Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 7, 2014, Pages 1681-1684

  Cox, Jason M ^a   Chu, Hong D ^a   Yang, Christine ^a   Shen, Hong C ^a   Wu, Zhicai ^a   Balsells, Jaume ^a   Crespo, Alejandro ^a   Brown, Patricia ^a   Zamlynny, Beata ^a   Wiltsie, Judyann ^a   Clemas, Joseph ^a   Gibson, Jack ^a   Contino, Lisa ^a   Lisnock, Jeanmarie ^a   Zhou, Gaochao ^a   Garcia Calvo, Margarita ^a   Bateman, Thomas ^a   Xu, Ling ^a   Tong, Xinchun ^a   Crook, Martin ^a   Sinclair, Peter ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hypertension; Lipophilic ligand efficiency; Mineralocorticoid receptor antagonist; Oxazolidinedione

Indexed keywords

AMIDE; EPLERENONE; HETEROCYCLIC AMIDE; HORMONE RECEPTOR; LIGAND; MINERALOCORTICOID ANTAGONIST; OXAZOLIDINEDIONE DERIVATIVE; SPIRONOLACTONE; UNCLASSIFIED DRUG; HETEROCYCLIC AMINE; IMIDAZOLE; TRIAZOLE DERIVATIVE; HETEROCYCLIC COMPOUND; MINERALOCORTICOID RECEPTOR; OXAZOLE DERIVATIVE;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CYCLIZATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IC 50; LIPOPHILIC LIGAND EFFICIENCY; LIPOPHILICITY; LIVER MICROSOME; NONHUMAN; PHARMACOLOGICAL PARAMETERS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; DRUG IDENTIFICATION; DRUG SAFETY; DRUG SYNTHESIS; PRODUCTIVITY; SUPERCRITICAL FLUID CHROMATOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; RAT; SYNTHESIS;

AMIDES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS; HUMANS; MICROSOMES, LIVER; MINERALOCORTICOID RECEPTOR ANTAGONISTS; MOLECULAR STRUCTURE; OXAZOLES; RATS; RECEPTORS, MINERALOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897381384     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.02.057     Document Type: Article

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