메뉴 건너뛰기




Volumn 17, Issue 1, 2007, Pages 17-23

Non-steroidal mineralocorticoid receptor antagonists

Author keywords

Aldosterone; Eplerenone; Heart failure; Hypertension; Mineralocorticoid; Mineralocorticoid receptor antagonist; Spironolactone

Indexed keywords

3 BENZYL INDOLE DERIVATIVE; 3,3 BISARYL OXINDOLE DERIVATIVE; 4 ARYL 1,4 DIHYDROPYRIDINE DERIVATIVE; ALDOSTERONE; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BENZOXAZINE DERIVATIVE; BENZOXAZINETHIONE DERIVATIVE; BENZOXAZINONE DERIVATIVE; DIBENZOSUBERANE DERIVATIVE; DIHYDROPYRIDINE DERIVATIVE; DIHYDROQUINOLINE DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; EPLERENONE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; LOSARTAN; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; NEW DRUG; OXEPINE DERIVATIVE; OXINDOLE; PLACEBO; PYRROLE DERIVATIVE; SODIUM CHLORIDE; SPIRONOLACTONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WATER;

EID: 33846180691     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.17.1.17     Document Type: Review
Times cited : (16)

References (28)
  • 1
    • 0025675680 scopus 로고
    • Remodeling of the rat right and left ventricles in experimental hypertension
    • BRILLA CG, PICK R, TAN LB, JANICKI JS, WEBER KT: Remodeling of the rat right and left ventricles in experimental hypertension. Circ. Res. (1990) 67(6):1355-1364.
    • (1990) Circ. Res. , vol.67 , Issue.6 , pp. 1355-1364
    • Brilla, C.G.1    Pick, R.2    Tan, L.B.3    Janicki, J.S.4    Weber, K.T.5
  • 3
    • 2942685646 scopus 로고    scopus 로고
    • Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism
    • NISHIZAKA MK, ZAMAN MA, GREEN SA, RENFROE KY, CALHOUN DA. Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. Circulation (2004) 109(23):2857-2861.
    • (2004) Circulation , vol.109 , Issue.23 , pp. 2857-2861
    • Nishizaka, M.K.1    Zaman, M.A.2    Green, S.A.3    Renfroe, K.Y.4    Calhoun, D.A.5
  • 4
    • 22944433179 scopus 로고    scopus 로고
    • Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone
    • HU X, LI S, MCMAHON EG, LALA DS, RUDOLPH AE: Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone. Mini Rev. Med. Chem. (2005) 5(8):709-718.
    • (2005) Mini Rev. Med. Chem. , vol.5 , Issue.8 , pp. 709-718
    • Hu, X.1    Li, S.2    Mcmahon, E.G.3    Lala, D.S.4    Rudolph, A.E.5
  • 5
    • 0035997359 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
    • WEINBERGER MH, RONIKER B, KRAUSE SL, WEISS RJ: Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am. J. Hypertens. (2002) 15(8):709-716.
    • (2002) Am. J. Hypertens. , vol.15 , Issue.8 , pp. 709-716
    • Weinberger, M.H.1    Roniker, B.2    Krause, S.L.3    Weiss, R.J.4
  • 6
    • 0037861923 scopus 로고    scopus 로고
    • Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension
    • WHITE WB, CARR AA, KRAUSE S et al: Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension. Am. J. Cardiol. (2003) 92(1):38-42.
    • (2003) Am. J. Cardiol. , vol.92 , Issue.1 , pp. 38-42
    • White, W.B.1    Carr, A.A.2    Krause, S.3
  • 7
    • 0038673178 scopus 로고    scopus 로고
    • Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension
    • WHITE WB, DUPREZ D, ST HILLAIRE R et al.: Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension. Hypertension (2003) 41(5):1021-1026.
    • (2003) Hypertension , vol.41 , Issue.5 , pp. 1021-1026
    • White, W.B.1    Duprez, D.2    St. Hillaire, R.3
  • 8
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy the 4E-left ventricular hypertrophy study
    • PITT B, REICHEK N, WILLENBROCK R et al.: Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy. the 4E-left ventricular hypertrophy study. Circulation (2003) 108(15):1831-1838.
    • (2003) Circulation , vol.108 , Issue.15 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 9
    • 1842688311 scopus 로고    scopus 로고
    • Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension
    • WILLIAMS GH, BURGESS E, KOLLOCH RE et al.: Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. Am. J. Cardiol. (2004) 93(8):990-996.
    • (2004) Am. J. Cardiol. , vol.93 , Issue.8 , pp. 990-996
    • Williams, G.H.1    Burgess, E.2    Kolloch, R.E.3
  • 10
    • 0037414091 scopus 로고    scopus 로고
    • Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients
    • FLACK JM, OPARIL S, PRATT JH et al: Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients. J. Am. Coll. Cardiol, (2003) 41(7):1148-1155.
    • (2003) J. Am. Coll. Cardiol , vol.41 , Issue.7 , pp. 1148-1155
    • Flack, J.M.1    Oparil, S.2    Pratt, J.H.3
  • 11
    • 24944492935 scopus 로고    scopus 로고
    • Effects of eplerenone versus losartan in patients with low-renin hypertension
    • WEINBERGER MH, WHITE WB, RUILOPE LM et al.: Effects of eplerenone versus losartan in patients with low-renin hypertension. Am. Heart J. (2005) 150(3):426-433.
    • (2005) Am. Heart J. , vol.150 , Issue.3 , pp. 426-433
    • Weinberger, M.H.1    White, W.B.2    Ruilope, L.M.3
  • 12
    • 0036330671 scopus 로고    scopus 로고
    • Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients
    • KRUM H, NOLLY H, WORKMAN D et al: Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients. Hypertension (2002) 40(2):117-123.
    • (2002) Hypertension , vol.40 , Issue.2 , pp. 117-123
    • Krum, H.1    Nolly, H.2    Workman, D.3
  • 13
    • 0142043927 scopus 로고    scopus 로고
    • Long-term safety and efficacy of the selective aldosterone blocker eplerenone in patients with essential hypertension
    • BURGESS ED, LACOURCIERE Y, RUILOPE-URIOSTE LM et al: Long-term safety and efficacy of the selective aldosterone blocker eplerenone in patients with essential hypertension. Clin. Ther. (2003) 25(9):2388-2404.
    • (2003) Clin. Ther. , vol.25 , Issue.9 , pp. 2388-2404
    • Burgess, E.D.1    Lacourciere, Y.2    Ruilope-Urioste, L.M.3
  • 14
    • 0038460302 scopus 로고    scopus 로고
    • The seventh report of the joint national committee on prevention, detection, evaluation and treatment of high blood pressure: The JNC 7 report
    • CHOBANIAN AV, BAKRIS GL, BLACK HR et al: The seventh report of the joint national committee on prevention, detection, evaluation and treatment of high blood pressure: the JNC 7 report. Jama (2003) 289(19):2560-2572.
    • (2003) Jama , vol.289 , Issue.19 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 15
    • 0036110762 scopus 로고    scopus 로고
    • The role of spironolactone in the treatment of patients with refractory hypertension
    • OUZAN J, PERAULT C, LINCOFF AM, CARRE E, MERTES M: The role of spironolactone in the treatment of patients with refractory hypertension. Am. J. Hypertens. (2002) 15(4 Pt 1):333-339.
    • (2002) Am. J. Hypertens. , vol.15 , Issue.4 PART 1 , pp. 333-339
    • Ouzan, J.1    Perault, C.2    Lincoff, A.M.3    Carre, E.4    Mertes, M.5
  • 16
    • 0142231538 scopus 로고    scopus 로고
    • Efficacy of low-dose spironolactone in subjects with resistant hypertension
    • NISHIZAKA MK, ZAMAN MA, CALHOUN DA: Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am. J. Hypertens. (2003) 16(11 Pt 1):925-930.
    • (2003) Am. J. Hypertens. , vol.16 , Issue.11 PART 1 , pp. 925-930
    • Nishizaka, M.K.1    Zaman, M.A.2    Calhoun, D.A.3
  • 17
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Randomized Aldactone Evaluation Study Investigators
    • PITT B, ZANNAD F, REMME WJ et al.: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N. Engl. J. Med. (1999) 341(10):709-717.
    • (1999) N. Engl. J. Med. , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 18
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • PITT B, REMME W, ZANNAD F et al: Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N. Engl. J. Med. (2003) 348(14):1309-1321.
    • (2003) N. Engl. J. Med. , vol.348 , Issue.14 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 19
    • 0001847493 scopus 로고    scopus 로고
