메뉴 건너뛰기




Volumn 26, Issue 6, 2014, Pages 608-614

Perspectives for immunotherapy in glioblastoma treatment

Author keywords

Chimeric antigen receptors; Dendritic cells; Glioblastoma; Immune checkpoints; Immunotherapy

Indexed keywords

BLINATUMOMAB; CANCER VACCINE; CARBOPLATIN; CHIMERIC ANTIGEN RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DACARBAZINE; DENDRITIC CELL VACCINE; EPHRIN A2; GAMMA INTERFERON; GLIOMA ASSOCIATED ANTIGEN; IMMUNOLOGIC AGENT; INTERLEUKIN 12; INTERLEUKIN 13 RECEPTOR ALPHA2; IPILIMUMAB; ISOCITRATE DEHYDROGENASE 1; NIMOTUZUMAB; NIVOLUMAB; PACLITAXEL; PEMBROLIZUMAB; PEPTIDE VACCINE; PROGRAMMED DEATH 1 LIGAND 1; RETROVIRUS VECTOR; RINDOPEPIMUT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SURVIVIN; TEMOZOLOMIDE; TRANSFORMING GROWTH FACTOR BETA; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 84927590905     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000135     Document Type: Review
Times cited : (28)

References (53)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84890814629 scopus 로고    scopus 로고
    • Breakthrough of the year 2013. Cancer immunotherapy
    • Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy. Science 2013; 342:1432-1433.
    • (2013) Science , vol.342 , pp. 1432-1433
    • Couzin-Frankel, J.1
  • 3
    • 84857793524 scopus 로고    scopus 로고
    • Decisions about dendritic cells: Past, present, and future
    • Steinman RM. Decisions about dendritic cells: past, present, and future. Annu Rev Immunol 2011. doi:10.1146/annurev-immunol-100311-102839.
    • (2011) Annu Rev Immunol
    • Steinman, R.M.1
  • 4
    • 84901405092 scopus 로고    scopus 로고
    • Clinical use of dendritic cells for cancer therapy
    • Anguille S, Smits EL, Lion E, et al. Clinical use of dendritic cells for cancer therapy. Lancet Oncol 2014; 15:e257-e267.
    • (2014) Lancet Oncol , vol.15 , pp. e257-e267
    • Anguille, S.1    Smits, E.L.2    Lion, E.3
  • 5
    • 84883554099 scopus 로고    scopus 로고
    • Active immunotherapy using dendritic cells in the treatment of glioblastoma multiforme
    • Bregy A, Wong TM, Shah AH, et al. Active immunotherapy using dendritic cells in the treatment of glioblastoma multiforme. Cancer Treat Rev 2013; 39:891-907.
    • (2013) Cancer Treat Rev , vol.39 , pp. 891-907
    • Bregy, A.1    Wong, T.M.2    Shah, A.H.3
  • 6
    • 84886943535 scopus 로고    scopus 로고
    • The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates
    • Pellegatta S, Eoli M, Frigerio S, et al. The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates. Oncoimmunology 2013; 2:e23401.
    • (2013) Oncoimmunology , vol.2 , pp. e23401
    • Pellegatta, S.1    Eoli, M.2    Frigerio, S.3
  • 7
    • 84899651334 scopus 로고    scopus 로고
    • Dendritic cell editing by natural killer cells
    • Ferlazzo G, Moretta L. Dendritic cell editing by natural killer cells. Crit Rev Oncog 2014; 19:67-75.
    • (2014) Crit Rev Oncog , vol.19 , pp. 67-75
    • Ferlazzo, G.1    Moretta, L.2
  • 8
    • 84873989551 scopus 로고    scopus 로고
    • Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients
    • Prins RM, Wang X, Soto H, et al. Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients. J Immunother 2013; 36:152-157.
    • (2013) J Immunother , vol.36 , pp. 152-157
    • Prins, R.M.1    Wang, X.2    Soto, H.3
  • 9
    • 84878194097 scopus 로고    scopus 로고
    • Autologous tumor lysate-pulsed dendritic cell immunotherapy for pediatric patients with newly diagnosed or recurrent high-grade gliomas
    • Lasky JL, Panosyan EH, Plant A, et al. Autologous tumor lysate-pulsed dendritic cell immunotherapy for pediatric patients with newly diagnosed or recurrent high-grade gliomas. Anticancer Res 2013; 33:2047-2056.
    • (2013) Anticancer Res , vol.33 , pp. 2047-2056
    • Lasky, J.L.1    Panosyan, E.H.2    Plant, A.3
  • 10
    • 84880948301 scopus 로고    scopus 로고
    • Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer
    • Najjar YG, Finke JH. Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer. Front Oncol 2013; 3:49.
    • (2013) Front Oncol , vol.3 , pp. 49
    • Najjar, Y.G.1    Finke, J.H.2
  • 11
    • 84875039618 scopus 로고    scopus 로고
    • Combining radiotherapy and cancer immunotherapy: A paradigm shift
    • Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 2013; 105:256-265.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 256-265
