Influence of aerobic training and detraining on serum BDNF, insulin resistance, and metabolic risk factors in middle-aged men diagnosed with metabolic syndrome

Clinical Journal of Sport Medicine

Volumn 24, Issue 6, 2014, Pages 513-518

  Damirchi, Arsalan ^a   Tehrani, Bahram Soltani ^b   Alamdari, Karim Azali ^c   Babaei, Parvin ^b,d  

^a UNIVERSITY OF GUILAN   (Iran)

^b GUILAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c AZARBAIJAN SHAHID MADANI UNIVERSITY   (Iran)

^d GUILAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aerobic training and detraining; BDNF; Metabolic syndrome

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ADULT; AEROBIC EXERCISE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FASTING BLOOD SUGAR; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; AGED; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; KINESIOTHERAPY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

AGED; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL, HDL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE THERAPY; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; RISK FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 84927628306     PISSN: 1050642X     EISSN: 15363724     Source Type: Journal    
DOI: 10.1097/JSM.0000000000000082     Document Type: Article

References (51)

1. Bateman LA, Slentz CA, Willis LH, et al. Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the Studies of a Targeted Risk Reduction Intervention through Defined Exercise-STRRIDE-AT/RT). Am J Cardiol. 2011;108:838-844.
2. Expert Panel on Detection, Evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the National cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285:2486-2497.
3. Park YW, Zhu S, Palaniappan L, et al. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med. 2003;163:427-436.
4. Katzmarzyk PT, Leon AS, Wilmore JH, et al. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE family study. Med Sci Sports Exerc. 2003;35:1703-1709.
5. Frank LL, Sorensen BE, Yasui Y, et al. Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. Obes Res. 2012;13:615-625.
6. Okura T, Nakata Y, Ohkawara K, et al. Effects of aerobic exercise on metabolic syndrome improvement in response to weight reduction. Obesity (Silver Spring). 2012;15:2478-2484.
7. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25:295-301.
8. Fox EA, Byerly MS. A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants. Am J Physiol Regul Integr Comp Physiol. 2004;286: R994-R1004.
9. Lebrun B, Bariohay B, Moyse E, et al. Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. Auton Neurosci. 2006; 126-127:30-38.
10. Nonomura T, Tsuchida A, Ono-Kishino M, et al. Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice. Int J Exp Diabetes Res. 2001;2:201-209.
11. Suwa M, Kishimoto H, Nofuji Y, et al. Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism. 2006;55:852-857.
12. Geroldi D, Minoretti P, Emanuele E. Brain-derived neurotrophic factor and the metabolic syndrome: more than just a hypothesis. Med Hypotheses. 2006:195-196.
13. Krabbe KS, Nielsen AR, Krogh-Madsen R, et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2007;50: 431-438.
14. Knaepen K, Goekint M, Heyman EM, et al. Neuroplasticity-exerciseinduced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med. 2010;40:765-801.
15. Seifert T, Brassard P, Wissenberg M, et al. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol. 2010;298:R372-R377.
16. Tang SW, Chu E, Hui T, et al. Influence of exercise on serum brainderived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett. 2008;431:62-65.
17. Schiffer T, Schulte S, Hollmann W, et al. Effects of strength and endurance training on brain-derived neurotrophic factor and insulin-like growth factor 1 in humans. Horm Metab Res. 2009;41:250-254.
18. Zoladz JA, Pilc A, Majerczak J, et al. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol. 2008;59:119-132.
19. Radák Z, Kaneco T, Tahara S, et al. Regular exercise improves cognitive function and decreases oxidative damage in rat brain. Neurochem Int. 2001;38:17-23.
20. Mitsuhashi T, Yamada C, Iida A, et al. Long-term detraining increases the risk of metabolic syndrome in Japanese men. Tokai J Exp Clin Med. 2011;36:95-99.
21. Ratel S, Gryson C, Rance M, et al. Detraining-induced alterations in metabolic and fitness markers after a multicomponent exercise-training program in older men. Appl Physiol Nutr Metab. 2012;37:72-79.
