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Volumn 21, Issue 7-8, 2015, Pages 1261-1274

Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; COLLAGEN; CYTOLOGY; EXPANSION; MONOLAYERS; PELLETIZING; STEM CELLS; TISSUE; TISSUE ENGINEERING;

EID: 84927660038     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2014.0240     Document Type: Article
Times cited : (13)

References (69)
  • 1
    • 0002869624 scopus 로고    scopus 로고
    • Structure and function of articular cartilage
    • Mow, V.C., and Hayes, W.C., eds. Philadelphia: Lippincott-Raven
    • Mow, V.C., and Ratcliffe, A. Structure and function of articular cartilage. In: Mow, V.C., and Hayes, W.C., eds. Basic Orthopaedic Biomechanics. Philadelphia: Lippincott-Raven, 1997, pp. 113-177.
    • (1997) Basic Orthopaedic Biomechanics , pp. 113-177
    • Mow, V.C.1    Ratcliffe, A.2
  • 3
    • 22244487984 scopus 로고    scopus 로고
    • Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: A prospective study
    • Cicuttini, F., Ding, C., Wluka, A., Davis, S., Ebeling, P.R., and Jones, G. Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study. Arthritis Rheum 52, 2033, 2005.
    • (2005) Arthritis Rheum , vol.52 , pp. 2033
    • Cicuttini, F.1    Ding, C.2    Wluka, A.3    Davis, S.4    Ebeling, P.R.5    Jones, G.6
  • 5
    • 0036083985 scopus 로고    scopus 로고
    • Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects
    • Hunziker, E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10, 432, 2002.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 432
    • Hunziker, E.B.1
  • 8
    • 60849084882 scopus 로고    scopus 로고
    • Calcification or dedifferentiation: Requirement to lock mesenchymal stem cells in a desired differentiation stage
    • Dickhut, A., Pelttari, K., Janicki, P., Wagner, W., Eckstein, V., Egermann, M., et al. Calcification or dedifferentiation: requirement to lock mesenchymal stem cells in a desired differentiation stage. J Cell Physiol 219, 219, 2009.
    • (2009) J Cell Physiol , vol.219 , pp. 219
    • Dickhut, A.1    Pelttari, K.2    Janicki, P.3    Wagner, W.4    Eckstein, V.5    Egermann, M.6
  • 9
    • 33750321974 scopus 로고    scopus 로고
    • Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice
    • Pelttari, K., Winter, A., Steck, E., Goetzke, K., Hennig, T., Ochs, B.G., et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54, 3254, 2006.
    • (2006) Arthritis Rheum , vol.54 , pp. 3254
    • Pelttari, K.1    Winter, A.2    Steck, E.3    Goetzke, K.4    Hennig, T.5    Ochs, B.G.6
  • 10
    • 34247587579 scopus 로고    scopus 로고
    • Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6
    • Hennig, T., Lorenz, H., Thiel, A., Goetzke, K., Dickhut, A., Geiger, F., et al. Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 211, 682, 2007.
    • (2007) J Cell Physiol , vol.211 , pp. 682
    • Hennig, T.1    Lorenz, H.2    Thiel, A.3    Goetzke, K.4    Dickhut, A.5    Geiger, F.6
  • 11
    • 77049109926 scopus 로고    scopus 로고
    • Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage-derived matrix
    • Diekman, B.O., Rowland, C.R., Lennon, D.P., Caplan, A.I., and Guilak, F. Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue Eng Part A 16, 523, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 523
    • Diekman, B.O.1    Rowland, C.R.2    Lennon, D.P.3    Caplan, A.I.4    Guilak, F.5
  • 12
    • 84896697411 scopus 로고    scopus 로고
    • Generating cartilage repair from pluripotent stem cells
    • Cheng, A., Hardingham, T.E., and Kimber, S.J. Generating cartilage repair from pluripotent stem cells. Tissue Eng Part B Rev 20, 257, 2014.
