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Volumn 3, Issue 10, 2014, Pages

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLASE MUTY; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LUCIFERASE; MESSENGER RNA; MISMATCH REPAIR PROTEIN; MITOCHONDRIAL DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN MLH1; PROTEIN P53;

EID: 84927702435     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2014.35     Document Type: Article
Times cited : (38)

References (50)
  • 1
    • 0021769657 scopus 로고
    • Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives
    • Kasai H, Hayami H, Yamaizumi Z, Saitǒ H, Nishimura S. Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives. Nucleic Acids Res 1984; 12: 2127-2136.
    • (1984) Nucleic Acids Res , vol.12 , pp. 2127-2136
    • Kasai, H.1    Hayami, H.2    Yamaizumi, Z.3    Saitǒ, H.4    Nishimura, S.5
  • 2
    • 0036948404 scopus 로고    scopus 로고
    • Origins of spontaneous mutations: Specificity and directionality of basesubstitution, frameshift, and sequence-substitution mutageneses
    • Maki H. Origins of spontaneous mutations: specificity and directionality of basesubstitution, frameshift, and sequence-substitution mutageneses. Annu Rev Genet 2002; 36: 279-303.
    • (2002) Annu Rev Genet , vol.36 , pp. 279-303
    • Maki, H.1
  • 3
    • 0034192265 scopus 로고    scopus 로고
    • The human ogg1 gene: Structure, functions, and its implication in the process of carcinogenesis
    • Boiteux S, Radicella JP. The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch Biochem Biophys 2000; 377: 1-8.
    • (2000) Arch Biochem Biophys , vol.377 , pp. 1-8
    • Boiteux, S.1    Radicella, J.P.2
  • 4
    • 33745257002 scopus 로고    scopus 로고
    • Mth1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides
    • Nakabeppu Y, Kajitani K, Sakamoto K, Yamaguchi H, Tsuchimoto D. MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides. DNA Repair 2006; 5: 761-772.
    • (2006) DNA Repair , vol.5 , pp. 761-772
    • Nakabeppu, Y.1    Kajitani, K.2    Sakamoto, K.3    Yamaguchi, H.4    Tsuchimoto, D.5
  • 5
    • 0030004207 scopus 로고    scopus 로고
    • Cloning and sequencing a human homolog (hmyh) of the escherichia coli muty gene whose function is required for the repair of oxidative dna damage
    • Slupska MM, Baikalov C, Luther WM, Chiang JH, Wei YF, Miller JH. Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J Bacteriol 1996; 178: 3885-3892.
    • (1996) J Bacteriol , vol.178 , pp. 3885-3892
    • Slupska, M.M.1    Baikalov, C.2    Luther, W.M.3    Chiang, J.H.4    Wei, Y.F.5    Miller, J.H.6
  • 6
    • 34547105083 scopus 로고    scopus 로고
    • Mutyh-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
    • Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, Yoshiyama K et al. MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. Cancer Res 2007; 67: 6599-6604.
    • (2007) Cancer Res , vol.67 , pp. 6599-6604
    • Sakamoto, K.1    Tominaga, Y.2    Yamauchi, K.3    Nakatsu, Y.4    Sakumi, K.5    Yoshiyama, K.6
  • 8
    • 0032526616 scopus 로고    scopus 로고
    • Mitochondrial targeting of human dna glycosylases for repair of oxidative dna damage
    • Takao M, Aburatani H, Kobayashi K, Yasui A. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res 1998; 26: 2917-2922.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2917-2922
    • Takao, M.1    Aburatani, H.2    Kobayashi, K.3    Yasui, A.4
  • 9
    • 79952765891 scopus 로고    scopus 로고
    • Dna glycosylase encoded by mutyh functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis
    • Oka S, Nakabeppu Y. DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis. Cancer Sci 2011; 102: 677-682.
    • (2011) Cancer Sci , vol.102 , pp. 677-682
    • Oka, S.1    Nakabeppu, Y.2
  • 10
    • 0033568099 scopus 로고    scopus 로고
    • Differential subcellular localization of human muty homolog (hmyh) and the functional activity of adenine: 8-oxoguanine dna glycosylase
    • Takao M, Zhang QM, Yonei S, Yasui A. Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine: 8-oxoguanine DNA glycosylase. Nucleic Acids Res 1999; 27: 3638-3644.
