Effects of crocetin on VCAM-1 expression in human umbilical vein endothelial cells and monocyte-endothelial cell adhesion

Yaoxue Xuebao

Volumn 50, Issue 1, 2015, Pages 34-38

  Zheng, Shu Guo ^a   Zhao, Meng Qiu ^a   Ren, You Nan ^a   Yang, Jie Ren ^a   Qian, Zhi Yu ^b  

^a Rising Star Group Warman Medical College   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antioxidant; Atherosclerosis; Crocetin; Human umbilical vein endothelial cell; Vascular cell adhesion molecule 1

Indexed keywords

ANGIOTENSIN II; CROCETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; VASCULAR CELL ADHESION MOLECULE 1; ANTIOXIDANT; CAROTENOID;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ADHESION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MONOCYTE; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; CYTOLOGY; DRUG EFFECTS; METABOLISM;

ANGIOTENSIN II; ANTIOXIDANTS; CAROTENOIDS; CELL ADHESION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MONOCYTES; NF-KAPPA B; REACTIVE OXYGEN SPECIES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84927587353     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Jaipersad AS, Lip GYH, Silverman S, et al The role of monocytes in angiogenesis and atherosclerosis [J]. J Am Coll Cardiol, 2014, 63: 1-11.
2. Blankenberg S, Barbaux S, Tiret L. Adhesion molecules and atherosclerosis [J]. Atherosclerosis, 2003, 170: 191-203.
3. Gai YT, Shu Q, Chen C.X., et al. Anti-atherosclerosis role of N-oleoylethanolamine in CB2 [J]. Acta Pharm Sin, 2014, 49: 316-321.
4. Park JG, Ryu SY, Jung I.H., et al. Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipo-protein E-deficient mice [J]. Atherosclerosis, 2013, 226: 356-363.
5. Zheng SG, Qian ZY, Tang F.T., et al. Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits [J]. Biochem Pharmacol, 2005, 70: 1192-1199.
6. Li DY, Mehta JL Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells [J]. Circulation, 2000, 101:2889-2895.
7. Libby P. Inflammation in atherosclerosis [J]. Nature, 2002, 420: 868-874.
8. Pacurari M, Kafoury R, Tchounwou P.B., et al. The renin-angiotensin-aldosterone system in vascular inflammation and remodeling [J]. Int J Inflam, 2014, doi: 10.1155/2014/689360.
9. Zheng SG, Qian ZY, Sheng L, et al Crocetin attenuates atherosclerosis in hyperlipidemic rabbits through inhibition of LDL oxidation [J]. J Cardiovasc Pharmacol, 2006, 47: 70-76.
10. Zhu YP, Shen T, Lin Y.J., et al. Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation [J]. Acta Pharmacol Sin, 2013, 34: 1036-1042.
11. Pateras I, Giaginis C, Tsigris C., et al. NF-κB at the crossroads of inflammation and atherosclerosis: searching for new therapeutic links [J]. Expert Opin Ther Targets, 2014, 8: 1-13.
12. Van der Heiden K, Cuhlmann S, Luongle A, et al. Role of nuclear factor KB in cardiovascular health and disease [J]. Clin Sci, 2010, 118:593-605.
13. Liang CJ, Wang SH, Chen Y.H., et al. Viscolin reduces VCAM-1 expression in TNF-a-treated endothelial cells via the JNK/NF-ΚB and ROS pathway [J]. Free Radic Biol Med, 2011, 51:1337-1346.
14. Zheng SG, Qian ZY, Wen N, et al Crocetin suppresses angiotensin II-induced vascular smooth-muscle cell proliferation through inhibition of ERK1/2 activation and cell-cycle progression [J]. J Cardiovasc Pharmacol, 2007, 50: 519-525.