    • (2014) Tissue Eng Part B Rev , vol.20 , pp. 257
    • Cheng, A.1    Hardingham, T.E.2    Kimber, S.J.3
  • 13
    • 79551630799 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation: An overview of technique and outcomes
    • Batty, L., Dance, S., Bajaj, S., and Cole, B.J. Autologous chondrocyte implantation: an overview of technique and outcomes. ANZ J Surg 81, 18, 2011.
    • (2011) ANZ J Surg , vol.81 , pp. 18
    • Batty, L.1    Dance, S.2    Bajaj, S.3    Cole, B.J.4
  • 14
    • 50349096522 scopus 로고    scopus 로고
    • Primary culture and phenotyping of murine chondrocytes
    • Gosset, M., Berenbaum, F., Thirion, S., and Jacques, C. Primary culture and phenotyping of murine chondrocytes. Nat Protoc 3, 1253, 2008.
    • (2008) Nat Protoc , vol.3 , pp. 1253
    • Gosset, M.1    Berenbaum, F.2    Thirion, S.3    Jacques, C.4
  • 15
    • 0018221370 scopus 로고
    • Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture
    • Benya, P.D., Padilla, S.R., and Nimni, M.E. Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture. Cell 15, 1313, 1978.
    • (1978) Cell , vol.15 , pp. 1313
    • Benya, P.D.1    Padilla, S.R.2    Nimni, M.E.3
  • 16
    • 0017723046 scopus 로고
    • Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
    • von der Mark, K., Gauss, V., von der Mark, H., and Muller, P. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature 267, 531, 1977.
    • (1977) Nature , vol.267 , pp. 531
    • Von Der Mark, K.1    Gauss, V.2    Von Der Mark, H.3    Muller, P.4
  • 17
    • 0020369710 scopus 로고
    • Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
    • Benya, P.D., and Shaffer, J.D. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30, 215, 1982.
    • (1982) Cell , vol.30 , pp. 215
    • Benya, P.D.1    Shaffer, J.D.2
  • 18
    • 14244270059 scopus 로고    scopus 로고
    • Rapid phenotypic changes in passaged articular chondrocyte subpopulations
    • Darling, E.M., and Athanasiou, K.A. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res 23, 425, 2005.
    • (2005) J Orthop Res , vol.23 , pp. 425
    • Darling, E.M.1    Athanasiou, K.A.2
  • 19
    • 77649243276 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells
    • Solchaga, L.A., Penick, K., Goldberg, V.M., Caplan, A.I., and Welter, J.F. Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue Eng Part A 16, 1009, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1009
    • Solchaga, L.A.1    Penick, K.2    Goldberg, V.M.3    Caplan, A.I.4    Welter, J.F.5
  • 20
    • 33750494316 scopus 로고    scopus 로고
    • Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adiposederived adult stem cells
    • Estes, B.T., Wu, A.W., Storms, R.W., and Guilak, F. Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adiposederived adult stem cells. J Cell Physiol 209, 987, 2006.
    • (2006) J Cell Physiol , vol.209 , pp. 987
    • Estes, B.T.1    Wu, A.W.2    Storms, R.W.3    Guilak, F.4
  • 22
    • 0034635914 scopus 로고    scopus 로고
    • Effects of p21Waf1/Cip1/ Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
    • Chang, B.D., Watanabe, K., Broude, E.V., Fang, J., Poole, J.C., Kalinichenko, T.V., et al. Effects of p21Waf1/Cip1/ Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A 97, 4291, 2000.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4291
    • Chang, B.D.1    Watanabe, K.2    Broude, E.V.3    Fang, J.4    Poole, J.C.5    Kalinichenko, T.V.6
  • 23
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., and Elledge, S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805, 1993.
    • (1993) Cell , vol.75 , pp. 805
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 24
    • 84890503702 scopus 로고    scopus 로고
    • FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors P21 and P27
    • Dombrowski, C., Helledie, T., Ling, L., Grunert, M., Canning, C.A., Jones, C.M., et al. FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors P21 and P27. Stem Cells 31, 2724, 2013.