    • (1999) Nucleic Acids Res , vol.27 , pp. 3638-3644
    • Takao, M.1    Zhang, Q.M.2    Yonei, S.3    Yasui, A.4
  • 12
  • 14
    • 38549153790 scopus 로고    scopus 로고
    • Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial dnas
    • Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y. Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J 2008; 27: 421-432.
    • (2008) EMBO J , vol.27 , pp. 421-432
    • Oka, S.1    Ohno, M.2    Tsuchimoto, D.3    Sakumi, K.4    Furuichi, M.5    Nakabeppu, Y.6
  • 16
    • 0025634118 scopus 로고
    • P53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990; 50: 7717-7722.
    • (1990) Cancer Res , vol.50 , pp. 7717-7722
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, J.M.3    Paraskeva, C.4    Markowitz, S.5    Willson, J.K.6
  • 17
    • 30744470687 scopus 로고    scopus 로고
    • The effect of p53-rnai and p53 knockout on human 8-oxoguanine dna glycosylase (hogg1) activity
    • Chatterjee A, Mambo E, Osada M, Upadhyay S, Sidransky D. The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. FASEB J 2006; 20: 112-114.
    • (2006) FASEB J , vol.20 , pp. 112-114
    • Chatterjee, A.1    Mambo, E.2    Osada, M.3    Upadhyay, S.4    Sidransky, D.5
  • 18
    • 0029143992 scopus 로고
    • Evidence for a connection between the mismatch repair system and the g2 cell cycle checkpoint
    • Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, Boland CR et al. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res 1995; 55: 3721-3725.
    • (1995) Cancer Res , vol.55 , pp. 3721-3725
    • Hawn, M.T.1    Umar, A.2    Carethers, J.M.3    Marra, G.4    Kunkel, T.A.5    Boland, C.R.6
  • 20
    • 0028221943 scopus 로고
    • Mutation in the dna mismatch repair gene homologue hmlh1 is associated with hereditary non-polyposis colon cancer
    • Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994; 368: 258-261.
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3    Warren, G.4    Smith, L.G.5    Lescoe, M.K.6
  • 21
    • 0026543204 scopus 로고
    • P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features
    • Mitsudomi T, Steinberg SM, Nau MM, Carbone D, D'Amico D, Bodner S et al. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 1992; 7: 171-180.
    • (1992) Oncogene , vol.7 , pp. 171-180
    • Mitsudomi, T.1    Steinberg, S.M.2    Nau, M.M.3    Carbone, D.4    D'Amico, D.5    Bodner, S.6
  • 22
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces n-methyl-n'-nitro-n-nitrosoguanidine tolerance in colon tumor cells with homozygous hmlh1 mutation
    • Koi M, Umar A, Chauhan DP, Cherian SP, Carethers JM, Kunkel TA et al. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 1994; 54: 4308-4312.
    • (1994) Cancer Res , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3    Cherian, S.P.4    Carethers, J.M.5    Kunkel, T.A.6
  • 23
    • 3042791562 scopus 로고    scopus 로고
    • Atm-mediated stabilization of hmutl dna mismatch repair proteins augments p53 activation during dna damage
    • Luo Y, Lin FT, Lin WC. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol 2004; 24: 6430-6444.
    • (2004) Mol Cell Biol , vol.24 , pp. 6430-6444
    • Luo, Y.1    Lin, F.T.2    Lin, W.C.3
  • 24
    • 0034654256 scopus 로고    scopus 로고
    • Identification of human muty homolog (hmyh) as a repair enzyme for 2-hydroxyadenine in dna and detection of multiple forms of hmyh located in nuclei and mitochondria
    • Ohtsubo T, Nishioka K, Imaiso Y, Iwai S, Shimokawa H, Oda H et al. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res 2000; 28: 1355-1364.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1355-1364
    • Ohtsubo, T.1    Nishioka, K.2    Imaiso, Y.3    Iwai, S.4    Shimokawa, H.5    Oda, H.6
  • 25
    • 0025886729 scopus 로고
    • Endogenous hela p53 proteins are easily detected in hela cells transfected with mouse deletion mutant p53 gene
    • May E, Jenkins JR, May P. Endogenous HeLa p53 proteins are easily detected in HeLa cells transfected with mouse deletion mutant p53 gene. Oncogene 1991; 6: 1363-1365.
