Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity

Phytomedicine

Volumn 22, Issue 5, 2015, Pages 536-544

  Hu, Tao ^a   Wang, Lin ^a   Zhang, Lin ^a   Lu, Lan ^a   Shen, Jing ^a   Chan, Ruby L Y ^a   Li, Mingxing ^a   Wu, William K K ^b   To, Kenneth K W ^a   Cho, Chi Hin ^a  

^a Prince of Wales Hospital   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis resistance; Autophagic cell death; Colon cancer; Cryptotanshinone; Dihydrotanshinone; p53 independent cytotoxicity

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CRYPTOTANSHINONE; DIHYDROTANSHINONE; DOXORUBICIN; FLUOROURACIL; IRINOTECAN; MICROTUBULE ASSOCIATED PROTEIN; MULTIDRUG RESISTANCE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXALIPLATIN; PROTEIN P53; TANSHINONE; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE; HERBACEOUS AGENT; PHENANTHRENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER CELL LINE; CANCER RESISTANCE; CELL ORGANELLE; CELL VIABILITY; COLON CANCER; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; DRUG SENSITIVITY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HUMAN; HUMAN CELL; LIPOPHILICITY; MTT ASSAY; MULTIDRUG RESISTANCE; NECROPTOSIS; PRIORITY JOURNAL; SALVIA MILTIORRHIZA; UPREGULATION; WESTERN BLOTTING; CELL SURVIVAL; COLON TUMOR; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

SALVIA MILTIORRHIZA;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DITERPENES, ABIETANE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUGS, CHINESE HERBAL; HUMANS; PHENANTHRENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84927702563     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.03.010     Document Type: Article

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