-
1
-
-
84903159476
-
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
-
Holderfield M, Deuker MM, McCormick F, McMahon M. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat Rev Cancer 2014;14:455-67.
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 455-467
-
-
Holderfield, M.1
Deuker, M.M.2
McCormick, F.3
McMahon, M.4
-
2
-
-
38949183695
-
Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy
-
Friday BB, Adjei AA. Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy. Clin Cancer Res 2008;14:342-6.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 342-346
-
-
Friday, B.B.1
Adjei, A.A.2
-
3
-
-
84900442808
-
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors
-
Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, et al. Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors. Cancer Cell 2014;25:697-710.
-
(2014)
Cancer Cell
, vol.25
, pp. 697-710
-
-
Lito, P.1
Saborowski, A.2
Yue, J.3
Solomon, M.4
Joseph, E.5
Gadal, S.6
-
4
-
-
84927609396
-
RAS synthetic lethal screens revisited: Still seeking the elusive prize?
-
Downward J. RAS synthetic lethal screens revisited: still seeking the elusive prize? Clin Cancer Res 2015;21:1802-9.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1802-1809
-
-
Downward, J.1
-
5
-
-
84927641895
-
Direct attack on RAS: Intramolecular communication and mutation-specific effects
-
Marcus K, Mattos C. Direct attack on RAS: intramolecular communication and mutation-specific effects. Clin Cancer Res 2015;21:1810-8.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1810-1818
-
-
Marcus, K.1
Mattos, C.2
-
6
-
-
84927620483
-
Targeting RAS membrane association: Back to the future for anti-RAS drug discovery?
-
Cox AD, Der CJ, Philips MR. Targeting RAS membrane association: back to the future for anti-RAS drug discovery? Clin Cancer Res 2015;21:1819-27.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1819-1827
-
-
Cox, A.D.1
Der, C.J.2
Philips, M.R.3
-
7
-
-
84927632705
-
Metabolic dependencies in RAS-driven cancers
-
Kimmelman AC. Metabolic dependencies in RAS-driven cancers. Clin Cancer Res 2015;21:1828-34.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1828-1834
-
-
Kimmelman, A.C.1
-
8
-
-
84927645077
-
-
[cited 2015 Feb 16]. Available from
-
The RAS Initiative; [about 2 screens]. [cited 2015 Feb 16]. Available from: http://www.cancer.gov/researchandfunding/priorities/ras
-
The RAS Initiative; [about 2 Screens]
-
-
-
10
-
-
84908491115
-
Drugging the undruggable RAS: Mission possible?
-
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: mission possible? Nat Rev Drug Discov 2014;13:828-51.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 828-851
-
-
Cox, A.D.1
Fesik, S.W.2
Kimmelman, A.C.3
Luo, J.4
Der, C.J.5
-
12
-
-
65649108558
-
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival
-
Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardeesy N, et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell 2009; 15:489-500.
-
(2009)
Cancer Cell
, vol.15
, pp. 489-500
-
-
Singh, A.1
Greninger, P.2
Rhodes, D.3
Koopman, L.4
Violette, S.5
Bardeesy, N.6
-
13
-
-
33846973375
-
Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells
-
Zhang Z, Jiang G, Yang F, Wang J. Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells. Cancer Biol Ther 2006;5:1481-6.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1481-1486
-
-
Zhang, Z.1
Jiang, G.2
Yang, F.3
Wang, J.4
-
14
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, et al. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 2001;15:3249-62.
-
(2001)
Genes Dev
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
Lenczowski, J.M.4
Tichelaar, J.W.5
Lizak, M.J.6
-
15
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012;149:656-70.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
-
16
-
-
84870709449
-
Metastatic pancreatic cancer is dependent on oncogenic Kras in mice
-
Collins MA, Brisset JC, Zhang Y, Bednar F, Pierre J, Heist KA, et al. Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. PloS ONE 2012;7:e49707.
-
(2012)
PloS ONE
, vol.7
, pp. e49707
-
-
Collins, M.A.1
Brisset, J.C.2
Zhang, Y.3
Bednar, F.4
Pierre, J.5
Heist, K.A.6
-
17
-
-
84861147473
-
A comprehensive survey of Ras mutations in cancer
-
Prior IA, Lewis PD, Mattos C. A comprehensive survey of Ras mutations in cancer. Cancer Res 2012;72:2457-67.
