Structure-metabolism relationships in the glucuronidation of d-amino acid oxidase inhibitors

ACS Medicinal Chemistry Letters

Volumn 5, Issue 11, 2014, Pages 1251-1253

  Zimmermann, Sarah C ^a   Rais, Rana ^a   Alt, Jesse ^a   Burzynski, Caitlin ^b   Slusher, Barbara S ^a   Tsukamoto, Takashi ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

d amino acid oxidase (DAAO); drug metabolism; glucuronidation

Indexed keywords

6 [2 (3,5 DIFLUOROPHENYL)ETHYL] 4 HYDROXYPYRIDAZIN 3 ( 2H)ONE; DEXTRO AMINO ACID OXIDASE; OXIDOREDUCTASE INHIBITOR; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ARTICLE; CARBOXYLATION; DRUG BIOAVAILABILITY; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; ENTEROHEPATIC CIRCULATION; HUMAN; IC50; IN VITRO STUDY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL;

MUS; RATTUS;

EID: 84927669977     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500335z     Document Type: Article

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