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1
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Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly
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Liu L, Liu Y, Cui J, et al. Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly. World J Gastroenterol 2013;19:9439-9446.
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Liu, L.1
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2
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84896315592
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Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: Enhancement of antimicrobial nitric oxide generation by depletion of spermine
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Chaturvedi R, Asim M, Barry DP, et al. Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Amino Acids 2014;46:531-542. This study demonstrates that spermine oxidase is a critical component in macrophage defense against H. pylori infection, by preventing blockade of nitric oxide synthesis.
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Chaturvedi, R.1
Asim, M.2
Barry, D.P.3
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3
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Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice
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Grasberger H, El-Zaatari M, Dang DT, Merchant JL. Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology 2013;145:1045-1054. This is the first study to evaluate the role of DUOX in higher vertebrates, which demonstrates the ability of DUOX to produce hydrogen peroxide as part of the intrinsic host antimicrobial defense system.
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Gastroenterology
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Grasberger, H.1
El-Zaatari, M.2
Dang, D.T.3
Merchant, J.L.4
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4
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A combination of pre and postexposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage
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Ito Y, Kinoshita M, Yamamoto T, et al. A combination of pre and postexposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage. Int J Mol Sci 2013;14:19618-19635.
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Ito, Y.1
Kinoshita, M.2
Yamamoto, T.3
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Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
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Takemura N, Kawasaki T, Kunisawa J, et al. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun 2014;5:3492.
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Nat Commun
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Takemura, N.1
Kawasaki, T.2
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6
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84896476977
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Innate immune detection of flagellin positively and negatively regulates salmonella infection
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Lai MA, Quarles EK, Lopez-Yglesias AH, et al. Innate immune detection of flagellin positively and negatively regulates salmonella infection. PLoS One 2013;8:e72047.
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Lai, M.A.1
Quarles, E.K.2
Lopez-Yglesias, A.H.3
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7
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84884151370
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TLR2 mediates Helicobacter pyloriinduced tolerogenic immune response in mice
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Sun X, Zhang M, El-Zataari M, et al. TLR2 mediates Helicobacter pyloriinduced tolerogenic immune response in mice. PLoS One 2013;8:e74595. This study demonstrates that H. pylori have the ability to evade innate immune defense via TLR-2 pathways, allowing for exploration of novel therapeutic agents.
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PLoS One
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Sun, X.1
Zhang, M.2
El-Zataari, M.3
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8
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Age-related expression of the polymeric immunoglobulin receptor (pIgR) in the gastric mucosa of young pigs
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Trevisi P, Gandolfi G, Priori D, et al. Age-related expression of the polymeric immunoglobulin receptor (pIgR) in the gastric mucosa of young pigs. PLoS One 2013;8:e81473.
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PLoS One
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Trevisi, P.1
Gandolfi, G.2
Priori, D.3
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9
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84883432951
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SIGIRR, a negative regulator of TLR/IL-1R signalling promotes microbiota dependent resistance to colonization by enteric bacterial pathogens
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Sham HP, Yu EY, Gulen MF, et al. SIGIRR, a negative regulator of TLR/IL-1R signalling promotes microbiota dependent resistance to colonization by enteric bacterial pathogens. PLoS Pathog 2013;9:e1003539. Among the first studies to demonstrate a mechanism behind intestinal epithelial cells' innate hyposensitivity to bacterial products.
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PLoS Pathog
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Sham, H.P.1
Yu, E.Y.2
Gulen, M.F.3
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10
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84878011115
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Effect of repeated Campylobacter jejuni infection on gut flora and mucosal defense in a rat model of post infectious functional and microbial bowel changes
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Sung J, Morales W, Kim G, et al. Effect of repeated Campylobacter jejuni infection on gut flora and mucosal defense in a rat model of post infectious functional and microbial bowel changes. Neurogastroenterol Motil 2013;25:529-537.
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Sung, J.1
Morales, W.2
Kim, G.3
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11
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84894289434
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Effects of stress on mouse betadefensin-3 expression in the upper digestive mucosa
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Kawashima R, Shimizu T, To M, et al. Effects of stress on mouse betadefensin-3 expression in the upper digestive mucosa. Yonsei Med J 2014;55:387-394. This study showed that chronic stress impairs immune function by inhibiting b-defensin expression in the upper gastrointestinal tract, allowing for opportunist infection.
