The risk of polyomavirus BK-associated hemorrhagic cystitis after allogeneic hematopoietic SCT is associated with myeloablative conditioning, CMV viremia and severe acute GVHD

Bone Marrow Transplantation

Volumn 49, Issue 12, 2014, Pages 1528-1534

  Uhm, J ^a   Hamad, N ^a   Michelis, F V ^a   Shanavas, M ^a   Kuruvilla, J ^a   Gupta, V ^a   Lipton, J H ^a   Messner, H A ^a   Seftel, M ^a   Kim, D D ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BUSULFAN; CIDOFOVIR; CIPROFLOXACIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; LEFLUNOMIDE; MELPHALAN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; VIRUS DNA;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; BK VIRUS; BK VIRUS INFECTION; COHORT ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE COURSE; DISEASE SEVERITY; DNA DETERMINATION; FEMALE; HEMORRHAGIC CYSTITIS; HLA MATCHING; HUMAN; HUMAN CELL; INCIDENCE; INFECTION RISK; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYELOABLATIVE CONDITIONING; NONHUMAN; OVERALL SURVIVAL; PAIN; POLYMERASE CHAIN REACTION; POSTOPERATIVE PERIOD; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RELAPSE; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SYMPTOM; URINALYSIS; VIREMIA;

EID: 84927177724     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2014.181     Document Type: Conference Paper

References (40)