    • (2013) Stem Cells , vol.31 , pp. 2724
    • Dombrowski, C.1    Helledie, T.2    Ling, L.3    Grunert, M.4    Canning, C.A.5    Jones, C.M.6
  • 25
    • 78751535908 scopus 로고    scopus 로고
    • Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through downregulation of E2A-p21 by HIF-TWIST
    • Tsai, C.C., Chen, Y.J., Yew, T.L., Chen, L.L., Wang, J.Y., Chiu, C.H., et al. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through downregulation of E2A-p21 by HIF-TWIST. Blood 117, 459, 2011.
    • (2011) Blood , vol.117 , pp. 459
    • Tsai, C.C.1    Chen, Y.J.2    Yew, T.L.3    Chen, L.L.4    Wang, J.Y.5    Chiu, C.H.6
  • 26
    • 34249661093 scopus 로고    scopus 로고
    • FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2
    • Ito, T., Sawada, R., Fujiwara, Y., Seyama, Y., and Tsuchiya, T. FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2. Biochem Biophys Res Commun 359, 108, 2007.
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 108
    • Ito, T.1    Sawada, R.2    Fujiwara, Y.3    Seyama, Y.4    Tsuchiya, T.5
  • 28
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H.M. Developmental regulation of the growth plate. Nature 423, 332, 2003.
    • (2003) Nature , vol.423 , pp. 332
    • Kronenberg, H.M.1
  • 29
    • 84864652528 scopus 로고    scopus 로고
    • Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells
    • Dexheimer, V., Frank, S., and Richter, W. Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells. Stem Cells Dev 21, 2160, 2012.
    • (2012) Stem Cells Dev , vol.21 , pp. 2160
    • Dexheimer, V.1    Frank, S.2    Richter, W.3
  • 31
    • 0034116607 scopus 로고    scopus 로고
    • Col2-GFP reporter marks chondrocyte lineage and chondrogenesis during mouse skeletal development
    • Grant, T.D., Cho, J., Ariail, K.S., Weksler, N.B., Smith, R.W., and Horton, W.A. Col2-GFP reporter marks chondrocyte lineage and chondrogenesis during mouse skeletal development. Dev Dyn 218, 394, 2000.
    • (2000) Dev Dyn , vol.218 , pp. 394
    • Grant, T.D.1    Cho, J.2    Ariail, K.S.3    Weksler, N.B.4    Smith, R.W.5    Horton, W.A.6
  • 32
    • 0043210428 scopus 로고    scopus 로고
    • Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
    • Wiznerowicz, M., and Trono, D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol 77, 8957, 2003.
    • (2003) J Virol , vol.77 , pp. 8957
    • Wiznerowicz, M.1    Trono, D.2
  • 34
    • 44449120988 scopus 로고    scopus 로고
    • Production and titration of lentiviral vectors
    • Crawley, J.N., et al., eds. Hoboken, NJ: John Wiley & Sons
    • Salmon, P., and Trono, D. Production and titration of lentiviral vectors. In: Crawley, J.N., et al., eds. Current Protocols in Neuroscience. Hoboken, NJ: John Wiley & Sons, 2006, pp. 4-21.
    • (2006) Current Protocols in Neuroscience , pp. 4-21
    • Salmon, P.1    Trono, D.2
  • 35
    • 4444373699 scopus 로고    scopus 로고
    • Analysis of cell cycle by flow cytometry
    • Pozarowski, P., and Darzynkiewicz, Z. Analysis of cell cycle by flow cytometry. Methods Mol Biol 281, 301, 2004.
    • (2004) Methods Mol Biol , vol.281 , pp. 301
    • Pozarowski, P.1    Darzynkiewicz, Z.2
  • 36
    • 77954286452 scopus 로고    scopus 로고
    • Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype
    • Estes, B.T., Diekman, B.O., Gimble, J.M., and Guilak, F. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc 5, 1294, 2010.