-
(2012)
Cancer Res
, vol.72
, pp. 2457-2467
-
-
Prior, I.A.1
Lewis, P.D.2
Mattos, C.3
-
18
-
-
42649125571
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
-
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 2008;40:600-8.
-
(2008)
Nat Genet
, vol.40
, pp. 600-608
-
-
Haigis, K.M.1
Kendall, K.R.2
Wang, Y.3
Cheung, A.4
Haigis, M.C.5
Glickman, J.N.6
-
19
-
-
33748988989
-
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
-
Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, et al. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A 2006; 103:14122-7.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14122-14127
-
-
Sansom, O.J.1
Meniel, V.2
Wilkins, J.A.3
Cole, A.M.4
Oien, K.A.5
Marsh, V.6
-
20
-
-
77949568748
-
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
-
Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, et al. Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J 2010;29:1091-104.
-
(2010)
EMBO J
, vol.29
, pp. 1091-1104
-
-
Drosten, M.1
Dhawahir, A.2
Sum, E.Y.3
Urosevic, J.4
Lechuga, C.G.5
Esteban, L.M.6
-
21
-
-
0031012426
-
Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex
-
Taveras AG, Remiszewski SW, Doll RJ, Cesarz D, Huang EC, Kirschmeier P, et al. Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex. Bioorg Med Chem 1997;5:125-33.
-
(1997)
Bioorg Med Chem
, vol.5
, pp. 125-133
-
-
Taveras, A.G.1
Remiszewski, S.W.2
Doll, R.J.3
Cesarz, D.4
Huang, E.C.5
Kirschmeier, P.6
-
22
-
-
0037088262
-
The new sulindac derivative IND 12 reverses Ras-induced cell transformation
-
Karaguni IM, Herter P, Debruyne P, Chtarbova S, Kasprzynski A, Herbrand U, et al. The new sulindac derivative IND 12 reverses Ras-induced cell transformation. Cancer Res 2002;62:1718-23.
-
(2002)
Cancer Res
, vol.62
, pp. 1718-1723
-
-
Karaguni, I.M.1
Herter, P.2
Debruyne, P.3
Chtarbova, S.4
Kasprzynski, A.5
Herbrand, U.6
-
23
-
-
84862649997
-
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation
-
Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl 2012;51:6140-3.
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 6140-6143
-
-
Sun, Q.1
Burke, J.P.2
Phan, J.3
Burns, M.C.4
Olejniczak, E.T.5
Waterson, A.G.6
-
24
-
-
84859463451
-
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
-
Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A 2012;109:5299-304.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 5299-5304
-
-
Maurer, T.1
Garrenton, L.S.2
Oh, A.3
Pitts, K.4
Anderson, D.J.5
Skelton, N.J.6
-
25
-
-
84888639050
-
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
-
Ostrem JM, Peters U, SosML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013; 503:548-51.
-
(2013)
Nature
, vol.503
, pp. 548-551
-
-
Ostrem, J.M.1
Peters, U.2
Sos, M.L.3
Wells, J.A.4
Shokat, K.M.5
-
26
-
-
84890947640
-
Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor
-
Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, et al. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl 2014;53:199-204.
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 199-204
-
-
Lim, S.M.1
Westover, K.D.2
Ficarro, S.B.3
Harrison, R.A.4
Choi, H.G.5
Pacold, M.E.6
-
27
-
-
84922287331
-
K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif
-
Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, et al. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proc Natl Acad Sci U S A 2015;112:779-84.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 779-784
-
-
Tsai, F.D.1
Lopes, M.S.2
Zhou, M.3
Court, H.4
Ponce, O.5
Fiordalisi, J.J.6
-
28
-
-
0034790751
-
Calmodulin binds to K-Ras, but not to H-or N-Ras, and modulates its downstream signaling
-
Villalonga P, Lopez-Alcala C, Bosch M, Chiloeches A, Rocamora N, Gil J, et al. Calmodulin binds to K-Ras, but not to H-or N-Ras, and modulates its downstream signaling. Mol Cell Biol 2001;21:7345-54.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7345-7354
-
-
Villalonga, P.1
Lopez-Alcala, C.2
Bosch, M.3
Chiloeches, A.4
Rocamora, N.5
Gil, J.6
-
29
-
-
84878401236
-
Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling
-
Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, et al. Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling. Nature 2013;497:638-42.
