Effect of hydroxy safflower yellow A on myocardial apoptosis after acute myocardial infarction in rats

Genetics and Molecular Research

Volumn 14, Issue 2, 2015, Pages 3133-3141

  Zhou, M X ^a   Fu, J H ^b   Zhang, Q ^b   Wang, J Q ^c  

^a BEIJING HOSPITAL OF TRADITIONAL CHINESE MEDICINE AFFILIATED TO CAPITAL MEDICAL UNIVERSITY   (China)

^b XIYUAN HOSPITAL   (China)

^c Taiyuan Hua Wei Pharmaceutical Co Ltd   (China)

Author keywords

Acute myocardial infarction; Hydroxy safflower yellow A; Myocardial apoptosis; Peroxisome proliferator activated receptor

Indexed keywords

HYDROXY SAFFLOWER YELLOW A; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; SAFFLOWER YELLOW; UNCLASSIFIED DRUG; CHALCONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; ELECTROCARDIOGRAM; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART RATE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LOW DRUG DOSE; NONHUMAN; PROTEIN EXPRESSION; RAT; ST SEGMENT ELEVATION; ANALOGS AND DERIVATIVES; ANIMAL; CARDIAC MUSCLE; DRUG EFFECTS; ELECTROCARDIOGRAPHY; GENE EXPRESSION; GENETICS; HEART; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

CARTHAMUS TINCTORIUS; RATTUS; RATTUS NORVEGICUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CHALCONE; ELECTROCARDIOGRAPHY; GENE EXPRESSION; HEART; IMMUNOHISTOCHEMISTRY; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84927536874     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2015.April.10.24     Document Type: Article

References (17)

1. Collino M, Patel NS, Lawrence KM, Collin M, et al. (2005). The selective PPARγ antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int. 68: 529-536.
2. Ferdinandy P, Schulz R and Baxter GF (2007). Interaction of cardiovascular risk factors with myocardial ischemia/ reperfusion injury, preconditioning, and postconditioning. Pharmacol. Rev. 59: 418-458.
3. Fu JH, Zhang Q, Fan CZ and Liu JG (2011). Protective effect of intravenous infusion injection of safflor yellow and hydroxyl safflor yellow A on acute myocardial ischemia injury in rats. Int. J. Trad. Chin. Med. 33: 692-694.
4. Ho YL, Chen CL, Hsu RB, Lin LC, et al. (2003). The correlation between expression of apoptosis-related proteins and myocardial functional reserve evaluated by dobutamine stress echocardiography in patients with dilated cardiomyopathy. J. Am. Soc. Echocardiogr. 16: 931-936.
5. Ji DB, Zhu MC, Zhu B, Zhu YZ, et al. (2008). Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax. J. Cardiovasc. Pharmacol. 52: 191-202.
6. Jin HJ, Xie XL, Ye JM and Li CG (2013). TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells. PLoS One 8: e51720.
7. Letavernier E, Perez J, Joye E, Bellocq A, et al. (2005). Peroxisome proliferator-activated receptor β/δ exerts a strong protection from ischemic acute renal failure. J. Am. Soc. Nephrol. 16: 2395-2402.
8. Li MY, Deng H, Zhao JM, Dai D, et al. (2003). PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells. World J. Gastroenterol. 9: 1220-1226.
9. Liu Y, Zhu ZA, Zhang SN, Mou J, et al. (2013). Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro. Tumour Biol. 34: 2409-2418.
10. Liu YN, Zhou ZM and Chen P (2008). Evidence that hydroxysafflor yellow A protects the heart against ischaemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Clin. Exp. Pharmacol. Physiol. 35: 211-216.
11. Mo X, Zhao N, Du X, Bai L, et al. (2011). The protective effect of peony extract on acute myocardial infarction in rats. Phytomedicine 18: 451-457.
12. Prince PS, Dhanasekar K and Rajakumar S (2011). Preventive effects of vanillic acid on lipids, bax, bcl-2 and myocardial infarct size on isoproterenol-induced myocardial infarcted rats: a biochemical and in vitro study. Cardiovasc. Toxicol. 11: 58-66.
13. Sivarajah A, Chatterjee PK, Patel NS, Todorovic Z, et al. (2003). Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am. J. Nephrol. 23: 267-276.
14. Tan XW, Xia H, Xu JH and Cao JG (2009). Induction of apoptosis in human liver carcinoma HepG2 cell line by 5-allyl-7-gen-difluoromethylenechrysin. World J. Gastroenterol. 15: 2234-2239.
15. Wann BP, Boucher M, Kaloustian S, Nim S, et al. (2006). Apoptosis detected in the amygdala following myocardial infarction in the rat. Biol. Psychiatry 59: 430-433.
16. Zhu H, Wang Z, Ma C, Tian J, et al. (2003). Neuroprotective effects of hydroxysafflor yellow A: in vivo and in vitro studies. Planta Med. 69: 429-433.
17. Zhu HB, Wang ZH, Tian JW, Fu FH, et al. (2005). Protective effect of hydroxysafflor yellow A on experimental cerebral ischemia in rats. Yao Xue Xue Bao 40: 1144-1146.