Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists

ACS Medicinal Chemistry Letters

Volumn 6, Issue 4, 2015, Pages 461-465

  Yang, Christine ^a   Balsells, Jaume ^a   Chu, Hong D ^a   Cox, Jason M ^a   Crespo, Alejandro ^a   Ma, Xiuying ^a   Contino, Lisa ^a   Brown, Patricia ^a   Gao, Sheng ^a   Zamlynny, Beata ^a   Wiltsie, Judyann ^a   Clemas, Joseph ^a   Lisnock, Jeanmarie ^a   Gibson, Jack ^a   Zhou, Gaochao ^a   Garcia Calvo, Margarita ^a   Bateman, Thomas J ^a   Tong, Vincent ^a   Xu, Ling ^a   Crook, Martin ^a   Sinclair, Peter ^a   Shen, Hong C ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

amide replacement; antagonist; mineralocorticoid receptor; natriuresis effect; oxazolidinedione

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; MINERALOCORTICOID ANTAGONIST; OXAZOLIDINEDIONE DERIVATIVE; SPIRONOLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; LIVER MICROSOME; NATRIURESIS; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

RATTUS;

EID: 84927616284     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00010     Document Type: Article

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