    • Antiproteinuric efficacy of eplerenone, enalapril, and eplerenone/ enalapril combination therapy in diabetic hypertensives with microalbuminuria
    • EPSTEIN M, BUCKALEW JV, MARTINEZ F et al: Antiproteinuric efficacy of eplerenone, enalapril, and eplerenone/enalapril combination therapy in diabetic hypertensives with microalbuminuria. Am. J. Hypertens. (2002) 15(1):A24.
    • (2002) Am. J. Hypertens. , vol.15 , Issue.1
    • Epstein, M.1    Buckalew, J.V.2    Martinez, F.3
  • 20
    • 2442490850 scopus 로고    scopus 로고
    • Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: A possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone
    • KEIDAR S, KAPLAN M, PAVLOTZKY E et al: Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Circulation (2004) 109(18):2213-2220.
    • (2004) Circulation , vol.109 , Issue.18 , pp. 2213-2220
    • Keidar, S.1    Kaplan, M.2    Pavlotzky, E.3
  • 21
    • 0037035471 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism in experimental atherosclerosis
    • RAJAGOPALAN S, DUQUAINE D, KING S, PITT B, PATEL P: Mineralocorticoid receptor antagonism in experimental atherosclerosis. Circulation (2002) 105(18):2212-2216.
    • (2002) Circulation , vol.105 , Issue.18 , pp. 2212-2216
    • Rajagopalan, S.1    Duquaine, D.2    King, S.3    Pitt, B.4    Patel, P.5
  • 22
    • 0037780685 scopus 로고    scopus 로고
    • Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice
    • KEIDAR S, HAYEK T, KAPLAN M et al.: Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc. Pharmacol. (2003) 41(6):955-963.
    • (2003) J Cardiovasc. Pharmacol. , vol.41 , Issue.6 , pp. 955-963
    • Keidar, S.1    Hayek, T.2    Kaplan, M.3
  • 23
    • 27444434640 scopus 로고    scopus 로고
    • Eplerenone inhibits atherosclerosis in nonhuman primates
    • TAKAI S, JIN D, MURAMATSU M et al.: Eplerenone inhibits atherosclerosis in nonhuman primates. Hypertension (2005) 46(5):1135-1139.
    • (2005) Hypertension , vol.46 , Issue.5 , pp. 1135-1139
    • Takai, S.1    Jin, D.2    Muramatsu, M.3
  • 24
    • 33646692656 scopus 로고    scopus 로고
    • Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation
    • SUZUKI J, IWAI M, MOGI M et al: Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation. Arterioscler. Thromb. Vasc. Biol. (2006) 26(4):917-921.
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , Issue.4 , pp. 917-921
    • Suzuki, J.1    Iwai, M.2    Mogi, M.3
  • 25
    • 0141520270 scopus 로고    scopus 로고
    • Primary aldosteronism treatment options
    • YOUNG WF Jr: Primary aldosteronism treatment options. Growth Horm. IGF Res. (2003) 13 (Suppl. A):S102-S108.
    • (2003) Growth Horm. IGF Res. , vol.13 , Issue.SUPPL. A
    • Young Jr., W.F.1
  • 26
    • 0033128378 scopus 로고    scopus 로고
    • Pathogenesis of ascites and renal salt retention in cirrhosis
    • PALMER BF: Pathogenesis of ascites and renal salt retention in cirrhosis. J. Investig. Med. (1999) 47(5):183-202.
    • (1999) J. Investig. Med. , vol.47 , Issue.5 , pp. 183-202
    • Palmer, B.F.1
  • 27
    • 33846136196 scopus 로고    scopus 로고
    • Discovery of orally bioavailable, non-steroidal mineralo-corticoid receptor antagonist: A tale of three platforms
    • Altanta MEDI 179
    • JADHAV PK, MATTHEWS DP, GREEN J et al: Discovery of orally bioavailable, non-steroidal mineralo-corticoid receptor antagonist: a tale of three platforms. 231st American Chemical Society National Meeting. Altanta (2006) MEDI 179.
    • (2006) 231st American Chemical Society National Meeting
    • Jadhav, P.K.1    Matthews, D.P.2    Green, J.3
  • 28
    • 20944441635 scopus 로고    scopus 로고
    • 3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists
    • NEEL DA, BROWN ML, LANDER PA et al: 3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists. Bioorg. Med. Chem. Lett. (2005) 15(10):2553-2557.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , Issue.10 , pp. 2553-2557
    • Neel, D.A.1    Brown, M.L.2    Lander, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.