1. Bedi A, Miller CB, Hanson JL, Goodman S, Ambinder RF, Charache P et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995; 13: 1103-1109.
2. Brugieres L, Hartmann O, Travagli JP, Benhamou E, Pico JL, Valteau D et al. Hemorrhagic cystitis following high-dose chemotherapy and bone marrow transplantation in children with malignancies: incidence, clinical course, and outcome. J Clin Oncol 1989; 7: 194-199.
3. Kloos RQ, Boelens JJ, de Jong TP, Versluys B, Bierings M. Hemorrhagic cystitis in a cohort of pediatric transplantations: incidence, treatment, outcome, and risk factors. Biol Blood Marrow Transplant 2013; 19: 1263-1266.
4. Rorije NM, Shea MM, Satyanarayana G, Hammond SP, Ho VT, Baden LR et al. BK virus disease after allogeneic stem cell transplantation: a cohort analysis. Biol Blood Marrow Transplant 2014; 20: 564-570.
5. Sencer SF, Haake RJ, Weisdorf DJ. Hemorrhagic cystitis after bone marrow transplantation. Risk factors and complications. Transplantation 1993; 56: 875-879.
6. Yang CC, Hurd DD, Case LD, Assimos DG. Hemorrhagic cystitis in bone marrow transplantation. Urology 1994; 44: 322-328.
7. Arthur RR, Shah KV, Baust SJ, Santos GW, Saral R. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. New Engl J Med 1986; 315: 230-234.
8. Erard V, Storer B, Corey L, Nollkamper J, Huang ML, Limaye A et al. BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis. Clin Infect Dis 2004; 39: 1861-1865.
9. Leung AY, Chan M, Kwong YL. Genotyping of the noncoding control region of BK virus in patients with haemorrhagic cystitis after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35: 531-532.
10. Leung AY, Mak R, Lie AK, Yuen KY, Cheng VC, Liang R et al. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant 2002; 29: 509-513.
11. Leung AY, Suen CK, Lie AK, Liang RH, Yuen KY, Kwong YL. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood 2001; 98: 1971-1978.
12. Vogeli TA, Peinemann F, Burdach S, Ackermann R. Urological treatment and clinical course of BK polyomavirus-associated hemorrhagic cystitis in children after bone marrow transplantation. Eur Urol 1999; 36: 252-257.
13. Gardner SD, Field AM, Coleman DV, Hulme B. New human papovavirus (BK) isolated from urine after renal transplantation. Lancet 1971; 1: 1253-1257.
14. Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ et al. Taxonomical developments in the family Polyomaviridae. Arch Virol 2011; 156: 1627-1634.
15. Nickeleit V, Hirsch HH, Zeiler M, Gudat F, Prince O, Thiel G et al. BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game. Nephrol Dial Transplant 2000; 15: 324-332.
16. Chesters PM, Heritage J, McCance DJ. Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 1983; 147: 676-684.
17. Grinnell BW, Padgett BL, Walker DL. Distribution of nonintegrated DNA from JC papovavirus in organs of patients with progressive multifocal leukoencephalo-pathy. J Infect Dis 1983; 147: 669-675.
18. Heritage J, Chesters PM, McCance DJ. The persistence of papovavirus BK DNA sequences in normal human renal tissue. J Med Virol 1981; 8: 143-150.
19. Reploeg MD, Storch GA, Clifford DB. Bk virus: a clinical review. Clin Infect Dis 2001; 33: 191-202.
20. Bennett SM, Broekema NM, Imperiale MJ. BK polyomavirus: emerging pathogen. Microbes Infect 2012; 14: 672-683.
21. Rinaldo CH, Tylden GD, Sharma BN. The human polyomavirus BK (BKPyV): vir-ological background and clinical implications. APMIS 2013; 121: 728-745.
22. Li R, Sharma BN, Linder S, Gutteberg TJ, Hirsch HH, Rinaldo CH. Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells. Virology 2013; 440: 41-50.
23. Giraud G, Bogdanovic G, Priftakis P, Remberger M, Svahn BM, Barkholt L et al. The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen. Haematologica 2006; 91: 401-404.
24. Silva Lde P, Patah PA, Saliba RM, Szewczyk NA, Gilman L, Neumann J et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Haematologica 2010; 95: 1183-1190.
25. Droller MJ, Saral R, Santos G. Prevention of cyclophosphamide-induced hemor-rhagic cystitis. Urology 1982; 20: 256-258.
26. Trotman J, Nivison-Smith I, Dodds A. Haemorrhagic cystitis: incidence and risk factors in a transplant population using hyperhydration. Bone Marrow Transplant 1999; 23: 797-801.
27. Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant 2013; 48: 452-458.
28. Gilis L, Morisset S, Billaud G, Ducastelle-Lepretre S, Labussiere-Wallet H, Nicolini FE et al. High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2014; 49: 664-670.
29. Azzi A, Cesaro S, Laszlo D, Zakrzewska K, Ciappi S, De Santis R et al. Human polyomavirus BK (BKV) load and haemorrhagic cystitis in bone marrow transplantation patients. J Clin Virol 1999; 14: 79-86.
30. Cesaro S, Facchin C, Tridello G, Messina C, Calore E, Biasolo MA et al. A prospective study of BK-virus-associated haemorrhagic cystitis in paediatric patients undergoing allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant 2008; 41: 363-370.
31. Laskin BL, Denburg M, Furth S, Diorio D, Goebel J, Davies SM et al. BK viremia precedes hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2013; 19: 1175-1182.
32. Wong AS, Chan KH, Cheng VC, Yuen KY, Kwong YL, Leung AY. Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 2007; 44: 830-837.
33. Bogdanovic G, Ljungman P, Wang F, Dalianis T. Presence of human polyomavirus DNA in the peripheral circulation of bone marrow transplant patients with and without hemorrhagic cystitis. Bone Marrow Transplant 1996; 17: 573-576.
34. Chan PK, Ip KW, Shiu SY, Chiu EK, Wong MP, Yuen KY. Association between polyomaviruria and microscopic haematuria in bone marrow transplant recipients. J Infect 1994; 29: 139-146.
35. Cottler-Fox M, Lynch M, Deeg HJ, Koss LG. Human polyomavirus: lack of relationship of viruria to prolonged or severe hemorrhagic cystitis after bone marrow transplant. Bone Marrow Transplant 1989; 4: 279-282.
36. Leung AY, Yuen KY, Kwong YL, Polyoma BK. virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm. Bone Marrow Transplant 2005; 36: 929-937.
37. Kroger N, Zabelina T, Kruger W, Renges H, Stute N, Kabisch H et al. Comparison of total body irradiation vs busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients. Bone Marrow Transplant 2001; 27: 349-354.
38. Peinemann F, de Villiers EM, Dorries K, Adams O, Vogeli TA, Burdach S. Clinical course and treatment of haemorrhagic cystitis associated with BK type of human polyomavirus in nine paediatric recipients of allogeneic bone marrow transplants. Eur J Pediatr 2000; 159: 182-188.
39. Seber A, Shu XO, Defor T, Sencer S, Ramsay N. Risk factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant 1999; 23: 35-40.
40. Babel N, Volk HD, Reinke P. BK polyomavirus infection and nephropathy: the virus-immune system interplay. Nat Rev Nephrol 2011; 7: 399-406.