    • (2010) Nat Protoc , vol.5 , pp. 1294
    • Estes, B.T.1    Diekman, B.O.2    Gimble, J.M.3    Guilak, F.4
  • 37
    • 2342565805 scopus 로고    scopus 로고
    • Effects of growth factors on temporomandibular joint disc cells
    • Detamore, M.S., and Athanasiou, K.A. Effects of growth factors on temporomandibular joint disc cells. Arch Oral Biol 49, 577, 2004.
    • (2004) Arch Oral Biol , vol.49 , pp. 577
    • Detamore, M.S.1    Athanasiou, K.A.2
  • 38
    • 79952650332 scopus 로고    scopus 로고
    • Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells
    • Yew, T.L., Chiu, F.Y., Tsai, C.C., Chen, H.L., Lee, W.P., Chen, Y.J., et al. Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells. Aging Cell 10, 349, 2011.
    • (2011) Aging Cell , vol.10 , pp. 349
    • Yew, T.L.1    Chiu, F.Y.2    Tsai, C.C.3    Chen, H.L.4    Lee, W.P.5    Chen, Y.J.6
  • 40
    • 64249113913 scopus 로고    scopus 로고
    • Photodegradable hydrogels for dynamic tuning of physical and chemical properties
    • Kloxin, A.M., Kasko, A.M., Salinas, C.N., and Anseth, K.S. Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 324, 59, 2009.
    • (2009) Science , vol.324 , pp. 59
    • Kloxin, A.M.1    Kasko, A.M.2    Salinas, C.N.3    Anseth, K.S.4
  • 41
    • 34748889531 scopus 로고    scopus 로고
    • Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion
    • Shibata, K.R., Aoyama, T., Shima, Y., Fukiage, K., Otsuka, S., Furu, M., et al. Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion. Stem Cells 25, 2371, 2007.
    • (2007) Stem Cells , vol.25 , pp. 2371
    • Shibata, K.R.1    Aoyama, T.2    Shima, Y.3    Fukiage, K.4    Otsuka, S.5    Furu, M.6
  • 42
    • 84885614963 scopus 로고    scopus 로고
    • The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit
    • Spencer, S.L., Cappell, S.D., Tsai, F.C., Overton, K.W., Wang, C.L., and Meyer, T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 155, 369, 2013.
    • (2013) Cell , vol.155 , pp. 369
    • Spencer, S.L.1    Cappell, S.D.2    Tsai, F.C.3    Overton, K.W.4    Wang, C.L.5    Meyer, T.6
  • 43
    • 0035980055 scopus 로고    scopus 로고
    • P21Cip-1/SDI-1/WAF-1 gene is involved in chondrogenic differentiation of ATDC5 cells in vitro
    • Negishi, Y., Ui, N., Nakajima, M., Kawashima, K., Maruyama, K., Takizawa, T., et al. p21Cip-1/SDI-1/WAF-1 gene is involved in chondrogenic differentiation of ATDC5 cells in vitro. J Biol Chem 276, 33249, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 33249
    • Negishi, Y.1    Ui, N.2    Nakajima, M.3    Kawashima, K.4    Maruyama, K.5    Takizawa, T.6
  • 44
    • 70349969991 scopus 로고    scopus 로고
    • Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo
    • Owen, H.C., Ahmed, S.F., and Farquharson, C. Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo. Calcif Tissue Int 85, 326, 2009.
    • (2009) Calcif Tissue Int , vol.85 , pp. 326
    • Owen, H.C.1    Ahmed, S.F.2    Farquharson, C.3
  • 45
    • 84860320670 scopus 로고    scopus 로고
    • Interleukin-1beta promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving downregulation of FGFR-3 and p21
    • Simsa-Maziel, S., and Monsonego-Ornan, E. Interleukin-1beta promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving downregulation of FGFR-3 and p21. Endocrinology 153, 2296, 2012.
    • (2012) Endocrinology , vol.153 , pp. 2296
    • Simsa-Maziel, S.1    Monsonego-Ornan, E.2
  • 46
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su, W.C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., et al. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 386, 288, 1997.
