-
1
-
-
69549083525
-
Promising molecular targets in ovarian cancer
-
Blagden S, Gabra H. Promising molecular targets in ovarian cancer. Curr Opin Oncol. 2009;21: 412-419.
-
(2009)
Curr Opin Oncol
, vol.21
, pp. 412-419
-
-
Blagden, S.1
Gabra, H.2
-
2
-
-
79956068932
-
New emerging drugs targeting the genomic integrity and replication machinery in ovarian cancer
-
Brüning A, Mylonas I. New emerging drugs targeting the genomic integrity and replication machinery in ovarian cancer. Arch Gynecol Obstet. 2011;283: 1087-1096.
-
(2011)
Arch Gynecol Obstet
, vol.283
, pp. 1087-1096
-
-
Brüning, A.1
Mylonas, I.2
-
4
-
-
84856055845
-
Recycling side-effects into clinical markers for drug repositioning
-
Duran-Frigola M, Aloy P. Recycling side-effects into clinical markers for drug repositioning. Genome Med. 2012;4: 3.
-
(2012)
Genome Med
, vol.4
, pp. 3
-
-
Duran-Frigola, M.1
Aloy, P.2
-
5
-
-
84858978535
-
Drug repositioning for personalized medicine
-
Li YY, Jones SJ. Drug repositioning for personalized medicine. Genome Med. 2012;4: 27.
-
(2012)
Genome Med
, vol.4
, pp. 27
-
-
Li, Y.Y.1
Jones, S.J.2
-
6
-
-
84871926181
-
Drug repurposing in pediatrics and pediatric hematology oncology
-
Blatt J, Corey SJ. Drug repurposing in pediatrics and pediatric hematology oncology. Drug Discov Today. 2013;18: 4-10.
-
(2013)
Drug Discov Today
, vol.18
, pp. 4-10
-
-
Blatt, J.1
Corey, S.J.2
-
7
-
-
84886953565
-
Phenotypic screens as a renewed approach for drug discovery
-
Zheng W, Thorne N, McKew JC. Phenotypic screens as a renewed approach for drug discovery. Drug Discov Today. 2013; doi: 10.1016/j.drudis.2013.07.001.
-
(2013)
Drug Discov Today
-
-
Zheng, W.1
Thorne, N.2
McKew, J.C.3
-
8
-
-
79951688311
-
Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome
-
Cvek B. Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome. Curr Cancer Drug Targets. 2011;11: 332-337.
-
(2011)
Curr Cancer Drug Targets
, vol.11
, pp. 332-337
-
-
Cvek, B.1
-
9
-
-
84879165730
-
A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
-
Kast RE, Boockvar JA, Brüning A, Cappello F, Chang WW, Cvek B, Dou QP, Duenas-Gonzalez A, Efferth T, Focosi D, Ghaffari SH, Karpel-Massler G, Ketola K, Khoshnevisan A, Keizman D, Magné N, Marosi C, McDonald K, Muñoz M, Paranjpe A, Pourgholami MH, Sardi I, Sella A, Srivenugopal KS, Tuccori M, Wang W, Wirtz CR, Halatsch ME. A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget. 2013;4: 502-530.
-
(2013)
Oncotarget
, vol.4
, pp. 502-530
-
-
Kast, R.E.1
Boockvar, J.A.2
Brüning, A.3
Cappello, F.4
Chang, W.W.5
Cvek, B.6
Dou, Q.P.7
Duenas-Gonzalez, A.8
Efferth, T.9
Focosi, D.10
Ghaffari, S.H.11
Karpel-Massler, G.12
Ketola, K.13
Khoshnevisan, A.14
Keizman, D.15
Magné, N.16
Marosi, C.17
McDonald, K.18
Muñoz, M.19
Paranjpe, A.20
Pourgholami, M.H.21
Sardi, I.22
Sella, A.23
Srivenugopal, K.S.24
Tuccori, M.25
Wang, W.26
Wirtz, C.R.27
Halatsch, M.E.28
more..