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Yonsei Med J
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Kawashima, R.1
Shimizu, T.2
To, M.3
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12
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84892484008
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Induction of human defensins by intestinal Caco-2 cells after interactions with opportunistic Candida species
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Gacser A, Tiszlavicz Z, Nemeth T, et al. Induction of human defensins by intestinal Caco-2 cells after interactions with opportunistic Candida species. Microbes Infect 2014;16:80-85.
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Microbes Infect
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Gacser, A.1
Tiszlavicz, Z.2
Nemeth, T.3
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13
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84888123097
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Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes
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Jiang W, Wang X, Zeng B, et al. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med 2013;210:2465-2476.
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J Exp Med
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Jiang, W.1
Wang, X.2
Zeng, B.3
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14
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84884315797
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The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release
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Brain O, Owens BM, Pichulik T, et al. The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. Immunity 2013;39:521-536.
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Immunity
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Brain, O.1
Owens, B.M.2
Pichulik, T.3
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15
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84891440141
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A balanced IL-1beta activity is required for host response to Citrobacter rodentium infection
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Alipour M, Lou Y, Zimmerman D, et al. A balanced IL-1beta activity is required for host response to Citrobacter rodentium infection. PLoS One 2013;8:e80656. This study suggests that a balanced cytokine response is necessary for innate mucosal defense and that complete inhibition of cytokines can cause deleterious effects.
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PLoS One
, vol.8
, pp. e80656
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Alipour, M.1
Lou, Y.2
Zimmerman, D.3
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16
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84876708413
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ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice
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Essien BE, Grasberger H, Romain RD, et al. ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology 2013;144:1466-1477. This is the first study to describe a mechanism by which enterochromaffin cells sense the luminal environment via a protein called ZBP-89.
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(2013)
Gastroenterology
, vol.144
, pp. 1466-1477
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Essien, B.E.1
Grasberger, H.2
Romain, R.D.3
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17
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84884254422
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Effects of polysaccharide isolated from Streptococcus thermophilus CRL1190 on human gastric epithelial cells
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Marcial G, Messing J, Menchicchi B, et al. Effects of polysaccharide isolated from Streptococcus thermophilus CRL1190 on human gastric epithelial cells. Int J Biol Macromol 2013;62:217-224.
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Marcial, G.1
Messing, J.2
Menchicchi, B.3
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18
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84925223037
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SerpinB2 mediated regulation of macrophage function during enteric infection
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Shea-Donohue T, Zhao A, Antalis T. SerpinB2 mediated regulation of macrophage function during enteric infection. Gut Microbes 2014;5. This study demonstrated that macrophages can protect themselves from induced apoptosis via upregulation of a protein known as Serpin B2.
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Gut Microbes
, pp. 5
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Shea-Donohue, T.1
Zhao, A.2
Antalis, T.3
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19
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84883172356
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Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
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Satpathy AT, Briseno CG, Lee JS, et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol 2013;14:937-948.
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Nat Immunol
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Satpathy, A.T.1
Briseno, C.G.2
Lee, J.S.3
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20
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84883420258
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Induction of porcine host defense peptide gene expression by short-chain fatty acids and their analogs
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Zeng X, Sunkara LT, Jiang W, et al. Induction of porcine host defense peptide gene expression by short-chain fatty acids and their analogs. PLoS One 2013;8:e72922.
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PLoS One
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Zeng, X.1
Sunkara, L.T.2
Jiang, W.3
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21
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84886057358
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Cyclic AMP synergizes with butyrate in promoting beta-defensin 9 expression in chickens
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Sunkara LT, Zeng X, Curtis AR, Zhang G. Cyclic AMP synergizes with butyrate in promoting beta-defensin 9 expression in chickens. Mol Immunol 2014;57:171-180.
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Mol Immunol
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Sunkara, L.T.1
Zeng, X.2
Curtis, A.R.3
Zhang, G.4
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22
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84885149402
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Human milk hyaluronan enhances innate defense of the intestinal epithelium
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Hill DR, Rho HK, Kessler SP, et al. Human milk hyaluronan enhances innate defense of the intestinal epithelium. J Biol Chem 2013;288:29090-29104.
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J Biol Chem
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Hill, D.R.1
Rho, H.K.2
Kessler, S.P.3
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23
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84892560661
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Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier
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Ehlers A, These A, Hessel S, et al. Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier. Toxicol Lett 2014;225:311-317.