    • Formenti, S.C.1    Demaria, S.2
  • 12
    • 84890111958 scopus 로고    scopus 로고
    • Immune-based mechanisms of cytotoxic chemotherapy: Implications for the design of novel and rationalebased combined treatments against cancer
    • Bracci L, Schiavoni G, Sistigu A, Belardelli F. Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationalebased combined treatments against cancer. Cell Death Differ 2014; 21:15-25.
    • (2014) Cell Death Differ , vol.21 , pp. 15-25
    • Bracci, L.1    Schiavoni, G.2    Sistigu, A.3    Belardelli, F.4
  • 13
    • 84953357992 scopus 로고    scopus 로고
    • Association of increased progressionfree survival in primary glioblastomas with lymphopenia at baseline and activation of NK and NKT cells after dendritic cell immunotherapy
    • abstr 2087
    • Eoli M, Pellegatta S, Frigerio S, et al. Association of increased progressionfree survival in primary glioblastomas with lymphopenia at baseline and activation of NK and NKT cells after dendritic cell immunotherapy. In ASCO Annual Meeting. 2014. J Clin Oncol 2014; 32:. 5s (suppl; abstr 2087).
    • (2014) ASCO Annual Meeting. 2014. J Clin Oncol , vol.32 , pp. 5s
    • Eoli, M.1    Pellegatta, S.2    Frigerio, S.3
  • 14
    • 84870380385 scopus 로고    scopus 로고
    • Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma
    • Hunn MK, Farrand KJ, Broadley KWR, et al. Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma. Clin Cancer Res 2012; 18:6446-6459.
    • (2012) Clin Cancer Res , vol.18 , pp. 6446-6459
    • Hunn, M.K.1    Farrand, K.J.2    Broadley, K.W.R.3
  • 15
    • 84894107349 scopus 로고    scopus 로고
    • New insights into cancer immunoediting and its three component phases-elimination, equilibrium and escape
    • Mittal D, Gubin MM, Schreiber RD, Smyth MJ. New insights into cancer immunoediting and its three component phases-elimination, equilibrium and escape. Curr Opin Immunol 2014; 27:16-25.
    • (2014) Curr Opin Immunol , vol.27 , pp. 16-25
    • Mittal, D.1    Gubin, M.M.2    Schreiber, R.D.3    Smyth, M.J.4
  • 16
    • 33751297619 scopus 로고    scopus 로고
    • Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas
    • Pellegatta S, Poliani PL, Corno D, et al. Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas. Cancer Res 2006; 66:10247-10252.
    • (2006) Cancer Res , vol.66 , pp. 10247-10252
    • Pellegatta, S.1    Poliani, P.L.2    Corno, D.3
  • 17
    • 84883458285 scopus 로고    scopus 로고
    • Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
    • Vik-Mo EO, Nyakas M, Mikkelsen BV, et al. Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. Cancer Immunol Immunother 2013; 62:1499-1509.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1499-1509
    • Vik-Mo, E.O.1    Nyakas, M.2    Mikkelsen, B.V.3
  • 18
    • 84906316004 scopus 로고    scopus 로고
    • Towards efficient cancer immunotherapy: Advances in developing artificial antigen-presenting cells
    • Epub ahead of print
    • Eggermont LJ, Paulis LE, Tel J, Figdor CG. Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells. Trends Biotechnol 2014. [Epub ahead of print]
    • (2014) Trends Biotechnol
    • Eggermont, L.J.1    Paulis, L.E.2    Tel, J.3    Figdor, C.G.4
  • 19
    • 84879673266 scopus 로고    scopus 로고
    • Nanoengineering approaches to the design of artificial antigen-presenting cells
    • Sunshine JC, Green JJ. Nanoengineering approaches to the design of artificial antigen-presenting cells. Nanomedicine (Lond) 2013; 8:1173-1189.
    • (2013) Nanomedicine (Lond) , vol.8 , pp. 1173-1189
    • Sunshine, J.C.1    Green, J.J.2
  • 20
    • 84873204700 scopus 로고    scopus 로고
    • Rindopepimut: An evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma
    • Babu R, Adamson DC. Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma. Core Evid 2012; 7:93-103.
    • (2012) Core Evid , vol.7 , pp. 93-103
    • Babu, R.1    Adamson, D.C.2
  • 21
    • 84877273676 scopus 로고    scopus 로고
    • In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging
    • Zhong J, Sakaki M, Okada H, Ahrens ET. In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging. PLoS One 2013; 8:e59479.
    • (2013) PLoS One , vol.8 , pp. e59479
    • Zhong, J.1    Sakaki, M.2    Okada, H.3    Ahrens, E.T.4
  • 22
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cellengaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp MS, Kufer P, Gökbuget N, et al. Targeted therapy with the T-cellengaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011; 29:2493-2498.