-
11
-
-
0037113878
-
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
-
Inoshita S, Takeda K, Hatai T, Terada Y, Sano M, Hata J, Umezawa A, Ichijo H. Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress. J Biol Chem. 2002;277(46): 43730-43734.
-
(2002)
J Biol Chem
, vol.277
, Issue.46
, pp. 43730-43734
-
-
Inoshita, S.1
Takeda, K.2
Hatai, T.3
Terada, Y.4
Sano, M.5
Hata, J.6
Umezawa, A.7
Ichijo, H.8
-
12
-
-
84872358363
-
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
-
Ciocca DR, Arrigo AP, Calderwood SK. Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol. 2013;87: 19-48.
-
(2013)
Arch Toxicol
, vol.87
, pp. 19-48
-
-
Ciocca, D.R.1
Arrigo, A.P.2
Calderwood, S.K.3
-
13
-
-
70350474677
-
Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
-
Kostenko S, Moens U. Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology. Cell Mol Life Sci. 2009;66: 3289-3307.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 3289-3307
-
-
Kostenko, S.1
Moens, U.2
-
14
-
-
84864488251
-
Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity?
-
Wettstein G, Bellaye PS, Micheau O, Bonniaud P. Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity? Int J Biochem Cell Biol. 2012;44: 1680-1686.
-
(2012)
Int J Biochem Cell Biol
, vol.44
, pp. 1680-1686
-
-
Wettstein, G.1
Bellaye, P.S.2
Micheau, O.3
Bonniaud, P.4
-
15
-
-
33751285781
-
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
-
Nov 1
-
Chen D, Cui QC, Yang H, Dou QP. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res. 2006 Nov 1;66: 10425-10433.
-
(2006)
Cancer Res
, vol.66
, pp. 10425-10433
-
-
Chen, D.1
Cui, Q.C.2
Yang, H.3
Dou, Q.P.4
-
16
-
-
79955805229
-
Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
-
Yip NC, Fombon IS, Liu P, Brown S, Kannappan V, Armesilla AL, Xu B, Cassidy J, Darling JL, Wang W. Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br J Cancer. 2011;104: 1564-1574.
-
(2011)
Br J Cancer
, vol.104
, pp. 1564-1574
-
-
Yip, N.C.1
Fombon, I.S.2
Liu, P.3
Brown, S.4
Kannappan, V.5
Armesilla, A.L.6
Xu, B.7
Cassidy, J.8
Darling, J.L.9
Wang, W.10
-
17
-
-
24644441050
-
The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy
-
Biaglow JE, Miller RA. The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy. Cancer Biol Ther. 2005;4: 6-13.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 6-13
-
-
Biaglow, J.E.1
Miller, R.A.2
-
18
-
-
4644235752
-
Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
-
Brar SS, Grigg C, Wilson KS, Holder WD Jr, Dreau D, Austin C, Foster M, Ghio AJ, Whorton AR, Stowell GW, Whittall LB, Whittle RR, White DP, Kennedy TP. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol Cancer Ther. 2004;3: 1049-1060.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1049-1060
-
-
Brar, S.S.1
Grigg, C.2
Wilson, K.S.3
Holder, W.D.4
Dreau, D.5
Austin, C.6
Foster, M.7
Ghio, A.J.8
Whorton, A.R.9
Stowell, G.W.10
Whittall, L.B.11
Whittle, R.R.12
White, D.P.13
Kennedy, T.P.14
-
19
-
-
0036050582
-
Disulfiram induces apoptosis in human melanoma cells: a redox-related process
-
Cen D, Gonzalez RI, Buckmeier JA, Kahlon RS, Tohidian NB, Meyskens FL Jr. Disulfiram induces apoptosis in human melanoma cells: a redox-related process. Mol Cancer Ther. 2002;1: 197-204.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 197-204
-
-
Cen, D.1
Gonzalez, R.I.2
Buckmeier, J.A.3
Kahlon, R.S.4
Tohidian, N.B.5
Meyskens, F.L.6
-
20
-
-
11144224746
-
Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells
-
Cen D, Brayton D, Shahandeh B, Meyskens FL Jr, Farmer PJ. Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J Med Chem. 2004;47: 6914-6920.