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Toxicol Lett
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Ehlers, A.1
These, A.2
Hessel, S.3
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24
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84883234781
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Zinc (II)-curcumin accelerates the healing of acetic acid-induced chronic gastric ulcers in rats by decreasing oxidative stress and downregulation of matrix metalloproteinase-9
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Mei XT, Xu DH, Xu SK, et al. Zinc (II)-curcumin accelerates the healing of acetic acid-induced chronic gastric ulcers in rats by decreasing oxidative stress and downregulation of matrix metalloproteinase-9. Food Chem Toxicol 2013;60:448-454.
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Food Chem Toxicol
, vol.60
, pp. 448-454
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Mei, X.T.1
Xu, D.H.2
Xu, S.K.3
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25
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84897464681
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Effect of dietary zinc oxide on morphological characteristics, mucin composition and gene expression in the colon of weaned piglets
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Liu P, Pieper R, Rieger J, et al. Effect of dietary zinc oxide on morphological characteristics, mucin composition and gene expression in the colon of weaned piglets. PLoS One 2014;9:e91091.
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PLoS One
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Liu, P.1
Pieper, R.2
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26
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84884406820
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The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis
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Zarepour M, Bhullar K, Montero M, et al. The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis. Infect Immun 2013;81:3672-3683.
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Infect Immun
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Zarepour, M.1
Bhullar, K.2
Montero, M.3
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27
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84896087919
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Changes in the mucus barrier during cisplatin-induced intestinal mucositis in rats
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Yamamoto H, Ishihara K, Takeda Y, et al. Changes in the mucus barrier during cisplatin-induced intestinal mucositis in rats. Biomed Res Int 2013;2013:276186.
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Biomed Res Int
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Yamamoto, H.1
Ishihara, K.2
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84881481673
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Reactive increase in gastric mucus secretion is an adaptive defense mechanism against low-dose aspirin-induced gastropathy
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Iijima K, Iwabuchi T, Ara N, et al. Reactive increase in gastric mucus secretion is an adaptive defense mechanism against low-dose aspirin-induced gastropathy. Dig Dis Sci 2013;58:2266-2274.
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Dig Dis Sci
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Iijima, K.1
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Ara, N.3
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29
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84896703971
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Modulation of mucin mRNA (MUC5AC and MUC5B) expression and protein production and secretion in Caco-2/HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins
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Wan LY, Allen KJ, Turner PC, El-Nezami H. Modulation of mucin mRNA (MUC5AC and MUC5B) expression and protein production and secretion in Caco-2/HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins. Toxicol Sci 2014;139:83-98. This study was the first to demonstrate that mucin genes can be upregulated in response to toxins, further defining their role in mucosal defense.
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Toxicol Sci
, vol.139
, pp. 83-98
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Wan, L.Y.1
Allen, K.J.2
Turner, P.C.3
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30
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Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: A murine model
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Chang SY, Lee SN, Yang JY, et al. Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: a murine model. PLoS One 2013;8:e81095. This is the first study to propose the phenomenon known as 'epithelial barrier turnover', an inflammation-free mechanism of innate host defense.
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PLoS One
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Chang, S.Y.1
Lee, S.N.2
Yang, J.Y.3
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84888223618
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Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection
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Conway KL, Kuballa P, Song JH, et al. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology 2013;145:1347-1357.
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Conway, K.L.1
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Song, J.H.3
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Activation of p38alpha in T cells regulates the intestinal host defense against attaching and effacing bacterial infections
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Shim EJ, Bang BR, Kang SG, et al. Activation of p38alpha in T cells regulates the intestinal host defense against attaching and effacing bacterial infections. J Immunol 2013;191:2764-2770. This study demonstrated that defense against attaching and effacing bacteria occurs via a p38a-mediated inflammatory response.
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J Immunol
, vol.191
, pp. 2764-2770
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Shim, E.J.1
Bang, B.R.2
Kang, S.G.3
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Tuning of protein kinase circuitry by p38alpha is vital for epithelial tissue homeostasis
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Caballero-Franco C, Choo MK, Sano Y, et al. Tuning of protein kinase circuitry by p38alpha is vital for epithelial tissue homeostasis. J Biol Chem 2013;288:23788-23797.
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J Biol Chem
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Caballero-Franco, C.1
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Sano, Y.3
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