Intervening in ageing to prevent the diseases of ageing

Trends in Endocrinology and Metabolism

Volumn 25, Issue 11, 2014, Pages 555-557

  Partridge, Linda ^a,b  

^a MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Ageing; Ageing related disease; Insulin insulin like growth factor and TOR signalling

Indexed keywords

AGING; ARTICLE; DIET; GENE MUTATION; GERIATRIC DISORDER; LIFESPAN; PRIORITY JOURNAL; ANIMAL; DISEASE; HUMAN; LIFE EXPECTANCY; PATHOLOGY; PHYSIOLOGY; PREVENTIVE MEDICINE; PROCEDURES; TRENDS;

AGING; ANIMALS; DISEASE; HUMANS; LIFE EXPECTANCY; PREVENTIVE MEDICINE;

EID: 84927649956     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.08.003     Document Type: Note

References (15)

1. Oeppen J., Vaupel J.W. Demography. Broken limits to life expectancy. Science 2002, 296:1029-3101.
2. Olshansky S.J., et al. Differences in life expectancy due to race and educational differences are widening, and many may not catch up. Health Aff. (Millwood) 2012, 31:1803-1813.
3. Fries J.F., et al. Compression of morbidity 1980-2011: a focused review of paradigms and progress. J. Aging Res. 2011, 2011:261702.
4. Niccoli T., Partridge L. Ageing as a risk factor for disease. Curr. Biol. 2012, 22:R741-R752.
5. Nussey D.H., et al. Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology. Ageing Res. Rev. 2013, 12:214-225.
6. Kenyon C.J. The genetics of ageing. Nature 2010, 464:504-512. erratum in Nature 467, 622.
7. Fontana L., et al. Extending healthy lifespan - from yeast to humans. Science 2010, 328:321-326.
8. Partridge L. The new biology of ageing. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2010, 365:147-154.
9. Martínez D.E. Mortality patterns suggest lack of senescence in Hydra. Exp. Gerontol. 1998, 33:217-225.
10. López-Otín C., et al. The hallmarks of aging. Cell 2013, 153:1194-1217.
11. Solon-Biet S.M., et al. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab. 2014, 19:418-430.
12. Harrison D.E., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
13. Metaxakis A., et al. Lowered insulin signaling ameliorates age-related sleep fragmentation in Drosophila. PLoS Biol. 2014, 12:e1001824.
14. Pinkston-Gosse J., Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat. Genet. 2007, 39:1403-1409.
15. Goldman D.P., et al. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff. (Millwood) 2013, 32:1698-1705.