    • (1991) Oncogene , vol.6 , pp. 1363-1365
    • May, E.1    Jenkins, J.R.2    May, P.3
  • 28
    • 0041928171 scopus 로고    scopus 로고
    • Potential role of mlh1 in the induction of p53 and apoptosis by blocking transcription on damaged dna templates
    • Yanamadala S, Ljungman M. Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates. Mol Cancer Res 2003; 1: 747-754.
    • (2003) Mol Cancer Res , vol.1 , pp. 747-754
    • Yanamadala, S.1    Ljungman, M.2
  • 29
    • 33645321089 scopus 로고    scopus 로고
    • Mechanism of dna damage induced by bromate differs from general types of oxidative stress
    • Kawanishi S, Murata M. Mechanism of DNA damage induced by bromate differs from general types of oxidative stress. Toxicology 2006; 221: 172-178.
    • (2006) Toxicology , vol.221 , pp. 172-178
    • Kawanishi, S.1    Murata, M.2
  • 30
    • 0035865399 scopus 로고    scopus 로고
    • A role for p53 in base excision repair
    • Zhou J, Ahn J, Wilson SH, Prives C. A role for p53 in base excision repair. EMBO J 2001; 20: 914-923.
    • (2001) EMBO J , vol.20 , pp. 914-923
    • Zhou, J.1    Ahn, J.2    Wilson, S.H.3    Prives, C.4
  • 32
    • 0000102949 scopus 로고
    • Poly(adp-ribose) polymerase: A molecular nick-sensor
    • de Murcia G, Menissier de Murcia J. Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem Sci 1994; 19: 172-176.
    • (1994) Trends Biochem Sci , vol.19 , pp. 172-176
    • De Murcia, G.1    Menissier De Murcia, J.2
  • 33
    • 0037067317 scopus 로고    scopus 로고
    • Mediation of poly(adp-ribose) polymerase-1-dependent cell death by apoptosisinducing factor
    • Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosisinducing factor. Science 2002; 297: 259-263.
    • (2002) Science , vol.297 , pp. 259-263
    • Yu, S.W.1    Wang, H.2    Poitras, M.F.3    Coombs, C.4    Bowers, W.J.5    Federoff, H.J.6
  • 35
    • 13744261252 scopus 로고    scopus 로고
    • Functional characterization of two human muty homolog (hmyh) missense mutations (r227w and v232f) that lie within the putative hmsh6 binding domain and are associated with hmyh polyposis
    • Bai H, Jones S, Guan X, Wilson TM, Sampson JR, Cheadle JP et al. Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis. Nucleic Acids Res 2005; 33: 597-604.
    • (2005) Nucleic Acids Res , vol.33 , pp. 597-604
    • Bai, H.1    Jones, S.2    Guan, X.3    Wilson, T.M.4    Sampson, J.R.5    Cheadle, J.P.6
  • 36
    • 0037192812 scopus 로고    scopus 로고
    • Human muty homolog, a dna glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human muts homolog 2/human muts homolog 6
    • Gu Y, Parker A, Wilson TM, Bai H, Chang DY, Lu AL. Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J Biol Chem 2002; 277: 11135-11142.
    • (2002) J Biol Chem , vol.277 , pp. 11135-11142
    • Gu, Y.1    Parker, A.2    Wilson, T.M.3    Bai, H.4    Chang, D.Y.5    Lu, A.L.6
  • 38
    • 54249144723 scopus 로고    scopus 로고
    • Genetic instability caused by loss of muts homologue 3 in human colorectal cancer
    • Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T et al. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res 2008; 68: 8465-8472.
    • (2008) Cancer Res , vol.68 , pp. 8465-8472
    • Haugen, A.C.1    Goel, A.2    Yamada, K.3    Marra, G.4    Nguyen, T.P.5    Nagasaka, T.6
  • 39
    • 84870586534 scopus 로고    scopus 로고
    • Oxidative stress induces nuclear-to-cytosol shift of hmsh3, a potential mechanism for emast in colorectal cancer cells
    • Tseng-Rogenski SS, Chung H, Wilk MB, Zhang S, Iwaizumi M, Carethers JM. Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. PLoS ONE 2012; 7: e50616.