    • (2011) J Clin Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gökbuget, N.3
  • 23
    • 84871965330 scopus 로고    scopus 로고
    • Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma
    • Choi BD, Kuan C-T, Cai M, et al. Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proc Natl Acad Sci U S A 2013; 110:270-275.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 270-275
    • Choi, B.D.1    Kuan, C.-T.2    Cai, M.3
  • 24
    • 84905817445 scopus 로고    scopus 로고
    • Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas
    • Pollack IF, Jakacki RI, Butterfield LH, et al. Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas. J Clin Oncol 2014; 32:2050-2058.
    • (2014) J Clin Oncol , vol.32 , pp. 2050-2058
    • Pollack, I.F.1    Jakacki, R.I.2    Butterfield, L.H.3
  • 25
    • 84922722281 scopus 로고    scopus 로고
    • Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria
    • Epub ahead of print
    • Jansen MH, Veldhuijzen van Zanten SE, Sanchez Aliaga E, et al. Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Neuro Oncol 2014. [Epub ahead of print]
    • (2014) Neuro Oncol
    • Jansen, M.H.1    Van Veldhuijzen Zanten, S.E.2    Sanchez Aliaga, E.3
  • 26
    • 84930980137 scopus 로고    scopus 로고
    • Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma
    • Epub ahead of print
    • Bartels U, Wolff J, Gore L, et al. Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma. Neuro Oncol 2014. [Epub ahead of print]
    • (2014) Neuro Oncol
    • Bartels, U.1    Wolff, J.2    Gore, L.3
  • 27
    • 84886945017 scopus 로고    scopus 로고
    • Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity
    • Cantini G, Pisati F, Pessina S, et al. Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity. Oncoimmunology 2012; 1:884-893.
    • (2012) Oncoimmunology , vol.1 , pp. 884-893
    • Cantini, G.1    Pisati, F.2    Pessina, S.3
  • 28
    • 84896514133 scopus 로고    scopus 로고
    • Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma
    • Favaro R, Appolloni I, Pellegatta S, et al. Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma. Cancer Res 2014; 74:1833-1844.
    • (2014) Cancer Res , vol.74 , pp. 1833-1844
    • Favaro, R.1    Appolloni, I.2    Pellegatta, S.3
  • 29
    • 84900406316 scopus 로고    scopus 로고
    • Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation
    • Berezovsky AD, Poisson LM, Cherba D, et al. Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation. Neoplasia 2014; 16:193.e25-206.e25.
    • (2014) Neoplasia , vol.16 , pp. 193e25-206e25
    • Berezovsky, A.D.1    Poisson, L.M.2    Cherba, D.3
  • 30
    • 84904246245 scopus 로고    scopus 로고
    • SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
    • Boumahdi S, Driessens G, Lapouge G, et al. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 2014; 511:246-250.
    • (2014) Nature , vol.511 , pp. 246-250
    • Boumahdi, S.1    Driessens, G.2    Lapouge, G.3
  • 31
    • 84906557615 scopus 로고    scopus 로고
    • A vaccine targeting mutant IDH1 induces antitumour immunity
    • Schumacher T, Bunse L, Pusch S, et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 2014; 512:324-327.
    • (2014) Nature , vol.512 , pp. 324-327
    • Schumacher, T.1    Bunse, L.2    Pusch, S.3
  • 32
    • 84867562009 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectives
    • Yang H, Ye D, Guan K-L, Xiong Y. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res 2012; 18:5562-5571.
    • (2012) Clin Cancer Res , vol.18 , pp. 5562-5571
    • Yang, H.1    Ye, D.2    Guan, K.-L.3    Xiong, Y.4
  • 33
    • 9244231204 scopus 로고    scopus 로고
    • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class IIknockout mice
    • Pajot A, Michel M-L, Fazilleau N, et al. A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class IIknockout mice. Eur J Immunol 2004; 34:3060-3069.
    • (2004) Eur J Immunol , vol.34 , pp. 3060-3069
    • Pajot, A.1    Michel, M.-L.2    Fazilleau, N.3
  • 34
    • 84877669593 scopus 로고    scopus 로고
    • Rivière I: The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R. Rivière I: the basic principles of chimeric antigen receptor design. Cancer Discov 2013; 3:388-398.
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2
  • 35
    • 84894459822 scopus 로고    scopus 로고
