Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice

Atherosclerosis

Volumn 226, Issue 2, 2013, Pages 356-363

  Park, Jong Gil ^a,b   Ryu, Su Yeon ^c   Jung, In Hyuk ^a,b   Lee, You Han ^a,b   Kang, Kyung Jae ^a,c   Lee, Mi Ran ^a   Lee, Mi Ni ^a   Sonn, Seong Keun ^a   Lee, Jeong Hwa ^a   Lee, Hang ^b   Oh, Goo Taeg ^a   Moon, Kyungduk ^c   Shim, Hyunbo ^a  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

^c Iljin Nanotech Co Ltd   (South Korea)

Author keywords

Antibody; Atherosclerosis; Inflammation; Plaque stability; Vascular cell adhesion molecule 1

Indexed keywords

ANTIBODY 7H; ANTIBODY H6; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; APOLIPOPROTEIN E; CD45 ANTIGEN; GELATINASE B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BINDING AFFINITY; CELL ADHESION; CELL INFILTRATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATORY CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL ADHESION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; MALE; MICE; PLAQUE, ATHEROSCLEROTIC; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84872385647     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.11.029     Document Type: Article

References (25)

1. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105:1135-1143.
2. Nageh M.F., Sandberg E.T., Marotti K.R., et al. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler Thromb Vasc Biol 1997, 17:1517-1520.
3. Dong Z.M., Brown A.A., Wagner D.D. Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice. Circulation 2000, 101:2290-2295.
4. Collins R.G., Velji R., Guevara N.V., et al. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 2000, 191:189-194.
5. Cybulsky M.I., Iiyama K., Li H., et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001, 107:1255-1262.
6. Ramos C.L., Huo Y., Jung U., et al. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 1999, 84:1237-1244.
7. Patel S.S., Thiagarajan R., Willerson J.T., et al. Inhibition of alpha4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice. Circulation 1998, 97:75-81.
8. Huo Y., Hafezi-Moghadam A., Ley K. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ Res 2000, 87:153-159.
9. Nakashima Y., Raines E.W., Plump A.S., et al. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol 1998, 18:842-851.
10. Iiyama K., Hajra L., Iiyama M., et al. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 1999, 85:199-207.
11. Tsai P.J., Chen Y.H., Hsueh C.H., et al. Streptococcus pyogenes induces epithelial inflammatory responses through NF-kappaB/MAPK signaling pathways. Microbes Infect 2006, 8:1440-1449.
12. Yang Y.Y., Hu C.J., Chang S.M., et al. Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells. Atherosclerosis 2004, 174:207-213.
13. Wittchen E.S. Endothelial signaling in paracellular and transcellular leukocyte transmigration. Front Biosci 2009, 14:2522-2545.
14. Charo I.F., Taubman M.B. Chemokines in the pathogenesis of vascular disease. Circ Res 2004, 95:858-866.
15. Loftus I.M., Naylor A.R., Goodall S., et al. Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption. Stroke 2000, 31:40-47.
16. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
17. Charo I.F., Taub R. Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat Rev Drug Discov 2011, 10:365-376.
18. Ulbrich H., Eriksson E.E., Lindbom L. Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol Sci 2003, 24:640-647.
19. Huo Y., Ley K. Adhesion molecules and atherogenesis. Acta Physiol Scand 2001, 173:35-43.
20. Lutters B.C., Leeuwenburgh M.A., Appeldoorn C.C., et al. Blocking endothelial adhesion molecules: a potential therapeutic strategy to combat atherogenesis. Curr Opin Lipidol 2004, 15:545-552.
21. Bedard P.W., Kaila N. Selectin inhibitors: a patent review. Expert Opin Ther Pat 2010, 20:781-793.
22. Cox D., Brennan M., Moran N. Integrins as therapeutic targets: lessons and opportunities. Nat Rev Drug Discov 2010, 9:804-820.
23. Oguchi S., Dimayuga P., Zhu J., et al. Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 2000, 20:1729-1736.
24. Li X., Johnson K.R., Bryant M., et al. Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice. PLoS One 2011, 6:e20620.
25. Cesena F.H., Dimayuga P.C., Yano J., et al. Immune-modulation by polyclonal IgM treatment reduces atherosclerosis in hypercholesterolemic apoE-/- mice. Atherosclerosis 2012, 220:59-65.