    • (1997) Nature , vol.386 , pp. 288
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6
  • 47
    • 0035047449 scopus 로고    scopus 로고
    • Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro
    • Jakob, M., Demarteau, O., Schafer, D., Hintermann, B., Dick, W., Heberer, M., et al. Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem 81, 368, 2001.
    • (2001) J Cell Biochem , vol.81 , pp. 368
    • Jakob, M.1    Demarteau, O.2    Schafer, D.3    Hintermann, B.4    Dick, W.5    Heberer, M.6
  • 48
    • 0038667428 scopus 로고    scopus 로고
    • Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes
    • Barbero, A., Ploegert, S., Heberer, M., and Martin, I. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthritis Rheum 48, 1315 2003.
    • (2003) Arthritis Rheum , vol.48 , pp. 1315
    • Barbero, A.1    Ploegert, S.2    Heberer, M.3    Martin, I.4
  • 49
    • 0033572770 scopus 로고    scopus 로고
    • Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue
    • Martin, I., Vunjak-Novakovic, G., Yang, J., Langer, R., and Freed, L.E. Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue. Exp Cell Res 253, 681, 1999.
    • (1999) Exp Cell Res , vol.253 , pp. 681
    • Martin, I.1    Vunjak-Novakovic, G.2    Yang, J.3    Langer, R.4    Freed, L.E.5
  • 50
    • 0031867056 scopus 로고    scopus 로고
    • In vivo cartilage formation from growth factor modulated articular chondrocytes
    • Bradham, D.M., and Horton, W.E., Jr. In vivo cartilage formation from growth factor modulated articular chondrocytes. Clin Orthop Relat Res 239, 1998.
    • (1998) Clin Orthop Relat Res , vol.239
    • Bradham, D.M.1    Horton, W.E.2
  • 52
    • 84896836202 scopus 로고    scopus 로고
    • Human pluripotent stem cell culture: Considerations for maintenance, expansion, and therapeutics
    • Chen, K.G., Mallon, B.S., McKay, R.D., and Robey, P.G. Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell 14, 13, 2014.
    • (2014) Cell Stem Cell , vol.14 , pp. 13
    • Chen, K.G.1    Mallon, B.S.2    McKay, R.D.3    Robey, P.G.4
  • 53
    • 84896282175 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: A randomized, double-blind, controlled study
    • Vangsness, C.T., Jr., Farr, J., II, Boyd, J., Dellaero, D.T., Mills, C.R., and Leroux-Williams, M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am 96, 90, 2014.
    • (2014) J Bone Joint Surg Am , vol.96 , pp. 90
    • Vangsness, C.T.1    Farr, I.I.J.2    Boyd, J.3    Dellaero, D.T.4    Mills, C.R.5    Leroux-Williams, M.6
  • 54
    • 84856079677 scopus 로고    scopus 로고
    • The role of human leukocyte antigen matching in the development of multiethnic "haplobank" of induced pluripotent stem cell lines
    • Gourraud, P.A., Gilson, L., Girard, M., and Peschanski, M. The role of human leukocyte antigen matching in the development of multiethnic "haplobank" of induced pluripotent stem cell lines. Stem Cells 30, 180, 2012.
    • (2012) Stem Cells , vol.30 , pp. 180
    • Gourraud, P.A.1    Gilson, L.2    Girard, M.3    Peschanski, M.4
  • 55
    • 33750824834 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation
    • Jones, D.G., and Peterson, L. Autologous chondrocyte implantation. J Bone Joint Surg Am 88, 2502, 2006.
    • (2006) J Bone Joint Surg Am , vol.88 , pp. 2502
    • Jones, D.G.1    Peterson, L.2
  • 56
    • 33846677220 scopus 로고    scopus 로고
    • A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage
    • Moutos, F.T., Freed, L.E., and Guilak, F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mater 6, 162, 2007.