-
(2004)
J Med Chem
, vol.47
, pp. 6914-6920
-
-
Cen, D.1
Brayton, D.2
Shahandeh, B.3
Meyskens, F.L.4
Farmer, P.J.5
-
21
-
-
77249117637
-
Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
-
Guo X, Xu B, Pandey S, Goessl E, Brown J, Armesilla AL, Darling JL, Wang W. Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines. Cancer Lett. 2010;290: 104-113.
-
(2010)
Cancer Lett
, vol.290
, pp. 104-113
-
-
Guo, X.1
Xu, B.2
Pandey, S.3
Goessl, E.4
Brown, J.5
Armesilla, A.L.6
Darling, J.L.7
Wang, W.8
-
22
-
-
84867897977
-
Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancerstem-like cells
-
Liu P, Brown S, Goktug T, Channathodiyil P, Kannappan V, Hugnot JP, Guichet PO, Bian X, Armesilla AL, Darling JL, Wang W. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancerstem-like cells. Br J Cancer. 2012;107: 1488-1497.
-
(2012)
Br J Cancer
, vol.107
, pp. 1488-1497
-
-
Liu, P.1
Brown, S.2
Goktug, T.3
Channathodiyil, P.4
Kannappan, V.5
Hugnot, J.P.6
Guichet, P.O.7
Bian, X.8
Armesilla, A.L.9
Darling, J.L.10
Wang, W.11
-
23
-
-
33845304732
-
Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients
-
Wickström M, Danielsson K, Rickardson L, Gullbo J, Nygren P, Isaksson A, Larsson R, Lövborg H. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol. 2007;73: 25-33.
-
(2007)
Biochem Pharmacol
, vol.73
, pp. 25-33
-
-
Wickström, M.1
Danielsson, K.2
Rickardson, L.3
Gullbo, J.4
Nygren, P.5
Isaksson, A.6
Larsson, R.7
Lövborg, H.8
-
24
-
-
45849148082
-
New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer
-
Chen D, Dou QP. New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer. Expert Opin Ther Targets. 2008;12: 739-748.
-
(2008)
Expert Opin Ther Targets
, vol.12
, pp. 739-748
-
-
Chen, D.1
Dou, Q.P.2
-
25
-
-
84878660014
-
The role of copper in disulfiram-induced toxicity and radiosensitization of cancer cells
-
Rae C, Tesson M, Babich JW, Boyd M, Sorensen A, Mairs RJ. The role of copper in disulfiram-induced toxicity and radiosensitization of cancer cells. J Nucl Med. 2013;54: 953-960.
-
(2013)
J Nucl Med
, vol.54
, pp. 953-960
-
-
Rae, C.1
Tesson, M.2
Babich, J.W.3
Boyd, M.4
Sorensen, A.5
Mairs, R.J.6
-
26
-
-
33644549964
-
Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram
-
Lövborg H, Oberg F, Rickardson L, Gullbo J, Nygren P, Larsson R. Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram Int J Cancer. 2006;118: 1577-1580.
-
(2006)
Int J Cancer
, vol.118
, pp. 1577-1580
-
-
Lövborg, H.1
Oberg, F.2
Rickardson, L.3
Gullbo, J.4
Nygren, P.5
Larsson, R.6
-
27
-
-
0031825806
-
Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species
-
Burkitt MJ, Bishop HS, Milne L, Tsang SY, Provan GJ, Nobel CS, Orrenius S, Slater AF. Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species. Arch Biochem Biophys. 1998;353: 73-84.
-
(1998)
Arch Biochem Biophys
, vol.353
, pp. 73-84
-
-
Burkitt, M.J.1
Bishop, H.S.2
Milne, L.3
Tsang, S.Y.4
Provan, G.J.5
Nobel, C.S.6
Orrenius, S.7
Slater, A.F.8
-
28
-
-
0026439016
-
A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites
-
Johansson B. A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr Scand Suppl. 1992;369: 15-26.
-
(1992)
Acta Psychiatr Scand Suppl
, vol.369
, pp. 15-26
-
-
Johansson, B.1
-
29
-
-
0029585809
-
How to get the best out of antabuse
-
Kristenson H. How to get the best out of antabuse. Alcohol Alcohol. 1995;30: 775-783.
