Prevalence and prognostic implications of anaemia and iron deficiency in Tanzanian patients with heart failure

Heart

Volumn 101, Issue 8, 2015, Pages 592-599

  Makubi, Abel ^a,b,c   Hage, Camilla ^b,d   Lwakatare, Johnson ^a,c   Mmbando, Bruno ^e,f   Kisenge, Peter ^c   Lund, Lars H ^b,d   Rydén, Lars ^b   Makani, Julie ^a,b,f,g  

^a Muhimbili University of Health and Allied Sciences   (India)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Muhimbili National Hospital Dar es Salaam   (India)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e National Institute of Medical Research Tanga Centre   (India)

^f Muhimbili Wellcome Programme Dar es Salaam   (India)

^g UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLESTEROL; CLOPIDOGREL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDRALAZINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOOP DIURETIC AGENT; NITRIC ACID DERIVATIVE; WARFARIN; IRON;

ADULT; AGED; ANEMIA; ARTICLE; CARDIOMYOPATHY; COMORBIDITY; CONTROLLED STUDY; CREATININE CLEARANCE; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DISEASE FREE SURVIVAL; FEMALE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HYPERTENSION; IRON DEFICIENCY; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; NORMOCHROMIC NORMOCYTIC ANEMIA; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PULMONARY HYPERTENSION; RHEUMATIC HEART DISEASE; RISK FACTOR; SURVIVAL TIME; TANZANIA; TANZANIAN; ANEMIA, IRON-DEFICIENCY; BLOOD; COMPLICATION; FOLLOW UP; HOSPITALIZATION; MIDDLE AGED; PROCEDURES; RISK ASSESSMENT; SURVIVAL RATE; TRENDS;

ADULT; AGED; ANEMIA, IRON-DEFICIENCY; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HOSPITALIZATION; HUMANS; IRON; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURVIVAL RATE; TANZANIA;

EID: 84927622042     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2014-306890     Document Type: Article

References (27)

1. Mahfoud F, Kindermann I, Kindermann M, et al. [Comorbidity: anemia and heart failure]. Dtsch Med Wochenschr 2009;134:825-30.
2. Groenveld HF, Januzzi JL, Damman K, et al. Anemia and mortality in heart failure patients a systematic review and meta-analysis. J Am Coll Cardiol 2008;52: 818-27.
3. O'Meara E, Clayton T, McEntegart MB, et al. Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: assessment of Reduction in Mortality and Morbidity (CHARM) Program. Circulation 2006;113:986-94.
4. Androne AS. Hemodilution is common in patients with advanced heart failure. Circulation 2003;107:226-9.
5. Nanas JN, Matsouka C, Karageorgopoulos D, et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006;48:2485-9.
6. Allen LA, Anstrom KJ, Horton JR, et al. Relationship between anemia and health care costs in heart failure. J Card Fail 2009;15:843-9.
7. Makubi A, Hage C, Lwakatare J, et al. Contemporary aetiology, clinical characteristics and prognosis of adults with heart failure observed in a tertiary hospital in Tanzania: the prospective Tanzania Heart Failure (TaHeF) study. Heart 2014;100:1235-41.
8. Karaye KM, Sani MU. Factors associated with poor prognosis among patients admitted with heart failure in a Nigerian tertiary medical centre: a cross-sectional study. BMC Cardiovasc Disord 2008;8:16.
9. Oyoo GO, Ogola EN. Clinical and socio demographic aspects of congestive heart failure patients at Kenyatta National Hospital, Nairobi. East Afr Med J 1999;76:23-7.
10. Inglis SC, Stewart S, Papachan A, et al. Anaemia and renal function in heart failure due to idiopathic dilated cardiomyopathy. Eur J Heart Fail 2007;9:384-90.
11. Kuule JK, Seremba E, Freers J. Anaemia among patients with congestive cardiac failure in Uganda-its impact on treatment outcomes. S Afr Med J 2009;99:876-80.
12. Jankowska EA, Rozentryt P, Witkowska A, et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J 2010;31:1872-80.
13. Klip IT, Comin-Colet J, Voors AA, et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 2013;165:575-82.
14. Horwich TB, Fonarow GC, Hamilton MA, et al. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol 2002;39:1780-6.
15. McKee PA, Castelli WP, McNamara PM, et al . The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971;285:1441-6.
16. World Health Organisation. Nutritional anaemias: report of a WHO scientific group. WHO Tech Rep Ser 1968;405:3-37.
17. Stewart S, Wilkinson D, Hansen C, et al. Predominance of heart failure in the heart of Soweto Study cohort: emerging challenges for urban African communities. Circulation 2008;118:2360-7.
18. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
19. Damasceno A, Mayosi BM, Sani M, et al. The causes, treatment, and outcome of acute heart failure in 1006 Africans from 9 countries. Arch Intern Med 2012;172:1386-94.
20. Edwards R, Unwin N, Mugusi F, et al. Hypertension prevalence and care in an urban and rural area of Tanzania. J Hypertens 2000;18:145-52.
21. Rangel I, Gonçalves A, de Sousa C, et al. Iron deficiency status irrespective of anemia: a predictor of unfavorable outcome in chronic heart failure patients. Cardiology 2014;128:320-6.
22. Enjuanes C, Klip IT, Bruguera J, et al. Iron deficiency and health-related quality of life in chronic heart failure: results from a multicenter European study. Int J Cardiol 2014;174:268-75.
23. Parikh A, Natarajan S, Lipsitz SR, et al. Iron deficiency in community-dwelling US adults with self-reported heart failure in the National Health and Nutrition Examination Survey III: prevalence and associations with anemia and inflammation. Circ Heart Fail 2011;4:599-606.
24. Ahluwalia N, Lammi-Keefe CJ, Bendel RB, et al. Iron deficiency and anemia of chronic disease in elderly women: a discriminant-analysis approach for differentiation. Am J Clin Nutr 1995;61:590-6.
25. Suominen P, Punnonen K, Rajamäki A, et al. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 1998;92:2934-9.
26. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure. Circulation 2003;107:223-5.
27. Silverberg DS, Wexler D, Blum M, et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol 2000;35:1737-44.