    • (2007) Nat Mater , vol.6 , pp. 162
    • Moutos, F.T.1    Freed, L.E.2    Guilak, F.3
  • 58
    • 80053466712 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells
    • Kim, M.J., Son, M.J., Son, M.Y., Seol, B., Kim, J., Park, J., et al. Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells. Arthritis Rheum 63, 3010, 2011.
    • (2011) Arthritis Rheum , vol.63 , pp. 3010
    • Kim, M.J.1    Son, M.J.2    Son, M.Y.3    Seol, B.4    Kim, J.5    Park, J.6
  • 59
    • 84863124595 scopus 로고    scopus 로고
    • Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix
    • Wei, Y., Zeng, W., Wan, R., Wang, J., Zhou, Q., Qiu, S., et al. Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix. Eur Cells Mater 23, 1, 2012.
    • (2012) Eur Cells Mater , vol.23 , pp. 1
    • Wei, Y.1    Zeng, W.2    Wan, R.3    Wang, J.4    Zhou, Q.5    Qiu, S.6
  • 60
    • 84879635430 scopus 로고    scopus 로고
    • Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells
    • Yamashita, A., Liu, S., Woltjen, K., Thomas, B., Meng, G., Hotta, A., et al. Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells. Sci Rep 3, 1978, 2013.
    • (2013) Sci Rep , vol.3 , pp. 1978
    • Yamashita, A.1    Liu, S.2    Woltjen, K.3    Thomas, B.4    Meng, G.5    Hotta, A.6
  • 61
    • 84897557412 scopus 로고    scopus 로고
    • Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: A first step toward a clinicalgrade cell source
    • Borestrom, C., Simonsson, S., Enochson, L., Bigdeli, N., Brantsing, C., Ellerstrom, C., et al. Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: a first step toward a clinicalgrade cell source. Stem Cells Transl Med 3, 433, 2014.
    • (2014) Stem Cells Transl Med , vol.3 , pp. 433
    • Borestrom, C.1    Simonsson, S.2    Enochson, L.3    Bigdeli, N.4    Brantsing, C.5    Ellerstrom, C.6
  • 62
    • 84908021919 scopus 로고    scopus 로고
    • A site-specific integrated Col2. 3GFP reporter identifies osteoblasts within mineralized tissue formed in vivo by human embryonic stem cells
    • Xin, X., Jiang, X., Wang, L., Stover, M.L., Zhan, S., Huang, J., et al. A site-specific integrated Col2.3GFP reporter identifies osteoblasts within mineralized tissue formed in vivo by human embryonic stem cells. Stem Cells Transl Med 3, 1125, 2014.
    • (2014) Stem Cells Transl Med , vol.3 , pp. 1125
    • Xin, X.1    Jiang, X.2    Wang, L.3    Stover, M.L.4    Zhan, S.5    Huang, J.6
  • 63
    • 77951181560 scopus 로고    scopus 로고
    • A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates
    • Blin, G., Nury, D., Stefanovic, S., Neri, T., Guillevic, O., Brinon, B., et al. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest 120, 1125, 2010.
    • (2010) J Clin Invest , vol.120 , pp. 1125
    • Blin, G.1    Nury, D.2    Stefanovic, S.3    Neri, T.4    Guillevic, O.5    Brinon, B.6
  • 64
    • 84893748014 scopus 로고    scopus 로고
    • Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application
    • Kamao, H., Mandai, M., Okamoto, S., Sakai, N., Suga, A., Sugita, S., et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Rep 2, 205, 2014.
    • (2014) Stem Cell Rep , vol.2 , pp. 205
    • Kamao, H.1    Mandai, M.2    Okamoto, S.3    Sakai, N.4    Suga, A.5    Sugita, S.6
  • 66
  • 67
    • 67649424560 scopus 로고    scopus 로고
    • P21 in cancer: Intricate networks and multiple activities
    • Abbas, T., and Dutta, A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9, 400, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 400
    • Abbas, T.1    Dutta, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.