22. Johnson JL, Slentz CA, Houmard JA, et al. Exercise training amount and intensity effects on metabolic syndrome (from studies of a targeted risk reduction intervention through defined exercise). Am J Cardiol. 2007; 100:1759-1766.
23. Herd SL, Hardman AE, Boobis LH, et al. The effect of 13 weeks of running training followed by 9 d of detraining on postprandial lipaemia. Br J Nutr. 1998;80:57-66.
24. Mankowitz K, Seipa R, Semenkovich CF, et al. Short-term interruption of training affects both fasting and post-prandial lipoproteins. Atherosclerosis. 1992;95:181-189.
25. Motoyama M, Sunami Y, Kinoshita F, et al. The effects of long-term low intensity aerobic training and detraining on serum lipid and lipoprotein concentrations in elderly men and women. Eur J Appl Physiol Occup Physiol. 1995;70:126-131.
26. Slentz CA, Houmard JA, Johnson JL, et al. Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol (1985). 2007;103:432-442.
27. Hardman AE, Lawrence JEM, Herd SL. Postprandial lipemia in endurance-trained people during a short interruption to training. J Appl Physiol (1985). 1998;84:1895-1901.
28. Petibois C, Cassaigne A, Gin H, et al. Lipid profile disorders induced by long-term cessation of physical activity in previously highly endurancetrained subjects. J Clin Endocrinol Metab. 2004;89:3377-3384.
29. Williams PT, Thompson PD. Dose-dependent effects of training and detraining on weight in 6406 runners during 7.4 years. Obesity. 2012; 14:1975-1984.
30. Goekint M, Roelands B, De Pauw K, et al. Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor? Neurosci Lett. 2010;486:146-149.
31. Radak Z, Toldy A, Szabo Z, et al. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int. 2006;49:387-392.
32. Masharani U, German MS. Panceratic hormones and diabetes mellitus. In: Gardner DG, Shoback D, eds. Greenspan's Basic & Clinical Endocrinology. 9th ed. New York: McGraw Hill; 2011:605.
33. Ross R, Janssen I, Dawson J, et al. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res. 2012;12:789-798.
34. Gill JMR, Caslake MJ, McAllister C, et al. Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. J Clin Endocrinol Metab. 2003;88: 4328-4335.
35. Friedenreich CM, Neilson HK, Woolcott CG, et al. Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr Relat Cancer. 2011;18:357-369.
36. Lakka TA, Laaksonen DE. Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab. 2007;32:76-88.
37. Golden E, Emiliano A, Maudsley S, et al. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PloS One. 2010;5:e10099.
38. Karolkiewicz J, Michalak E, Pospieszna B, et al. Response of oxidative stress markers and antioxidant parameters to an 8-week aerobic physical activity program in healthy, postmenopausal women. Arch Gerontol Geriatr. 2009;49:e67-e71.
39. Wallace T, Matthews D. The assessment of insulin resistance in man. Diabet Med. 2002;19:527-534.
40. Chaldakov G. The metabotrophic NGF and BDNF: an emerging concept. Arch Ital Biol. 2011;149:257-263.
41. Hristova MG. Metabolic syndrome and neurotrophins: effects of metformin and non-steroidal antiinflammatory drug treatment. Eurasian J Med. 2011;43:141-145.
42. Newman A. Obesity in older adults. OJIN. 2009;14.
43. Fujimura H, Altar CA, Chen R, et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost. 2002;87:728-734.
44. Raffaelli F, Nanetti L, D'Angelo M, et al. Interactions between lipoproteins and platelet membranes in obesity. Obesity. 2009:17:1375-1380.
45. Nofuji Y, Suwa M, Moriyama Y, et al. Decreased serum brain-derived neurotrophic factor in trained men. Neurosci Lett. 2008;437:29-32.
46. Rasmussen P, Brassard P, Adser H, et al. Evidence for a release of brainderived neurotrophic factor from the brain during exercise. Exp Physiol. 2009;94:1062-1069.
47. Pelleymounter MA, Cullen MJ, Wellman CL. Characteristics of BDNF-induced weight loss. Exp Neurol. 1995;131:229-238.
48. Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci. 2005;6:603-614.
49. Marques-Aleixo I, Oliveira P, Moreira P, et al. Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms. Prog Neurobiol. 2012;99:149-162.
50. Seidah NG, Benjannet S, Pareek S, et al. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Lett. 1996;379:247-250.
51. Egan MF, Kojima M, Callicott JH, et al. The BDNF val66Met polymorphism affect sactivity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112:257-269.