    • Diverse solid tumors expressing a restricted epitope of L1-CAM can be targeted by chimeric antigen receptor redirected T lymphocytes
    • Hong H, Stastny M, Brown C, et al. Diverse solid tumors expressing a restricted epitope of L1-CAM can be targeted by chimeric antigen receptor redirected T lymphocytes. J Immunother 2014; 37:93-104.
    • (2014) J Immunother , vol.37 , pp. 93-104
    • Hong, H.1    Stastny, M.2    Brown, C.3
  • 36
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013; 368:1509-1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 37
    • 84896734231 scopus 로고    scopus 로고
    • EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss
    • Sampson JH, Choi BD, Sanchez-Perez L, et al. EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res 2014; 20:972-984.
    • (2014) Clin Cancer Res , vol.20 , pp. 972-984
    • Sampson, J.H.1    Choi, B.D.2    Sanchez-Perez, L.3
  • 38
    • 84890559796 scopus 로고    scopus 로고
    • Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma
    • Choi BD, Suryadevara CM, Gedeon PC, et al. Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. J Clin Neurosci 2014; 21:189-190.
    • (2014) J Clin Neurosci , vol.21 , pp. 189-190
    • Choi, B.D.1    Suryadevara, C.M.2    Gedeon, P.C.3
  • 39
    • 84880656055 scopus 로고    scopus 로고
    • Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
    • Tran E, Chinnasamy D, Yu Z, et al. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J Exp Med 2013; 210:1125-1135.
    • (2013) J Exp Med , vol.210 , pp. 1125-1135
    • Tran, E.1    Chinnasamy, D.2    Yu, Z.3
  • 40
    • 84881322406 scopus 로고    scopus 로고
    • The weal and woe of costimulation in the adoptive therapy of cancer with chimeric antigen receptor (CAR)-redirected T cells
    • Hombach AA, Holzinger A, Abken H. The weal and woe of costimulation in the adoptive therapy of cancer with chimeric antigen receptor (CAR)-redirected T cells. Curr Mol Med 2013; 13:1079-1088.
    • (2013) Curr Mol Med , vol.13 , pp. 1079-1088
    • Hombach, A.A.1    Holzinger, A.2    Abken, H.3
  • 41
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 42
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995; 270:985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 43
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'day, S.J.2    McDermott, D.F.3
  • 44
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011; 364:2517-2526.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 45
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV nonsmall-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV nonsmall-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 2012; 30:2046-2054.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 46
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013; 24:75-83.
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 47
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 2009; 15:7412-7420.
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'day, S.3
  • 48
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013; 369:122-133.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 49
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014; 32:1020-1030.
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 50
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369:134-144.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 51
    • 84890846323 scopus 로고    scopus 로고
    • Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection
    • Vom Berg J, Vrohlings M, Haller S, et al. Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection. J Exp Med 2013; 210:2803-2811.
    • (2013) J Exp Med , vol.210 , pp. 2803-2811
    • Vom Berg, J.1    Vrohlings, M.2    Haller, S.3
  • 52
    • 84904061991 scopus 로고    scopus 로고
    • Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4 and PD-L1 in mice with brain tumors
    • Epub ahead of print
    • Wainwright DA, Chang AL, Dey M, et al. Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4 and PD-L1 in mice with brain tumors. Clin Cancer Res 2014. [Epub ahead of print]
    • (2014) Clin Cancer Res
    • Wainwright, D.A.1    Chang, A.L.2    Dey, M.3
  • 53
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • Zeng J, See AP, Phallen J, et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 2013; 86:343-349.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.