-
(1995)
Alcohol Alcohol
, vol.30
, pp. 775-783
-
-
Kristenson, H.1
-
30
-
-
84866466140
-
Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells
-
Skrott Z, Cvek B. Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells. Mini Rev Med Chem. 2012;12: 1184-1192.
-
(2012)
Mini Rev Med Chem
, vol.12
, pp. 1184-1192
-
-
Skrott, Z.1
Cvek, B.2
-
31
-
-
0030854374
-
Carbamoylation of brain glutamate receptors by a disulfiram metabolite
-
Sep 26
-
Nagendra SN, Faiman MD, Davis K, Wu JY, Newby X, Schloss JV. Carbamoylation of brain glutamate receptors by a disulfiram metabolite. J Biol Chem. 1997 Sep 26;272(39): 24247-51.
-
(1997)
J Biol Chem
, vol.272
, Issue.39
, pp. 24247-24251
-
-
Nagendra, S.N.1
Faiman, M.D.2
Davis, K.3
Wu, J.Y.4
Newby, X.5
Schloss, J.V.6
-
32
-
-
84877117741
-
Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiolconjugating and-nitrosylating drugs in human tumor cells
-
Paranjpe A, Srivenugopal KS. Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiolconjugating and-nitrosylating drugs in human tumor cells. Carcinogenesis. 2013;34: 990-1000.
-
(2013)
Carcinogenesis
, vol.34
, pp. 990-1000
-
-
Paranjpe, A.1
Srivenugopal, K.S.2
-
33
-
-
0035969887
-
Overview-in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites
-
Lipsky JJ, Shen ML, Naylor S. Overview-in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites. Chem Biol Interact. 2001;130-132(1-3): 81-91.
-
(2001)
Chem Biol Interact
, vol.130-132
, Issue.1-3
, pp. 81-91
-
-
Lipsky, J.J.1
Shen, M.L.2
Naylor, S.3
-
34
-
-
19244365393
-
Stress, protein (mis)folding, and signaling: the redox connection
-
Sitia R, Molteni SN. Stress, protein (mis)folding, and signaling: the redox connection. Sci STKE. 2004;239: pe27.
-
(2004)
Sci STKE
, vol.239
-
-
Sitia, R.1
Molteni, S.N.2
-
35
-
-
84876917760
-
Thioredoxins, Glutaredoxins, and Peroxiredoxins-Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling
-
Mar 28
-
Hanschmann EM, Godoy JR, Berndt C, Hudemann C, Lillig CH. Thioredoxins, Glutaredoxins, and Peroxiredoxins-Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling. Antioxid Redox Signal. 2013; Mar 28.
-
(2013)
Antioxid Redox Signal
-
-
Hanschmann, E.M.1
Godoy, J.R.2
Berndt, C.3
Hudemann, C.4
Lillig, C.H.5
-
36
-
-
0035114701
-
Adenoviral transduction efficiency of ovarian cancer cells can be limited by loss of integrin beta3 subunit expression and increased by reconstitution of integrin alphavbeta3
-
Brüning A, Köhler T, Quist S, Wang-Gohrke S, Moebus VJ, Kreienberg R, Runnebaum IB. Adenoviral transduction efficiency of ovarian cancer cells can be limited by loss of integrin beta3 subunit expression and increased by reconstitution of integrin alphavbeta3. Hum Gene Ther. 2001;12: 391-399.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 391-399
-
-
Brüning, A.1
Köhler, T.2
Quist, S.3
Wang-Gohrke, S.4
Moebus, V.J.5
Kreienberg, R.6
Runnebaum, I.B.7
-
37
-
-
79951624230
-
Analysis of nelfinavir-induced endoplasmic reticulum stress
-
Brüning A. Analysis of nelfinavir-induced endoplasmic reticulum stress. Methods Enzymol. 2011;491: 127-142.
-
(2011)
Methods Enzymol
, vol.491
, pp. 127-142
-
-
Brüning, A.1
|