    • (2012) PLoS ONE , vol.7 , pp. e50616
    • Tseng-Rogenski, S.S.1    Chung, H.2    Wilk, M.B.3    Zhang, S.4    Iwaizumi, M.5    Carethers, J.M.6
  • 42
    • 84871188238 scopus 로고    scopus 로고
    • Host immune defense peptide ll-37 activates caspase-independent apoptosis and suppresses colon cancer
    • Ren SX, Cheng AS, To KF, Tong JH, Li MS, Shen J et al. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res 2012; 72: 6512-6523.
    • (2012) Cancer Res , vol.72 , pp. 6512-6523
    • Ren, S.X.1    Cheng, A.S.2    To, K.F.3    Tong, J.H.4    Li, M.S.5    Shen, J.6
  • 43
    • 0033560927 scopus 로고    scopus 로고
    • Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation
    • Johnson MD, Kinoshita Y, Xiang H, Ghatan S, Morrison RS. Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation. J Neurosci 1999; 19: 2996-3006.
    • (1999) J Neurosci , vol.19 , pp. 2996-3006
    • Johnson, M.D.1    Kinoshita, Y.2    Xiang, H.3    Ghatan, S.4    Morrison, R.S.5
  • 45
    • 19944434132 scopus 로고    scopus 로고
    • Intracellular a?42 activates p53 promoter: A pathway to neurodegeneration in alzheimer's disease
    • Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K et al. Intracellular A?42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease. FASEB J 2005; 19: 255-257.
    • (2005) FASEB J , vol.19 , pp. 255-257
    • Ohyagi, Y.1    Asahara, H.2    Chui, D.H.3    Tsuruta, Y.4    Sakae, N.5    Miyoshi, K.6
  • 46
    • 0032709404 scopus 로고    scopus 로고
    • Increased 8-oxo-dgtpase in the mitochondria of substantia nigral neurons in parkinson's disease
    • Shimura-Miura H, Hattori N, Kang D, Miyako K, Nakabeppu Y, Mizuno Y. Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease. Ann Neurol 1999; 46: 920-924.
    • (1999) Ann Neurol , vol.46 , pp. 920-924
    • Shimura-Miura, H.1    Hattori, N.2    Kang, D.3    Miyako, K.4    Nakabeppu, Y.5    Mizuno, Y.6
  • 47
    • 84870491613 scopus 로고    scopus 로고
    • 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair
    • Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K et al. 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. J Clin Invest 2012; 122: 4344-4361.
    • (2012) J Clin Invest , vol.122 , pp. 4344-4361
    • Sheng, Z.1    Oka, S.2    Tsuchimoto, D.3    Abolhassani, N.4    Nomaru, H.5    Sakumi, K.6
  • 48
    • 33847616097 scopus 로고    scopus 로고
    • Up-regulation of hmutyh, a dna repair enzyme, in the mitochondria of substantia nigra in parkinson's disease
    • Arai T, Fukae J, Hatano T, Kubo S, Ohtsubo T, Nakabeppu Y et al. Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. Acta Neuropathol 2006; 112: 139-145.
    • (2006) Acta Neuropathol , vol.112 , pp. 139-145
    • Arai, T.1    Fukae, J.2    Hatano, T.3    Kubo, S.4    Ohtsubo, T.5    Nakabeppu, Y.6
  • 49
    • 0026740294 scopus 로고
    • Interaction of the human papillomavirus type 16 e6 oncoprotein with wild-type and mutant human p53 proteins
    • Scheffner M, Takahashi T, Huibregtse JM, Minna JD, Howley PM. Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins. J Virol 1992; 66: 5100-5105.
    • (1992) J Virol , vol.66 , pp. 5100-5105
    • Scheffner, M.1    Takahashi, T.2    Huibregtse, J.M.3    Minna, J.D.4    Howley, P.M.5
  • 50
    • 0032945268 scopus 로고    scopus 로고
    • Expression and differential intracellular localization of two major forms of human 8-oxoguanine dna glycosylase encoded by alternatively spliced ogg1 mrnas
    • Nishioka K, Ohtsubo T, Oda H, Fujiwara T, Kang D, Sugimachi K et al. Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol Biol Cell 1999; 10: 1637-1652.
    • (1999) Mol Biol Cell , vol.10 , pp. 1637-1652
    • Nishioka, K.1    Ohtsubo, T.2    Oda, H.3    Fujiwara, T.4    Kang, D.5    Sugimachi, K.6


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