-
(2013)
Nature
, vol.497
, pp. 638-642
-
-
Zimmermann, G.1
Papke, B.2
Ismail, S.3
Vartak, N.4
Chandra, A.5
Hoffmann, M.6
-
30
-
-
84907528772
-
Development of siRNA payloads to target KRAS-mutant cancer
-
Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, et al. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discov 2014;4:1182-97.
-
(2014)
Cancer Discov
, vol.4
, pp. 1182-1197
-
-
Yuan, T.L.1
Fellmann, C.2
Lee, C.S.3
Ritchie, C.D.4
Thapar, V.5
Lee, L.C.6
-
31
-
-
84906706945
-
Small RNA combination therapy for lung cancer
-
Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, et al. Small RNA combination therapy for lung cancer. Proc Natl Acad Sci U S A 2014;111: E3553-61.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. E3553-E3561
-
-
Xue, W.1
Dahlman, J.E.2
Tammela, T.3
Khan, O.F.4
Sood, S.5
Dave, A.6
-
32
-
-
84890824325
-
Mutant KRAS is a druggable target for pancreatic cancer
-
Zorde Khvalevsky E, Gabai R, Rachmut IH, Horwitz E, Brunschwig Z, Orbach A, et al. Mutant KRAS is a druggable target for pancreatic cancer. Proc Natl Acad Sci U S A 2013;110:20723-8.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 20723-20728
-
-
Zorde Khvalevsky, E.1
Gabai, R.2
Rachmut, I.H.3
Horwitz, E.4
Brunschwig, Z.5
Orbach, A.6
-
33
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014;371:2189-99.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
Yuan, J.4
Zaretsky, J.M.5
Desrichard, A.6
-
34
-
-
84904024982
-
KRAS and YAP1 converge to regulate EMT and tumor survival
-
Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell 2014;158:171-84.
-
(2014)
Cell
, vol.158
, pp. 171-184
-
-
Shao, D.D.1
Xue, W.2
Krall, E.B.3
Bhutkar, A.4
Piccioni, F.5
Wang, X.6
-
35
-
-
84903984143
-
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
-
Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 2014;158:185-97.
-
(2014)
Cell
, vol.158
, pp. 185-197
-
-
Kapoor, A.1
Yao, W.2
Ying, H.3
Hua, S.4
Liewen, A.5
Wang, Q.6
-
36
-
-
84923957819
-
The Hippo effector YAP promotes resistance to RAF-and MEK-targeted cancer therapies
-
Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, et al. The Hippo effector YAP promotes resistance to RAF-and MEK-targeted cancer therapies. Nat Genet 2015;47:250-6.
-
(2015)
Nat Genet
, vol.47
, pp. 250-256
-
-
Lin, L.1
Sabnis, A.J.2
Chan, E.3
Olivas, V.4
Cade, L.5
Pazarentzos, E.6
-
37
-
-
84872853570
-
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
-
Young A, Lou D, McCormick F. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov 2013;3:112-23.
-
(2013)
Cancer Discov
, vol.3
, pp. 112-123
-
-
Young, A.1
Lou, D.2
McCormick, F.3
-
38
-
-
63149194964
-
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
-
Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, et al. (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci U S A 2009;106:4519-24.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4519-4524
-
-
Pratilas, C.A.1
Taylor, B.S.2
Ye, Q.3
Viale, A.4
Sander, C.5
Solit, D.B.6
-
39
-
-
58349091262
-
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3- kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
-
Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3- kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res 2009;69:565-72.
-
(2009)
Cancer Res
, vol.69
, pp. 565-572
-
-
Mirzoeva, O.K.1
Das, D.2
Heiser, L.M.3
Bhattacharya, S.4
Siwak, D.5
Gendelman, R.6
-
40
-
-
84899513979
-
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
-
Nissan MH, Pratilas CA, Jones AM, Ramirez R, Won H, Liu C, et al. Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res 2014;74:2340-50.
-
(2014)
Cancer Res
, vol.74
, pp. 2340-2350
-
-
Nissan, M.H.1
Pratilas, C.A.2
Jones, A.M.3
Ramirez, R.4
Won, H.5
Liu, C.6
-
41
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence MS, Stojanov P, Mermel CH, Robinson JT, Garraway LA, Golub TR, et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 2014;505:495-501.
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
Robinson, J.T.4
Garraway, L.A.5
Golub, T.R.6
|