Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: A prospective multicentre study

Critical Care

Volumn 18, Issue 6, 2014, Pages

  Boulain, Thierry ^a   Garot, Denis ^b   Vignon, Philippe ^c,d   Lascarrou, Jean Baptiste ^e   Desachy, Arnaud ^f   Botoc, Vlad ^e   Follin, Arnaud ^g   Frat, Jean Pierre ^h   Bellec, Frédéric ⁱ   Quenot, Jean Pierre ^a,b   Mathonnet, Armelle ^j   Dequin, Pierre François ^k  

^a Service d'urologie andrologie   (France)

^b UNIVERSITY HOSPITAL OF TOURS   (France)

^c LIMOGES UNIVERSITY HOSPITAL   (France)

^d UMR 1092   (France)

^e Medical Surgical Intensive Care Unit District Hospital Center   (France)

^f Medical Surgical Intensive Care Unit   (France)

^g District Hospital Center   (France)

^h POITIERS UNIVERSITY HOSPITAL   (France)

ⁱ District Hospital Center   (France)

^j DIJON UNIVERSITY HOSPITAL   (France)

^k Institut Médical de Génétique et d Immunologie   (France)

^l CRICS) Group   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; DOBUTAMINE; HYPERTENSIVE FACTOR; LACTIC ACID; NORADRENALIN; OXYGEN;

AGED; ARTICLE; ARTIFICIAL VENTILATION; BLOOD SAMPLING; BLOOD TRANSFUSION; BODY WEIGHT; CENTRAL VENOUS OXYGEN SATURATION; CENTRAL VENOUS PRESSURE; DISEASE SEVERITY; FEMALE; FRANCE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; MULTICENTER STUDY; OBSERVATIONAL STUDY; OXYGEN SATURATION; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; RESUSCITATION; SEPSIS; SEPTIC SHOCK; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; URINE VOLUME; VENOUS OXYGEN TENSION; BLOOD; CLINICAL TRIAL; STATISTICS AND NUMERICAL DATA; SURVIVAL;

AGED; FEMALE; HUMANS; INTENSIVE CARE UNITS; LACTIC ACID; MALE; OXYGEN; PREVALENCE; PROSPECTIVE STUDIES; SHOCK, SEPTIC; SURVIVAL ANALYSIS;

EID: 84927717611     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0609-7     Document Type: Article

References (39)

