependent transport of organic cations in the renal brush border membrane. J. Bio. Chem. 262(9): 3964-3968, 1987.
6. KOSOGLOU, T. AND VLASSES, P. H.: Drug interactions involving renal transport mechanisms: An overview. DICP, The Annals of Pharmacotherapy. 23: 116-122, 1989.
7. LALONDE, R. L., STRAKA, R. J., PIEPER, J. A., BOTTORFF, M. B. AND MIRVIS, D. M.: Propranolol pharmacodynamic modeling using unbound and total concentrations in healthy volunteers. J. Pharmacokin. Biopharm. 15(6): 569-581, 1987.
8. LECORRE P., GIBASSIER D., SADO, P. AND VEVERGE, R.: Stereoselective metabolism and pharmacokinetics of disopyramide enantiomers in humans. Drug Metab. Disp. 16(6): 858-864, 1988.
9. LEMAIRE, M. AND TILLEMENT, J. P.: The binding characteristics of some adrenergic beta-receptor antagonists to human serum proteins. Biochem. Pharmacol. 31(3): 359-365, 1982.
10. MCKINNEY, T. D.: Further studies of organic base secretion by rabbit proximal tubules. Am. J. Physiol. 246: F282-F289, 1984.
11. MCKINNEY, T. D. AND HOSFORD, M. A.: Organic cation transport by rat hepato-cyte basolateral membrane vesicles. Am. J. Physiol. 263: G939-G946, 1992.
12. MCKINNEY, T. D. AND KUNNEMANN, M. E.: Procainamide transport in rabbit renal cortical brush border membrane vesicles. Am. J. Physiol. 249: F832-F541, 1985.
13. MUIRIHEAD, M., BOCHNER, F. AND SOMOGYI, A.: Pharmacokinetic drug interactions between triamterene and ranitidine in humans: Alterations in renal and hepatic clearances and gastrointestinal absorption. J, Pharmacol. Exp. Ther. 244(2): 734-739, 1988.
14. NOTTERMAN, D. A., DRAYER, D. E., METAKIS, L. AND REIDENBERG, M. M.: Stereoselective renal tubular secretion of quinidine and quinine. Clin. Pharmacol. Ther. 40: 511-517, 1986.
15. OHNHAUS, E. E., HEIDEMANN, H., MEIER, J. AND MAURER, G.: Metabolism of pindolol in patients with renal failure. Eur. J. Clin. Pharmacol. 22:423-428, 1982.
16. OTT, R. J. AND GIACOMINI, K. M.: Stereoselective interactions of organic cations with the organic cation transporter in OK cells. Pharmaceutical Research. 10(8): 1169-1173, 1993.
17. OTT, R. J., HUI, A. C., WONG, F. M., HSYU, P-H. AND GIACOMINI, K. M.: Interactions of quinidine and quinine and (+)- and (-)- pindolol with the organic cation/proton antiporter in renal border membrane vesicles. Biochem. Pharmacol. 41(1): 142-145, 1991.
18. RENNICK, B. R.: Renal tubule transport of organic cations. Am. J. Physiol. 240: F83-P89, 1981.
19. SOKOL, P. O., HOLOHAN, P. D., GRASS, S. M. AND Ross, C. R.: Proton-coupled organic cation transport in renal brush-border membrane vesicles. Biochim. Biophys. Acta 940: 209-218, 1988.
20. SOMOGYI, A.: New insights into the renal secretion of drugs. TIPS. 8: 354-357, 1987.
21. SOMOGYI, A. A., BOCHNER, F. AND SALLUSTIO, B. C.: Stereoselective inhibition of pindolol renal clearance by cimetidine in humans. Clin. Pharmacol. Ther. 51(4): 379-387, 1992.
22. TUCKER, G. T. AND LENNARD, M S.: Enantiomer specific pharmacokinetics.: Pharmacol. Ther. 45: 309-329, 1990.
23. UJHELYI, M., SCHUR, M., BOTTORFF, M., ZHANG, H., STEWART, J. AND MARKEL, M.: Effects of inhibition and stimulation of organic cation secretion on stereoselective renal clearance. Clin. Pharmacol. Ther. 57(2): 217, 1995.
24. WONG, L. T. Y., SMYTH, D. D. AND SITAR, D. S.: Stereoselective inhibition of amantadine accumulation by quinine and quinidine in rat renal proximal tubules and cortical slices. J. Pharmacol. Exp. Ther. 255: 271-275, 1990.
25. + metabolism and the intracellular pH in isolated perfused rat liver. Biochem. J. 293: 667-73, 1993.
26. ZHANG, H., STEWART, J. T. AND UJHELYI, M. R : HPLC analysis of pindolol enantiomers in human serum using a reversed phase chiral column and solid phase extraction. J. Chromatogr. 668: 309-13, 1995.