1. Rady MY, Rivers EP, Nowak RM. Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 1996, 14:218-225. 10.1016/S0735-6757(96)90136-9, 8924150.
2. Dueck MH, Klimek M, Appenrodt S, Weigand C, Boerner U. Trends but not individual values of central venous oxygen saturation agree with mixed venous oxygen saturation during varying hemodynamic conditions. Anesthesiology 2005, 103:249-257. 10.1097/00000542-200508000-00007, 16052106.
3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early Goal-Directed Therapy Collaborative Group: early goal directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377. 10.1056/NEJMoa010307, 11794169.
4. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013, 41:580-637. 10.1097/CCM.0b013e31827e83af, 23353941.
5. Bellomo R, Reade MC, Warrillow SJ. The pursuit of a high central venous oxygen saturation in sepsis: growing concerns. Crit Care 2008, 12:130. 10.1186/cc6841, 18423058.
6. Perel A. Bench-to-bedside review: the initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelines-does one size fit all?. Crit Care 2008, 12:223. 10.1186/cc6979, 18828870.
7. Peake S, Webb S, Delaney A. Early goal-directed therapy of septic shock: we honestly remain skeptical. Crit Care Med 2007, 35:994-995. 10.1097/01.CCM.0000257481.37623.3B, 17421118.
8. van Beest PA, Hofstra JJ, Schultz MJ, Boerma EC, Spronk PE, Kuiper MA. The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands. Crit Care 2008, 12:R33. 10.1186/cc6811, 18318895.
9. Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemsen SP, Bakker J. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010, 182:752-761. 10.1164/rccm.200912-1918OC, 20463176.
10. Chung KP, Chang HT, Huang YT, Liao CH, Ho CC, Jerng JS, Yu CJ. Central venous oxygen saturation under non-protocolized resuscitation is not related to survival in severe sepsis or septic shock. Shock 2012, 38:584-591. 10.1097/SHK.0b013e318274c674, 23143064.
11. Bracht H, Hänggi M, Jeker B, Wegmüller N, Porta F, Tüller D, Takala J, Jakob SM. Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study. Crit Care 2007, 11:R2. 10.1186/cc5144, 17212816.
12. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med 2010, 55:40-46. 10.1016/j.annemergmed.2009.08.014, 19854541.
13. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003, 31:1250-1256. 10.1097/01.CCM.0000050454.01978.3B, 12682500.
14. McCabe WR, Jackson GG. Gram-negative bacteremia I. Etiology and ecology. Arch Intern Med 1962, 110:847-891. 10.1001/archinte.1962.03620240029006.
15. Akaike H. A new look at statistical model identification. IEEE Trans Automat Contr 1974, 19:716-722. 10.1109/TAC.1974.1100705.
16. Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on " sepsis-related problems" of the European Society of Intensive Care Med. Crit Care Med 1998, 26:1793-1800. 10.1097/00003246-199811000-00016, 9824069.
17. Loi 2004-806 (August 9, 2004) relative à la politique de santé publique. J French Repub 2004, 185:14277.
18. Antonelli M, Levy M, Andrews PJ, Chastre J, Hudson LD, Manthous C, Meduri GU, Moreno RP, Putensen C, Stewart T, Torres A. Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006. Intensive Care Med 2007, 33:575-590. 10.1007/s00134-007-0531-4, 17285286.
19. Pottecher T, Calvat S, Dupont H, Durand-Gasselin J, Gerbeaux P. Hemodynamic management of severe sepsis: recommendations of the French Intensive Care' Societies (SFAR/SRLF) Consensus Conference, 13 October 2005, Paris. France Crit Care 2006, 10:311. 10.1186/cc4658.
20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188. 10.1016/0197-2456(86)90046-2, 3802833.
21. Cleveland WS, Devlin SJ. Locally-weighted regression: an approach to regression analysis by local fitting. J Am Stat Assoc 1988, 83:596-610. 10.1080/01621459.1988.10478639.
22. Boulain T, Runge I, Benzekri-Lefèvre D, Mathonnet A, Bretagnol A, Fleury C. Saturation veineuse cave supérieure (ScvO2) à la prise en charge du sepsis sévère en réanimation : fréquence des valeurs basses [Abstract]. Reanimation 2011, 20:S226. 10.1007/s13546-011-0230-6.
23. R Core Team: R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2013. ISBN 3-900051-07-0 []., http://www.R-project.org/
24. Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/north American multicenter study. JAMA 1993, 270:2957-2963. 10.1001/jama.1993.03510240069035, 8254858.
25. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A, Ressler JA, Tomlanovich MC. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004, 32:1637-1642. 10.1097/01.CCM.0000132904.35713.A7, 15286537.
26. Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009, 37:1670-1677. 10.1097/CCM.0b013e31819fcf68, 19325467.
27. Marik PE, Bellomo R. Lactate clearance as a target of therapy in sepsis: a flawed paradigm. OA Critical Care 2013, 1:3. 10.13172/2052-9309-1-1-431.
28. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010, 303:739-746. 10.1001/jama.2010.158, 20179283.
29. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009, 32:35-39. 10.1097/SHK.0b013e3181971d47, 19533847.
30. Investigators PCESS, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014, 370:1683-1693. 10.1056/NEJMoa1401602.
31. Gattinoni L, Brazzi L, Pelosi P, Latini R, Tognoni G, Pesenti A, Fumagalli R. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 1995, 333:1025-1032. 10.1056/NEJM199510193331601, 7675044.
32. van Beest P, Wietasch G, Scheeren T, Spronk P, Kuiper M. Clinical review: use of venous oxygen saturations as a goal - a yet unfinished puzzle. Crit Care 2011, 15:232. 10.1186/cc10351, 22047813.
33. Gallet R, Lellouche N, Mitchell-Heggs L, Bouhemad B, Bensaid A, Dubois-Randé JL, Gueret P, Lim P. Prognosis value of central venous oxygen saturation in acute decompensated heart failure. Arch Cardiovasc Dis 2012, 105:5-12. 10.1016/j.acvd.2011.10.005, 22369912.
34. Astiz ME, Rackow EC, Falk JL, Kaufman BS, Weil MH. Oxygen delivery and consumption in patients with hyperdynamic septic shock. Crit Care Med 1987, 15:26-28. 10.1097/00003246-198701000-00005, 3792011.
35. Kalliokoski KK, Oikonen V, Takala TO, Sipila H, Knuuti J, Nuutila P. Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men. Am J Physiol Endocrinol Metab 2001, 280:E1015-E1021. 11350784.
36. Ellis CG, Bateman RM, Sharpe MD, Sibbald WJ, Gill R. Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis. Am J Physiol Heart Circ Physiol 2002, 282:H156-H164. 11748059.
37. Textoris J, Fouché L, Wiramus S, Antonini F, Tho S, Martin C, Leone M. High central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality. Crit Care 2011, 15:R176. 10.1186/cc10325, 21791065.
38. Ho BC, Bellomo R, McGain F, Ones D, Naka T, Wan L, Braitberg G. The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care 2006, 10:R80. 10.1186/cc4918, 16704743.
39. Subramanian G, Anitha VP, Ranjit S. Comparison of central venous saturation by standard ABG machine versus co-oximeter: Is 18 carat as good as the 24 carat gold standard?. Indian J Crit Care Med 2013, 17:82-86. 10.4103/0972-5229.114824, 23983412.